FI832557A - Nya karbacykliner, foerfarande foer deras framstaellning och deras anvaendning som laekemedel - Google Patents

Nya karbacykliner, foerfarande foer deras framstaellning och deras anvaendning som laekemedel Download PDF

Info

Publication number
FI832557A
FI832557A FI832557A FI832557A FI832557A FI 832557 A FI832557 A FI 832557A FI 832557 A FI832557 A FI 832557A FI 832557 A FI832557 A FI 832557A FI 832557 A FI832557 A FI 832557A
Authority
FI
Finland
Prior art keywords
group
denotes
radical
atoms
hydrogen atom
Prior art date
Application number
FI832557A
Other languages
English (en)
Other versions
FI77645B (fi
FI77645C (fi
FI832557A0 (fi
Inventor
Werner Skuballa
Bernd Raduechel
Helmut Vorbrueggen
Jorge Casals-Stenzel
Gerda Mannesmann
Ekkehardt Schillinger
Michael Harold Town
Original Assignee
Schering Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Ag filed Critical Schering Ag
Publication of FI832557A0 publication Critical patent/FI832557A0/fi
Publication of FI832557A publication Critical patent/FI832557A/fi
Publication of FI77645B publication Critical patent/FI77645B/fi
Application granted granted Critical
Publication of FI77645C publication Critical patent/FI77645C/fi

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D317/00Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/72Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 spiro-condensed with carbocyclic rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • A61P11/08Bronchodilators
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/12Antihypertensives
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C405/00Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
    • C07C405/005Analogues or derivatives having the five membered ring replaced by other rings
    • C07C405/0075Analogues or derivatives having the five membered ring replaced by other rings having the side-chains or their analogues or derivatives attached to a condensed ring system
    • C07C405/0083Analogues or derivatives having the five membered ring replaced by other rings having the side-chains or their analogues or derivatives attached to a condensed ring system which is only ortho or peri condensed, e.g. carbacyclins
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D317/00Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/10Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings
    • C07D317/14Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D317/16Radicals substituted by halogen atoms or nitro radicals
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H13/00Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids
    • C07H13/02Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids
    • C07H13/04Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids having the esterifying carboxyl radicals attached to acyclic carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Pulmonology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Inks, Pencil-Leads, Or Crayons (AREA)
  • Drawers Of Furniture (AREA)
  • Ink Jet Recording Methods And Recording Media Thereof (AREA)
  • Pyrane Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Medicinal Preparation (AREA)
FI832557A 1982-07-13 1983-07-13 Foerfarande foer framstaellning av nya, terapeutiskt anvaendbara 1a,1b-dihomo-3-oxakarbacyklinderivat. FI77645C (fi)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19823226550 DE3226550A1 (de) 1982-07-13 1982-07-13 Neue carbacycline, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
DE3226550 1982-07-13

Publications (4)

Publication Number Publication Date
FI832557A0 FI832557A0 (fi) 1983-07-13
FI832557A true FI832557A (fi) 1984-01-14
FI77645B FI77645B (fi) 1988-12-30
FI77645C FI77645C (fi) 1989-04-10

Family

ID=6168531

Family Applications (1)

Application Number Title Priority Date Filing Date
FI832557A FI77645C (fi) 1982-07-13 1983-07-13 Foerfarande foer framstaellning av nya, terapeutiskt anvaendbara 1a,1b-dihomo-3-oxakarbacyklinderivat.

Country Status (19)

Country Link
EP (1) EP0099538B1 (fi)
JP (1) JPS5921636A (fi)
AT (1) ATE67182T1 (fi)
AU (1) AU571841B2 (fi)
CA (1) CA1248525A (fi)
CS (1) CS235329B2 (fi)
DD (1) DD210027B3 (fi)
DE (2) DE3226550A1 (fi)
DK (1) DK163579C (fi)
ES (1) ES524058A0 (fi)
FI (1) FI77645C (fi)
GR (1) GR78873B (fi)
HU (1) HU191057B (fi)
IE (1) IE57233B1 (fi)
IL (1) IL69199A (fi)
NZ (1) NZ204875A (fi)
PH (1) PH25119A (fi)
SU (1) SU1316555A3 (fi)
ZA (1) ZA835109B (fi)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3225288A1 (de) * 1982-07-02 1984-01-19 Schering AG, 1000 Berlin und 4709 Bergkamen Neue carbacycline, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
DE3225287A1 (de) * 1982-07-02 1984-01-05 Schering AG, 1000 Berlin und 4709 Bergkamen Neue carbacyclinamide, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
JPS59141536A (ja) * 1983-02-01 1984-08-14 Sumitomo Chem Co Ltd 新規ビシクロオクタン誘導体
DE3405181A1 (de) * 1984-02-10 1985-08-22 Schering AG, 1000 Berlin und 4709 Bergkamen Neue carbacycline, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
US4971987A (en) * 1984-07-27 1990-11-20 Schering Aktiengesellschaft New carbacycline, process for their production and their use as a drug
DE3933523A1 (de) * 1989-10-05 1991-04-11 Schering Ag Antimetastatisch wirkende mittel
EP0431571A3 (en) * 1989-12-05 1992-01-02 Sagami Chemical Research Center Cis-bicyclo(4.3.0)non-2-ene derivatives
DE4104607A1 (de) * 1991-02-12 1992-08-13 Schering Ag Prostacyclin- und carbacyclinderivate als mittel zur behandlung von fiebrigen erkrankungen
CA2382759A1 (en) 1999-08-05 2001-02-15 Teijin Limited Agent for the remedy of neural damage having a nitrogen-containing compound as the active ingredient
US8183286B2 (en) 2006-11-16 2012-05-22 Gemmus Pharma Inc. EP2 and EP4 agonists as agents for the treatment of influenza a viral infection
NZ599128A (en) 2009-10-14 2014-02-28 Gemmus Pharma Inc Combination therapy treatment for viral infections
JP6694385B2 (ja) 2013-08-09 2020-05-13 アーデリクス,インコーポレーテッド リン酸塩輸送阻害のための化合物及び方法
JP2022533251A (ja) 2019-05-21 2022-07-21 アルデリックス, インコーポレイテッド 患者において血清リン酸塩を低下させるための組み合わせ

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2040928B (en) * 1978-01-26 1982-12-08 Erba Farmitalia Bicycloalkane derivatives useful as intermediates in preparing pg1 isosteres
US4705806A (en) * 1978-02-13 1987-11-10 Morton Jr Douglas R Prostacyclin analogs
DE3048906A1 (de) * 1980-12-19 1982-07-15 Schering Ag, 1000 Berlin Und 4619 Bergkamen Neue carbacycline, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
IE54303B1 (en) * 1981-08-19 1989-08-16 Merrell Dow France Fluorinated diaminoalkene derivatives
GR77976B (fi) * 1982-03-12 1984-09-25 Schering Ag
DE3225287A1 (de) * 1982-07-02 1984-01-05 Schering AG, 1000 Berlin und 4709 Bergkamen Neue carbacyclinamide, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel

Also Published As

Publication number Publication date
EP0099538B1 (de) 1991-09-11
ATE67182T1 (de) 1991-09-15
IE831630L (en) 1984-01-13
CS235329B2 (en) 1985-05-15
FI77645B (fi) 1988-12-30
HU191057B (en) 1986-12-28
EP0099538A1 (de) 1984-02-01
JPS5921636A (ja) 1984-02-03
DK321283D0 (da) 1983-07-12
AU1671883A (en) 1984-01-19
DE3382408D1 (de) 1991-10-17
JPH0324457B2 (fi) 1991-04-03
DK321283A (da) 1984-01-14
ZA835109B (en) 1984-08-29
CA1248525A (en) 1989-01-10
IL69199A0 (en) 1983-11-30
GR78873B (fi) 1984-10-02
PH25119A (en) 1991-02-19
SU1316555A3 (ru) 1987-06-07
FI77645C (fi) 1989-04-10
DD210027B3 (de) 1990-07-18
ES8403865A1 (es) 1984-04-16
DK163579C (da) 1992-08-03
NZ204875A (en) 1986-11-12
DD210027A5 (de) 1984-05-30
AU571841B2 (en) 1988-04-28
DK163579B (da) 1992-03-16
IL69199A (en) 1987-08-31
DE3226550A1 (de) 1984-01-19
IE57233B1 (en) 1992-06-17
ES524058A0 (es) 1984-04-16
FI832557A0 (fi) 1983-07-13

Similar Documents

Publication Publication Date Title
FI832557A (fi) Nya karbacykliner, foerfarande foer deras framstaellning och deras anvaendning som laekemedel
DK132789A (da) 9-halogen-(z)-prostaglandinderivater, fremgangsmaade til deres fremstilling og deres anvendelse som laegemiddel
DK303481A (da) Fremgangsmaade til fremstilling af amider af hydroxyfenyl-alkylaminoaetanoler eller terapeutisk acceptable salte deraf
DK154501C (da) 5-amino-2,4,6-trijodisophthalsyre-bis-amid-derivater og deres salte med roentgenkontrastsyrer
IL91913A0 (en) Fluorosubstituted benzene derivatives,processes for the preparation thereof and diagnostic compositions containing the same
ES8703424A1 (es) Procedimiento para la obtencion de compuestos de amida
AU576477B2 (en) 5-fluoro-carbacyclins
RO87991A (ro) Procedeu pentru prepararea unor esteri tiazolidinici substituiti ai unor acizi minerali
EP0069049A3 (en) Delta-8,9-prostaglandin derivatives, process for their preparation and their use as medicaments
GB2104515B (en) Sulphimines
JPS52100470A (en) Synthesis of hydantoin derivatives
DK545884A (da) Ammoniumsalte af polysyrer til anvendelse som fungicider samt fremgangsmaade til fremstilling af saadanne salte
ATE61341T1 (de) N-substituierte, estergruppen enthaltende acrylamide.
FI850519A0 (fi) Nya karbacykliner, foerfarande foer deras framstaellning och deras anvaendning som laekemedel.
FI850885L (fi) Nya karbacykliner, foerfarande foer deras framstaellning och deras anvaendning som laekemedel.
ES8603172A1 (es) Procedimiento para la preparacion de derivados de 9-haloge- no-prostano
DK573487A (da) Cyklodextrinclathrater af carbacyklinderivater og anvendelse deraf som laegemiddel
FI824061L (fi) Foerfarande foer framstaellning av nya 3'''-dehydro-kardenolid-tridigitoxosidoximer och anvaendningdem som laekemedel
DE3275083D1 (en) Cycloaliphatic alcohols
GB2022583A (en) New ionic polyiodo benzene derivatives useful as X-ray contrast media

Legal Events

Date Code Title Description
MM Patent lapsed
MM Patent lapsed

Owner name: SCHERING AKTIENGESELLSCHAFT