FI67386B - Foerfarande foer framstaellning av nya terapeutiskt anvaendbara sockerderivat - Google Patents

Foerfarande foer framstaellning av nya terapeutiskt anvaendbara sockerderivat Download PDF

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Publication number
FI67386B
FI67386B FI801472A FI801472A FI67386B FI 67386 B FI67386 B FI 67386B FI 801472 A FI801472 A FI 801472A FI 801472 A FI801472 A FI 801472A FI 67386 B FI67386 B FI 67386B
Authority
FI
Finland
Prior art keywords
formula
compounds
tetramethyl
naphthyl
acetyl
Prior art date
Application number
FI801472A
Other languages
English (en)
Finnish (fi)
Other versions
FI801472A (fi
FI67386C (fi
Inventor
Werner Bollag
Pierre-Charles Wyss
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of FI801472A publication Critical patent/FI801472A/fi
Priority to FI840363A priority Critical patent/FI68628C/fi
Priority to FI840362A priority patent/FI69471C/fi
Application granted granted Critical
Publication of FI67386B publication Critical patent/FI67386B/fi
Publication of FI67386C publication Critical patent/FI67386C/fi

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H3/00—Compounds containing only hydrogen atoms and saccharide radicals having only carbon, hydrogen, and oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C33/00—Unsaturated compounds having hydroxy or O-metal groups bound to acyclic carbon atoms
    • C07C33/38—Alcohols containing six-membered aromatic rings and other rings and having unsaturation outside the aromatic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/45—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by condensation
    • C07C45/46—Friedel-Crafts reactions
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/76—Ketones containing a keto group bound to a six-membered aromatic ring
    • C07C49/782—Ketones containing a keto group bound to a six-membered aromatic ring polycyclic
    • C07C49/792—Ketones containing a keto group bound to a six-membered aromatic ring polycyclic containing rings other than six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C63/00—Compounds having carboxyl groups bound to a carbon atoms of six-membered aromatic rings
    • C07C63/33—Polycyclic acids
    • C07C63/49—Polycyclic acids containing rings other than six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H13/00—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids
    • C07H13/02—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids
    • C07H13/08—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids having the esterifying carboxyl radicals directly attached to carbocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/02—Acyclic radicals, not substituted by cyclic structures
    • C07H15/04—Acyclic radicals, not substituted by cyclic structures attached to an oxygen atom of the saccharide radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/18—Acyclic radicals, substituted by carbocyclic rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Dermatology (AREA)
  • Immunology (AREA)
  • Rheumatology (AREA)
  • Pulmonology (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)

Claims (4)

1. Förfarande för framställning av nya terapeutiskt användbara sockerderivat med formeln: COR7 J~ °\ icl/- OR4 2 3 4 väri R är väte eller lägre alkanoyl; R och R är väte, lägre 6 6 alkanoyl eller en rest R ; R är en rest med formeln: CO - och R7 är lägre alkoxi, kännetecknat därav, att man omsätter en förening med formeln COR7 /τ V 2 ' \j / rzo M-/ OR4 med en syra R6OH eller ett reaktionskapabelt derivat därav i närvaro av ett vatten- eller syrabindande medel.
2. Förfarande enligt patentkravet 1, kännetecknat därav, att man vid förfarandet framställer föreningar med formeln:
FI801472A 1979-06-21 1980-05-07 Foerfarande foer framstaellning av nya terapeutiskt anvaendbara sockerderivat FI67386C (fi)

Priority Applications (2)

Application Number Priority Date Filing Date Title
FI840363A FI68628C (fi) 1979-06-21 1984-01-30 Foerfarande foer framstaellning av nya terapeutiskt verksamma sockerderivat
FI840362A FI69471C (fi) 1979-06-21 1984-01-30 Foerfarande foer framstaellning av nya terapeutiskt anvaendbara sockerderivat

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CH580879 1979-06-21
CH580879 1979-06-21

Publications (3)

Publication Number Publication Date
FI801472A FI801472A (fi) 1980-12-22
FI67386B true FI67386B (fi) 1984-11-30
FI67386C FI67386C (fi) 1985-03-11

Family

ID=4299652

Family Applications (1)

Application Number Title Priority Date Filing Date
FI801472A FI67386C (fi) 1979-06-21 1980-05-07 Foerfarande foer framstaellning av nya terapeutiskt anvaendbara sockerderivat

Country Status (22)

Country Link
US (1) US4316983A (sv)
EP (1) EP0021339B1 (sv)
JP (1) JPS567798A (sv)
KR (2) KR840000678B1 (sv)
AR (2) AR225312A1 (sv)
AT (1) ATE2434T1 (sv)
AU (1) AU530478B2 (sv)
CA (1) CA1134819A (sv)
DE (1) DE3061891D1 (sv)
DK (1) DK154650C (sv)
ES (2) ES8104322A1 (sv)
FI (1) FI67386C (sv)
GR (1) GR69283B (sv)
HU (1) HU184915B (sv)
IE (1) IE50463B1 (sv)
IL (1) IL60324A (sv)
MC (1) MC1338A1 (sv)
NO (1) NO148644C (sv)
NZ (1) NZ194061A (sv)
PH (1) PH16243A (sv)
PT (1) PT71435B (sv)
ZA (1) ZA803538B (sv)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4987223A (en) * 1981-12-23 1991-01-22 Choay S.A. Derivatives of the uronic acid
US4388457A (en) * 1982-02-11 1983-06-14 University Patents, Inc. Phyllanthostatin compounds
CH661516A5 (de) * 1983-12-08 1987-07-31 Hoffmann La Roche Phenylnonatetraenoylzuckerderivate.
AU582758B2 (en) * 1984-06-28 1989-04-13 Mect Corporation Sialic acid derivatives, galactose derivatives and method for producing the same
CH667868A5 (fr) * 1984-09-05 1988-11-15 Oreal Derives du benzonorbornene, leurs procedes de preparation et compositions medicamenteuse et cosmetique les contenant.
LU85726A1 (fr) * 1985-01-10 1986-08-04 Cird Nouveaux derives naphtaleniques du benzonorbornene,leur procede de preparation et compositions medicamenteuse et cosmetique les contenant
DE3787403D1 (de) * 1986-05-09 1993-10-21 Pulverer Gerhard Verwendung von spezifischen Monosacchariden zur Herstellung eines Arzneimittels zur Verhinderung von Metastasen maligner Tumore.
AU608415B2 (en) * 1988-01-19 1991-03-28 University Of Texas System, The Esters of 3'-deaminodoxorubicin, liposomal compositions thereof
SE462229B (sv) * 1988-01-19 1990-05-21 Exma Extern Marknadsfoering Ab Laasanordning foer ett roerligt organ som aer svaengbart i foerhaallande till ett annat organ
US4943563A (en) * 1988-10-03 1990-07-24 Cornell Research Foundation, Inc. 2,3,4-triacylhexose insect repellants
DE3929355A1 (de) * 1989-09-04 1991-03-07 Boehringer Mannheim Gmbh Verfahren zur spezifischen bestimmung von pankreas-(alpha)-amylase
JP2674843B2 (ja) * 1989-10-31 1997-11-12 新日本製鐵株式会社 鋳鉄用被覆アーク溶接棒
US5523398A (en) * 1994-08-31 1996-06-04 The Center For Innovative Technology Cellulose derivatives with a low degree of substitution

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3629238A (en) * 1968-09-20 1971-12-21 Sumitomo Chemical Co Novel glucuronides of 3-indolylaliphatic acid derivatives
FR2141532B1 (sv) * 1971-06-14 1974-08-23 Anvar
FR2307820A1 (fr) * 1975-04-17 1976-11-12 Hayashibara Seibutsu Chem Inst Glycosides d'echinatine et leur preparation
JPS51125362A (en) * 1975-04-17 1976-11-01 Hayashibara Biochem Lab Inc Process for synthesizing echinatin glycosides
LU77254A1 (sv) * 1977-05-04 1979-01-18
DK159967C (da) * 1977-12-22 1991-06-03 Hoffmann La Roche Analogifremgangsmaade til fremstilling af terapeutisk aktive stilbenderivater

Also Published As

Publication number Publication date
US4316983A (en) 1982-02-23
ATE2434T1 (de) 1983-03-15
ZA803538B (en) 1981-06-24
PT71435A (en) 1980-07-01
ES8201175A1 (es) 1981-12-01
DK262480A (da) 1980-12-22
KR830002800A (ko) 1983-05-30
AR229247A1 (es) 1983-07-15
DE3061891D1 (en) 1983-03-17
AU5902980A (en) 1981-01-08
PT71435B (en) 1981-10-22
EP0021339A1 (de) 1981-01-07
HU184915B (en) 1984-11-28
ES492616A0 (es) 1981-04-16
IE801280L (en) 1980-12-21
PH16243A (en) 1983-08-11
JPH0131518B2 (sv) 1989-06-26
AR225312A1 (es) 1982-03-15
NZ194061A (en) 1982-09-07
AU530478B2 (en) 1983-07-14
FI801472A (fi) 1980-12-22
EP0021339B1 (de) 1983-02-09
ES8104322A1 (es) 1981-04-16
IL60324A0 (en) 1980-09-16
DK154650C (da) 1989-05-01
MC1338A1 (fr) 1981-04-21
GR69283B (sv) 1982-05-13
IL60324A (en) 1984-01-31
FI67386C (fi) 1985-03-11
DK154650B (da) 1988-12-05
KR840000678B1 (ko) 1984-05-18
NO801862L (no) 1980-12-22
ES498607A0 (es) 1981-12-01
JPS567798A (en) 1981-01-27
CA1134819A (en) 1982-11-02
IE50463B1 (en) 1986-04-30
KR840000850B1 (ko) 1984-06-19
NO148644B (no) 1983-08-08
NO148644C (no) 1983-11-16

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Owner name: F. HOFFMANN-LA ROCHE AG