FI101704B1 - Menetelmä uusien, antiateroskleroottisina aineina käytettävien bis[4-(2,6-dialkyyli)fenoli]silaanijohdannaisten valmistamiseksi - Google Patents

Menetelmä uusien, antiateroskleroottisina aineina käytettävien bis[4-(2,6-dialkyyli)fenoli]silaanijohdannaisten valmistamiseksi

Info

Publication number
FI101704B1
FI101704B1 FI913253A FI913253A FI101704B1 FI 101704 B1 FI101704 B1 FI 101704B1 FI 913253 A FI913253 A FI 913253A FI 913253 A FI913253 A FI 913253A FI 101704 B1 FI101704 B1 FI 101704B1
Authority
FI
Finland
Prior art keywords
phenol
dialkyl
preparation
silane derivatives
antiatherosclerotic agents
Prior art date
Application number
FI913253A
Other languages
English (en)
Swedish (sv)
Other versions
FI913253A0 (fi
FI101704B (fi
FI913253A (fi
Inventor
Roger Alan Parker
Simon Jen Tan Mao
Original Assignee
Merrell Dow Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merrell Dow Pharma filed Critical Merrell Dow Pharma
Publication of FI913253A0 publication Critical patent/FI913253A0/fi
Publication of FI913253A publication Critical patent/FI913253A/fi
Application granted granted Critical
Publication of FI101704B publication Critical patent/FI101704B/fi
Publication of FI101704B1 publication Critical patent/FI101704B1/fi

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09K—MATERIALS FOR MISCELLANEOUS APPLICATIONS, NOT PROVIDED FOR ELSEWHERE
    • C09K15/00—Anti-oxidant compositions; Compositions inhibiting chemical change
    • C09K15/04—Anti-oxidant compositions; Compositions inhibiting chemical change containing organic compounds
    • C09K15/32—Anti-oxidant compositions; Compositions inhibiting chemical change containing organic compounds containing two or more of boron, silicon, phosphorus, selenium, tellurium or a metal
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/38—Drugs for disorders of the endocrine system of the suprarenal hormones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/0803—Compounds with Si-C or Si-Si linkages
    • C07F7/081—Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Materials Engineering (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Endocrinology (AREA)
  • Diabetes (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Anti-Oxidant Or Stabilizer Compositions (AREA)
  • Compositions Of Macromolecular Compounds (AREA)
  • Compounds Of Unknown Constitution (AREA)
  • Fats And Perfumes (AREA)
  • Solid-Sorbent Or Filter-Aiding Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
FI913253A 1990-07-05 1991-07-04 Menetelmä uusien, antiateroskleroottisina aineina käytettävien bis[4-(2,6-dialkyyli)fenoli]silaanijohdannaisten valmistamiseksi FI101704B1 (fi)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US54805190A 1990-07-05 1990-07-05
US54805190 1990-07-05
US69668491A 1991-05-07 1991-05-07
US69668491 1991-05-07

Publications (4)

Publication Number Publication Date
FI913253A0 FI913253A0 (fi) 1991-07-04
FI913253A FI913253A (fi) 1992-01-06
FI101704B FI101704B (fi) 1998-08-14
FI101704B1 true FI101704B1 (fi) 1998-08-14

Family

ID=27068750

Family Applications (1)

Application Number Title Priority Date Filing Date
FI913253A FI101704B1 (fi) 1990-07-05 1991-07-04 Menetelmä uusien, antiateroskleroottisina aineina käytettävien bis[4-(2,6-dialkyyli)fenoli]silaanijohdannaisten valmistamiseksi

Country Status (20)

Country Link
US (1) US5281738A (fi)
EP (1) EP0464844B1 (fi)
JP (1) JP2963557B2 (fi)
KR (1) KR0186006B1 (fi)
CN (1) CN1029614C (fi)
AT (1) ATE132154T1 (fi)
AU (1) AU639807B2 (fi)
CA (1) CA2046050C (fi)
DE (1) DE69115771T2 (fi)
DK (1) DK0464844T3 (fi)
ES (1) ES2084062T3 (fi)
FI (1) FI101704B1 (fi)
GR (1) GR3018926T3 (fi)
HU (1) HU210695B (fi)
IE (1) IE72155B1 (fi)
IL (1) IL98711A (fi)
NO (1) NO179914C (fi)
NZ (1) NZ238807A (fi)
PT (1) PT98219B (fi)
TW (1) TW213919B (fi)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2707989B1 (fr) * 1993-07-22 1995-10-13 Pf Medicament Nouveaux dérivés de benzylamines silylées, leurs sels, leurs procédés de fabrication et les compositions pharmaceutiques les renfermant.
AU681731B2 (en) * 1993-12-10 1997-09-04 Aventis Inc. Method of lowering serum cholesterol levels with 2,6-di-alkyl-4-silyl-phenols
US5677291A (en) * 1993-12-10 1997-10-14 Hoechst Marion Roussel, Inc. Method of lowering serum cholesterol levels with 2,6-di-alkyl-4-silyl-phenols
US5449679A (en) * 1994-07-29 1995-09-12 Leonard; Robert J. Process and products for reducing biological fluid levels of a lipid soluble waste
US5795876A (en) * 1996-04-30 1998-08-18 Hoechst Marion Rousssel, Inc. Method of inhibiting vascular cell adhesion molecule-1 and treating chronic inflammatory diseases with 2, 6-di-alkyl-4-silyl-phenols
US5608095A (en) * 1996-04-30 1997-03-04 Hoechst Marion Roussel, Inc. Alkyl-4-silyl-phenols and esters thereof as antiatherosclerotic agents
US6114572A (en) * 1996-11-20 2000-09-05 Hoechst Marion Roussel, Inc. Substituted phenols and thiophenols useful as antioxidant agents
US6121463A (en) * 1997-06-24 2000-09-19 Hoechst Marion Roussel, Inc. Alkyl-4-silylheterocyclic phenols and thiophenols useful as antioxidant agents
US6133467A (en) * 1997-06-25 2000-10-17 Hoechst Marion Roussel, Inc. 2,6-di-t-butyl-4-[(dimethyl-4-methoxyphenylsilyl)-methyl-oxy]phenol and 2,6-di-t-butyl-4-[(dimethyl-2-methoxy-phenylsilyl)methyloxy]phenol
AUPO787897A0 (en) 1997-07-14 1997-08-07 Cardiac Crc Nominees Pty Limited Silicon-containing chain extenders
JP6001676B2 (ja) * 2011-12-30 2016-10-05 ダウ コーニング コーポレーションＤｏｗ Ｃｏｒｎｉｎｇ Ｃｏｒｐｏｒａｔｉｏｎ 固体ライト及び形成方法
CN104817581B (zh) * 2015-05-07 2018-01-02 衢州学院 一种含硅二元酚及其制备方法
US20230146294A1 (en) * 2020-02-24 2023-05-11 Dow Global Technologies Llc Non-cryogenic synthesis of heteroatom-bridge precursors of metal-ligand complex catalysts

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3506674A (en) * 1967-07-03 1970-04-14 Gen Electric Certain pyridyl thio ether silanes
US3853776A (en) * 1972-09-29 1974-12-10 Monsanto Co Low pour point fluids and blends containing same
US3801617A (en) * 1973-07-24 1974-04-02 Nasa Thiophenyl ether disiloxanes and trisiloxanes useful as lubricant fluids
AR208203A1 (es) * 1974-09-10 1976-12-09 Cortial Proceso para la preparacion de acido p-trialquilsilil benzoico y derivados del mismo
JPS61263988A (ja) * 1985-05-16 1986-11-21 Shionogi & Co Ltd シリル置換エ−テル類および殺虫・殺ダニ剤
US4636573A (en) * 1985-09-09 1987-01-13 Pastor Stephen D Hindered silicon ester stabilizers
US4804653A (en) * 1986-05-02 1989-02-14 Uniroyal Chemical Company, Inc. Thiomethyl-substituted organosilane compounds and their use as pesticides
US4783495A (en) * 1987-11-20 1988-11-08 Ciba-Geigy Corporation (Hydroxyphenyl) silane stabilizers
US5155250A (en) * 1990-07-05 1992-10-13 Merrell Dow Pharmaceuticals Inc. 2,6-di-alkyl-4-silyl-phenols as antiatheroscerotic agents
DE4031001A1 (de) * 1990-10-01 1992-04-02 Hoechst Ag Verfahren zur herstellung von 4-ethoxyphenyl-3-arylpropyl-(dimethyl)silanen

Also Published As

Publication number Publication date
NZ238807A (en) 1994-03-25
PT98219A (pt) 1992-05-29
IL98711A0 (en) 1992-07-15
FI913253A0 (fi) 1991-07-04
HUT58748A (en) 1992-03-30
NO179914C (no) 1997-01-08
FI101704B (fi) 1998-08-14
KR920002616A (ko) 1992-02-28
IL98711A (en) 1996-07-23
GR3018926T3 (en) 1996-05-31
CN1057842A (zh) 1992-01-15
FI913253A (fi) 1992-01-06
CA2046050A1 (en) 1992-01-06
PT98219B (pt) 1998-12-31
ES2084062T3 (es) 1996-05-01
DE69115771D1 (de) 1996-02-08
EP0464844A1 (en) 1992-01-08
KR0186006B1 (ko) 1999-05-15
HU210695B (en) 1995-06-28
CN1029614C (zh) 1995-08-30
NO912629D0 (no) 1991-07-04
JPH04230394A (ja) 1992-08-19
IE912341A1 (en) 1992-01-15
EP0464844B1 (en) 1995-12-27
IE72155B1 (en) 1997-03-26
DE69115771T2 (de) 1996-06-05
TW213919B (fi) 1993-10-01
ATE132154T1 (de) 1996-01-15
CA2046050C (en) 2001-09-18
DK0464844T3 (da) 1996-01-29
US5281738A (en) 1994-01-25
HU912271D0 (en) 1991-12-30
NO912629L (no) 1992-01-06
AU8011491A (en) 1992-01-09
JP2963557B2 (ja) 1999-10-18
NO179914B (no) 1996-09-30
AU639807B2 (en) 1993-08-05

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