FI920656A - Foerfarande foer framstaellning av disubstituerade urea- och tioureaderivat - Google Patents

Foerfarande foer framstaellning av disubstituerade urea- och tioureaderivat Download PDF

Info

Publication number
FI920656A
FI920656A FI920656A FI920656A FI920656A FI 920656 A FI920656 A FI 920656A FI 920656 A FI920656 A FI 920656A FI 920656 A FI920656 A FI 920656A FI 920656 A FI920656 A FI 920656A
Authority
FI
Finland
Prior art keywords
alkyl
substituted
halogen
independently chosen
substituents independently
Prior art date
Application number
FI920656A
Other languages
English (en)
Other versions
FI920656A0 (fi
Inventor
Paolo Cozzi
Daniele Francelli
Dino Severino
Augusto Chiari
Giancarlo Ghiselli
Original Assignee
Erba Carlo Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB919103446A external-priority patent/GB9103446D0/en
Priority claimed from GB919106961A external-priority patent/GB9106961D0/en
Priority claimed from GB919126322A external-priority patent/GB9126322D0/en
Application filed by Erba Carlo Spa filed Critical Erba Carlo Spa
Publication of FI920656A0 publication Critical patent/FI920656A0/fi
Publication of FI920656A publication Critical patent/FI920656A/fi

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C275/00Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C275/04Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to acyclic carbon atoms
    • C07C275/20Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to acyclic carbon atoms of an unsaturated carbon skeleton
    • C07C275/24Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing six-membered aromatic rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D231/00Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/06Antihyperlipidemics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D233/00Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D249/00Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/081,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D317/00Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/10Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings
    • C07D317/14Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D317/28Radicals substituted by nitrogen atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D319/00Heterocyclic compounds containing six-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D319/041,3-Dioxanes; Hydrogenated 1,3-dioxanes
    • C07D319/061,3-Dioxanes; Hydrogenated 1,3-dioxanes not condensed with other rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D339/00Heterocyclic compounds containing rings having two sulfur atoms as the only ring hetero atoms
    • C07D339/02Five-membered rings
    • C07D339/06Five-membered rings having the hetero atoms in positions 1 and 3, e.g. cyclic dithiocarbonates
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D339/00Heterocyclic compounds containing rings having two sulfur atoms as the only ring hetero atoms
    • C07D339/08Six-membered rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D405/00Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/10Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing aromatic rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Diabetes (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Exhaust Gas Treatment By Means Of Catalyst (AREA)
  • Production Of Liquid Hydrocarbon Mixture For Refining Petroleum (AREA)
  • Solid-Sorbent Or Filter-Aiding Compositions (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Fats And Perfumes (AREA)
  • Treating Waste Gases (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
FI920656A 1991-02-19 1992-02-14 Foerfarande foer framstaellning av disubstituerade urea- och tioureaderivat FI920656A (fi)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB919103446A GB9103446D0 (en) 1991-02-19 1991-02-19 Disubstituted ureas and thioureas derivatives
GB919106961A GB9106961D0 (en) 1991-04-03 1991-04-03 Ureas and thioureas derivatives
GB919126322A GB9126322D0 (en) 1991-12-11 1991-12-11 Antiatherosclerotic disubstituted ureas and thioureas

Publications (2)

Publication Number Publication Date
FI920656A0 FI920656A0 (fi) 1992-02-14
FI920656A true FI920656A (fi) 1992-08-20

Family

ID=27265519

Family Applications (1)

Application Number Title Priority Date Filing Date
FI920656A FI920656A (fi) 1991-02-19 1992-02-14 Foerfarande foer framstaellning av disubstituerade urea- och tioureaderivat

Country Status (19)

Country Link
US (1) US5264441A (fi)
EP (1) EP0500348B1 (fi)
JP (1) JPH04338373A (fi)
KR (1) KR920016416A (fi)
AT (1) ATE122670T1 (fi)
AU (1) AU648143B2 (fi)
CA (1) CA2061447A1 (fi)
DE (1) DE69202491T2 (fi)
DK (1) DK0500348T3 (fi)
ES (1) ES2075610T3 (fi)
FI (1) FI920656A (fi)
GR (1) GR3017065T3 (fi)
HU (1) HUT60259A (fi)
IE (1) IE67966B1 (fi)
IL (1) IL100915A (fi)
MX (1) MX9200665A (fi)
MY (1) MY130090A (fi)
NZ (1) NZ241595A (fi)
RU (1) RU2090555C1 (fi)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9316020D0 (en) * 1993-08-03 1993-09-15 Erba Carlo Spa Urea and thiourea derivatives and process for their preparation
GB9504066D0 (en) * 1995-03-01 1995-04-19 Pharmacia Spa Phosphate derivatives of ureas and thioureas
JP2001526625A (ja) * 1995-11-13 2001-12-18 オールバニ メジカル カレッジ 鎮痛性化合物およびその使用

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4623662A (en) * 1985-05-23 1986-11-18 American Cyanamid Company Antiatherosclerotic ureas and thioureas
US4387105A (en) * 1982-01-26 1983-06-07 American Cyanamid Company Methods of treating atherosclerosis with dialkylureas and dialkylthioureas
US5003106A (en) * 1983-07-19 1991-03-26 American Cyanamid Company Antiatherosclerotic ureas and thioureas
US5015644A (en) * 1987-06-02 1991-05-14 Warner-Lambert Company Antihyperlipidemic and antiatherosclerotic urea and carbamate compounds
IE61716B1 (en) * 1987-06-02 1994-11-30 Warner Lambert Co Antihyperlipidemic and antiatherosclerotic urea compounds
EP0297610B1 (en) * 1987-07-02 1991-03-13 Warner-Lambert Company N-[(2,6-disubstituted)phenyl]-urea and carbamate inhibitors of acyl-CoA:cholesterol acyl-transferase
US5116848A (en) * 1988-03-30 1992-05-26 Warner-Lambert Company N-(((2,6-disubstituted)phenyl)-n-diarylalkyl)ureas as antihyperlipidemic and antiatherosclerotic agents
EP0344425B1 (en) * 1988-03-30 1993-12-08 Warner-Lambert Company N-[[(2,6-disubstituted)phenyl]-N'- arylalkyl] ureas as antihypercholesterolemic and antiatherosclerotic agents
US4868210A (en) * 1988-03-30 1989-09-19 Warner-Lambert Company Antihyperlipidemic and antiatherosclerotic compounds and compositions
GB8827152D0 (en) * 1988-11-21 1988-12-29 Wellcome Found Anti-atherosclerotic diaryl compounds
CA2010184A1 (en) * 1989-02-17 1990-08-17 Bharat K. Trivedi Antihyperlipidemic and antiatherosclerotic trisubstituted urea compounds
AU632809B2 (en) * 1989-05-25 1993-01-14 Takeda Chemical Industries Ltd. Benzocycloalkane benzopyran and benzothiopyran urea derivatives and production thereof
JPH0395153A (ja) * 1989-06-15 1991-04-19 Mitsubishi Kasei Corp ジフェニル尿素誘導体
CA2022346A1 (en) * 1989-08-04 1991-02-05 Mitsubishi Chemical Corporation 1-phenylalkyl-3-phenylurea derivatives
JPH05310678A (ja) * 1990-01-22 1993-11-22 Mitsubishi Kasei Corp 1−フェニルアルキル−3−フェニル尿素誘導体

Also Published As

Publication number Publication date
HU9200425D0 (en) 1992-04-28
IE920507A1 (en) 1992-08-26
RU2090555C1 (ru) 1997-09-20
KR920016416A (ko) 1992-09-24
US5264441A (en) 1993-11-23
DE69202491T2 (de) 1995-10-12
NZ241595A (en) 1994-07-26
DE69202491D1 (de) 1995-06-22
HUT60259A (en) 1992-08-28
EP0500348A1 (en) 1992-08-26
MY130090A (en) 2007-05-31
MX9200665A (es) 1992-08-31
AU1093692A (en) 1992-08-27
AU648143B2 (en) 1994-04-14
JPH04338373A (ja) 1992-11-25
ATE122670T1 (de) 1995-06-15
EP0500348B1 (en) 1995-05-17
CA2061447A1 (en) 1992-08-20
GR3017065T3 (en) 1995-11-30
FI920656A0 (fi) 1992-02-14
IE67966B1 (en) 1996-05-15
IL100915A0 (en) 1992-11-15
IL100915A (en) 1996-03-31
ES2075610T3 (es) 1995-10-01
DK0500348T3 (da) 1995-07-10

Similar Documents

Publication Publication Date Title
NO953305L (no) Antranilsyrederivat
MY101208A (en) Phenyl-piperazine anti-arrhythmia agents.
FI921222A0 (fi) Aminoguanidiner.
NO1997007I1 (no) Mykofenolatmofetil eller et farmasøytisk akseptabelt salt derav
NO179142C (no) 3-benzyliden-1-karbamoyl-2-pyrrolidon-analoger
ES2105099T3 (es) Derivados de imidazopiridina condensados con actividad psicotropica.
DE3781080T2 (de) 2-substituierte-e-kondensierte(1,2,4)triazolo-(1,5-c)pyrimidine, pharmazeutische zubereitungen und ihre verwendung.
NO934792D0 (no) Xantinderivater
KR880002829A (ko) 디하이드로피리딘 항알러지제 및 소염제
DE69004598D1 (de) 6-Amino-6-desoxyfumagillole, ihre Herstellung und ihre Verwendung.
ATE34394T1 (de) Therapeutisch aktive di-, tri-, tetra- und penta- aza-indene.
FI920656A (fi) Foerfarande foer framstaellning av disubstituerade urea- och tioureaderivat
PT87005A (pt) Process for preparing n-phenethylaminoalkyl-benzamide anti-arrhythmic agents
FR2448544A1 (fr) Derives de thiazole et leur application en therapeutique
DE69714709T2 (de) Cyclische amic-säurederivate
DE3781249T2 (de) Einige cycloalka(b)pyrazolo(3,4-d)pyridin-3-on-derivate.
ATE44741T1 (de) 2-(n-substituierte guanidino)-4heteroarylthiazole als mittel gegen geschwuere.
MX9703112A (es) Nitro-benzamidas utiles como agentes antiarritmicos.

Legal Events

Date Code Title Description
FD Application lapsed