FI903917A0 - Foerfarande foer framstaellning av med metallradionuklider maerkta proteiner. - Google Patents
Foerfarande foer framstaellning av med metallradionuklider maerkta proteiner.Info
- Publication number
- FI903917A0 FI903917A0 FI903917A FI903917A FI903917A0 FI 903917 A0 FI903917 A0 FI 903917A0 FI 903917 A FI903917 A FI 903917A FI 903917 A FI903917 A FI 903917A FI 903917 A0 FI903917 A0 FI 903917A0
- Authority
- FI
- Finland
- Prior art keywords
- protein
- proteinaceous material
- radionuclide
- reacting
- coupling
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D335/00—Heterocyclic compounds containing six-membered rings having one sulfur atom as the only ring hetero atom
- C07D335/02—Heterocyclic compounds containing six-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
- A61K51/081—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins the protein being an albumin, e.g. human serum albumin [HSA], bovine serum albumin [BSA], ovalbumin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
- A61K51/088—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins conjugates with carriers being peptides, polyamino acids or proteins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
- A61K51/10—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody
- A61K51/1093—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody conjugates with carriers being antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D333/30—Hetero atoms other than halogen
- C07D333/36—Nitrogen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2121/00—Preparations for use in therapy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2123/00—Preparations for testing in vivo
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Physics & Mathematics (AREA)
- Optics & Photonics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Molecular Biology (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
NL8800302 | 1988-02-09 | ||
NL8801728 | 1988-07-08 | ||
NL8802408 | 1988-09-30 | ||
PCT/US1989/000500 WO1989007456A1 (en) | 1988-02-09 | 1989-02-08 | Method of preparing a metal-radionuclide-labelled protein |
Publications (1)
Publication Number | Publication Date |
---|---|
FI903917A0 true FI903917A0 (fi) | 1990-08-08 |
Family
ID=27352196
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
FI903917A FI903917A0 (fi) | 1988-02-09 | 1990-08-08 | Foerfarande foer framstaellning av med metallradionuklider maerkta proteiner. |
Country Status (7)
Country | Link |
---|---|
EP (1) | EP0401302B1 (de) |
AT (1) | ATE124269T1 (de) |
AU (2) | AU635204B2 (de) |
DE (1) | DE68923274T2 (de) |
FI (1) | FI903917A0 (de) |
IL (1) | IL89222A (de) |
WO (1) | WO1989007456A1 (de) |
Families Citing this family (26)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR910700242A (ko) * | 1988-12-22 | 1991-03-14 | 마틴 골드스타인 | 간섭 결합제 및 그 방법 |
FR2650749B1 (fr) * | 1989-08-08 | 1994-09-02 | Univ Rouen | Methode de diagnostic et/ou de traitement, notamment du cancer |
WO1991002547A1 (en) * | 1989-08-24 | 1991-03-07 | Australian Nuclear Science & Technology Organisation | Radio-labelled antibodies for imaging |
WO1991007991A1 (en) * | 1989-11-30 | 1991-06-13 | Mallinckrodt Medical, Inc. | Method for preparing a metal-radionuclide-labelled protein |
EP0485664A1 (de) * | 1990-11-13 | 1992-05-20 | Mallinckrodt Diagnostica (Holland) B.V. | Verfahren zur Herstellung von einem diagnostischen Mittel zur Feststellung von Entzündungen |
EP0498333B1 (de) * | 1991-02-05 | 1997-01-15 | Cis Bio International | Verfahren zur Herstellung einer mit Technetium-99m markierten organspezifischen Substanz |
US5965107A (en) * | 1992-03-13 | 1999-10-12 | Diatide, Inc. | Technetium-99m labeled peptides for imaging |
US5443815A (en) * | 1991-11-27 | 1995-08-22 | Diatech, Inc. | Technetium-99m labeled peptides for imaging |
US5997844A (en) * | 1991-02-08 | 1999-12-07 | Diatide, Inc. | Technetium-99m labeled peptides for imaging |
US7238340B1 (en) | 1991-11-27 | 2007-07-03 | Cis Bio International | Monoamine, diamide, thiol-containing metal chelating agents |
US5849261A (en) * | 1991-02-08 | 1998-12-15 | Diatide, Inc. | Radiolabeled vasoactive intestinal peptides for diagnosis and therapy |
ATE186550T1 (de) * | 1991-04-22 | 1999-11-15 | Mallinckrodt Medical Inc | Verbindungen und pharmazeutische zusammensetzungen zum nachweis und zur lokalisierung von geweben mit neurokinin-1- rezeptoren |
US5783170A (en) * | 1991-11-27 | 1998-07-21 | Diatide, Inc. | Peptide-metal chelate conjugates |
US5403573A (en) * | 1992-04-23 | 1995-04-04 | The Curators Of The University Of Missouri | Radiolabeled protein composition and method for radiation synovectomy |
US5508020A (en) * | 1992-06-05 | 1996-04-16 | Diatech, Inc. | Technetium-99M labeled peptides for imaging |
US5879657A (en) * | 1993-03-30 | 1999-03-09 | The Dupont Merck Pharmaceutical Company | Radiolabeled platelet GPIIb/IIIa receptor antagonists as imaging agents for the diagnosis of thromboembolic disorders |
WO1994025488A1 (en) * | 1993-05-03 | 1994-11-10 | Mallinckrodt Medical, Inc. | Method for preparing a metal-radionuclide-labelled protein |
AU7261994A (en) * | 1993-07-19 | 1995-02-20 | Resolution Pharmaceuticals Inc. | Hydrazino-type radionuclide chelators having an n3s configuration |
US5858327A (en) * | 1993-09-03 | 1999-01-12 | Resolutions Pharmaceuticals, Inc. | Hydrazino-type N2 S2 radionuclide chelating compounds |
US5574140A (en) * | 1993-09-03 | 1996-11-12 | Resolution Pharmaceutical Inc. | Hydrazino-type N2 S2 chelators |
DE19505960A1 (de) * | 1995-02-21 | 1996-08-22 | Deutsches Krebsforsch | Konjugat zur individuellen Dosierung von Arzneimitteln |
US6043256A (en) * | 1996-09-16 | 2000-03-28 | Grassetti; Davide R. | Antimutagenic agents |
KR100367125B1 (ko) * | 1996-12-02 | 2003-08-27 | 그라코 인크. | 패턴제어식분배장치 |
EP2380596A1 (de) | 2010-04-20 | 2011-10-26 | Technische Universität München | Cyclopentapeptid-Derivate und deren Verwendungen |
EP2380597A1 (de) | 2010-04-20 | 2011-10-26 | Technische Universität München | Cyclopeptid-Derivate und deren Verwendungen |
AU2014396468B2 (en) | 2014-06-06 | 2019-02-21 | Technische Universitat Munchen | Modified cyclopentapeptides and uses thereof |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3223585A (en) * | 1965-02-23 | 1965-12-14 | American Cyanamid Co | Pesticidal monosulfur heterocyclic compositions |
JPS5835520B2 (ja) * | 1976-06-01 | 1983-08-03 | 株式会社第一ラジオアイソト−プ研究所 | 6−カルボキシメチルチオコルチゾ−ルおよびその誘導体 |
US4479930A (en) * | 1982-07-26 | 1984-10-30 | Trustees Of The University Of Massachusetts | Amines coupled wth dicyclic dianhydrides capable of being radiolabeled product |
US4652519A (en) * | 1983-02-03 | 1987-03-24 | Yeda Research And Development Company Limited | Bifunctional chelating agents and process for their production |
ATE66469T1 (de) * | 1985-01-14 | 1991-09-15 | Neorx Corp | Metall-radionuklid markiertes protein fuer diagnose und therapie. |
US4678667A (en) * | 1985-07-02 | 1987-07-07 | 501 Regents of the University of California | Macrocyclic bifunctional chelating agents |
US4877868A (en) * | 1986-03-12 | 1989-10-31 | Neorx Corporation | Radionuclide antibody coupling |
-
1989
- 1989-02-08 EP EP89904426A patent/EP0401302B1/de not_active Expired - Lifetime
- 1989-02-08 DE DE68923274T patent/DE68923274T2/de not_active Expired - Fee Related
- 1989-02-08 AU AU33686/89A patent/AU635204B2/en not_active Ceased
- 1989-02-08 WO PCT/US1989/000500 patent/WO1989007456A1/en active IP Right Grant
- 1989-02-08 AT AT89904426T patent/ATE124269T1/de not_active IP Right Cessation
- 1989-02-08 IL IL8922289A patent/IL89222A/en not_active IP Right Cessation
-
1990
- 1990-08-08 FI FI903917A patent/FI903917A0/fi not_active Application Discontinuation
-
1993
- 1993-01-06 AU AU31056/93A patent/AU658959B2/en not_active Ceased
Also Published As
Publication number | Publication date |
---|---|
AU635204B2 (en) | 1993-03-18 |
WO1989007456A1 (en) | 1989-08-24 |
EP0401302A4 (de) | 1994-03-30 |
AU3105693A (en) | 1993-02-25 |
AU3368689A (en) | 1989-09-06 |
ATE124269T1 (de) | 1995-07-15 |
IL89222A0 (en) | 1989-09-10 |
EP0401302A1 (de) | 1990-12-12 |
DE68923274T2 (de) | 1995-11-09 |
AU658959B2 (en) | 1995-05-04 |
IL89222A (en) | 1995-03-30 |
DE68923274D1 (de) | 1995-08-03 |
EP0401302B1 (de) | 1995-06-28 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FD | Application lapsed |
Owner name: MALLINCKRODT, INC. |