FI64371C - Foerfarande foer framstaellning av kardiovaskulaera 5h,7h-imidazo(4,5-h)-isokinolin-4,6-dioner - Google Patents

Foerfarande foer framstaellning av kardiovaskulaera 5h,7h-imidazo(4,5-h)-isokinolin-4,6-dioner Download PDF

Info

Publication number: FI64371C
Authority: FI; Finland
Prior art keywords: group; general formula; phenyl; isoquinoline; imidazo
Prior art date: 1977-07-21

Application number

FI782011A

Other languages

English (en)

Finnish (fi)

Other versions

FI782011A (fi

FI64371B (fi

Inventor

Volkhard Austel

Eberhard Kutter

Joachim Heider

Wolfgang Eberlein

Willi Diederen

Walter Haarmann

Walter Kobinger

Christian Lillie

Original Assignee

Thomae Gmbh Dr K

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1977-07-21

Filing date

1978-06-22

Publication date

1983-11-10

1977-07-21 Priority to DE2732906A priority Critical patent/DE2732906C2/de

1977-07-21 Priority claimed from DE19772732951 external-priority patent/DE2732951A1/de

1977-07-21 Priority claimed from DE2732906A external-priority patent/DE2732906C2/de

1978-06-22 Application filed by Thomae Gmbh Dr K filed Critical Thomae Gmbh Dr K

1979-01-22 Publication of FI782011A publication Critical patent/FI782011A/fi

1979-05-30 Priority to DE19792921912 priority patent/DE2921912A1/de

1983-07-29 Application granted granted Critical

1983-07-29 Publication of FI64371B publication Critical patent/FI64371B/fi

1983-11-10 Publication of FI64371C publication Critical patent/FI64371C/fi

Links

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
- C07D217/24—Oxygen atoms

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Hematology (AREA)
Vascular Medicine (AREA)
Hospice & Palliative Care (AREA)
Diabetes (AREA)
Urology & Nephrology (AREA)
Anesthesiology (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)

FI782011A 1977-07-21 1978-06-22 Foerfarande foer framstaellning av kardiovaskulaera 5h,7h-imidazo(4,5-h)-isokinolin-4,6-dioner FI64371C (fi)

Priority Applications (2)

Application Number	Priority Date	Filing Date	Title
DE2732906A DE2732906C2 (de)	1977-07-21	1977-07-21	In 5-Stellung durch einen Aminoalkylrest substituierte Imidazo-isochinolin-dione, Verfahren zu ihrer Herstellung und Arzneimittel
DE19792921912 DE2921912A1 (de)	1977-07-21	1979-05-30	2-phenyl-5-(3-aethylaminopropyl)- 7,7-dimethyl-5h,7h-imidazo eckige klammer auf 4,5-h eckige klammer zu isochinolin-4,6-dion und dessen verwendung als arzneimittel

Applications Claiming Priority (4)

Application Number	Priority Date	Filing Date	Title
DE19772732951 DE2732951A1 (de)	1977-07-21	1977-07-21	Neue imidazo-isochinolin-dione
DE2732951		1977-07-21
DE2732906		1977-07-21
DE2732906A DE2732906C2 (de)	1977-07-21	1977-07-21	In 5-Stellung durch einen Aminoalkylrest substituierte Imidazo-isochinolin-dione, Verfahren zu ihrer Herstellung und Arzneimittel

Publications (3)

Publication Number	Publication Date
FI782011A FI782011A (fi)	1979-01-22
FI64371B FI64371B (fi)	1983-07-29
FI64371C true FI64371C (fi)	1983-11-10

Family

ID=25772367

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
FI782011A FI64371C (fi)	1977-07-21	1978-06-22	Foerfarande foer framstaellning av kardiovaskulaera 5h,7h-imidazo(4,5-h)-isokinolin-4,6-dioner

Country Status (29)

Country	Link
US (1)	US4176184A (de)
JP (1)	JPS5422400A (de)
AT (1)	AT366383B (de)
AU (1)	AU519769B2 (de)
BG (1)	BG30021A3 (de)
CA (1)	CA1091232A (de)
CH (1)	CH642367A5 (de)
CS (1)	CS204032B2 (de)
DD (1)	DD137933A5 (de)
DK (1)	DK323378A (de)
ES (4)	ES471254A1 (de)
FI (1)	FI64371C (de)
FR (1)	FR2398069A1 (de)
GB (1)	GB2002751B (de)
GR (1)	GR65025B (de)
HK (1)	HK20685A (de)
HU (1)	HU181000B (de)
IL (1)	IL55168A (de)
IT (1)	IT1107653B (de)
LU (1)	LU80001A1 (de)
NL (1)	NL7807760A (de)
NO (1)	NO149314C (de)
NZ (1)	NZ187916A (de)
PL (1)	PL110398B1 (de)
PT (1)	PT68329A (de)
SE (1)	SE441746B (de)
SG (1)	SG185G (de)
SU (1)	SU688129A3 (de)
YU (1)	YU40340B (de)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE3531678A1 (de) *	1985-09-05	1987-03-12	Boehringer Mannheim Gmbh	Neue pyrrolo-benzimidazole, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel
JP2558707Y2 (ja) *	1986-06-25	1998-01-14	松下電工株式会社	蓄積式防排煙受信機
DE4027592A1 (de) *	1990-08-31	1992-03-05	Beiersdorf Ag	Neue pyrrolobenzimidazole, imidazobenzoxazinone und imidazochinolone, verfahren zu ihrer herstellung und ihre verwendung sowie die verbindungen enthaltende zubereitungen
DE19918211A1 (de)	1999-04-22	2000-10-26	Basf Ag	Cycloalkylsubstituierte Benzimidazole, deren Herstellung und Anwendung
EP1222187B1 (de) *	1999-10-06	2004-09-22	Boehringer Ingelheim Pharmaceuticals Inc.	Heterocyclische verbindungen verwendbar als tyrosinkinase inhibitoren
US6506769B2 (en) *	1999-10-06	2003-01-14	Boehringer Ingelheim Pharmaceuticals, Inc.	Heterocyclic compounds useful as inhibitors of tyrosine kinases
CA2417635C (en)	2000-08-11	2008-02-05	Boehringer Ingelheim Pharmaceuticals, Inc.	Heterocyclic compounds useful as inhibitors of tyrosine kinases
WO2005042530A1 (en) *	2003-10-30	2005-05-12	Boehringer Ingelheim (Canada) Ltd.	Rsv polymerase inhibitors

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
SE368009B (de) *	1971-09-16	1974-06-17	Kabi Ab
US3878206A (en) *	1973-06-06	1975-04-15	Morton Norwich Products Inc	9-(Substituted amino)imidazo{8 4,5-f{9 quinolines
US3919238A (en) *	1973-06-06	1975-11-11	Morton Norwich Products Inc	9-(Substituted amino)imidazo(4,5-f) quinolines

1978
- 1978-06-07 GR GR56730A patent/GR65025B/el unknown
- 1978-06-22 FI FI782011A patent/FI64371C/fi not_active IP Right Cessation
- 1978-06-29 ES ES471254A patent/ES471254A1/es not_active Expired
- 1978-07-11 AT AT0498878A patent/AT366383B/de active
- 1978-07-12 BG BG7840381A patent/BG30021A3/xx unknown
- 1978-07-17 US US05/925,461 patent/US4176184A/en not_active Expired - Lifetime
- 1978-07-17 IT IT50337/78A patent/IT1107653B/it active
- 1978-07-18 CH CH772778A patent/CH642367A5/de not_active IP Right Cessation
- 1978-07-19 SU SU782636902A patent/SU688129A3/ru active
- 1978-07-19 DD DD78206810A patent/DD137933A5/de unknown
- 1978-07-19 LU LU80001A patent/LU80001A1/de unknown
- 1978-07-19 DK DK323378A patent/DK323378A/da not_active Application Discontinuation
- 1978-07-19 CS CS784822A patent/CS204032B2/cs unknown
- 1978-07-19 CA CA307,712A patent/CA1091232A/en not_active Expired
- 1978-07-19 IL IL55168A patent/IL55168A/xx unknown
- 1978-07-20 SE SE7808018A patent/SE441746B/sv not_active IP Right Cessation
- 1978-07-20 JP JP8889578A patent/JPS5422400A/ja active Granted
- 1978-07-20 NZ NZ187916A patent/NZ187916A/xx unknown
- 1978-07-20 PT PT68329A patent/PT68329A/de unknown
- 1978-07-20 HU HU78TO1085A patent/HU181000B/hu unknown
- 1978-07-20 AU AU38210/78A patent/AU519769B2/en not_active Expired
- 1978-07-20 PL PL1978208543A patent/PL110398B1/pl unknown
- 1978-07-20 GB GB7830585A patent/GB2002751B/en not_active Expired
- 1978-07-20 NO NO782498A patent/NO149314C/no unknown
- 1978-07-20 YU YU1747/78A patent/YU40340B/xx unknown
- 1978-07-20 NL NL7807760A patent/NL7807760A/xx not_active Application Discontinuation
- 1978-07-21 FR FR7821745A patent/FR2398069A1/fr active Granted
- 1978-12-20 ES ES476167A patent/ES476167A1/es not_active Expired
- 1978-12-20 ES ES476168A patent/ES476168A1/es not_active Expired
- 1978-12-20 ES ES476166A patent/ES476166A1/es not_active Expired
1985
- 1985-01-03 SG SG1/85A patent/SG185G/en unknown
- 1985-03-21 HK HK206/85A patent/HK20685A/xx unknown

Also Published As

Publication number	Publication date
CH642367A5 (de)	1984-04-13
GR65025B (en)	1980-06-16
AT366383B (de)	1982-04-13
FR2398069A1 (fr)	1979-02-16
FR2398069B1 (de)	1981-05-22
NO149314B (no)	1983-12-19
ES471254A1 (es)	1979-10-01
PL110398B1 (en)	1980-07-31
PL208543A1 (pl)	1979-05-21
DK323378A (da)	1979-01-22
IT7850337A0 (it)	1978-07-17
NL7807760A (nl)	1979-01-23
AU519769B2 (en)	1981-12-24
ES476166A1 (es)	1979-06-01
GB2002751B (en)	1982-02-10
ATA498878A (de)	1981-08-15
BG30021A3 (en)	1981-03-16
GB2002751A (en)	1979-02-28
NZ187916A (en)	1981-05-01
AU3821078A (en)	1980-01-24
JPS5422400A (en)	1979-02-20
ES476167A1 (es)	1979-04-16
HK20685A (en)	1985-03-29
NO149314C (no)	1984-03-28
FI782011A (fi)	1979-01-22
ES476168A1 (es)	1979-05-16
YU40340B (en)	1985-12-31
IL55168A (en)	1981-09-13
LU80001A1 (de)	1979-09-06
YU174778A (en)	1983-02-28
PT68329A (de)	1978-08-01
SE7808018L (sv)	1979-01-22
IL55168A0 (en)	1978-09-29
SU688129A3 (ru)	1979-09-25
CA1091232A (en)	1980-12-09
US4176184A (en)	1979-11-27
CS204032B2 (en)	1981-03-31
FI64371B (fi)	1983-07-29
DD137933A5 (de)	1979-10-03
JPS6112912B2 (de)	1986-04-10
NO782498L (no)	1979-01-23
SG185G (en)	1985-06-14
SE441746B (sv)	1985-11-04
IT1107653B (it)	1985-11-25
HU181000B (en)	1983-05-30

Legal Events

Date	Code	Title	Description
2004-08-31	MM	Patent lapsed	Owner name: DR. KARL THOMAE GMBH

Publication	Publication Date	Title
US3813384A (en)	1974-05-28	Basically substituted benzyl phthalazone derivatives,acid salts thereof and process for the production thereof
FI64371C (fi)	1983-11-10	Foerfarande foer framstaellning av kardiovaskulaera 5h,7h-imidazo(4,5-h)-isokinolin-4,6-dioner
NO813066L (no)	1982-03-11	Isokinolinderivater, fremgangsmaate til deres fremstilling, farmasoeytiske tilberedninger, innhold og deres anvendelse
GB1581500A (en)	1980-12-17	Pyridobenzodiazepines
US3227715A (en)	1966-01-04	Benzisothiazolones
CA1109064A (en)	1981-09-15	New, in 11-position substituted, 5,11-dihydro-6h- pyrido [2,3-b] - [1,4] benzodiazepine-6-ones, processes for their production and pharmaceutical compositions containing them
US3644366A (en)	1972-02-22	1-amino-3 4-dihydroisoquinolines
Hermecz et al.	1987	Nitrogen bridgehead compounds. 66. Bronchodilator nitrogen bridgehead compounds with a pyrimidinone moiety
US3322759A (en)	1967-05-30	Bicyclic diaza compounds
DE69523259T2 (de)	2002-07-04	Amine Derivate, ihre Herstellung und Anwendung
US3118884A (en)	1964-01-21	Derivatives of 3-azaphenothiazine and 3-azaphenoxazine
NO139386B (no)	1978-11-20	Analogifremgangsmaate for fremstilling av farmakologisk aktive imidazopyridiner
US3753981A (en)	1973-08-21	4-amino-2-styrylquinazoline compounds
US3420823A (en)	1969-01-07	Dibenzothiazines
US4118494A (en)	1978-10-03	Substituted 3,4-dihydro-2H-isoquinolin-1-thiones
Tatarczyñska et al.	2001	Synthesis, 5-HT1A and 5-HT2A receptor activity of new 1-phenylpiperazinylpropyl derivatives with arylalkyl substituents in position 7 of purine-2, 6-dione
CA1080219A (en)	1980-06-24	Piperazine derivatives and a process for the preparation thereof
US3133930A (en)	1964-05-19	Ester and amide derivatives of thieno-[3, 2-b] indole 3-carboxylic acids
US3845037A (en)	1974-10-29	Polycyclic pentanones
US4350698A (en)	1982-09-21	Antiallergic imidosulfamides
Huckle et al.	1971	4-Amino-2, 3, 4, 5-tetrahydro-1-benzoxepin-5-ols, 4-amino-2, 3, 4, 5-tetrahydro-1-benzothiepin-5-ols, and related compounds
US3781293A (en)	1973-12-25	Methanobenzo(b)thiophenes
US4904688A (en)	1990-02-27	Tricyclic amine derivatives
US3427311A (en)	1969-02-11	5,11-dihydroindolo(3,2-c)(2,1)-benzothiazine-6,6-dioxide compounds
US3657238A (en)	1972-04-18	3-morpholinoalkyl-2 1-benzoisothiazolines