FI90980B - Förfarande för framställning av N-heterocykliska N-(4-piperidyl)-amider - Google Patents

Förfarande för framställning av N-heterocykliska N-(4-piperidyl)-amider Download PDF

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Publication number
FI90980B
FI90980B FI880452A FI880452A FI90980B FI 90980 B FI90980 B FI 90980B FI 880452 A FI880452 A FI 880452A FI 880452 A FI880452 A FI 880452A FI 90980 B FI90980 B FI 90980B
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FI
Finland
Prior art keywords
piperidyl
formula
compound
compounds
carbon atoms
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Application number
FI880452A
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English (en)
Finnish (fi)
Other versions
FI90980C (sv
FI880452A (sv
FI880452A0 (sv
Inventor
Jerome R Bagley
H Kenneth Spencer
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Boc Inc
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Publication of FI880452A0 publication Critical patent/FI880452A0/sv
Publication of FI880452A publication Critical patent/FI880452A/sv
Application granted granted Critical
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Publication of FI90980C publication Critical patent/FI90980C/sv

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/10—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with radicals containing only carbon and hydrogen atoms attached to ring carbon atoms
    • C07D211/12—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with radicals containing only carbon and hydrogen atoms attached to ring carbon atoms with only hydrogen atoms attached to the ring nitrogen atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P23/00—Anaesthetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P23/00—Anaesthetics
    • A61P23/02—Local anaesthetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/56—Nitrogen atoms
    • C07D211/58—Nitrogen atoms attached in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D211/72—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Anesthesiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)

Claims (3)

1. Förfarande för framställning av en farmaceutisk N-hete-rocyklisk N-(4-piperidyl)amid med formeln 10 ,» y-\ , R1 - C-N —( N — R2 tV_y 15 i vilken formel R är en pyrrolyl, piperidyl, pyrazyl, triazo-lyl, kinolyl, bensisoxazolyl eller bensisotiazolyl, vilka kan vara substituerade eller osubstituerade, varvid substituen-ten/substituenterna är valda ur gruppen bestäende av en halo-20 gen, alkyl, alkoxi, halogeniserad alkyl och alkyltio, väri varje alkylgrupp har 1-7 kolatomer; R1 är en furanyl eller tienyl eller alkoxialkyl, vilka varje alkylgrupp har 1-7 kolatomer; R2 är en fenylalkyl, vilken varje alkylgrupp har 1-7 kolatomer; eller dess farmaceutiskt acceptabla syraadditions-25 salter, kannetecknat av att förfarandet omfattar omsättning av en förening med formeln / \ HN -( N - R2 30 med en förening med formeln 0 , 11 R1—C—X eller (R*C0)20 35 vilka R, R1 och R2 har beteckningar som ovan anförts och X be-tecknar en halid eller dess reaktivt ekvivalent. 90980 33
1 I' .1 Rx-C-X tai (RxC0)20 1 2 joissa R, R ja R :11a on yllä annettu merkitys ja X esittää 35 halidia tai sen reaktiivista ekvivalenttia. Patenttivaatimuksen 1 mukainen menetelmä, tunnettu siitä, että siinä kaavassa substituentti/substituentit hetero-syklisessä renkaassa R ovat halogeeni tai alkyyliryhmä, jos- 40 sa on 1-7 hiiliatomia ja R1 on furanyyli tai tienyyli tai alkoksialkyyli, jossa on 2-6 hiiliatomia. 32
3. Patenttivaatimuksen 2 mukainen menetelmä, tunnettu siitä, että valmistettava yhdiste on N-(2-pyratsyyli)-N-[1-(2-fenyylietyyli)-4-piperidyyli]-2-furamidi tai N-(1-piperidyy-li)-N- [l-(2-fenyylietyyli)-4-piperidyyli]-2-furamidi. 5
2. Förfarande enligt patentkravet 1, kannetecknat av att där i formeln substituenten/substituentema i den hetero-cykliska ringen R är en halogen eller alkylgrupp med 1-7 kol-atomer och R1 är en furanyl eller tienyl eller en alkoxialkyl 5 med 2-6 kolatomer.
3. Förfarande enligt patentkravet 2, kännetecknat av att den framställda föreningen är N-(2-pyrazyl)-N-[1-(2-fenyl-etyl)-4-piperidyl]-2-furamid eller N-(1-piperidyl)-N-[l-(2- 10 fenyletyl)-4-piperidyl]-2-furamid.
FI880452A 1987-02-02 1988-02-01 Förfarande för framställning av N-heterocykliska N-(4-piperidyl)-amider FI90980C (sv)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US07/009,857 US4791112A (en) 1987-02-02 1987-02-02 N-heterocyclic-N-(4-piperidyl)amides and pharmaceutical compositions and methods employing such compounds
US985787 1992-12-04

Publications (4)

Publication Number Publication Date
FI880452A0 FI880452A0 (sv) 1988-02-01
FI880452A FI880452A (sv) 1988-08-03
FI90980B true FI90980B (sv) 1994-01-14
FI90980C FI90980C (sv) 1994-04-25

Family

ID=21740121

Family Applications (1)

Application Number Title Priority Date Filing Date
FI880452A FI90980C (sv) 1987-02-02 1988-02-01 Förfarande för framställning av N-heterocykliska N-(4-piperidyl)-amider

Country Status (13)

Country Link
US (1) US4791112A (sv)
EP (1) EP0277794B1 (sv)
JP (1) JPH0662565B2 (sv)
KR (1) KR900008317B1 (sv)
CN (1) CN88100563A (sv)
AU (1) AU598905B2 (sv)
DE (1) DE3889133T2 (sv)
DK (1) DK49388A (sv)
ES (1) ES2063030T3 (sv)
FI (1) FI90980C (sv)
MX (1) MX9203099A (sv)
NO (1) NO169070C (sv)
NZ (1) NZ223314A (sv)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK623586A (da) * 1985-12-27 1987-06-28 Eisai Co Ltd Piperidinderivater eller salte deraf og farmaceutiske kompositioner indeholdende forbindelserne
DE3784401T2 (de) * 1986-07-31 1993-08-12 Otsuka Pharma Co Ltd Karbostyril-derivate und ihre salze, verfahren zu ihrer herstellung und diese enthaltende kardiotonische zusammensetzung.
CA1305148C (en) * 1987-08-19 1992-07-14 Hiromu Matsumura Carbamoylpyrrolidone derivatives and drugs for senile dementia
USRE34201E (en) * 1989-04-20 1993-03-23 Anaquest, Inc. N-aryl-N-[4-(1-heterocyclicalkyl)piperidinyl]amides and pharmaceutical compositions and methods employing such compounds
JPH0667923B2 (ja) * 1989-05-11 1994-08-31 東洋紡績株式会社 新規なベンゾチアゾール誘導体
FR2662162B1 (fr) * 1990-05-18 1995-01-20 Adir Nouveaux derives de l'amino piperidine, de l'amino pyrrolidine et de l'amino perhydroazepine, leurs procedes de preparation et les compositions pharmaceutiques qui les contiennent.
FR2665898B1 (fr) * 1990-08-20 1994-03-11 Sanofi Derives d'amido-3 pyrazole, procede pour leur preparation et compositions pharmaceutiques les contenant.
US5345554A (en) * 1992-04-17 1994-09-06 Intel Corporation Visual frame buffer architecture
RU2202344C2 (ru) 1998-03-26 2003-04-20 Джапан Тобакко Инк. Антагонисты ноцицептина, производные амида, аналгетик, способ инициирования антагонистического действия к ноцицептину, способ лечения боли, фармацевтические композиции
US6927214B1 (en) 1999-01-15 2005-08-09 Novo Nordisk A/S Non-peptide GLP-1 agonists
US7361666B2 (en) 1999-05-25 2008-04-22 Sepracor, Inc. Heterocyclic analgesic compounds and methods of use thereof
US6635661B2 (en) 2000-05-25 2003-10-21 Sepracor Inc. Heterocyclic analgesic compounds and methods of use thereof
US6677332B1 (en) 1999-05-25 2004-01-13 Sepracor, Inc. Heterocyclic analgesic compounds and methods of use thereof
US6476050B2 (en) 2000-03-14 2002-11-05 Sepracor, Inc. 3-substituted piperidines comprising urea functionality, and methods of use thereof
WO2001092226A1 (en) * 2000-05-25 2001-12-06 Sepracor, Inc. Heterocyclic analgesic compounds and method of use thereof
US7375115B2 (en) * 2001-10-09 2008-05-20 Kyorin Pharmaceutical Co., Ltd. 4-(2-furoyl) aminopiperidines, intermediates in synthesizing the same, process for producing the same and medicinal use of the same
GB0205176D0 (en) * 2002-03-06 2002-04-17 Astrazeneca Ab Chemical compounds
TW200526626A (en) * 2003-09-13 2005-08-16 Astrazeneca Ab Chemical compounds
UA94901C2 (ru) * 2005-02-18 2011-06-25 Астразенека Аб Антибактериальные производные пиперидина
WO2006087548A2 (en) * 2005-02-18 2006-08-24 Astrazeneca Ab Pyrrole derivatives as dna gyrase and topoisomerase inhibitors
CN101171247A (zh) * 2005-03-04 2008-04-30 阿斯利康(瑞典)有限公司 作为dna促旋酶和拓扑异构酶抑制剂的吡咯衍生物
US20090253671A1 (en) * 2005-03-04 2009-10-08 Astrazeneca Ab Tricyclic derivatives of azetidine and pyrrole with antibacterial activity
TW200906412A (en) * 2007-06-12 2009-02-16 Astrazeneca Ab Piperidine compounds and uses thereof
CN106642052A (zh) * 2017-01-05 2017-05-10 郑州坤博科技有限公司 一种流化床锅炉
CN108503579B (zh) * 2018-03-28 2021-03-26 南京医科大学 芬太尼类似物及其应用

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2341965C3 (de) * 1973-08-20 1979-01-25 C.H. Boehringer Sohn, 6507 Ingelheim 4- [N- (o-PyridyD- N-acyl] -aminolphenäthylpiperidine, Verfahren zu deren Herstellung sowie deren Verwendung bei der Bekämpfung von Schmerzzuständen
ZA765684B (en) * 1975-09-23 1978-04-26 Janssen Pharmaceutica Nv Novel n-aryl-n-(1-l-4-piperidinyl)-arylacetamides
US4584303A (en) * 1984-04-09 1986-04-22 The Boc Group, Inc. N-aryl-N-(4-piperidinyl)amides and pharmaceutical compositions and method employing such compounds
US4589303A (en) * 1984-08-24 1986-05-20 Borg-Warner Corporation Continuously variable transmission with synchronous shift
US4546105A (en) * 1984-09-04 1985-10-08 Hoechst-Roussel Pharmaceuticals Inc. Pyrrolylaminopiperidines, compositions thereof and methods of use

Also Published As

Publication number Publication date
CN88100563A (zh) 1988-08-17
NO169070C (no) 1992-05-06
EP0277794A2 (en) 1988-08-10
DK49388A (da) 1988-08-03
NO880443D0 (no) 1988-02-02
AU1114288A (en) 1988-08-04
US4791112A (en) 1988-12-13
JPH0662565B2 (ja) 1994-08-17
FI90980C (sv) 1994-04-25
MX9203099A (es) 1992-07-31
FI880452A (sv) 1988-08-03
NZ223314A (en) 1989-09-27
ES2063030T3 (es) 1995-01-01
KR900008317B1 (en) 1990-11-12
DK49388D0 (da) 1988-02-01
AU598905B2 (en) 1990-07-05
EP0277794A3 (en) 1989-10-25
NO169070B (no) 1992-01-27
FI880452A0 (sv) 1988-02-01
EP0277794B1 (en) 1994-04-20
NO880443L (no) 1988-08-03
DE3889133T2 (de) 1994-08-25
JPS63264460A (ja) 1988-11-01
DE3889133D1 (de) 1994-05-26
KR880009928A (ko) 1988-10-05

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