FI91636B - Process for the preparation of antibacterial quinoline compounds - Google Patents

Process for the preparation of antibacterial quinoline compounds

Info

Publication number
FI91636B
FI91636B FI913697A FI913697A FI91636B FI 91636 B FI91636 B FI 91636B FI 913697 A FI913697 A FI 913697A FI 913697 A FI913697 A FI 913697A FI 91636 B FI91636 B FI 91636B
Authority
FI
Finland
Prior art keywords
alkyl
substituted
aryl
preparation
hydroxy
Prior art date
Application number
FI913697A
Other languages
Finnish (fi)
Swedish (sv)
Other versions
FI913697A0 (en
FI91636C (en
Inventor
Joseph Peter Sanchez
Original Assignee
Warner Lambert Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US07/220,177 external-priority patent/US4851418A/en
Application filed by Warner Lambert Co filed Critical Warner Lambert Co
Publication of FI913697A0 publication Critical patent/FI913697A0/en
Application granted granted Critical
Publication of FI91636B publication Critical patent/FI91636B/en
Publication of FI91636C publication Critical patent/FI91636C/en

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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

The invention relates to a process for the preparation of antibacterial quinoline-3-carboxylic acids at the 7 position substituted with α amino acid of the formula [see Swedish original for formula] wherein X is CH, CF, CC1, CCF3, COR2 or CNR2R3, Y is H, F, NH2 or OR2, Z is [see Swedish original for formula] R is H, C1-6 alkyl or a cation, R1 is C1-6 alkyl, haloalkyl, wherein the alkyl has 1-4 carbon atoms, vinyl, C3-6 cycloalkyl, aryl or aryl substituted with halogen, hydroxy, amino or C1-4 alkyl, R2 and R3 are each independently hydrogen or C1-4 alkyl, R4 is -(CR2R3)n- NR2R5, wherein n is 0, 1 or 2, R5 is -C(=0)-CH(NH2)-R6, wherein R6 is hydrogen, C1-10 alkyl, C1-10 alkyl substituted with OR2, NR2R3, CO2H, CO2R2, CONR2R3, -CN(=NH)R2R3, SR2, SS-CH2-CH(NH2)-CO2H, CN, aryl or aryl substituted with halogen, hydroxy, amino or C1-4 alkyl, or it is phenyl, p-hydroxyphenyl or when taken together with nitrogen atom of a α amino group trimethylene or trimethylene substituted with hydroxy, for the preparation of optically active isomers or pharmaceutically accepted acid addition salts thereof.
FI913697A 1987-08-21 1991-08-02 Method for preparing antibacterial quinolone compounds FI91636C (en)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US8795087A 1987-08-21 1987-08-21
US8795087 1987-08-21
US07/220,177 US4851418A (en) 1987-08-21 1988-07-20 Naphthyridine antibacterial agents containing an α-amino acid in the side chain of the 7-substituent
US22017788 1988-07-20
FI883807A FI90237C (en) 1987-08-21 1988-08-17 Process for the preparation of pharmacologically active 7- (3-substituted-1-pyrrolidinyl) -1-cyclopropyl-1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylic acid derivative
FI883807 1988-08-17

Publications (3)

Publication Number Publication Date
FI913697A0 FI913697A0 (en) 1991-08-02
FI91636B true FI91636B (en) 1994-04-15
FI91636C FI91636C (en) 1994-07-25

Family

ID=27241291

Family Applications (1)

Application Number Title Priority Date Filing Date
FI913697A FI91636C (en) 1987-08-21 1991-08-02 Method for preparing antibacterial quinolone compounds

Country Status (1)

Country Link
FI (1) FI91636C (en)

Also Published As

Publication number Publication date
FI913697A0 (en) 1991-08-02
FI91636C (en) 1994-07-25

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