FI863488A - Foereningar. - Google Patents

Foereningar. Download PDF

Info

Publication number: FI863488A
Authority: FI; Finland
Prior art keywords: alkyl; phenyl; hydrogen; group; atoms
Prior art date: 1985-08-31

Application number

FI863488A

Other languages

English (en)

Other versions

FI87205C (fi

FI863488A0 (fi

FI87205B (fi

Inventor

Roger Charles Brown

David Hulme Robinson

John Dixon

Original Assignee

Fisons Plc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1985-08-31

Filing date

1986-08-28

Publication date

1987-03-01

1985-08-31 Priority claimed from GB858521697A external-priority patent/GB8521697D0/en

1985-10-09 Priority claimed from GB858524932A external-priority patent/GB8524932D0/en

1985-12-06 Priority claimed from GB858530143A external-priority patent/GB8530143D0/en

1986-04-22 Priority claimed from GB868609793A external-priority patent/GB8609793D0/en

1986-05-17 Priority claimed from GB868612060A external-priority patent/GB8612060D0/en

1986-08-28 Application filed by Fisons Plc filed Critical Fisons Plc

1986-08-28 Publication of FI863488A0 publication Critical patent/FI863488A0/fi

1987-02-09 Priority claimed from SU874202059A external-priority patent/RU1804458C/ru

1987-03-01 Publication of FI863488A publication Critical patent/FI863488A/fi

1992-08-31 Application granted granted Critical

1992-08-31 Publication of FI87205B publication Critical patent/FI87205B/fi

1992-12-10 Publication of FI87205C publication Critical patent/FI87205C/fi

Links

125000000217 alkyl group Chemical group 0.000 abstract 6
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 5
229910052739 hydrogen Inorganic materials 0.000 abstract 4
239000001257 hydrogen Substances 0.000 abstract 4
229910052760 oxygen Inorganic materials 0.000 abstract 4
229910052717 sulfur Inorganic materials 0.000 abstract 4
125000004429 atom Chemical group 0.000 abstract 2
150000001875 compounds Chemical class 0.000 abstract 2
125000000623 heterocyclic group Chemical group 0.000 abstract 2
150000002431 hydrogen Chemical group 0.000 abstract 2
125000003884 phenylalkyl group Chemical group 0.000 abstract 2
125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 2
125000002373 5 membered heterocyclic group Chemical group 0.000 abstract 1
125000004070 6 membered heterocyclic group Chemical group 0.000 abstract 1
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
206010020772 Hypertension Diseases 0.000 abstract 1
-1 NR4R5 Chemical group 0.000 abstract 1
125000003545 alkoxy group Chemical group 0.000 abstract 1
150000001408 amides Chemical class 0.000 abstract 1
125000000753 cycloalkyl group Chemical group 0.000 abstract 1
OFDNQWIFNXBECV-VFSYNPLYSA-N dolastatin 10 Chemical compound CC(C)[C@H](N(C)C)C(=O)N[C@@H](C(C)C)C(=O)N(C)[C@@H]([C@@H](C)CC)[C@H](OC)CC(=O)N1CCC[C@H]1[C@H](OC)[C@@H](C)C(=O)N[C@H](C=1SC=CN=1)CC1=CC=CC=C1 OFDNQWIFNXBECV-VFSYNPLYSA-N 0.000 abstract 1
150000002148 esters Chemical class 0.000 abstract 1
229910052736 halogen Inorganic materials 0.000 abstract 1
150000002367 halogens Chemical class 0.000 abstract 1
125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
238000004519 manufacturing process Methods 0.000 abstract 1
150000002825 nitriles Chemical class 0.000 abstract 1
125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
125000004430 oxygen atom Chemical group O* 0.000 abstract 1
239000008194 pharmaceutical composition Substances 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
125000004434 sulfur atom Chemical group 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D253/00—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00
- C07D253/02—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00 not condensed with other rings
- C07D253/06—1,2,4-Triazines
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D271/00—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms
- C07D271/02—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms not condensed with other rings
- C07D271/10—1,3,4-Oxadiazoles; Hydrogenated 1,3,4-oxadiazoles
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D285/00—Heterocyclic compounds containing rings having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by groups C07D275/00 - C07D283/00
- C07D285/01—Five-membered rings
- C07D285/02—Thiadiazoles; Hydrogenated thiadiazoles
- C07D285/04—Thiadiazoles; Hydrogenated thiadiazoles not condensed with other rings
- C07D285/12—1,3,4-Thiadiazoles; Hydrogenated 1,3,4-thiadiazoles
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D285/00—Heterocyclic compounds containing rings having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by groups C07D275/00 - C07D283/00
- C07D285/01—Five-membered rings
- C07D285/02—Thiadiazoles; Hydrogenated thiadiazoles
- C07D285/04—Thiadiazoles; Hydrogenated thiadiazoles not condensed with other rings
- C07D285/12—1,3,4-Thiadiazoles; Hydrogenated 1,3,4-thiadiazoles
- C07D285/125—1,3,4-Thiadiazoles; Hydrogenated 1,3,4-thiadiazoles with oxygen, sulfur or nitrogen atoms, directly attached to ring carbon atoms, the nitrogen atoms not forming part of a nitro radical
- C07D285/135—Nitrogen atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D285/00—Heterocyclic compounds containing rings having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by groups C07D275/00 - C07D283/00
- C07D285/15—Six-membered rings
- C07D285/16—Thiadiazines; Hydrogenated thiadiazines
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
- C07K5/022—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2
- C07K5/0222—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2 with the first amino acid being heterocyclic, e.g. Pro, Trp
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06086—Dipeptides with the first amino acid being basic
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Molecular Biology (AREA)
Genetics & Genomics (AREA)
Biophysics (AREA)
Biochemistry (AREA)
Veterinary Medicine (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Public Health (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Heart & Thoracic Surgery (AREA)
Cardiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Plural Heterocyclic Compounds (AREA)
Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Peptides Or Proteins (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Oscillators With Electromechanical Resonators (AREA)

FI863488A 1985-08-31 1986-08-28 Foerfarande foer framstaellning av farmakologiskt anvaendbara foereningar FI87205C (fi)

Applications Claiming Priority (12)

Application Number	Priority Date	Filing Date	Title
GB858521697A GB8521697D0 (en)	1985-08-31	1985-08-31	Nitrogen & sulphur heterocycles
GB8521697		1985-08-31
GB8524932		1985-10-09
GB858524932A GB8524932D0 (en)	1985-10-09	1985-10-09	Nitrogen & sulphur heterocycles
GB858530143A GB8530143D0 (en)	1985-12-06	1985-12-06	Nitrogen
GB8530143		1985-12-06
GB8609793		1986-04-22
GB868609793A GB8609793D0 (en)	1986-04-22	1986-04-22	Nitrogen containing heterocycles
GB8612060		1986-05-17
GB868612060A GB8612060D0 (en)	1986-05-17	1986-05-17	Nitrogen containing heterocycles
SU4202059		1987-02-09
SU874202059A RU1804458C (ru)	1985-08-31	1987-02-09	Способ получени производных 1,3,4-тиадиазол-2-карбоновых кислот или их фармацевтически приемлемых солей, сложных эфиров или амидов

Publications (4)

Publication Number	Publication Date
FI863488A0 FI863488A0 (fi)	1986-08-28
FI863488A true FI863488A (fi)	1987-03-01
FI87205B FI87205B (fi)	1992-08-31
FI87205C FI87205C (fi)	1992-12-10

Family

ID=27546912

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
FI863488A FI87205C (fi)	1985-08-31	1986-08-28	Foerfarande foer framstaellning av farmakologiskt anvaendbara foereningar

Country Status (19)

Country	Link
US (1)	US4927822A (fi)
EP (1)	EP0217519B1 (fi)
JP (1)	JPH0788365B2 (fi)
KR (1)	KR940009528B1 (fi)
AT (1)	ATE72431T1 (fi)
AU (1)	AU591165B2 (fi)
BE (1)	BE905351A (fi)
CA (1)	CA1305286C (fi)
CH (1)	CH671397A5 (fi)
DK (1)	DK406386A (fi)
FI (1)	FI87205C (fi)
FR (1)	FR2586679B1 (fi)
GR (1)	GR862234B (fi)
IE (1)	IE59432B1 (fi)
IL (1)	IL79841A (fi)
LU (1)	LU86569A1 (fi)
NO (1)	NO166180C (fi)
NZ (1)	NZ217398A (fi)
PT (1)	PT83277B (fi)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
PT87616B (pt) *	1987-06-24	1992-09-30	Smithkline Beecham Corp	Processo de preparacao de antagonistas do leucotrieno e de composicoes farmaceuticas
GB8825541D0 (en) *	1988-11-01	1988-12-07	Fisons Plc	Formulation
WO1994020460A1 (en) *	1993-03-11	1994-09-15	Smithkline Beecham Corporation	Chemical compounds
EP1454903B9 (en)	2001-12-11	2011-10-05	Kyowa Hakko Kirin Co., Ltd.	Thiadiazoline derivatives for treating cancer
US7851635B2 (en) *	2003-04-18	2010-12-14	Kyowa Hakko Kirin Co., Ltd.	Mitotic kinesin inhibitor
WO2004111023A1 (ja) *	2003-06-10	2004-12-23	Kyowa Hakko Kogyo Co., Ltd.	チアジアゾリン－１－オキシド誘導体
AU2004247551A1 (en) *	2003-06-10	2004-12-23	Fuji Photo Film Co., Ltd.	Thiadiazoline derivative
WO2005035512A1 (ja) *	2003-10-10	2005-04-21	Kyowa Hakko Kogyo Co., Ltd.	チアジアゾリン誘導体
US7449486B2 (en) *	2004-10-19	2008-11-11	Array Biopharma Inc.	Mitotic kinesin inhibitors and methods of use thereof
JP5060285B2 (ja) *	2005-03-22	2012-10-31	協和発酵キリン株式会社	固形腫瘍治療剤
JPWO2006101103A1 (ja) *	2005-03-22	2008-09-04	協和醗酵工業株式会社	造血器腫瘍治療剤
UA95907C2 (en) *	2005-05-02	2011-09-26	Эррей Биофарма Инк.	Mitotic kinesin inhibitors and methods of use thereof
EP1908755A4 (en)	2005-06-24	2009-06-24	Kyowa Hakko Kirin Co Ltd	THERAPEUTIC AGENT AGAINST RESTENOSIS
DE102006002065B4 (de) *	2006-01-16	2007-11-29	Infineon Technologies Austria Ag	Kompensationsbauelement mit reduziertem und einstellbarem Einschaltwiderstand
MX2009001877A (es)	2006-08-21	2009-03-02	Synta Pharmaceuticals Corp	Compuestos para el tratamiento de trastornos proliferativos.
JP2010505870A (ja) *	2006-10-03	2010-02-25	アレイバイオファーマ、インコーポレイテッド	有糸***キネシン阻害剤としてのオキサジアゾール誘導体およびチアジアゾール誘導体、ならびにそれらの使用方法
TW200940050A (en) *	2007-11-28	2009-10-01	Synta Pharmaceuticals Corp	Polymorphs of N-malonyl-bis(N'-methyl-N'-thiobenzoylhydrazide)
EP2225201A2 (en) *	2007-11-28	2010-09-08	Synta Pharmaceuticals Corp.	Polymorphs of n-malonyl-bis(n'-methyl-n'-thiobenzoylhydrazide)

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4091024A (en) *	1976-12-03	1978-05-23	E. R. Squibb & Sons, Inc.	Pyrrolidine and piperidine-2-carboxylic acid derivatives
US4198517A (en) *	1976-12-03	1980-04-15	E. R. Squibb & Sons, Inc.	Histidine derivatives
IL58849A (en)	1978-12-11	1983-03-31	Merck & Co Inc	Carboxyalkyl dipeptides and derivatives thereof,their preparation and pharmaceutical compositions containing them
US4254267A (en) *	1979-10-25	1981-03-03	E. R. Squibb & Sons, Inc.	Mercaptoacyldihydropyrazole carboxylic acid derivatives
US4312990A (en) *	1980-09-11	1982-01-26	E. R. Squibb & Sons, Inc.	1-Mercaptoacyl-3-[(aminosulfonyl) phenyl]-4,5-dihydro-1H-pyrazole-5-carboxylic acid
EP0048159A3 (en) *	1980-09-17	1982-05-12	University Of Miami	Novel carboxyalkyl peptides and thioethers and ethers of peptides as antihypertensive agents

1986
- 1986-08-15 AT AT86306325T patent/ATE72431T1/de not_active IP Right Cessation
- 1986-08-15 EP EP86306325A patent/EP0217519B1/en not_active Expired - Lifetime
- 1986-08-25 AU AU61798/86A patent/AU591165B2/en not_active Ceased
- 1986-08-26 DK DK406386A patent/DK406386A/da not_active Application Discontinuation
- 1986-08-26 IL IL79841A patent/IL79841A/xx not_active IP Right Cessation
- 1986-08-26 CH CH3427/86A patent/CH671397A5/fr not_active IP Right Cessation
- 1986-08-27 US US06/901,048 patent/US4927822A/en not_active Expired - Fee Related
- 1986-08-28 NO NO863457A patent/NO166180C/no unknown
- 1986-08-28 FI FI863488A patent/FI87205C/fi not_active IP Right Cessation
- 1986-08-29 CA CA000517181A patent/CA1305286C/en not_active Expired - Fee Related
- 1986-08-29 PT PT83277A patent/PT83277B/pt not_active IP Right Cessation
- 1986-08-29 JP JP61201875A patent/JPH0788365B2/ja not_active Expired - Lifetime
- 1986-08-29 LU LU86569A patent/LU86569A1/fr unknown
- 1986-08-29 BE BE0/217101A patent/BE905351A/fr not_active IP Right Cessation
- 1986-08-29 IE IE232286A patent/IE59432B1/en not_active IP Right Cessation
- 1986-08-29 GR GR862234A patent/GR862234B/el unknown
- 1986-08-29 NZ NZ217398A patent/NZ217398A/xx unknown
- 1986-08-29 FR FR8612233A patent/FR2586679B1/fr not_active Expired
- 1986-08-30 KR KR1019860007234A patent/KR940009528B1/ko not_active IP Right Cessation

Also Published As

Publication number	Publication date
NO863457L (no)	1987-03-02
NO166180B (no)	1991-03-04
IE862322L (en)	1987-02-28
IL79841A0 (en)	1986-11-30
LU86569A1 (fr)	1986-12-02
EP0217519A1 (en)	1987-04-08
KR870002107A (ko)	1987-03-30
AU591165B2 (en)	1989-11-30
IE59432B1 (en)	1994-02-23
GR862234B (en)	1986-12-31
NO166180C (no)	1991-06-19
FR2586679A1 (fr)	1987-03-06
JPH0788365B2 (ja)	1995-09-27
FR2586679B1 (fr)	1988-12-30
FI87205C (fi)	1992-12-10
BE905351A (fr)	1987-03-02
KR940009528B1 (ko)	1994-10-14
NO863457D0 (no)	1986-08-28
US4927822A (en)	1990-05-22
NZ217398A (en)	1989-04-26
EP0217519B1 (en)	1992-02-05
PT83277B (pt)	1989-03-30
FI863488A0 (fi)	1986-08-28
CA1305286C (en)	1992-07-14
CH671397A5 (fi)	1989-08-31
DK406386D0 (da)	1986-08-26
ATE72431T1 (de)	1992-02-15
PT83277A (en)	1986-09-01
DK406386A (da)	1987-03-01
FI87205B (fi)	1992-08-31
IL79841A (en)	1992-02-16
JPS6253976A (ja)	1987-03-09
AU6179886A (en)	1987-03-05

Legal Events

Date	Code	Title	Description
1997-08-28	MM	Patent lapsed
2004-08-31	MM	Patent lapsed	Owner name: FISONS PLC

Publication	Publication Date	Title
FI863488A (fi)	1987-03-01	Foereningar.
SE8303208D0 (sv)	1983-06-07	Heterocykliska foreningar
FI894061A0 (fi)	1989-08-30	Menetelmä lääkeaineina käyttökelpoisten , -disubstituoitujen N-sykloalkyylialkyylibentsyyliamiinien valmistamiseksi ja niiden synteesivälituotteita
NO924949L (no)	1993-02-19	Piperidylsubstituerte indoler
ES520526A0 (es)	1983-12-16	Procedimiento para la obtencion de derivados de piridina.
FI852130A0 (fi)	1985-05-29	Nya substituerade pyrrolidinoner, foerfarande foer deras framstaellning och laekemedel.
DE3861926D1 (de)	1991-04-11	Polyzyklische aromatische verbindungen, verfahren zu deren herstellung, deren verwendung in menschlicher und tierischer medizin und in der kosmetik.
DK157489C (da)	1990-06-11	N-substituerede pyridiniumforbindelser og farmaceutiske praeparater indeholdende disse
PT99502A (pt)	1992-09-30	Processo para a preparacao de novos derivados de imidazol
YU140491A (sh)	1994-01-20	6-supstituisani-tetrahidrobenz(c,d) indoli
ES8401456A1 (es)	1983-12-01	Procedimiento para la preparacion de 2-aminometilfenoles.
MY101878A (en)	1992-02-15	1,3,4-thiadiazole
PT92494A (pt)	1990-06-29	Processo para a preparacao de novos derivados do indol
SE8302452D0 (sv)	1983-04-29	Method for treatment of senile dementia
DE3860117D1 (de)	1990-06-07	2,3-dihydro-3-phenyl-benzofuran-2-on-acetamidderivate, verfahren zu ihrer herstellung und diese enthaltende arzneimittel.
ES8608509A1 (es)	1986-06-16	Procedimiento para preparar nuevos derivador de 2-(1-imidazolil)-etanol
DK513281A (da)	1982-05-21	Fremgangsaade til fremstilling af 3-thiovinylcephalosproner
ES8103749A1 (es)	1981-03-16	Procedimiento para la preparacion de 5,6,7,8-tetrahidropira-zolo (3,4-b)(1,5)diazepin-1h,4h-5,7-dionas