FI91636B - Process for the preparation of antibacterial quinoline compounds - Google Patents
Process for the preparation of antibacterial quinoline compoundsInfo
- Publication number
- FI91636B FI91636B FI913697A FI913697A FI91636B FI 91636 B FI91636 B FI 91636B FI 913697 A FI913697 A FI 913697A FI 913697 A FI913697 A FI 913697A FI 91636 B FI91636 B FI 91636B
- Authority
- FI
- Finland
- Prior art keywords
- alkyl
- substituted
- aryl
- preparation
- hydroxy
- Prior art date
Links
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- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
The invention relates to a process for the preparation of antibacterial quinoline-3-carboxylic acids at the 7 position substituted with α amino acid of the formula [see Swedish original for formula] wherein X is CH, CF, CC1, CCF3, COR2 or CNR2R3, Y is H, F, NH2 or OR2, Z is [see Swedish original for formula] R is H, C1-6 alkyl or a cation, R1 is C1-6 alkyl, haloalkyl, wherein the alkyl has 1-4 carbon atoms, vinyl, C3-6 cycloalkyl, aryl or aryl substituted with halogen, hydroxy, amino or C1-4 alkyl, R2 and R3 are each independently hydrogen or C1-4 alkyl, R4 is -(CR2R3)n- NR2R5, wherein n is 0, 1 or 2, R5 is -C(=0)-CH(NH2)-R6, wherein R6 is hydrogen, C1-10 alkyl, C1-10 alkyl substituted with OR2, NR2R3, CO2H, CO2R2, CONR2R3, -CN(=NH)R2R3, SR2, SS-CH2-CH(NH2)-CO2H, CN, aryl or aryl substituted with halogen, hydroxy, amino or C1-4 alkyl, or it is phenyl, p-hydroxyphenyl or when taken together with nitrogen atom of a α amino group trimethylene or trimethylene substituted with hydroxy, for the preparation of optically active isomers or pharmaceutically accepted acid addition salts thereof.
Applications Claiming Priority (6)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US8795087A | 1987-08-21 | 1987-08-21 | |
US8795087 | 1987-08-21 | ||
US07/220,177 US4851418A (en) | 1987-08-21 | 1988-07-20 | Naphthyridine antibacterial agents containing an α-amino acid in the side chain of the 7-substituent |
US22017788 | 1988-07-20 | ||
FI883807A FI90237C (en) | 1987-08-21 | 1988-08-17 | Process for the preparation of pharmacologically active 7- (3-substituted-1-pyrrolidinyl) -1-cyclopropyl-1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylic acid derivative |
FI883807 | 1988-08-17 |
Publications (3)
Publication Number | Publication Date |
---|---|
FI913697A0 FI913697A0 (en) | 1991-08-02 |
FI91636B true FI91636B (en) | 1994-04-15 |
FI91636C FI91636C (en) | 1994-07-25 |
Family
ID=27241291
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
FI913697A FI91636C (en) | 1987-08-21 | 1991-08-02 | Method for preparing antibacterial quinolone compounds |
Country Status (1)
Country | Link |
---|---|
FI (1) | FI91636C (en) |
-
1991
- 1991-08-02 FI FI913697A patent/FI91636C/en not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
FI913697A0 (en) | 1991-08-02 |
FI91636C (en) | 1994-07-25 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
BB | Publication of examined application | ||
MA | Patent expired |