FI842614A - KEHALOSPORINDERIVAT OF HALOGENERATES. - Google Patents
KEHALOSPORINDERIVAT OF HALOGENERATES. Download PDFInfo
- Publication number
- FI842614A FI842614A FI842614A FI842614A FI842614A FI 842614 A FI842614 A FI 842614A FI 842614 A FI842614 A FI 842614A FI 842614 A FI842614 A FI 842614A FI 842614 A FI842614 A FI 842614A
- Authority
- FI
- Finland
- Prior art keywords
- salt
- see diagramm
- hydrate
- salts
- compounds
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- C07D501/14—Compounds having a nitrogen atom directly attached in position 7
- C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
- C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
- C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
- C07D501/38—Methylene radicals, substituted by nitrogen atoms; Lactams thereof with the 2-carboxyl group; Methylene radicals substituted by nitrogen-containing hetero rings attached by the ring nitrogen atom; Quaternary compounds thereof
- C07D501/46—Methylene radicals, substituted by nitrogen atoms; Lactams thereof with the 2-carboxyl group; Methylene radicals substituted by nitrogen-containing hetero rings attached by the ring nitrogen atom; Quaternary compounds thereof with the 7-amino radical acylated by carboxylic acids containing hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- C07D501/14—Compounds having a nitrogen atom directly attached in position 7
- C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
- C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
- C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
- C07D501/36—Methylene radicals, substituted by sulfur atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Oncology (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Communicable Diseases (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Cephalosporin Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Laminated Bodies (AREA)
- Suspension Of Electric Lines Or Cables (AREA)
- Table Devices Or Equipment (AREA)
- Optical Fibers, Optical Fiber Cores, And Optical Fiber Bundles (AREA)
- Peptides Or Proteins (AREA)
Abstract
For the Contracting States : BE, CH, DE, FR, GB, IT, LI, LU, NL, SE 1. A process for the manufacture of acyl derivatives of general formula I see diagramm : EP0030294,P12,F1 in which R represents hydrogen or a readily hydrolyzable ester group, as well as of salts of these compounds and hydrates of these compounds or of their salts by reating a halide of general formula II see diagramm : EP0030294,P12,F2 in which R has the significance given above and Y represents a halogen atom, or a salt of this compound with thiourea and, if desired, converting a compound of formula I obtained into a salt or hydrate or into a hydrate of this salt, characterized in that X signifies one of the groups see diagramm : EP0030294,P13,F3 in which R' represents hydrogen or a readily hydrolysable ether group.
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CH1038479 | 1979-11-21 | ||
| CH1038479 | 1979-11-21 | ||
| FI793768 | 1979-11-30 | ||
| FI793768A FI67385C (en) | 1979-11-21 | 1979-11-30 | PROCEDURE FOR FRAMSTATION OF AV (6R 7R) -7- (2- (2-AMINO-4-THIAZOLYL) -2- (Z-METHOXYIMINO) ACETAMIDO) -3-CEFEM-4-CARBOXYL SYRATER DERIVATIVES |
Publications (4)
| Publication Number | Publication Date |
|---|---|
| FI842614A true FI842614A (en) | 1984-06-28 |
| FI842614A0 FI842614A0 (en) | 1984-06-28 |
| FI71563B FI71563B (en) | 1986-10-10 |
| FI71563C FI71563C (en) | 1987-01-19 |
Family
ID=4362652
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FI793768A FI67385C (en) | 1979-11-21 | 1979-11-30 | PROCEDURE FOR FRAMSTATION OF AV (6R 7R) -7- (2- (2-AMINO-4-THIAZOLYL) -2- (Z-METHOXYIMINO) ACETAMIDO) -3-CEFEM-4-CARBOXYL SYRATER DERIVATIVES |
| FI842614A FI71563C (en) | 1979-11-21 | 1984-06-28 | (6R, 7R) 4-Halogen-2 - [(Z) -methoxyimino [acetamido -3- [substituted-as-triazin-3-yl] thio] -methyl-8-oxo-5-thia-1-azabicyclo [alpha] 4.2.0 / oct-2-ene-2-carboxylic acids and their esters. |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FI793768A FI67385C (en) | 1979-11-21 | 1979-11-30 | PROCEDURE FOR FRAMSTATION OF AV (6R 7R) -7- (2- (2-AMINO-4-THIAZOLYL) -2- (Z-METHOXYIMINO) ACETAMIDO) -3-CEFEM-4-CARBOXYL SYRATER DERIVATIVES |
Country Status (21)
| Country | Link |
|---|---|
| EP (1) | EP0030294B1 (en) |
| JP (2) | JPS5692894A (en) |
| KR (1) | KR860000852B1 (en) |
| AT (1) | ATE8896T1 (en) |
| AU (1) | AU533088B2 (en) |
| CA (1) | CA1146165A (en) |
| DE (1) | DE3068905D1 (en) |
| DK (1) | DK166728B1 (en) |
| ES (2) | ES8200694A1 (en) |
| FI (2) | FI67385C (en) |
| GR (1) | GR71879B (en) |
| HU (1) | HU184941B (en) |
| IE (1) | IE50516B1 (en) |
| IL (1) | IL61486A (en) |
| NO (2) | NO166229C (en) |
| NZ (1) | NZ195547A (en) |
| PH (2) | PH17359A (en) |
| PT (1) | PT72084B (en) |
| SI (1) | SI8012952A8 (en) |
| YU (1) | YU42364B (en) |
| ZA (1) | ZA807099B (en) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH0830051B2 (en) * | 1986-05-21 | 1996-03-27 | 武田薬品工業株式会社 | Process for producing 4-halogeno-2-substituted oxyimino-3-oxobutyric acid ester or amide |
| JP2595605B2 (en) * | 1988-01-18 | 1997-04-02 | 武田薬品工業株式会社 | Method for producing 2-substituted oxyimino-3-oxobutyric acid |
| AT398764B (en) * | 1992-01-28 | 1995-01-25 | Lek Tovarna Farmacevtskih | METHOD FOR PRODUCING CEFTRIAXONDINATRIUM SALZHEMIHEPTAHYDRATE |
| AT399877B (en) * | 1992-02-20 | 1995-08-25 | Biochemie Gmbh | NEW METHOD FOR PRODUCING CEFTRIAXONE |
| AT411598B (en) * | 1999-04-29 | 2004-03-25 | Biochemie Gmbh | Preparation of beta-lactam derivatives used as antibacterial agents by reacting cephalosporanic acid derivative with imine compound, then thiourea compound |
| AT408225B (en) * | 1999-04-29 | 2001-09-25 | Biochemie Gmbh | Process for the preparation of cephalosporins |
| EP1399429A1 (en) * | 2001-06-14 | 2004-03-24 | Orchid Chemicals and Pharmaceuticals Ltd | 1,3,4-oxadiazol-2-yl thioesters and their use for acylating 7-aminocephalosporins |
| IN192139B (en) | 2001-11-26 | 2004-02-21 | Lupin Ltd | |
| AU2002337437A1 (en) * | 2002-04-19 | 2003-11-03 | Orchid Chemicals And Pharmaceuticals Limited | A process for the preparation of cephalosporin intermediate and its use for the manufacture of cephalosporin compounds |
| US6919449B2 (en) | 2002-04-19 | 2005-07-19 | Orchid Chemicals And Pharmaceuticals Limited | Process for the preparation of cephalosporin intermediate and its use for the manufacture of cephalosporin compounds |
| US6800756B2 (en) * | 2002-05-03 | 2004-10-05 | Orchid Chemicals And Pharmaceuticals, Ltd. | Method for the preparation of ceftiofur sodium and its intermediates |
| WO2004083216A1 (en) * | 2003-03-20 | 2004-09-30 | Orchid Chemicals & Pharmaceuticals Ltd | A process for the preparation of cephalosporins |
| US7847093B2 (en) | 2003-04-16 | 2010-12-07 | Sandoz Ag | Processes for the preparations of cefepime |
| DE602004028111D1 (en) | 2003-04-16 | 2010-08-26 | Sandoz Ag | PROCESS FOR THE PREPARATION OF CEFEPIM |
| US7098329B2 (en) * | 2003-06-19 | 2006-08-29 | Orchid Chemicals & Pharmaceuticals Ltd. | Process for the preparation of a cephalosporin antibiotic |
| WO2005019227A1 (en) | 2003-08-22 | 2005-03-03 | Orchid Chemicals & Pharmaceuticals Ltd | Process for the preparation of cephalosporin antibiotic |
| US20050059820A1 (en) * | 2003-09-17 | 2005-03-17 | Debashish Datta | Method for manufacture of ceftriaxone sodium |
| WO2005040175A2 (en) * | 2003-10-22 | 2005-05-06 | Ranbaxy Laboratories Limited | Process for the preparation of cephem carboxylic acids |
| US20050119244A1 (en) | 2003-12-02 | 2005-06-02 | Acs Dobfar S.P.A. | Process for preparing cephalosporins with salified intermediate |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4200745A (en) * | 1977-12-20 | 1980-04-29 | Eli Lilly And Company | 7[2-(2-Aminothiazol-4-yl)-2-alkoxyimino]acetamido 3[4-alkyl-5-oxo-6-hydroxy-3,4 dihydro 1,2,4-triazin 3-yl]thio methyl cephalosporins |
| JPS5498795A (en) * | 1978-01-13 | 1979-08-03 | Takeda Chem Ind Ltd | Cephalosporin derivative and its preparation |
| MC1259A1 (en) * | 1978-05-30 | 1980-01-14 | Hoffmann La Roche | ACYL DERIVATIVES |
-
1979
- 1979-11-30 FI FI793768A patent/FI67385C/en not_active IP Right Cessation
-
1980
- 1980-11-07 PH PH24818A patent/PH17359A/en unknown
- 1980-11-14 NZ NZ195547A patent/NZ195547A/en unknown
- 1980-11-14 ZA ZA00807099A patent/ZA807099B/en unknown
- 1980-11-14 CA CA000364648A patent/CA1146165A/en not_active Expired
- 1980-11-14 IL IL61486A patent/IL61486A/en not_active IP Right Cessation
- 1980-11-17 AU AU64438/80A patent/AU533088B2/en not_active Expired
- 1980-11-17 HU HU802744A patent/HU184941B/en unknown
- 1980-11-18 DE DE8080107160T patent/DE3068905D1/en not_active Expired
- 1980-11-18 JP JP16148780A patent/JPS5692894A/en active Granted
- 1980-11-18 GR GR63382A patent/GR71879B/el unknown
- 1980-11-18 AT AT80107160T patent/ATE8896T1/en not_active IP Right Cessation
- 1980-11-18 EP EP80107160A patent/EP0030294B1/en not_active Expired
- 1980-11-20 PT PT72084A patent/PT72084B/en unknown
- 1980-11-20 IE IE2408/80A patent/IE50516B1/en not_active IP Right Cessation
- 1980-11-20 SI SI8012952A patent/SI8012952A8/en unknown
- 1980-11-20 DK DK496380A patent/DK166728B1/en not_active IP Right Cessation
- 1980-11-20 YU YU2952/80A patent/YU42364B/en unknown
- 1980-11-20 ES ES496994A patent/ES8200694A1/en not_active Expired
- 1980-11-20 NO NO803516A patent/NO166229C/en unknown
- 1980-11-20 KR KR1019800004446A patent/KR860000852B1/en active
-
1981
- 1981-06-18 NO NO81812083A patent/NO166228C/en unknown
- 1981-07-01 ES ES503583A patent/ES8204997A1/en not_active Expired
- 1981-12-16 PH PH26633A patent/PH18468A/en unknown
-
1984
- 1984-06-28 FI FI842614A patent/FI71563C/en not_active IP Right Cessation
-
1985
- 1985-12-20 JP JP60285859A patent/JPS61143392A/en active Granted
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MA | Patent expired |
Owner name: F. HOFFMANN-LA ROCHE AG |