FI106863B - Menetelmä uusien, terapeuttisesti käyttökelpoisten 5- tai 6-deoksiheksofuranoosimonosakkaridien valmistamiseksi, joissa on 5- tai 6-asemassa tyydyttynyt typpeä sisältävä heterosykli, joka kiinnittyy typpiatomin kautta - Google Patents

Menetelmä uusien, terapeuttisesti käyttökelpoisten 5- tai 6-deoksiheksofuranoosimonosakkaridien valmistamiseksi, joissa on 5- tai 6-asemassa tyydyttynyt typpeä sisältävä heterosykli, joka kiinnittyy typpiatomin kautta Download PDF

Info

Publication number
FI106863B
FI106863B FI933654A FI933654A FI106863B FI 106863 B FI106863 B FI 106863B FI 933654 A FI933654 A FI 933654A FI 933654 A FI933654 A FI 933654A FI 106863 B FI106863 B FI 106863B
Authority
FI
Finland
Prior art keywords
isopropylidene
deoxy
pyrrolidinyl
glucofuranose
monosaccharide
Prior art date
Application number
FI933654A
Other languages
English (en)
Finnish (fi)
Swedish (sv)
Other versions
FI933654A (fi
FI933654A0 (fi
Inventor
Sudershan K Arora
David S Thomson
M Nayeem Akhtar
Original Assignee
Boston Life Sciences Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boston Life Sciences Inc filed Critical Boston Life Sciences Inc
Publication of FI933654A publication Critical patent/FI933654A/fi
Publication of FI933654A0 publication Critical patent/FI933654A0/fi
Application granted granted Critical
Publication of FI106863B publication Critical patent/FI106863B/fi

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/02—Acyclic radicals, not substituted by cyclic structures
    • C07H15/12—Acyclic radicals, not substituted by cyclic structures attached to a nitrogen atom of the saccharide radical
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/24—Heterocyclic radicals containing oxygen or sulfur as ring hetero atom
FI933654A 1991-12-20 1993-08-19 Menetelmä uusien, terapeuttisesti käyttökelpoisten 5- tai 6-deoksiheksofuranoosimonosakkaridien valmistamiseksi, joissa on 5- tai 6-asemassa tyydyttynyt typpeä sisältävä heterosykli, joka kiinnittyy typpiatomin kautta FI106863B (fi)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US81090691A 1991-12-20 1991-12-20
US81090691 1991-12-20
US07/905,320 US5360792A (en) 1991-12-20 1992-06-29 Anti-proliferative and anti-inflammatory compounds: 5- or 6-deoxy hexose monosaccharides having a saturated nitrogen-containing heterocycle at the 5- or 6-position bound through the nitrogen atom
US90532092 1992-06-29
US9210775 1992-12-18
PCT/US1992/010775 WO1993013117A2 (en) 1991-12-20 1992-12-18 5- or 6-aminodeoxyfuranoside derivatives with antiinflammatory and antiproliferative activity

Publications (3)

Publication Number Publication Date
FI933654A FI933654A (fi) 1993-08-19
FI933654A0 FI933654A0 (fi) 1993-08-19
FI106863B true FI106863B (fi) 2001-04-30

Family

ID=27123396

Family Applications (1)

Application Number Title Priority Date Filing Date
FI933654A FI106863B (fi) 1991-12-20 1993-08-19 Menetelmä uusien, terapeuttisesti käyttökelpoisten 5- tai 6-deoksiheksofuranoosimonosakkaridien valmistamiseksi, joissa on 5- tai 6-asemassa tyydyttynyt typpeä sisältävä heterosykli, joka kiinnittyy typpiatomin kautta

Country Status (12)

Country Link
US (1) US5360792A (ja)
EP (1) EP0581916B1 (ja)
JP (1) JPH06508152A (ja)
CN (1) CN1077198A (ja)
AT (1) ATE163422T1 (ja)
CA (1) CA2104477A1 (ja)
DE (1) DE69224520T2 (ja)
FI (1) FI106863B (ja)
IL (1) IL104112A (ja)
NZ (1) NZ246305A (ja)
TW (1) TW293013B (ja)
WO (1) WO1993013117A2 (ja)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5432163A (en) * 1992-11-13 1995-07-11 Greenwich Pharmaceuticals Incorporated Anti-proliferative and anti-inflammatory compounds: derivatives of pentose monosaccharides
EP0715519B1 (en) * 1993-06-11 2003-05-02 Boston Life Sciences, Inc. Immunomodulatory, anti-inflammatory, and anti-proliferative compounds: 5,6-dideoxy, 5-amino derivatives of idose and 6-deoxy, 6-amino derivatives of glucose
US6329344B1 (en) * 1998-10-22 2001-12-11 Ranbaxy Laboratories Limited Derivatives of monosaccharides as cell adhesion inhibitors
ATE515258T1 (de) 1999-02-05 2011-07-15 Alk Abello As Mukosales verabreichungssytem
WO2005092907A2 (en) * 2004-03-26 2005-10-06 Ranbaxy Laboratories Limited Monosaccharide derivatives as anti-cancer and anti-inflammatory agents
WO2005100373A2 (en) * 2004-04-13 2005-10-27 Ranbaxy Laboratories Limited Monosaccharide derivatives as anti-cancer and anti-inflammatory agents
CA2571710A1 (en) * 2004-06-24 2006-11-02 Nicholas Valiante Small molecule immunopotentiators and assays for their detection
WO2006024926A1 (en) * 2004-09-02 2006-03-09 Ranbaxy Laboratories Limited Monosaccharide derivatives
JP2008525421A (ja) * 2004-12-22 2008-07-17 ランバクシー ラボラトリーズ リミテッド モノサッカリド誘導体
US20080114031A1 (en) * 2006-03-29 2008-05-15 Sattigeri Viswajanani J Monosaccharide derivatives
US7790689B2 (en) * 2006-05-30 2010-09-07 Ranbaxy Laboratories Limited Monosaccharide derivatives
EP1953170A1 (en) * 2006-10-03 2008-08-06 Ranbaxy Laboratories Limited Monosaccharide derivatives as anti-inflammatory agents

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2715121A (en) * 1950-09-09 1955-08-09 American Home Prod Alkyl sugar derivatives and their preparation
USRE30379E (en) * 1973-03-01 1980-08-19 Strategic Medical Research Corp. Ethereal monosubstitutions of monosaccharide derivatives
USRE32268E (en) * 1973-03-01 1986-10-21 Strategic Medical Research Corp. Therapeutic composition and method of therapeutically treating warm blooded animals therewith
US3939146A (en) * 1973-03-01 1976-02-17 Strategic Medical Research Corporation Novel ethereal monosubstitutions of monosaccharide derivatives
US3939145A (en) * 1973-03-01 1976-02-17 Strategic Medical Research Corporation Novel ethereally monosubstituted monosaccharides
US4016261A (en) * 1973-03-01 1977-04-05 Strategic Medical Research Corporation Therapeutic composition and method of therapeutically treating warm blooded animals therewith
US3965262A (en) * 1973-03-01 1976-06-22 Strategic Medical Research Corporation Method of enhancing learning and/or memory in warm blooded animals
US4017608A (en) * 1973-12-14 1977-04-12 Strategic Medical Research Corporation Therapeutic composition and method of therapeutically treating warm blooded animals therewith
US4056322A (en) * 1973-12-14 1977-11-01 Strategic Medical Research Corporation Preparation of ethers of monosaccharides
GB1589916A (en) * 1976-11-16 1981-05-20 Prodotti Antibiotici Spa Glucofuranose derivatives
USRE30354E (en) * 1978-02-17 1980-07-29 Strategic Medical Research Corp. Novel ethereally monosubstituted monosaccharides
USRE33000E (en) * 1981-01-12 1989-07-25 Greenwich Pharmaceuticals, Incorporated Therapeutic composition and method of treating viruses
US4735934A (en) * 1981-02-17 1988-04-05 Greenwich Pharmaceuticals Incorporated Method of therapeutically treating a warm blooded animal afflicted with an autoimmune disease
US4738953A (en) * 1981-02-17 1988-04-19 Greenwich Pharmaceuticals Incorporated Method of therapeutically treating a warm blooded animal afflicted with an autoimmune disease and a synergistic composition therefor
US4996195A (en) * 1989-01-09 1991-02-26 Greenwich Pharmaceuticals Inc. Derivatives of α,D-glucofuranose or α,D-allofuranose and intermediates for preparing these derivatives
US5010058A (en) * 1989-06-22 1991-04-23 501 Greenwich Pharmaceuticals Incorporated 3,5,6-substituted derivatives of 1,2-O-isopropylidene-α,D-glucofuranose and intermediates for preparing these derivatives
WO1992004359A2 (en) * 1990-09-12 1992-03-19 Greenwich Pharmaceuticals, Inc. Monosaccharides having anti-proliferation and anti-inflammatory activity, compositions and uses thereof
IL100833A0 (en) * 1991-02-20 1992-09-06 Greenwich Pharma Method for synthesis of ethereally substituted blocked monosaccharides

Also Published As

Publication number Publication date
ATE163422T1 (de) 1998-03-15
CN1077198A (zh) 1993-10-13
CA2104477A1 (en) 1993-06-21
TW293013B (ja) 1996-12-11
IL104112A (en) 1997-09-30
AU665977B2 (en) 1996-01-25
JPH06508152A (ja) 1994-09-14
WO1993013117A2 (en) 1993-07-08
IL104112A0 (en) 1993-05-13
AU3249593A (en) 1993-07-28
DE69224520T2 (de) 1998-07-23
FI933654A (fi) 1993-08-19
WO1993013117A3 (en) 1993-09-30
EP0581916B1 (en) 1998-02-25
DE69224520D1 (de) 1998-04-02
EP0581916A1 (en) 1994-02-09
US5360792A (en) 1994-11-01
FI933654A0 (fi) 1993-08-19
NZ246305A (en) 1996-10-28

Similar Documents

Publication Publication Date Title
FI106863B (fi) Menetelmä uusien, terapeuttisesti käyttökelpoisten 5- tai 6-deoksiheksofuranoosimonosakkaridien valmistamiseksi, joissa on 5- tai 6-asemassa tyydyttynyt typpeä sisältävä heterosykli, joka kiinnittyy typpiatomin kautta
US5010058A (en) 3,5,6-substituted derivatives of 1,2-O-isopropylidene-α,D-glucofuranose and intermediates for preparing these derivatives
AU616335B2 (en) Derivatives of alpha, d-glucofuranose or alpha d-allofuranose and intermediates for preparing these derivatives
ES2223447T3 (es) Derivados de monosacaridos como inhibidores de la adhesion celular.
US5432163A (en) Anti-proliferative and anti-inflammatory compounds: derivatives of pentose monosaccharides
US5360794A (en) Disubstituted and deoxy disubstituted derivatives of α-D-mannofuranosides and β-L-gulofuranosides having anti-inflammatory and anti-proliferative activity
EP1147119A1 (en) 2,3-o-isoproylidene derivatives of monosaccharides as cell adhesion inhibitors
US6060453A (en) Immunomodulatory, anti-inflammatory, and anti-proliferative compounds: 5,6-dideoxy, 5-amino derivatives of idose and 6-deoxy, 6-amino derivatives of glucose
EP0548226A1 (en) Monosaccharides having anti-proliferation and anti-inflammatory activity, compositions and uses thereof
EP1996603B1 (en) Lipid a antagonists with anti-septic shock, anti-inflammatory, anti-ischemia and analgesic activity
AU665977C (en) 5-or-6-aminodeoxyfuranoside derivatives with antiinflammatory and antiproliferative activity
BRPI0411068B1 (pt) Anchorages of colchicosides
FR2551068A1 (fr) Nouveaux derives de nitrosourees, leurs procedes de preparation et compositions therapeutiques les contenant
GB1596007A (en) Non-glycosidic theophylline-sugar compounds and pharmaceutical compositions containing them
BE897845A (fr) B-oxo-x-carbamoyl-pyrrolptropionitriles, procede pour leur preparation preparations pharmaceutiques contenant ces composes ainsi que leur application
Wells et al. Some derivatives of phenethanolamine as MAO inhibitors
FR2471386A1 (fr) Procede de production de composes de glucopyranose-nitrosouree, nouveaux produits ainsi obtenus a activite antitumeurs et compositions pharmaceutiques les renfermant
Mavrova et al. Submitted by Academician E. Golovinsky on April 3, 2003
FR2524885A1 (fr) Nouveaux derives de 3-amino-3-demethoxyfortimicines et nouveaux medicaments antibiotiques les contenant
MXPA01007089A (en) Derivatives of monosaccharides as cell adhesion inhibitors
JPS6341491A (ja) ガングリオシドｇｍ↓１関連化合物及びその製造方法
FR2559155A1 (fr) Nouveaux a-d-arabino-hexapyranosides utiles pour la preparation des derives de nitrosourees

Legal Events

Date Code Title Description
GB Transfer or assigment of application

Owner name: BOSTON LIFE SCIENCES, INC.