DK118791D0 - 1-BENZOPYRANE-4-ONER AND 2-AMINO-1,3-BENZOXAZINE-4-ONER, THEIR PREPARATION AND USE, AS OR FOR THE PREPARATION OF MEDICINAL PRODUCTS - Google Patents

1-BENZOPYRANE-4-ONER AND 2-AMINO-1,3-BENZOXAZINE-4-ONER, THEIR PREPARATION AND USE, AS OR FOR THE PREPARATION OF MEDICINAL PRODUCTS

Info

Publication number
DK118791D0
DK118791D0 DK911187A DK118791A DK118791D0 DK 118791 D0 DK118791 D0 DK 118791D0 DK 911187 A DK911187 A DK 911187A DK 118791 A DK118791 A DK 118791A DK 118791 D0 DK118791 D0 DK 118791D0
Authority
DK
Denmark
Prior art keywords
oner
preparation
benzopyrane
benzoxazine
amino
Prior art date
Application number
DK911187A
Other languages
Danish (da)
Other versions
DK118791A (en
Inventor
Ronald B Gammill
Thomas M Judge
Joel Morris
Original Assignee
Upjohn Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Upjohn Co filed Critical Upjohn Co
Publication of DK118791A publication Critical patent/DK118791A/en
Publication of DK118791D0 publication Critical patent/DK118791D0/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D265/04—1,3-Oxazines; Hydrogenated 1,3-oxazines
    • C07D265/12—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems
    • C07D265/14—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D265/20—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems condensed with one six-membered ring with hetero atoms directly attached in position 4
    • C07D265/22—Oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/22—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Urology & Nephrology (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Vascular Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
DK911187A 1988-12-21 1991-06-19 1-BENZOPYRANE-4-ONER AND 2-AMINO-1,3-BENZOXAZINE-4-ONER, THEIR PREPARATION AND USE, AS OR FOR THE PREPARATION OF MEDICINAL PRODUCTS DK118791D0 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US28779688A 1988-12-21 1988-12-21
PCT/US1989/005526 WO1990006921A1 (en) 1988-12-21 1989-12-15 Antiatherosclerotic and antithrombotic 1-benzopyran-4-ones and 2-amino-1,3-benzoxazine-4-ones

Publications (2)

Publication Number Publication Date
DK118791A DK118791A (en) 1991-06-19
DK118791D0 true DK118791D0 (en) 1991-06-19

Family

ID=23104392

Family Applications (1)

Application Number Title Priority Date Filing Date
DK911187A DK118791D0 (en) 1988-12-21 1991-06-19 1-BENZOPYRANE-4-ONER AND 2-AMINO-1,3-BENZOXAZINE-4-ONER, THEIR PREPARATION AND USE, AS OR FOR THE PREPARATION OF MEDICINAL PRODUCTS

Country Status (8)

Country Link
EP (1) EP0459983A1 (en)
JP (1) JPH04502322A (en)
AU (1) AU634994B2 (en)
DK (1) DK118791D0 (en)
FI (1) FI912995A0 (en)
HU (2) HUT58310A (en)
RU (1) RU2118321C1 (en)
WO (1) WO1990006921A1 (en)

Families Citing this family (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH05509302A (en) * 1990-06-20 1993-12-22 ジ・アップジョン・カンパニー Antiatherosclerotic and antithrombotic 1-benzopyran-4-ones and 2-amino-1,3-benzoxazin-4-ones
US5302613A (en) * 1990-06-29 1994-04-12 The Upjohn Company Antiatheroscleroic and antithrombotic 2-amino-6-phenyl-4H-pyran-4-ones
US5252735A (en) * 1990-06-29 1993-10-12 The Upjohn Company Antiatherosclerotic and antithrombotic 2-amino-6-phenyl-4H-pyran-4-ones
AU630822B2 (en) * 1990-06-29 1992-11-05 Upjohn Company, The Antiatherosclerotic and antithrombotic 2-amino-6-phenyl-4h-pyran-4-ones
IL112764A0 (en) * 1994-03-18 1995-05-26 Ferrer Int New chromene derivatives
CA2182932A1 (en) * 1995-08-10 1997-02-11 Koju Watanabe Chromone derivative, process for preparing same and pharmaceutical composition
DE19850131A1 (en) * 1998-10-30 2000-05-04 Merck Patent Gmbh Chromenon and chromanone derivatives
WO2000051992A1 (en) * 1999-03-04 2000-09-08 E.I. Du Pont De Nemours And Company Fused bicyclic oxazinone and thiazinone fungicides
CA2398163C (en) * 2000-01-24 2011-02-22 Kinacia Pty Ltd. Therapeutic morpholino-substituted compounds
GB0119863D0 (en) 2001-08-14 2001-10-10 Cancer Res Campaign Tech DNA-PK inhibitors
GB0119865D0 (en) * 2001-08-14 2001-10-10 Cancer Res Campaign Tech DNA-PK inhibitors
US7049313B2 (en) 2002-02-25 2006-05-23 Kudos Pharmaceuticals Ltd. ATM inhibitors
CA2482041C (en) 2002-04-17 2012-06-05 Cytokinetics, Inc. 4-chromanone derivatives for treating cellular proliferative diseases and disorders
AU2003252025A1 (en) 2002-07-17 2004-02-02 Cytokinetics, Inc. Compounds, compositions, and methods
NZ538420A (en) 2002-08-16 2007-06-29 Kinacia Pty Ltd Inhibition of phosphoinositide 3-kinase beta
CN100430389C (en) * 2002-08-16 2008-11-05 阿斯利康(瑞典)有限公司 Inhibition of phsphoinostide 3-dinase beta
ATE459359T1 (en) * 2003-06-06 2010-03-15 Arexis Ab USE OF CONDENSED HETEROCYCLIC COMPOUNDS AS SCCE INHIBITORS FOR THE TREATMENT OF SKIN CONDITIONS
CN100518740C (en) * 2003-06-06 2009-07-29 阿里克斯股份公司 Use of heterocyclic compounds as SCCE inhibitors
KR20060066722A (en) 2003-08-13 2006-06-16 쿠도스 파마슈티칼스 리미티드 Aminopyrones and their use as atm inhibitors
TR200808208T1 (en) * 2003-12-09 2008-12-22 The Government Of The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Suppression of an immune response or treatment of a proliferative disease
TW200616986A (en) 2004-09-20 2006-06-01 Kudos Pharm Ltd DNA-pk inhibitors
EP1848712A1 (en) 2005-02-09 2007-10-31 Kudos Pharmaceuticals Ltd Atm inhibitors
AR054438A1 (en) 2005-04-15 2007-06-27 Kudos Pharm Ltd DNA INHIBITORS -PK
WO2009038064A1 (en) * 2007-09-19 2009-03-26 Institute Of Medicinal Molecular Design, Inc. Heterocyclic derivative having inhibitory activity on type-i 11β-hydroxysteroid dehydrogenase
CN102227417B (en) * 2008-09-29 2015-09-16 西特里斯药业公司 As the chromene keto analog of Sirtuin conditioning agent
US8399460B2 (en) 2009-10-27 2013-03-19 Astrazeneca Ab Chromenone derivatives
UY34013A (en) 2011-04-13 2012-11-30 Astrazeneca Ab ? CHROMENONE COMPOUNDS WITH ANTI-TUMORAL ACTIVITY ?.
RU2468018C1 (en) * 2011-10-06 2012-11-27 Федеральное государственное бюджетное образовательное учреждение высшего профессионального образования "Российский университет дружбы народов" (РУДН) Method of producing 4-oxo-4h-chromene derivatives containing vinyl and enamine groups
JP6000986B2 (en) * 2012-01-26 2016-10-05 第一三共株式会社 Chromone derivative with bone formation promoting action
WO2014030688A1 (en) * 2012-08-24 2014-02-27 第一三共株式会社 Chromone derivative having linear side chain
CN105142629B (en) 2013-03-04 2018-11-23 阿斯利康(瑞典)有限公司 It is treated in combination
CN108947952B (en) * 2017-05-24 2021-09-21 中国医学科学院药物研究所 2-substituted amino-5-trifluoromethyl-8-nitrobenz (thio) pyran-4-ketone compound and preparation method and application thereof
CN108929329B (en) * 2017-05-24 2020-12-11 中国医学科学院药物研究所 2-azacyclo-5-trifluoromethyl-8-nitrobenz (thio) pyran-4-ones
AR121719A1 (en) 2020-04-03 2022-06-29 Petra Pharma Corp ALLESTERIC INHIBITORS OF CHROMENONE OF PHOSPHOINOSITIDE 3-KINASE (PI3K) FOR THE TREATMENT OF DISEASES
IL307950A (en) 2021-05-03 2023-12-01 Petra Pharma Corp Allosteric chromenone inhibitors of phosphoinositide 3-kinase (pi3k) for the treatment of disease
BR112023022890A2 (en) 2021-05-27 2024-01-23 Petra Pharma Corp ALLOSTERIC PHOSPHOINOSITIDE 3-KINASE (PI3K) CHROMENONE INHIBITORS, PHARMACEUTICAL COMPOSITIONS COMPRISING THEM AND USES THEREOF

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2205913A1 (en) * 1972-02-08 1973-08-16 Thiemann Chem Pharm Fab 2-AMINO-3-HYDROXY-CHROMONE DERIVATIVES, THE PROCESS FOR THEIR MANUFACTURING AND MEDICINAL PRODUCTS CONTAINING THESE COMPOUNDS
DE2555290A1 (en) * 1975-12-09 1977-06-16 Boehringer Mannheim Gmbh NEW BENZOPYRONE DERIVATIVES AND METHOD FOR THEIR PRODUCTION
US4412071A (en) * 1982-05-17 1983-10-25 The Upjohn Company Antiatherosclerotic compositions
ZA873745B (en) * 1986-06-04 1988-10-26 Daiichi Seiyaku Co Benzopyran derivatives
MA21528A1 (en) * 1988-04-06 1989-12-31 Lipha SUBSTITUTE COMPONENTS OF FLAVONOIDE, THEIR SALTS, THEIR MANUFACTURES AND PRODUCTS CONTAINING THESE MATERIALS.

Also Published As

Publication number Publication date
DK118791A (en) 1991-06-19
EP0459983A1 (en) 1991-12-11
JPH04502322A (en) 1992-04-23
HUT58310A (en) 1992-02-28
WO1990006921A1 (en) 1990-06-28
AU634994B2 (en) 1993-03-11
AU4807190A (en) 1990-07-10
HU211339A9 (en) 1995-11-28
FI912995A0 (en) 1991-06-19
RU2118321C1 (en) 1998-08-27
HU900394D0 (en) 1991-09-30

Similar Documents

Publication Publication Date Title
DK118791D0 (en) 1-BENZOPYRANE-4-ONER AND 2-AMINO-1,3-BENZOXAZINE-4-ONER, THEIR PREPARATION AND USE, AS OR FOR THE PREPARATION OF MEDICINAL PRODUCTS
DK267489D0 (en) 1-DEOXY-NOJIRIMYCIN DERIVATIVES, THEIR PREPARATION AND USE AS MEDICINAL PRODUCTS
DK143588A (en) SUBSTITUTED 9-AMINO-TETRAHYDROACRIDINES, THEIR PREPARATION AND USE AS MEDICINAL PRODUCTS
DK298984D0 (en) TETRAHYDROPYRIDAZINONES OR ACID ADDITION SALTS THEREOF, THEIR PREPARATION AND USE AS MEDICINAL PRODUCTS, AND INTERMEDIATES AND THEIR PREPARATION
DK166590A (en) SUBSTITUTED ALLYLAMINE DERIVATIVES, THEIR PREPARATION AND USE AS MEDICINAL PRODUCTS
DK219685D0 (en) HETEROCYCLIC COMPOUNDS, THEIR PREPARATION AND USE AS MEDICINAL PRODUCTS
DK539087D0 (en) 4,5-DIHYDRO- AND 4,5,6,7-TETRAHYDRO-PYRAZOLOOE1,5-AAAPYRIMIDINES, PROCEDURES FOR THEIR PREPARATION AND THEIR USE AS MEDICINES
DK154382A (en) HIS UNKNOWN DERIVATIVES OF 2-PIPERAZINOPYRIMIDINE, PROCEDURES FOR THEIR PREPARATION AND THEIR USE AS MEDICINAL OR MEDICINAL PRODUCTS FOR THE PREPARATION OF MEDICINAL PRODUCTS
DK366888A (en) CASTANOSPERMINESTERS AND GYCOSIDES, THEIR PREPARATION AND USE AS MEDICINAL PRODUCTS
DK349688D0 (en) BOMOLOGIST OF HUMANT APROTININ, HEART STRAINS AND EXPRESSION VECTORS FOR THEIR PREPARATION AND THEIR USE AS MEDICINES
DK303688D0 (en) POLYOXYGENERATED LABORATIVE DERIVATIVES, PROCEDURES FOR THEIR PREPARATION AND THEIR USE AS MEDICINES
DK165985C (en) 1-CYTOSIN DERIVATIVES, PROCEDURES FOR THEIR PREPARATION, AND USE OF THEM IN AND FOR THE PREPARATION OF MEDICINAL PRODUCTS
DK103987D0 (en) SUBSTITUTED 1,3,4,9-TETRAHYDROPYRANOE3,4-BAAINDOL-L-ACETIC ACIDS, THEIR PREPARATION AND USE AS MEDICINAL PRODUCTS
DK144885D0 (en) SUBSTITUTED 4-HYDROXYBENZOPYRANES OR PHARMACEUTICAL ACCEPTABLE ADDITIONAL SALTS THEREOF, THEIR PREPARATION AND USE AS MEDICINAL PRODUCTS
NO863460D0 (en) PROCEDURE FOR THE PREPARATION OF 6-PHENOXYMETHYL-4-HYDROXY-TETRAHYDROPYRAN-2-ON, PROCEDURE FOR THEIR PREPARATION, AND THEIR USE AS MEDICINE, PHARMACEUTICAL AND PREPARATORY PREPARATORY PREPARES.
DK437287D0 (en) 2,3-DIHYDROFURAND DERIVATIVES, THEIR PREPARATION AND THEIR USE AS INTERMEDIATES FOR THE PREPARATION OF TETRAHYDROFURAND DERIVATIVES
DK648389D0 (en) ANTHRACYLIN DERIVATIVES, THEIR PREPARATION AND USE AS MEDICINAL PRODUCTS
DK394085D0 (en) SUBSTITUTED ARYLSULPHONYLGUANIDINES OR ADDITIONAL PRODUCTS THEREOF, THEIR PREPARATION AND USE AS HERBICIDES
DK501888D0 (en) 6-MERCAPTOPURIN DERIVATIVES, THEIR PREPARATION AND USE AS MEDICINAL PRODUCTS
DK343486A (en) DIHYDROQUINOLINON DERIVATIVES, THEIR PREPARATION AND USE OF THE MEDICINAL PRODUCTS AND THE PREPARATION USED IN THE PREPARATION AND THEIR PREPARATION
DK225189A (en) HYDRAZINOCARBONYLOXYLABADANES, PROCEDURES FOR THEIR PREPARATION AND THEIR USE AS MEDICINES
DK111887D0 (en) AROMATIC OMEGA-ALKYLIMINO-TETRAHYDRO-6H-1,3-THIAZIN-6-ON DERIVATIVES, THEIR PREPARATION AND USE AS MEDICINAL PRODUCTS
DK321387D0 (en) CYTORHODINE S-DERIVATIVES, PROCEDURES FOR THEIR PREPARATION AND THEIR USE AS MEDICINES
NO901892L (en) PROCEDURE FOR THE PREPARATION OF (2,1-C) (1,3) -BENZODIAZEPINES AND THEIR USE AS MEDICINES.
DK393585D0 (en) UNYMMETRIC SULPHONYLGUANIDINES OR ACID ADDITION PRODUCTS THEREOF, THEIR PREPARATION AND USE AS HERBICIDES

Legal Events

Date Code Title Description
AHB Application shelved due to non-payment