FI912995A0 - ATIATEROSKLEROTISKA OCH ANTIROMBOTISKA 1-BENZOPYRAN-4-ONER OCH 2-AMINO-1,3-BENZOXAZIN-4-ONER. - Google Patents
ATIATEROSKLEROTISKA OCH ANTIROMBOTISKA 1-BENZOPYRAN-4-ONER OCH 2-AMINO-1,3-BENZOXAZIN-4-ONER.Info
- Publication number
- FI912995A0 FI912995A0 FI912995A FI912995A FI912995A0 FI 912995 A0 FI912995 A0 FI 912995A0 FI 912995 A FI912995 A FI 912995A FI 912995 A FI912995 A FI 912995A FI 912995 A0 FI912995 A0 FI 912995A0
- Authority
- FI
- Finland
- Prior art keywords
- oner
- och
- atiaterosklerotiska
- antirombotiska
- benzoxazin
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
- C07D265/04—1,3-Oxazines; Hydrogenated 1,3-oxazines
- C07D265/12—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems
- C07D265/14—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems condensed with one six-membered ring
- C07D265/20—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems condensed with one six-membered ring with hetero atoms directly attached in position 4
- C07D265/22—Oxygen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
- C07D311/22—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Urology & Nephrology (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Vascular Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US28779688A | 1988-12-21 | 1988-12-21 | |
PCT/US1989/005526 WO1990006921A1 (en) | 1988-12-21 | 1989-12-15 | Antiatherosclerotic and antithrombotic 1-benzopyran-4-ones and 2-amino-1,3-benzoxazine-4-ones |
Publications (1)
Publication Number | Publication Date |
---|---|
FI912995A0 true FI912995A0 (en) | 1991-06-19 |
Family
ID=23104392
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
FI912995A FI912995A0 (en) | 1988-12-21 | 1991-06-19 | ATIATEROSKLEROTISKA OCH ANTIROMBOTISKA 1-BENZOPYRAN-4-ONER OCH 2-AMINO-1,3-BENZOXAZIN-4-ONER. |
Country Status (8)
Country | Link |
---|---|
EP (1) | EP0459983A1 (en) |
JP (1) | JPH04502322A (en) |
AU (1) | AU634994B2 (en) |
DK (1) | DK118791D0 (en) |
FI (1) | FI912995A0 (en) |
HU (2) | HUT58310A (en) |
RU (1) | RU2118321C1 (en) |
WO (1) | WO1990006921A1 (en) |
Families Citing this family (36)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH05509302A (en) * | 1990-06-20 | 1993-12-22 | ジ・アップジョン・カンパニー | Antiatherosclerotic and antithrombotic 1-benzopyran-4-ones and 2-amino-1,3-benzoxazin-4-ones |
US5302613A (en) * | 1990-06-29 | 1994-04-12 | The Upjohn Company | Antiatheroscleroic and antithrombotic 2-amino-6-phenyl-4H-pyran-4-ones |
US5252735A (en) * | 1990-06-29 | 1993-10-12 | The Upjohn Company | Antiatherosclerotic and antithrombotic 2-amino-6-phenyl-4H-pyran-4-ones |
AU630822B2 (en) * | 1990-06-29 | 1992-11-05 | Upjohn Company, The | Antiatherosclerotic and antithrombotic 2-amino-6-phenyl-4h-pyran-4-ones |
IL112764A0 (en) * | 1994-03-18 | 1995-05-26 | Ferrer Int | New chromene derivatives |
CA2182932A1 (en) * | 1995-08-10 | 1997-02-11 | Koju Watanabe | Chromone derivative, process for preparing same and pharmaceutical composition |
DE19850131A1 (en) * | 1998-10-30 | 2000-05-04 | Merck Patent Gmbh | Chromenon and chromanone derivatives |
WO2000051992A1 (en) * | 1999-03-04 | 2000-09-08 | E.I. Du Pont De Nemours And Company | Fused bicyclic oxazinone and thiazinone fungicides |
CA2398163C (en) * | 2000-01-24 | 2011-02-22 | Kinacia Pty Ltd. | Therapeutic morpholino-substituted compounds |
GB0119863D0 (en) | 2001-08-14 | 2001-10-10 | Cancer Res Campaign Tech | DNA-PK inhibitors |
GB0119865D0 (en) * | 2001-08-14 | 2001-10-10 | Cancer Res Campaign Tech | DNA-PK inhibitors |
US7049313B2 (en) | 2002-02-25 | 2006-05-23 | Kudos Pharmaceuticals Ltd. | ATM inhibitors |
CA2482041C (en) | 2002-04-17 | 2012-06-05 | Cytokinetics, Inc. | 4-chromanone derivatives for treating cellular proliferative diseases and disorders |
AU2003252025A1 (en) | 2002-07-17 | 2004-02-02 | Cytokinetics, Inc. | Compounds, compositions, and methods |
NZ538420A (en) | 2002-08-16 | 2007-06-29 | Kinacia Pty Ltd | Inhibition of phosphoinositide 3-kinase beta |
CN100430389C (en) * | 2002-08-16 | 2008-11-05 | 阿斯利康(瑞典)有限公司 | Inhibition of phsphoinostide 3-dinase beta |
ATE459359T1 (en) * | 2003-06-06 | 2010-03-15 | Arexis Ab | USE OF CONDENSED HETEROCYCLIC COMPOUNDS AS SCCE INHIBITORS FOR THE TREATMENT OF SKIN CONDITIONS |
CN100518740C (en) * | 2003-06-06 | 2009-07-29 | 阿里克斯股份公司 | Use of heterocyclic compounds as SCCE inhibitors |
KR20060066722A (en) | 2003-08-13 | 2006-06-16 | 쿠도스 파마슈티칼스 리미티드 | Aminopyrones and their use as atm inhibitors |
TR200808208T1 (en) * | 2003-12-09 | 2008-12-22 | The Government Of The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Suppression of an immune response or treatment of a proliferative disease |
TW200616986A (en) | 2004-09-20 | 2006-06-01 | Kudos Pharm Ltd | DNA-pk inhibitors |
EP1848712A1 (en) | 2005-02-09 | 2007-10-31 | Kudos Pharmaceuticals Ltd | Atm inhibitors |
AR054438A1 (en) | 2005-04-15 | 2007-06-27 | Kudos Pharm Ltd | DNA INHIBITORS -PK |
WO2009038064A1 (en) * | 2007-09-19 | 2009-03-26 | Institute Of Medicinal Molecular Design, Inc. | Heterocyclic derivative having inhibitory activity on type-i 11β-hydroxysteroid dehydrogenase |
CN102227417B (en) * | 2008-09-29 | 2015-09-16 | 西特里斯药业公司 | As the chromene keto analog of Sirtuin conditioning agent |
US8399460B2 (en) | 2009-10-27 | 2013-03-19 | Astrazeneca Ab | Chromenone derivatives |
UY34013A (en) | 2011-04-13 | 2012-11-30 | Astrazeneca Ab | ? CHROMENONE COMPOUNDS WITH ANTI-TUMORAL ACTIVITY ?. |
RU2468018C1 (en) * | 2011-10-06 | 2012-11-27 | Федеральное государственное бюджетное образовательное учреждение высшего профессионального образования "Российский университет дружбы народов" (РУДН) | Method of producing 4-oxo-4h-chromene derivatives containing vinyl and enamine groups |
JP6000986B2 (en) * | 2012-01-26 | 2016-10-05 | 第一三共株式会社 | Chromone derivative with bone formation promoting action |
WO2014030688A1 (en) * | 2012-08-24 | 2014-02-27 | 第一三共株式会社 | Chromone derivative having linear side chain |
CN105142629B (en) | 2013-03-04 | 2018-11-23 | 阿斯利康(瑞典)有限公司 | It is treated in combination |
CN108947952B (en) * | 2017-05-24 | 2021-09-21 | 中国医学科学院药物研究所 | 2-substituted amino-5-trifluoromethyl-8-nitrobenz (thio) pyran-4-ketone compound and preparation method and application thereof |
CN108929329B (en) * | 2017-05-24 | 2020-12-11 | 中国医学科学院药物研究所 | 2-azacyclo-5-trifluoromethyl-8-nitrobenz (thio) pyran-4-ones |
AR121719A1 (en) | 2020-04-03 | 2022-06-29 | Petra Pharma Corp | ALLESTERIC INHIBITORS OF CHROMENONE OF PHOSPHOINOSITIDE 3-KINASE (PI3K) FOR THE TREATMENT OF DISEASES |
IL307950A (en) | 2021-05-03 | 2023-12-01 | Petra Pharma Corp | Allosteric chromenone inhibitors of phosphoinositide 3-kinase (pi3k) for the treatment of disease |
BR112023022890A2 (en) | 2021-05-27 | 2024-01-23 | Petra Pharma Corp | ALLOSTERIC PHOSPHOINOSITIDE 3-KINASE (PI3K) CHROMENONE INHIBITORS, PHARMACEUTICAL COMPOSITIONS COMPRISING THEM AND USES THEREOF |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE2205913A1 (en) * | 1972-02-08 | 1973-08-16 | Thiemann Chem Pharm Fab | 2-AMINO-3-HYDROXY-CHROMONE DERIVATIVES, THE PROCESS FOR THEIR MANUFACTURING AND MEDICINAL PRODUCTS CONTAINING THESE COMPOUNDS |
DE2555290A1 (en) * | 1975-12-09 | 1977-06-16 | Boehringer Mannheim Gmbh | NEW BENZOPYRONE DERIVATIVES AND METHOD FOR THEIR PRODUCTION |
US4412071A (en) * | 1982-05-17 | 1983-10-25 | The Upjohn Company | Antiatherosclerotic compositions |
ZA873745B (en) * | 1986-06-04 | 1988-10-26 | Daiichi Seiyaku Co | Benzopyran derivatives |
MA21528A1 (en) * | 1988-04-06 | 1989-12-31 | Lipha | SUBSTITUTE COMPONENTS OF FLAVONOIDE, THEIR SALTS, THEIR MANUFACTURES AND PRODUCTS CONTAINING THESE MATERIALS. |
-
1989
- 1989-12-15 AU AU48071/90A patent/AU634994B2/en not_active Ceased
- 1989-12-15 WO PCT/US1989/005526 patent/WO1990006921A1/en not_active Application Discontinuation
- 1989-12-15 EP EP90900649A patent/EP0459983A1/en not_active Ceased
- 1989-12-15 JP JP2501394A patent/JPH04502322A/en active Pending
- 1989-12-15 HU HU90394A patent/HUT58310A/en unknown
- 1989-12-15 RU SU4895676A patent/RU2118321C1/en active
-
1991
- 1991-06-19 DK DK911187A patent/DK118791D0/en not_active Application Discontinuation
- 1991-06-19 FI FI912995A patent/FI912995A0/en unknown
-
1995
- 1995-06-23 HU HU95P/P00411P patent/HU211339A9/en unknown
Also Published As
Publication number | Publication date |
---|---|
DK118791A (en) | 1991-06-19 |
EP0459983A1 (en) | 1991-12-11 |
JPH04502322A (en) | 1992-04-23 |
HUT58310A (en) | 1992-02-28 |
WO1990006921A1 (en) | 1990-06-28 |
AU634994B2 (en) | 1993-03-11 |
DK118791D0 (en) | 1991-06-19 |
AU4807190A (en) | 1990-07-10 |
HU211339A9 (en) | 1995-11-28 |
RU2118321C1 (en) | 1998-08-27 |
HU900394D0 (en) | 1991-09-30 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
HC | Name/ company changed in application |
Owner name: PHARMACIA & UPJOHN COMPANY |