FI873841A - Cis-platina-komplex, foerfarande foer deras framstaellning och dessa foereningar innehaollande farmaceutisk produkt. - Google Patents

Cis-platina-komplex, foerfarande foer deras framstaellning och dessa foereningar innehaollande farmaceutisk produkt. Download PDF

Info

Publication number: FI873841A
Authority: FI; Finland
Prior art keywords: group; hydrogen atom; formula; pharmaceutisk; produkt
Prior art date: 1986-09-08

Application number

FI873841A

Other languages

English (en)

Other versions

FI86304B (fi

FI873841A0 (fi

FI86304C (fi

Inventor

Cenek Kolar

Konrad Dehmel

Hans Peter Kraemer

Original Assignee

Behringwerke Ag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1986-09-08

Filing date

1987-09-04

Publication date

1988-03-09

1987-09-04 Application filed by Behringwerke Ag filed Critical Behringwerke Ag

1987-09-04 Publication of FI873841A0 publication Critical patent/FI873841A0/fi

1988-03-09 Publication of FI873841A publication Critical patent/FI873841A/fi

1992-04-30 Publication of FI86304B publication Critical patent/FI86304B/fi

1992-08-10 Application granted granted Critical

1992-08-10 Publication of FI86304C publication Critical patent/FI86304C/fi

Links

125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 5
125000000217 alkyl group Chemical group 0.000 abstract 3
125000004432 carbon atom Chemical group C* 0.000 abstract 3
125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 3
125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 abstract 2
150000001875 compounds Chemical class 0.000 abstract 2
125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 2
QZTKDVCDBIDYMD-UHFFFAOYSA-N 2,2'-[(2-amino-2-oxoethyl)imino]diacetic acid Chemical compound NC(=O)CN(CC(O)=O)CC(O)=O QZTKDVCDBIDYMD-UHFFFAOYSA-N 0.000 abstract 1
QTBSBXVTEAMEQO-UHFFFAOYSA-M Acetate Chemical compound CC([O-])=O QTBSBXVTEAMEQO-UHFFFAOYSA-M 0.000 abstract 1
CPELXLSAUQHCOX-UHFFFAOYSA-M Bromide Chemical compound [Br-] CPELXLSAUQHCOX-UHFFFAOYSA-M 0.000 abstract 1
BVKZGUZCCUSVTD-UHFFFAOYSA-L Carbonate Chemical compound [O-]C([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-L 0.000 abstract 1
VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 abstract 1
229910002651 NO3 Inorganic materials 0.000 abstract 1
NHNBFGGVMKEFGY-UHFFFAOYSA-N Nitrate Chemical compound [O-][N+]([O-])=O NHNBFGGVMKEFGY-UHFFFAOYSA-N 0.000 abstract 1
229930182473 O-glycoside Natural products 0.000 abstract 1
150000008444 O-glycosides Chemical class 0.000 abstract 1
QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 abstract 1
DTQVDTLACAAQTR-UHFFFAOYSA-M Trifluoroacetate Chemical compound [O-]C(=O)C(F)(F)F DTQVDTLACAAQTR-UHFFFAOYSA-M 0.000 abstract 1
125000003545 alkoxy group Chemical group 0.000 abstract 1
229910052799 carbon Inorganic materials 0.000 abstract 1
SUSAGCZZQKACKE-UHFFFAOYSA-N cyclobutane-1,2-dicarboxylic acid Chemical compound OC(=O)C1CCC1C(O)=O SUSAGCZZQKACKE-UHFFFAOYSA-N 0.000 abstract 1
239000003814 drug Substances 0.000 abstract 1
XMBWDFGMSWQBCA-UHFFFAOYSA-N hydrogen iodide Chemical compound I XMBWDFGMSWQBCA-UHFFFAOYSA-N 0.000 abstract 1
125000004029 hydroxymethyl group Chemical group [H]OC([H])([H])* 0.000 abstract 1
125000001570 methylene group Chemical group [H]C([H])([*:1])[*:2] 0.000 abstract 1
150000007524 organic acids Chemical class 0.000 abstract 1
-1 oxalic Chemical class 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H23/00—Compounds containing boron, silicon, or a metal, e.g. chelates, vitamin B12
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C247/00—Compounds containing azido groups
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F15/00—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table
- C07F15/0006—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table compounds of the platinum group
- C07F15/0086—Platinum compounds
- C07F15/0093—Platinum compounds without a metal-carbon linkage

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Biotechnology (AREA)
Engineering & Computer Science (AREA)
Molecular Biology (AREA)
Genetics & Genomics (AREA)
Biochemistry (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Animal Behavior & Ethology (AREA)
Chemical Kinetics & Catalysis (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

FI873841A 1986-09-08 1987-09-04 Foerfarande foer framstaellning av terapeutiskt anvaendbara cis-platinadiaminkomplex. FI86304C (fi)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
DE3630497		1986-09-08
DE19863630497 DE3630497A1 (de)	1986-09-08	1986-09-08	Cis-platin-komplexe, verfahren zu ihrer herstellung und diese verbindungen enthaltende pharmazeutische mittel

Publications (4)

Publication Number	Publication Date
FI873841A0 FI873841A0 (fi)	1987-09-04
FI873841A true FI873841A (fi)	1988-03-09
FI86304B FI86304B (fi)	1992-04-30
FI86304C FI86304C (fi)	1992-08-10

Family

ID=6309120

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
FI873841A FI86304C (fi)	1986-09-08	1987-09-04	Foerfarande foer framstaellning av terapeutiskt anvaendbara cis-platinadiaminkomplex.

Country Status (15)

Country	Link
US (1)	US5091521A (fi)
EP (1)	EP0263956B1 (fi)
JP (1)	JPS6368546A (fi)
AT (1)	ATE68500T1 (fi)
AU (1)	AU611394B2 (fi)
CA (1)	CA1313655C (fi)
DE (2)	DE3630497A1 (fi)
DK (1)	DK168387B1 (fi)
ES (1)	ES2039220T3 (fi)
FI (1)	FI86304C (fi)
GR (1)	GR3003522T3 (fi)
MX (1)	MX8132A (fi)
NO (1)	NO174055C (fi)
PT (1)	PT85655B (fi)
ZA (1)	ZA876619B (fi)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
AU593608B2 (en) *	1986-10-07	1990-02-15	Board Of Regents, The University Of Texas System	Hydrophobic CIS-platinum complexes efficiently incorporated into liposomes
EP0290280B1 (en) *	1987-05-08	1994-01-19	Sankyo Company Limited	Anti-tumor platinum complexes, their preparation and their therapeutic use
US4956459A (en) *	1987-07-17	1990-09-11	Georgetown University	Platinum compounds suitable for use as pharmaceuticals
IT1216687B (it) *	1988-04-01	1990-03-08	Boehringer Biochemia Srl	Complessi di platino (ii), loro preparazione e impiego come antitumorali.
DE3834098A1 (de) *	1988-10-07	1990-04-19	Behringwerke Ag	Cis-platin-komplexe mit einem 1,3-diaminopropan-derivat als liganden, verfahren zu ihrer herstellung und diese verbindung enthaltende pharmazeutische mittel
US5871710A (en) *	1992-09-04	1999-02-16	The General Hospital Corporation	Graft co-polymer adducts of platinum (II) compounds
WO1996000079A1 (en) *	1994-06-27	1996-01-04	The General Hospital Corporation	Graft co-polymer adducts of platinum (ii) compounds
US5760480A (en) *	1995-09-20	1998-06-02	Advanced Micro Devics, Inc.	Low RC interconnection
US6235782B1 (en)	1998-11-12	2001-05-22	Rifat Pamukcu	Method for treating a patient with neoplasia by treatment with a platinum coordination complex
US6235776B1 (en)	1998-11-12	2001-05-22	Cell Pathways, Inc.	Method for treating a patient with neoplasia by treatment with a paclitaxel derivative
WO2006091790A1 (en) *	2005-02-23	2006-08-31	Xenoport, Inc.	Platinum-containing compounds exhibiting cytostatic activity, synthesis and methods of use
JP5579618B2 (ja) *	2007-12-07	2014-08-27	プラナバイオテクノロジーリミティッド	治療および診断用化合物
RU2538199C2 (ru)	2009-02-04	2015-01-10	Дзе Бригхэм Энд Вимен'З Хоспитэл, Инк.	Наносоединения платины и способы их применения
ES2588979T3 (es)	2010-08-24	2016-11-08	Dana-Farber Cancer Institute, Inc.	Procedimientos para la predicción de una respuesta contra el cáncer
WO2012174378A2 (en)	2011-06-17	2012-12-20	Myriad Genetics, Inc.	Methods and materials for assessing allelic imbalance
ES2759533T5 (es)	2011-12-21	2023-06-22	Myriad Genetics Inc	Métodos y materiales para evaluar la pérdida de heterocigosidad
CA3080441A1 (en)	2012-02-23	2013-09-06	The Children's Hospital Corporation	Methods for predicting anti-cancer response
EP2859118B1 (en)	2012-06-07	2017-11-22	Institut Curie	Methods for detecting inactivation of the homologous recombination pathway (brca1/2) in human tumors
WO2014160080A1 (en)	2013-03-14	2014-10-02	Children's Medical Center Corporation	Cancer diagnosis, treatment selection and treatment
CA2931181C (en)	2013-12-09	2023-01-24	Institut Curie	Methods for detecting inactivation of the homologous recombination pathway (brca1/2) in human tumors
ES2946251T3 (es)	2014-08-15	2023-07-14	Myriad Genetics Inc	Métodos y materiales para evaluar la deficiencia de recombinación homóloga

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
NL7807334A (nl) *	1978-07-06	1980-01-08	Tno	Platina-diaminecomplexen, werkwijze voor het bereiden daarvan, werkwijze voor het bereiden van een genees- middel met toepassing van een dergelijk platina-dia- minecomplex voor de behandeling van kanker, alsmede al- dus verkregen gevormd geneesmiddel.
NL8204067A (nl) *	1982-10-21	1984-05-16	Tno	Platina-diaminecomplexen, werkwijze voor het bereiden daarvan, werkwijze voor het bereiden van een geneesmiddel met toepassing van een dergelijk platinadiaminecomplex voor de behandeling van kanker, alsmede aldus verkregen gevormd geneesmiddel.
US4500465A (en) *	1982-06-28	1985-02-19	Engelhard Corporation	Solubilized platinum (II) complexes
DE3503620A1 (de) *	1984-06-30	1986-01-23	Hoechst Ag, 6230 Frankfurt	Verfahren zur herstellung von 1-azidoaldosen
DE3432320A1 (de) *	1984-09-03	1986-03-13	Behringwerke Ag, 3550 Marburg	Cis-platin-komplexe mit einem pentaerythritderivat als liganden, verfahren zu ihrer herstellung und diese verbindungen enthaltendes pharmazeutisches mittel
JPS6259294A (ja) *	1985-09-09	1987-03-14	Ajinomoto Co Inc	白金錯体および抗腫瘍剤
US4760157A (en) *	1986-01-31	1988-07-26	American Cyanamid Company	(2,2,-bis(aminomethyl)-1,3-propanediol-N,N')platinum complexes

1986
- 1986-09-08 DE DE19863630497 patent/DE3630497A1/de not_active Withdrawn
1987
- 1987-09-02 EP EP87112768A patent/EP0263956B1/de not_active Expired - Lifetime
- 1987-09-02 ES ES198787112768T patent/ES2039220T3/es not_active Expired - Lifetime
- 1987-09-02 AT AT87112768T patent/ATE68500T1/de not_active IP Right Cessation
- 1987-09-02 DE DE8787112768T patent/DE3773829D1/de not_active Expired - Lifetime
- 1987-09-04 FI FI873841A patent/FI86304C/fi not_active IP Right Cessation
- 1987-09-04 CA CA000546144A patent/CA1313655C/en not_active Expired - Fee Related
- 1987-09-04 ZA ZA876619A patent/ZA876619B/xx unknown
- 1987-09-07 NO NO873721A patent/NO174055C/no unknown
- 1987-09-07 PT PT85655A patent/PT85655B/pt not_active IP Right Cessation
- 1987-09-07 DK DK464787A patent/DK168387B1/da active
- 1987-09-07 AU AU78103/87A patent/AU611394B2/en not_active Ceased
- 1987-09-07 MX MX813287A patent/MX8132A/es unknown
- 1987-09-07 JP JP62222163A patent/JPS6368546A/ja active Pending
1990
- 1990-08-28 US US07/576,185 patent/US5091521A/en not_active Expired - Fee Related
1992
- 1992-01-08 GR GR910401654T patent/GR3003522T3/el unknown

Also Published As

Publication number	Publication date
NO174055B (no)	1993-11-29
NO174055C (no)	1994-03-09
AU7810387A (en)	1988-03-10
PT85655B (pt)	1990-05-31
FI86304B (fi)	1992-04-30
FI873841A0 (fi)	1987-09-04
DE3773829D1 (de)	1991-11-21
ES2039220T3 (es)	1993-09-16
CA1313655C (en)	1993-02-16
JPS6368546A (ja)	1988-03-28
DK168387B1 (da)	1994-03-21
EP0263956A3 (en)	1988-10-05
NO873721D0 (no)	1987-09-07
PT85655A (de)	1987-10-01
ATE68500T1 (de)	1991-11-15
NO873721L (no)	1988-03-09
EP0263956A2 (de)	1988-04-20
DE3630497A1 (de)	1988-03-10
AU611394B2 (en)	1991-06-13
DK464787A (da)	1988-03-09
GR3003522T3 (fi)	1993-03-16
EP0263956B1 (de)	1991-10-16
FI86304C (fi)	1992-08-10
US5091521A (en)	1992-02-25
MX8132A (es)	1994-02-28
DK464787D0 (da)	1987-09-07
ZA876619B (en)	1988-04-27

Legal Events

Date	Code	Title	Description
1995-04-18	MM	Patent lapsed
2004-08-31	MM	Patent lapsed	Owner name: BEHRINGWERKE AKTIENGESELLSCHAFT

Publication	Publication Date	Title
FI873841A (fi)	1988-03-09	Cis-platina-komplex, foerfarande foer deras framstaellning och dessa foereningar innehaollande farmaceutisk produkt.
PT72305A (de)	1981-02-01	Neue sulfonamide verfahren zu deren herstellung sowie diese verbindungen enthaltende arzneimittel
FI812158L (fi)	1982-01-10	Foerfarande foer framstaellning av terapeutiskt aktiva foereningar och mellanprodukt foer framstaellning av dessa
DE3571240D1 (en)	1989-08-03	Cis-platinum-complexes having a pentaerythritol derivative as ligand, process for their preparation and pharmaceutical agent containing these compounds
KR960022553A (ko)	1996-07-18	신규한 에리스로마이신 유도체, 그의 제조 방법 및 의약으로서의 용도
RU2001102262A (ru)	2003-01-20	Нитроэфиры и нитратные соли специфических лекарственных средств
ATE108440T1 (de)	1994-07-15	Arylaralkylether, verfahren zu deren herstellung und diese enthaltende pharmazeutische zusammensetzung.
JPS6431752A (en)	1989-02-02	Amide derivative and skin external preparation containing said derivative
ES8702379A1 (es)	1986-12-16	Un procedimiento para la produccion de 1h-tetrazol-5-carboxamidas-n-sustituidas.
ATE156803T1 (de)	1997-08-15	Substituierte 1,1,2,-triphenylbutene und ihre verwendung zur behandlung und diagnose von krebs
JPS56120669A (en)	1981-09-22	Allophanoylpiperazine compound and analgesic agent containing the same as active constituent
JPS5340742A (en)	1978-04-13	Prostagilandin analogues, their preparation and medical composition containing the same as active constituents
ATE19871T1 (de)	1986-06-15	Derivate von biologisch aktiven phenolverbindungen und diese enthaltende pharmazeutische komposition.
RU2053228C1 (ru)	1996-01-27	Производные пептидов, способ их получения, фармацевтическая композиция, ингибирующая эластазу человеческих лейкоцитов
DK574083A (da)	1985-06-14	3-aminopropoxyphenylderivater
ES420717A1 (es)	1977-03-01	Procedimiento para la obtencion de dibenzazecinas.
FR2550189B1 (fr)	1986-03-28	Nouveaux derives acetyleniques possedant une activite d'inhibiteurs d'enzyme, leur preparation et leur application comme medicament
FI824061A0 (fi)	1982-11-25	Foerfarande foer framstaellning av nya 3'''-dehydro-kardenolid-tridigitoxosidoximer och anvaendning dem som laekemedel