FI49497C - Förfarande för framställning av terapeutiskt verksamma 1-fenoxi-2-hydr oxi-3-alkylaminopropaner. - Google Patents

Förfarande för framställning av terapeutiskt verksamma 1-fenoxi-2-hydr oxi-3-alkylaminopropaner.

Info

Publication number: FI49497C
Authority: FI; Finland
Prior art keywords: alkylaminopropanes; phenoxy; preparation; therapeutically active; therapeutically
Prior art date: 1967-12-13

Application number

FI683535A

Other languages

English (en)

Finnish (fi)

Other versions

FI49497B (sv

Inventor

Herbert Koeppe

Werner Kummer

Helmut Staehle

Karl Zeile

Albrecht Engelhardt

Original Assignee

Boehringer Sohn Ingelheim

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1967-12-13

Filing date

1968-12-11

Publication date

1975-07-10

1968-12-11 Application filed by Boehringer Sohn Ingelheim filed Critical Boehringer Sohn Ingelheim

1975-04-01 Application granted granted Critical

1975-04-01 Publication of FI49497B publication Critical patent/FI49497B/fi

1975-07-10 Publication of FI49497C publication Critical patent/FI49497C/sv

Links

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
- C07D309/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
- C07D309/08—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D309/10—Oxygen atoms
- C07D309/12—Oxygen atoms only hydrogen atoms and one oxygen atom directly attached to ring carbon atoms, e.g. tetrahydropyranyl ethers
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Life Sciences & Earth Sciences (AREA)
Pharmacology & Pharmacy (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Medicinal Chemistry (AREA)
Epidemiology (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Vascular Medicine (AREA)
Urology & Nephrology (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

FI683535A 1967-12-13 1968-12-11 Förfarande för framställning av terapeutiskt verksamma 1-fenoxi-2-hydr oxi-3-alkylaminopropaner. FI49497C (sv)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
DE1643262A DE1643262C3 (de)	1967-12-13	1967-12-13	i-Phenoxy^-hydroxy-S-alklyaminopropane, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende Arzneimittel

Publications (2)

Publication Number	Publication Date
FI49497B FI49497B (sv)	1975-04-01
FI49497C true FI49497C (sv)	1975-07-10

Family

ID=5684274

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
FI683535A FI49497C (sv)	1967-12-13	1968-12-11	Förfarande för framställning av terapeutiskt verksamma 1-fenoxi-2-hydr oxi-3-alkylaminopropaner.

Country Status (21)

Country	Link
US (1)	US3872147A (sv)
JP (1)	JPS5220457B1 (sv)
AT (13)	AT292679B (sv)
BE (1)	BE725490A (sv)
BG (9)	BG17298A3 (sv)
BR (1)	BR6804840D0 (sv)
CA (1)	CA954528A (sv)
CH (2)	CH556816A (sv)
DE (1)	DE1643262C3 (sv)
DK (1)	DK131029B (sv)
ES (11)	ES361189A1 (sv)
FI (1)	FI49497C (sv)
FR (2)	FR1596100A (sv)
GB (1)	GB1260866A (sv)
HU (1)	HU162734B (sv)
IE (1)	IE32758B1 (sv)
IL (1)	IL31266A (sv)
NL (3)	NL146709B (sv)
PH (1)	PH9266A (sv)
SE (1)	SE367396B (sv)
YU (12)	YU33949B (sv)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3541130A (en) *	1967-02-06	1970-11-17	Boehringer Sohn Ingelheim	1-(cyanophenoxy)-2-hydroxy-3-tert.-butylamine propanes
US4086272A (en) *	1970-07-18	1978-04-25	Pfizer Inc.	Phenyl-alkanolamine, alkylamine and alpha-aminoalkyl ketone derivatives as heart stimulants
US3998874A (en) *	1971-03-23	1976-12-21	Gist-Brocades N.V.	Phenylene di-ethers
US4038414A (en) *	1972-06-08	1977-07-26	Ciba-Geigy Corporation	Amines and processes for their manufacture
US4084002A (en) *	1973-02-28	1978-04-11	Boehringer Ingelheim Gmbh	Pharmaceutical compositions containing a 1-phenoxy-2-hydroxy-3-alkynylamino-propane and method of use
DE2309887C2 (de) *	1973-02-28	1983-11-10	C.H. Boehringer Sohn, 6507 Ingelheim	1-Aryloxy-2-hydroxy-3-alkinylaminopropan-Derivate und deren physiologisch verträgliche Säureadditionssalze, pharmazeutische Präparate und Herstellungsverfahren für die Verbindungen
US4161530A (en) *	1975-01-06	1979-07-17	Ciba-Geigy Corporation	Pharmaceutical combination preparations as hypnotics
US4094991A (en) *	1975-06-17	1978-06-13	Nippon Shinyaku Co., Ltd.	Substituted n-(carboxymethyl)-3-aminopropan-2-ol derivatives
US4243681A (en) *	1977-10-11	1981-01-06	Mead Johnson & Company	Alkylthiophenoxypropanolamines and pharmaceutical compositions and uses thereof
DE2839475A1 (de) *	1978-09-11	1980-03-20	Dolorgiet Arzneimittelfabrik	Isopropylamin-verbindungen, verfahren zu ihrer herstellung und sie enthaltende arzneimittel
EP0025331B1 (en) *	1979-09-06	1983-03-02	Beecham Group Plc	Cinnamic acid derivatives, their preparation, and pharmaceutical compositions containing them
JPS56142262A (en)	1980-04-08	1981-11-06	Nippon Shinyaku Co Ltd	Piperazine derivative
US4405642A (en) *	1980-11-28	1983-09-20	American Hospital Supply Corporation	Method for treatment or prophylaxis of cardiac disorders
US4593119A (en) *	1980-11-28	1986-06-03	American Hospital Supply Corporation	Method for treatment or prophylaxis of cardiac disorders
US4387103A (en) *	1980-11-28	1983-06-07	American Hospital Supply Corporation	Method for treatment or prophylaxis of cardiac disorders
US4396629A (en) *	1980-12-29	1983-08-02	Sterling Drug Inc.	Compositions, processes and method
DE3131527A1 (de) *	1981-08-08	1983-02-24	Kali-Chemie Pharma Gmbh, 3000 Hannover	1-phenyl-2-aminocarbonylindol-verbindungen sowie verfahren und zwischenprodukte zu ihrer herstellung und diese verbindungen enthaltende arzneimittel
JPH0720861B2 (ja) *	1984-04-09	1995-03-08	ザデュポンマークファーマソウテイカルカンパニー	心臓障害の処置または予防用の医薬組成物および方法
US4652584A (en) *	1984-07-13	1987-03-24	Mcneilab, Inc.	Acetylenic phenoxypropanol derivatives and pharmaceutical compositions for the treatment of hypertension
US4665094A (en) *	1985-08-29	1987-05-12	Merck & Co., Inc.	Oculoselective beta-blockers for treatment of elevated intraocular pressure
ES2011255B3 (es) *	1985-12-24	1990-01-01	Merck & Co Inc	Bloqueadores beta selectivos para los ojos.
US4945182A (en) *	1985-12-24	1990-07-31	Merck & Co., Inc.	Oculoselective beta-blockers
US5480908A (en) *	1993-12-13	1996-01-02	American Cyanamid Company	β3 -adrenergic agents benzodioxole dicarboxylates and their use in pharmaceutical compositions

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3459782A (en) *	1963-08-26	1969-08-05	Boehringer Sohn Ingelheim	1-substituted phenoxy-2-hydroxy-3-isopropylamino-propanes

1967
- 1967-12-13 DE DE1643262A patent/DE1643262C3/de not_active Expired
1968
- 1968-04-03 BG BG12150A patent/BG17298A3/xx unknown
- 1968-04-30 BG BG12149A patent/BG17297A3/xx unknown
- 1968-12-07 ES ES361189A patent/ES361189A1/es not_active Expired
- 1968-12-10 CH CH848471A patent/CH556816A/xx not_active IP Right Cessation
- 1968-12-10 CH CH1843568A patent/CH532015A/de not_active IP Right Cessation
- 1968-12-11 FI FI683535A patent/FI49497C/sv active
- 1968-12-11 NL NL686817768A patent/NL146709B/xx not_active IP Right Cessation
- 1968-12-11 PH PH9832*UA patent/PH9266A/en unknown
- 1968-12-12 DK DK608568AA patent/DK131029B/da not_active IP Right Cessation
- 1968-12-12 SE SE17070/68A patent/SE367396B/xx unknown
- 1968-12-12 JP JP43091282A patent/JPS5220457B1/ja active Pending
- 1968-12-12 YU YU2949/68A patent/YU33949B/xx unknown
- 1968-12-12 CA CA037,721A patent/CA954528A/en not_active Expired
- 1968-12-13 AT AT880170A patent/AT292679B/de active
- 1968-12-13 BE BE725490D patent/BE725490A/xx not_active IP Right Cessation
- 1968-12-13 IL IL31266A patent/IL31266A/xx unknown
- 1968-12-13 BG BG011231A patent/BG16329A3/bg unknown
- 1968-12-13 AT AT879570A patent/AT292674B/de active
- 1968-12-13 AT AT880270A patent/AT292680B/de active
- 1968-12-13 AT AT879970A patent/AT298459B/de not_active IP Right Cessation
- 1968-12-13 IE IE1519/68A patent/IE32758B1/xx unknown
- 1968-12-13 AT AT1216668A patent/AT292670B/de not_active IP Right Cessation
- 1968-12-13 FR FR1596100D patent/FR1596100A/fr not_active Expired
- 1968-12-13 BG BG12146A patent/BG19135A3/xx unknown
- 1968-12-13 AT AT879870A patent/AT292677B/de active
- 1968-12-13 GB GB59518/68A patent/GB1260866A/en not_active Expired
- 1968-12-13 AT AT595771A patent/AT298463B/de not_active IP Right Cessation
- 1968-12-13 AT AT879370A patent/AT292673B/de active
- 1968-12-13 AT AT880070A patent/AT292678B/de not_active IP Right Cessation
- 1968-12-13 AT AT879770A patent/AT292676B/de active
- 1968-12-13 AT AT879470A patent/AT294799B/de not_active IP Right Cessation
- 1968-12-13 HU HUBO1162A patent/HU162734B/hu unknown
- 1968-12-13 BR BR204840/68A patent/BR6804840D0/pt unknown
- 1968-12-13 AT AT879670A patent/AT292675B/de not_active IP Right Cessation
1969
- 1969-03-13 FR FR183279A patent/FR8328M/fr not_active Expired
- 1969-04-30 BG BG012148A patent/BG16332A3/bg unknown
- 1969-04-30 BG BG012144A patent/BG16444A3/bg unknown
- 1969-04-30 BG BG012145A patent/BG16445A3/bg unknown
- 1969-04-30 BG BG012147A patent/BG16331A3/bg unknown
- 1969-04-30 BG BG012143A patent/BG16330A3/bg unknown
1970
- 1970-01-15 ES ES375450A patent/ES375450A1/es not_active Expired
- 1970-01-15 ES ES375446A patent/ES375446A1/es not_active Expired
- 1970-01-15 ES ES375453A patent/ES375453A1/es not_active Expired
- 1970-01-15 ES ES375447A patent/ES375447A1/es not_active Expired
- 1970-01-15 ES ES375445A patent/ES375445A1/es not_active Expired
- 1970-01-15 ES ES375451A patent/ES375451A1/es not_active Expired
- 1970-01-15 ES ES375448A patent/ES375448A1/es not_active Expired
- 1970-01-15 ES ES375444A patent/ES375444A1/es not_active Expired
- 1970-01-15 ES ES375449A patent/ES375449A1/es not_active Expired
- 1970-01-15 ES ES375452A patent/ES375452A1/es not_active Expired
- 1970-12-13 AT AT08803/70A patent/AT292681B/de active
1971
- 1971-12-02 US US204316A patent/US3872147A/en not_active Expired - Lifetime
1974
- 1974-09-03 YU YU2379/74A patent/YU33853B/xx unknown
- 1974-09-03 YU YU2377/74A patent/YU33947B/xx unknown
- 1974-09-03 YU YU2383/74A patent/YU33856B/xx unknown
- 1974-09-03 YU YU2375/74A patent/YU33946B/xx unknown
- 1974-09-03 YU YU2374/74A patent/YU33851B/xx unknown
- 1974-09-03 YU YU2380/74A patent/YU33854B/xx unknown
- 1974-09-03 YU YU2381/74A patent/YU33774B/xx unknown
- 1974-09-03 YU YU2376/74A patent/YU33773B/xx unknown
- 1974-09-03 YU YU2378/74A patent/YU33852B/xx unknown
- 1974-09-03 YU YU2382/74A patent/YU33855B/xx unknown
- 1974-09-03 YU YU2384/74A patent/YU33948B/xx unknown
1975
- 1975-02-14 NL NL757501794A patent/NL151354B/xx not_active IP Right Cessation
- 1975-02-14 NL NL7501792A patent/NL7501792A/xx unknown

Also Published As

Publication number	Publication date
YU237874A (en)	1977-12-31
GB1260866A (en)	1972-01-19
BG16329A3 (bg)	1972-08-20
CH556816A (de)	1974-12-13
ES375453A1 (es)	1972-05-16
YU237774A (en)	1978-02-28
NL6817768A (sv)	1969-06-17
YU237674A (en)	1977-10-31
ES375444A1 (es)	1972-05-01
DE1643262B2 (de)	1974-11-07
ES375448A1 (es)	1972-05-01
ES375449A1 (es)	1972-05-01
YU238374A (en)	1977-12-31
IE32758B1 (en)	1973-11-28
BG16444A3 (bg)	1972-11-20
YU294968A (en)	1978-02-28
YU237574A (en)	1978-02-28
AT292674B (de)	1971-09-10
SE367396B (sv)	1974-05-27
HU162734B (sv)	1973-04-28
YU33855B (en)	1978-06-30
AT292679B (de)	1971-09-10
AT292678B (de)	1971-09-10
DK131029C (sv)	1975-10-06
YU33852B (en)	1978-06-30
NL7501794A (nl)	1975-05-30
DK131029B (da)	1975-05-20
FR1596100A (sv)	1970-06-15
YU33773B (en)	1978-05-15
AT292680B (de)	1971-09-10
IL31266A (en)	1974-09-10
AT292673B (de)	1971-09-10
AT292675B (de)	1971-09-10
CH532015A (de)	1972-12-31
ES361189A1 (es)	1970-08-16
ES375451A1 (es)	1972-05-01
ES375445A1 (es)	1972-05-16
BG19135A3 (sv)	1975-04-30
DE1643262C3 (de)	1975-06-26
YU33853B (en)	1978-06-30
FR8328M (sv)	1970-12-07
BG16332A3 (bg)	1972-08-20
PH9266A (en)	1975-07-30
BG16445A3 (bg)	1972-11-20
FI49497B (sv)	1975-04-01
CA954528A (en)	1974-09-10
YU238174A (en)	1977-10-31
AT298459B (de)	1972-05-10
YU33946B (en)	1978-09-08
AT292677B (de)	1971-09-10
AT298463B (de)	1972-05-10
YU238474A (en)	1978-02-28
ES375446A1 (es)	1972-05-01
NL151354B (nl)	1976-11-15
ES375447A1 (es)	1972-05-01
YU237474A (en)	1977-12-31
YU33947B (en)	1978-09-08
BG16331A3 (bg)	1972-08-20
AT292670B (de)	1971-09-10
YU237974A (en)	1977-12-31
YU33774B (en)	1978-05-15
NL7501792A (nl)	1975-05-30
DE1643262A1 (de)	1972-04-20
US3872147A (en)	1975-03-18
BR6804840D0 (pt)	1973-03-08
YU33854B (en)	1978-06-30
YU33851B (en)	1978-06-30
AT292676B (de)	1971-09-10
NL146709B (nl)	1975-08-15
BE725490A (sv)	1969-06-13
BG16330A3 (bg)	1972-08-20
ES375450A1 (es)	1972-05-01
YU33856B (en)	1978-06-30
BG17298A3 (sv)	1973-07-25
YU33948B (en)	1978-09-08
AT292681B (de)	1971-08-15
YU238274A (en)	1977-12-31
IL31266A0 (en)	1969-02-27
ES375452A1 (es)	1972-05-16
AT294799B (de)	1971-12-10
JPS5220457B1 (sv)	1977-06-03
BG17297A3 (sv)	1973-07-25
YU33949B (en)	1978-09-08
IE32758L (en)	1969-06-13
YU238074A (en)	1977-12-31

Publication	Publication Date	Title
DK128318B (da)	1974-04-08	Analogifremgangsmåde til fremstilling af terapeutisk aktive bischromoner.
FI42712C (fi)	1970-10-12	Menetelmä terapeuttisesti vaikuttavien bifenyylialkaanijohdannaisten valmistamiseksi
FI49957C (sv)	1975-11-10	Förfarande för framställning av terapeutiskt verksamma oximetrar.
FI49497C (sv)	1975-07-10	Förfarande för framställning av terapeutiskt verksamma 1-fenoxi-2-hydr oxi-3-alkylaminopropaner.
FI48727C (sv)	1974-12-10	Förfarande vid framställning av acetylguanidiner.
FI50707C (sv)	1976-06-10	Förfarande för framställning av nya farmakologiskt aktiva hydroxicyklo hexylaminer.
FI49720C (sv)	1975-09-10	Förfarande för framställning av terapeutiskt verksamma 2-metyl-3-karbo nsyraamidokinoxalin-di-N-oxider-(1,4).
FI52857C (sv)	1977-12-12	Förfarande för framställning av terapeutiskt verksamma amidoximer.
FI45551C (sv)	1972-07-10	Förfarande för framställning av terapeutiskt användbart dehydroepiandr osteronönantat.
DK117635B (da)	1970-05-19	Analogifremgangsmåde til fremstilling af terapeutisk virksomme 3-(piperazinoalkyl)-pyrazoler.
FI49718C (sv)	1975-09-10	Förfarande för framställning av terapeutiskt verksamma 2-halogenmetyl- 3-karbonsyraamidokinoxalin-di-N-oxider-(1,4)
FI51175C (sv)	1976-11-10	Förfarande för framställning av terapeutiskt användbara indanyltiokarb amater.
FI49032C (sv)	1975-03-10	Förfarande för framställning av terapeutiskt aktiva 7-nitro-8-hydroxi- kinolin-estrar.
FI50420C (sv)	1976-03-10	Förfarande för framställning av terapeutiskt aktiva 4-pyrimidinyl-1,4- dihydropyridinderivat
FI47189C (sv)	1973-10-10	Förfarande för framställning av terapeutiskt aktiva d-lyserginsyra-N-f enylpiperazider.
FI48576C (sv)	1974-11-11	Förfaringssätt för framställning av terapeutiskt aktiva alfa-fluor-mal onsyraderivat.
FI46066C (sv)	1972-12-11	Analogiförfarande för framställning av terapeutiskt verksamma N,N-dime tylaminoetyl-14beta-hydroxi-5beta-pregn-20-en-21-karboxylat.
FI48190C (sv)	1974-07-10	Förfarande för framställning av terapeutiskt aktiva 10alfa-metoxi-9,10 -dihydroergolinderivat
FI50879C (sv)	1976-08-10	Förfarande för framställning av terapeutiskt verksamma sybstituerade 3 -aminoacylamino-tiofener.
FI48841C (sv)	1975-01-10	Analogiförfarande för framställning av farmakologiskt aktiva 5-nitro-2 -furfurylidenaminooxazolidinoner.
FI45553C (sv)	1972-07-10	Förfarande för framställning av terapeutiskt användbara 16-tiosubstitu erade 9beta,10alfa-pregnener
FI47661C (sv)	1974-02-11	Förfarande för framställning av terapeutiskt verkande bensofuranderiva t.
FI47651C (sv)	1974-02-11	Sätt att framställa dikvävetetroxid.
FI49722C (sv)	1975-09-10	Förfarande för framställning av terapeutiskt verksamma 3-karbonsyraami do-kinoxalin-di-N-oxider-(1,4).
DK122763B (da)	1972-04-10	Analogifremgangsmåde til fremstilling af terapeutisk aktive 1,2α-methylen-4-pregnen-3,20-dionderivater.