FI106457B - Förfarande för framställning av terapeutiskt aktiva 4-amino-substituerade 2-azabicyklo[3.3.1]nonanderivat - Google Patents

Förfarande för framställning av terapeutiskt aktiva 4-amino-substituerade 2-azabicyklo[3.3.1]nonanderivat Download PDF

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Publication number
FI106457B
FI106457B FI20000085A FI20000085A FI106457B FI 106457 B FI106457 B FI 106457B FI 20000085 A FI20000085 A FI 20000085A FI 20000085 A FI20000085 A FI 20000085A FI 106457 B FI106457 B FI 106457B
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FI
Finland
Prior art keywords
formula
compound
phenyl
azabicyclo
compounds
Prior art date
Application number
FI20000085A
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English (en)
Finnish (fi)
Other versions
FI20000085A (sv
Inventor
Manoj C Desai
Original Assignee
Pfizer
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Publication date
Application filed by Pfizer filed Critical Pfizer
Publication of FI20000085A publication Critical patent/FI20000085A/sv
Application granted granted Critical
Publication of FI106457B publication Critical patent/FI106457B/sv

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/22—Bridged ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C271/06—Esters of carbamic acids
    • C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
    • C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C271/22—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by carboxyl groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
    • C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D205/06—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D205/08—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams
    • C07D205/085—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams with a nitrogen atom directly attached in position 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/16—Systems containing only non-condensed rings with a six-membered ring the ring being unsaturated

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Separation Using Semi-Permeable Membranes (AREA)
  • Treatment Of Liquids With Adsorbents In General (AREA)
  • Solid-Sorbent Or Filter-Aiding Compositions (AREA)

Claims (2)

1. Förfarande för framställning av terapeutiskt ak-tiva 4-amino-substituerade 2 azabicyklo[3.3.1]- 5 nonanderivat med formeln (I) (CH2)3 \ r3 '"H * H X —Ph / H väri Ph är fenyl och R3 är fenyl som är substituerad med en (Ci-C6) -alkoxygrupp, och av dess farmaceutiskt ac-10 ceptabla salter, kännetecknat av att (a) förening med formeln (III) (CH2)3 \ ν^\ζη r3 |H ^ Cbz H Ph III väri Ph och R3 är ovan definierade och Cbz är benzy-15 loxykarbonyl, omsätts med ammoniumformiat i närvaro av en • - palladium-karbonkatalyt, och (b) eventuellt omvandlas den erhällna förening med formeln I tili sitt farmaceutiskt acceptabla sait.
2. Förfarande enligt patentkravet 1, känne-20 tecknat av att man framställer (3RS,4RS)-3-fenyl-4- * (2-metoxybenzyl)amino-2-azabicyklo-[3.3.1]nonan.
FI20000085A 1992-05-18 2000-01-17 Förfarande för framställning av terapeutiskt aktiva 4-amino-substituerade 2-azabicyklo[3.3.1]nonanderivat FI106457B (sv)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US88511092A 1992-05-18 1992-05-18
US88511092 1992-05-18

Publications (2)

Publication Number Publication Date
FI20000085A FI20000085A (sv) 2000-01-17
FI106457B true FI106457B (sv) 2001-02-15

Family

ID=25386157

Family Applications (2)

Application Number Title Priority Date Filing Date
FI932229A FI932229A (fi) 1992-05-18 1993-05-17 Azabicykliska bryggderivat
FI20000085A FI106457B (sv) 1992-05-18 2000-01-17 Förfarande för framställning av terapeutiskt aktiva 4-amino-substituerade 2-azabicyklo[3.3.1]nonanderivat

Family Applications Before (1)

Application Number Title Priority Date Filing Date
FI932229A FI932229A (fi) 1992-05-18 1993-05-17 Azabicykliska bryggderivat

Country Status (11)

Country Link
US (1) US5498614A (sv)
EP (1) EP0641328B1 (sv)
JP (1) JP2757234B2 (sv)
AT (1) ATE209186T1 (sv)
CA (1) CA2134964C (sv)
DE (1) DE69331190T2 (sv)
DK (1) DK0641328T3 (sv)
ES (1) ES2164657T3 (sv)
FI (2) FI932229A (sv)
PT (1) PT641328E (sv)
WO (1) WO1993023380A1 (sv)

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Also Published As

Publication number Publication date
DE69331190D1 (de) 2002-01-03
JP2757234B2 (ja) 1998-05-25
DK0641328T3 (da) 2002-05-21
EP0641328A1 (en) 1995-03-08
DE69331190T2 (de) 2002-04-18
FI20000085A (sv) 2000-01-17
CA2134964C (en) 1997-12-30
ES2164657T3 (es) 2002-03-01
EP0641328B1 (en) 2001-11-21
CA2134964A1 (en) 1993-11-25
PT641328E (pt) 2002-04-29
US5498614A (en) 1996-03-12
JPH07503483A (ja) 1995-04-13
ATE209186T1 (de) 2001-12-15
WO1993023380A1 (en) 1993-11-25
FI932229A0 (fi) 1993-05-17
FI932229A (fi) 1993-11-19

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