FI823278L - FRAMEWORK FOR TREATMENT OF TRIAZOLOKINAZOLONER OCH DERAS SALTER - Google Patents

FRAMEWORK FOR TREATMENT OF TRIAZOLOKINAZOLONER OCH DERAS SALTER

Info

Publication number
FI823278L
FI823278L FI823278A FI823278A FI823278L FI 823278 L FI823278 L FI 823278L FI 823278 A FI823278 A FI 823278A FI 823278 A FI823278 A FI 823278A FI 823278 L FI823278 L FI 823278L
Authority
FI
Finland
Prior art keywords
carbon atoms
alkyl
group
aralkyl
aryl
Prior art date
Application number
FI823278A
Other languages
Finnish (fi)
Other versions
FI73435C (en
FI73435B (en
FI823278A0 (en
Inventor
Wilfred Roger Tully
Robert Westwood
David Alun Rowlands
Stephen Clements-Jewery
Original Assignee
Roussel Uclaf
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Roussel Uclaf filed Critical Roussel Uclaf
Publication of FI823278A0 publication Critical patent/FI823278A0/en
Publication of FI823278L publication Critical patent/FI823278L/en
Application granted granted Critical
Publication of FI73435B publication Critical patent/FI73435B/en
Publication of FI73435C publication Critical patent/FI73435C/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C07D239/95—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in positions 2 and 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C07D239/95—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in positions 2 and 4
    • C07D239/96—Two oxygen atoms

Abstract

Novel triazoloquinazolones of the formula <IMAGE> I wherein R and R' are individually selected from the group consisting of hydrogen, halogen, nitro and alkyl and alkoxy of 1 to 3 carbon atoms, Y is selected from the group consisting of alkyl of 1 to 6 carbon atoms, alkenyl of 2 to 4 carbon atoms, cycloalkyl of 3 to 8 carbon atoms, aryl of 6 to 8 carbon atoms and aralkyl of 7 to 8 carbon atoms, B is an alkylene of 1 to 3 carbon atoms, X is selected from the group consisting of <IMAGE> R1 and R2 are individually selected from the group consisting of hydrogen, alkyl of 1 to 6 carbon atoms, cycloalkyl of 3 to 8 carbon atoms, aryl of 6 to 8 carbon atoms, aralkyl of 7 to 8 carbon atoms, aminoalkyl of 2 to 4 carbon atoms, mono- and dialkylaminoalkyl with each alkyl having 2 to 4 carbon atoms, piperidinoalkyl of 1 to 4 alkyl carbon atoms, morpholinoalkyl of 1 to 4 alkyl carbon atoms and piperazinylalkyl of 1 to 4 alkyl carbon atoms or R1 and R2 taken together with the nitrogen to which they are attached form a saturated mono- or bicyclic heterocyclic ring with 4 to 8 carbon atoms optionally substituted with 1 to 2 methyls and optionally containing in the ring a heteroatom selected from -O-, -S- and <IMAGE> and R3 is selected from the group consisting of hydrogen, alkyl of 1 to 3 carbon atoms, hydroxyalkyl of 1 to 3 carbon atoms, alkoxycarbonyl of 2 to 5 carbon atoms, aryl of 6 to 8 carbon atoms and aralkyl of 7 to 8 carbon atoms and their non-toxic, pharmaceutically acceptable acid addition salts having antihistaminic and bronchospasmolytic activity and their preparation and intermediates.
FI823278A 1981-09-24 1982-09-23 Process for the preparation of therapeutically useful novel 1,2,4-triazolo / 4,3-a / quinazoline-5 (4H) -ones and their salts. FI73435C (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB8128875 1981-09-24
GB8128875 1981-09-24

Publications (4)

Publication Number Publication Date
FI823278A0 FI823278A0 (en) 1982-09-23
FI823278L true FI823278L (en) 1983-03-25
FI73435B FI73435B (en) 1987-06-30
FI73435C FI73435C (en) 1987-10-09

Family

ID=10524710

Family Applications (1)

Application Number Title Priority Date Filing Date
FI823278A FI73435C (en) 1981-09-24 1982-09-23 Process for the preparation of therapeutically useful novel 1,2,4-triazolo / 4,3-a / quinazoline-5 (4H) -ones and their salts.

Country Status (18)

Country Link
US (1) US4472400A (en)
EP (1) EP0076199B1 (en)
JP (1) JPS5865292A (en)
AT (1) ATE24509T1 (en)
AU (1) AU554959B2 (en)
CA (1) CA1193597A (en)
DE (1) DE3274860D1 (en)
DK (1) DK160308C (en)
ES (1) ES515904A0 (en)
FI (1) FI73435C (en)
GB (1) GB2108495B (en)
GR (1) GR78044B (en)
HU (1) HU186975B (en)
IE (1) IE53858B1 (en)
IL (1) IL66835A (en)
MA (1) MA19604A1 (en)
PT (1) PT75602B (en)
ZA (1) ZA826891B (en)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5442062A (en) * 1991-10-24 1995-08-15 The Upjohn Company Imidazole derivatives and pharmaceutical compositions containing the same
RU2145606C1 (en) * 1994-05-24 2000-02-20 Ф.Хоффманн-Ля Рош Аг Tricyclic dicarbonyl derivatives and drug based on said
US5756502A (en) * 1994-08-08 1998-05-26 Warner-Lambert Company Quinazolinone derivatives as cholyecystokinin (CCK) ligands
US6897213B1 (en) 1995-11-21 2005-05-24 Warner-Lambert Company Heterocycles as cholecystokinin (CCK) ligands
US6492364B1 (en) * 1998-12-04 2002-12-10 Toray Industries, Inc. Triazolo and derivatives as chemokine inhibitors
FR2792938B1 (en) * 1999-04-28 2001-07-06 Warner Lambert Co NEWS 1-AMINO TRIAZOLO [4,3-a] QUINAZOLINE-5-ONES PHOSPHODIESTERASE IV INHIBITORS
PA8539501A1 (en) 2001-02-14 2002-09-30 Warner Lambert Co TRIAZOLO COMPOUNDS AS MMP INHIBITORS
EP1285922A1 (en) * 2001-08-13 2003-02-26 Warner-Lambert Company 1-Alkyl or 1-cycloalkyltriazolo[4,3-a]quinazolin-5-ones as phosphodiesterase inhibitors
FR2832711B1 (en) 2001-11-26 2004-01-30 Warner Lambert Co TRIAZOLO [4,3-A] PYRIDO [2,3-D] PYRIMIDIN-5-ONES DERIVATIVES, COMPOSITIONS CONTAINING SAME, PROCESS FOR PREPARATION AND USE
CN1891704A (en) * 2005-07-08 2007-01-10 中国科学院上海药物研究所 Dipetidase tetrainhibitor, and its preparing method and use
CN115197225B (en) * 2021-09-03 2023-04-11 贵州大学 Five-membered heterocyclic quinazolinone compound and preparation method thereof

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS50116498A (en) * 1974-02-27 1975-09-11
US4145419A (en) * 1976-05-21 1979-03-20 Roussel Uclaf Novel imidazobenzoxazines
GB1596652A (en) * 1977-01-20 1981-08-26 Roussel Lab Ltd Imidazo (1,2-a) quinoline-2-carboxylic acid and derivatives
GB1576077A (en) * 1977-04-13 1980-10-01 Roussel Lab Ltd 4,5-dihydro-4-oxophyrrolo(1,2-)-quinoxaline-2-carboxylic acids and derivatives
SE444319B (en) * 1977-11-18 1986-04-07 Roussel Uclaf NEW IMIDAZOBENOXAZINE DERIVATIVES, PROCEDURES FOR PREPARING THEREOF AND PHARMACEUTICAL COMPOSITIONS CONTAINING THESE ASSOCIATIONS
SE439308B (en) * 1978-08-02 1985-06-10 Roussel Uclaf IMIDAZO (1,2-A) KINOXALINES AND PHARMACEUTICAL COMPOSITIONS THEREOF
DD139715A1 (en) * 1978-09-29 1980-01-16 Karl Kottke PROCESS FOR PREPARING 1-SUBSTITUTED 4-ARYL-S-TRIAZOLO (4,3-A) CHINAZOLONES (5)
IL59104A (en) * 1979-02-09 1984-02-29 Roussel Uclaf Heterotricyclic derivatives,process for their preparation and pharmaceutical compositions incorporating them
FR2448541A1 (en) * 1979-02-09 1980-09-05 Roussel Uclaf NOVEL OXOIMIDAZOQUINOXALINE DERIVATIVES AND SALTS THEREOF, PROCESS FOR THEIR PREPARATION, THEIR APPLICATION AS MEDICAMENTS AND THE PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
ZA81708B (en) * 1980-02-14 1982-06-30 Roussel Uclaf Triazoloquinazolinone derivatives

Also Published As

Publication number Publication date
AU554959B2 (en) 1986-09-11
EP0076199A2 (en) 1983-04-06
CA1193597A (en) 1985-09-17
DK420682A (en) 1983-03-25
GR78044B (en) 1984-09-26
DK160308C (en) 1991-07-29
IE53858B1 (en) 1989-03-29
AU8862382A (en) 1983-03-31
HU186975B (en) 1985-10-28
IL66835A0 (en) 1982-12-31
GB2108495B (en) 1985-07-24
PT75602B (en) 1985-12-09
FI73435C (en) 1987-10-09
US4472400A (en) 1984-09-18
IL66835A (en) 1988-05-31
ATE24509T1 (en) 1987-01-15
PT75602A (en) 1982-10-01
GB2108495A (en) 1983-05-18
IE822310L (en) 1983-03-24
ZA826891B (en) 1983-10-26
JPH0322389B2 (en) 1991-03-26
DE3274860D1 (en) 1987-02-05
EP0076199A3 (en) 1984-03-21
EP0076199B1 (en) 1986-12-30
ES8400440A1 (en) 1983-10-16
ES515904A0 (en) 1983-10-16
DK160308B (en) 1991-02-25
FI73435B (en) 1987-06-30
MA19604A1 (en) 1983-04-01
JPS5865292A (en) 1983-04-18
FI823278A0 (en) 1982-09-23

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Legal Events

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MM Patent lapsed

Owner name: ROUSSEL-UCLAF