FI885679A - Samuttryckning i eukariotiska celler. - Google Patents
Samuttryckning i eukariotiska celler. Download PDFInfo
- Publication number
- FI885679A FI885679A FI885679A FI885679A FI885679A FI 885679 A FI885679 A FI 885679A FI 885679 A FI885679 A FI 885679A FI 885679 A FI885679 A FI 885679A FI 885679 A FI885679 A FI 885679A
- Authority
- FI
- Finland
- Prior art keywords
- interest
- protein
- samuttryckning
- eukariotiska
- celler
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
- C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
- C12N9/6424—Serine endopeptidases (3.4.21)
- C12N9/647—Blood coagulation factors not provided for in a preceding group or according to more than one of the proceeding groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/81—Protease inhibitors
- C07K14/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
- C07K14/811—Serine protease (E.C. 3.4.21) inhibitors
- C07K14/8121—Serpins
- C07K14/8125—Alpha-1-antitrypsin
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/67—General methods for enhancing the expression
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/80—Vectors or expression systems specially adapted for eukaryotic hosts for fungi
- C12N15/81—Vectors or expression systems specially adapted for eukaryotic hosts for fungi for yeasts
- C12N15/815—Vectors or expression systems specially adapted for eukaryotic hosts for fungi for yeasts for yeasts other than Saccharomyces
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
- C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
- C12N9/6424—Serine endopeptidases (3.4.21)
- C12N9/6435—Plasmin (3.4.21.7), i.e. fibrinolysin
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
- C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
- C12N9/6424—Serine endopeptidases (3.4.21)
- C12N9/6456—Plasminogen activators
- C12N9/6459—Plasminogen activators t-plasminogen activator (3.4.21.68), i.e. tPA
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
- C12Y304/21—Serine endopeptidases (3.4.21)
- C12Y304/21007—Plasmin (3.4.21.7), i.e. fibrinolysin
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
- C12Y304/21—Serine endopeptidases (3.4.21)
- C12Y304/21069—Protein C activated (3.4.21.69)
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Zoology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Wood Science & Technology (AREA)
- Biomedical Technology (AREA)
- General Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Biotechnology (AREA)
- Molecular Biology (AREA)
- Microbiology (AREA)
- Medicinal Chemistry (AREA)
- Biophysics (AREA)
- Plant Pathology (AREA)
- Physics & Mathematics (AREA)
- Mycology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Hematology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Production Of Multi-Layered Print Wiring Board (AREA)
- Magnetic Record Carriers (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Compression Or Coding Systems Of Tv Signals (AREA)
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US13037087A | 1987-12-08 | 1987-12-08 | |
US13037087 | 1987-12-08 | ||
US14435788A | 1988-01-15 | 1988-01-15 | |
US14435788 | 1988-01-15 |
Publications (3)
Publication Number | Publication Date |
---|---|
FI885679A0 FI885679A0 (fi) | 1988-12-07 |
FI885679A true FI885679A (fi) | 1989-06-09 |
FI104734B FI104734B (fi) | 2000-03-31 |
Family
ID=26828428
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
FI885679A FI104734B (fi) | 1987-12-08 | 1988-12-07 | Menetelmä plasminogeenin valmistamiseksi |
Country Status (8)
Country | Link |
---|---|
EP (1) | EP0319944B1 (fi) |
AT (1) | ATE111956T1 (fi) |
AU (1) | AU2670688A (fi) |
CA (1) | CA1340740C (fi) |
DE (1) | DE3851613T2 (fi) |
DK (1) | DK684388A (fi) |
ES (1) | ES2059478T3 (fi) |
FI (1) | FI104734B (fi) |
Families Citing this family (28)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5648254A (en) * | 1988-01-15 | 1997-07-15 | Zymogenetics, Inc. | Co-expression in eukaryotic cells |
FR2645174B1 (fr) * | 1989-03-31 | 1994-01-07 | Transgene Sa | Souches de levure ameliorees pour la production de proteines heterologues matures en particulier d'hirudine et procede de preparation d'hirudine correspondant |
US5879926A (en) * | 1989-03-31 | 1999-03-09 | Transgene S.A. | Yeast strains for the production of mature heterologous proteins, especially hirudin |
NL9000917A (nl) * | 1989-10-25 | 1991-05-16 | Holland Biotechnology | Farmaceutisch preparaat met endoproteolytische activiteit; werkwijze voor endoproteolytische processing van (precursor) eiwitten en voor de (micro) biologische bereiding van eiwitten. |
GB8927722D0 (en) * | 1989-12-07 | 1990-02-07 | British Bio Technology | Proteins and nucleic acids |
WO1991009951A2 (en) * | 1989-12-22 | 1991-07-11 | Zymogenetics, Inc. | Recombinant protein c with truncated light chain |
ES2113878T3 (es) * | 1989-12-29 | 1998-05-16 | Zymogenetics Inc | Proteina c hibrida. |
US5358932A (en) * | 1989-12-29 | 1994-10-25 | Zymogenetics, Inc. | Hybrid protein C |
US5116944A (en) * | 1989-12-29 | 1992-05-26 | Neorx Corporation | Conjugates having improved characteristics for in vivo administration |
JPH05506354A (ja) * | 1990-02-09 | 1993-09-22 | ザイモジェネティクス,インコーポレイティド | 端が切り取られた軽鎖を有する活性プロテインc |
EP0477739A3 (en) * | 1990-09-27 | 1992-12-09 | F. Hoffmann-La Roche Ag | Glycosyl-phosphatidylinositol-specific phospholipase d |
ATE158816T1 (de) * | 1990-11-26 | 1997-10-15 | Genetics Inst | Expression von pace in wirtszellen und verfahren zu dessen verwendung |
US5965789A (en) * | 1991-01-11 | 1999-10-12 | American Red Cross | Engineering protein posttranslational modification by PACE/furin in transgenic non-human mammals |
NL9102009A (nl) * | 1991-11-29 | 1993-06-16 | Stichting Katholieke Univ | Produktie van bioactieve peptiden met recombinante cellen. |
US6348327B1 (en) | 1991-12-06 | 2002-02-19 | Genentech, Inc. | Non-endocrine animal host cells capable of expressing variant proinsulin and processing the same to form active, mature insulin and methods of culturing such cells |
JPH08508875A (ja) * | 1992-05-01 | 1996-09-24 | 帝人株式会社 | 蛋白分泌細胞の流加回分培養法 |
US5474914A (en) * | 1992-07-29 | 1995-12-12 | Chiron Corporation | Method of producing secreted CMV glycoprotein H |
DK52293D0 (fi) * | 1993-05-05 | 1993-05-05 | Novo Nordisk As | |
US5639940A (en) | 1994-03-03 | 1997-06-17 | Pharmaceutical Proteins Ltd. | Production of fibrinogen in transgenic animals |
DK0732340T3 (da) * | 1995-03-14 | 2004-10-25 | Akzo Nobel Nv | Ekspression af porcine reproduktions- og respirationssyndromviruspolypeptider i den samme celle |
US5851800A (en) * | 1996-05-14 | 1998-12-22 | Pharmacia & Upjohn Ab | Process for producing a protein |
IL128872A0 (en) * | 1996-09-11 | 2000-01-31 | Ortho Mcneil Pharm Inc | TNF-beta-like protein for treating prostate cancer and related nucleic acid molecules pharmaceutical compositions and methods |
BR9712838A (pt) * | 1996-09-24 | 2000-12-05 | Procter & Gamble | Proteases e suas variantes apresentando inibidores de proteases de peptìdio fundido à elas |
GB2318732A (en) | 1996-11-01 | 1998-05-06 | Johnson & Johnson Medical | Wound healing compositions containing alpha-1-antitrypsin |
EP1012307B1 (de) * | 1997-08-22 | 2005-05-04 | Roche Diagnostics GmbH | Autokatalytisch aktivierbare zymogene vorstufen von proteasen und deren verwendung |
WO2000028065A1 (en) * | 1998-11-06 | 2000-05-18 | Novo Nordisk A/S | Method for the production of fvii |
JP2002531093A (ja) | 1998-12-01 | 2002-09-24 | アベンティス、パストゥール、リミテッド | クラミジア抗原および対応するdna断片ならびにその使用 |
WO2008135498A2 (en) * | 2007-05-04 | 2008-11-13 | Novo Nordisk A/S | Prevention of protein degradation in mammalian cell cultures |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA1207253A (en) * | 1981-08-17 | 1986-07-08 | Lee D. Simon | T4 dna fragment as a stabilizer for proteins expressed by cloned dna |
ATE190461T1 (de) * | 1983-11-02 | 2000-04-15 | Applied Research Systems | Produkte und methoden für die herstellung einer heterodimerer menschlicher lh mit einem met42 val55 alpha untereinheit |
JP2525022B2 (ja) * | 1986-01-03 | 1996-08-14 | ジェネティックス・インスチチュ−ト・インコ−ポレ−テッド | ▲VIII▼:c因子型タンパク質の改良生産方法 |
IL83192A (en) * | 1986-07-18 | 1992-11-15 | Gist Brocades Nv | Method for the preparation of proteins with factor viii activity by microbial host cells;expression vectors,host cells,antibodies |
AU606925B2 (en) * | 1987-01-30 | 1991-02-21 | Biogen, Inc. | A method for producing factor viii in high yield |
CA1331157C (en) * | 1987-04-06 | 1994-08-02 | Randal J. Kaufman | Method for producing factor viii:c-type proteins |
-
1988
- 1988-12-02 CA CA000584774A patent/CA1340740C/en not_active Expired - Lifetime
- 1988-12-07 ES ES88120423T patent/ES2059478T3/es not_active Expired - Lifetime
- 1988-12-07 AT AT88120423T patent/ATE111956T1/de not_active IP Right Cessation
- 1988-12-07 EP EP88120423A patent/EP0319944B1/en not_active Expired - Lifetime
- 1988-12-07 DE DE3851613T patent/DE3851613T2/de not_active Expired - Lifetime
- 1988-12-07 FI FI885679A patent/FI104734B/fi not_active IP Right Cessation
- 1988-12-08 AU AU26706/88A patent/AU2670688A/en not_active Abandoned
- 1988-12-08 DK DK684388A patent/DK684388A/da not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
DK684388A (da) | 1989-08-11 |
DK684388D0 (da) | 1988-12-08 |
EP0319944B1 (en) | 1994-09-21 |
DE3851613D1 (de) | 1994-10-27 |
FI104734B (fi) | 2000-03-31 |
ES2059478T3 (es) | 1994-11-16 |
FI885679A0 (fi) | 1988-12-07 |
ATE111956T1 (de) | 1994-10-15 |
AU2670688A (en) | 1989-06-08 |
DE3851613T2 (de) | 1995-01-19 |
CA1340740C (en) | 1999-09-14 |
EP0319944A2 (en) | 1989-06-14 |
EP0319944A3 (en) | 1990-05-16 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG | Patent granted |
Owner name: ZYMOGENETICS, INC. |
|
MA | Patent expired |