FI100799B - Menetelmä terapeuttisesti aktiivisten tetraliinijohdannaisten valmista miseksi - Google Patents

Menetelmä terapeuttisesti aktiivisten tetraliinijohdannaisten valmista miseksi

Info

Publication number
FI100799B
FI100799B FI900083A FI900083A FI100799B FI 100799 B FI100799 B FI 100799B FI 900083 A FI900083 A FI 900083A FI 900083 A FI900083 A FI 900083A FI 100799 B FI100799 B FI 100799B
Authority
FI
Finland
Prior art keywords
preparation
therapeutically active
tetraline derivatives
tetraline
derivatives
Prior art date
Application number
FI900083A
Other languages
English (en)
Swedish (sv)
Other versions
FI900083A (fi
FI900083A0 (fi
Inventor
Orchymont Hugues D
Celine Tarnus
Original Assignee
Merrell Dow Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merrell Dow Pharma filed Critical Merrell Dow Pharma
Publication of FI900083A0 publication Critical patent/FI900083A0/fi
Publication of FI900083A publication Critical patent/FI900083A/fi
Application granted granted Critical
Publication of FI100799B publication Critical patent/FI100799B/fi

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D263/00Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/52Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings condensed with carbocyclic rings or ring systems
    • C07D263/60Naphthoxazoles; Hydrogenated naphthoxazoles
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C225/00Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones
    • C07C225/02Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones having amino groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C225/04Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones having amino groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being saturated
    • C07C225/08Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones having amino groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being saturated and containing rings
    • C07C225/12Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones having amino groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being saturated and containing rings with doubly-bound oxygen atoms bound to carbon atoms being part of rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C205/00Compounds containing nitro groups bound to a carbon skeleton
    • C07C205/01Compounds containing nitro groups bound to a carbon skeleton having nitro groups bound to acyclic carbon atoms
    • C07C205/03Compounds containing nitro groups bound to a carbon skeleton having nitro groups bound to acyclic carbon atoms of an unsaturated carbon skeleton
    • C07C205/04Compounds containing nitro groups bound to a carbon skeleton having nitro groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing six-membered aromatic rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C205/00Compounds containing nitro groups bound to a carbon skeleton
    • C07C205/27Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by etherified hydroxy groups
    • C07C205/28Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by etherified hydroxy groups having nitro groups and etherified hydroxy groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C205/31Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by etherified hydroxy groups having nitro groups and etherified hydroxy groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton containing six-membered aromatic rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C205/00Compounds containing nitro groups bound to a carbon skeleton
    • C07C205/27Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by etherified hydroxy groups
    • C07C205/32Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by etherified hydroxy groups having nitro groups bound to acyclic carbon atoms and etherified hydroxy groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C225/00Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones
    • C07C225/20Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones having amino groups bound to carbon atoms of rings other than six-membered aromatic rings of the carbon skeleton
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00Carboxylic acid amides
    • C07C233/01Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C233/34Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups
    • C07C233/41Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a ring other than a six-membered aromatic ring
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D303/00Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
    • C07D303/02Compounds containing oxirane rings
    • C07D303/04Compounds containing oxirane rings containing only hydrogen and carbon atoms in addition to the ring oxygen atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2602/00Systems containing two condensed rings
    • C07C2602/02Systems containing two condensed rings the rings having only two atoms in common
    • C07C2602/04One of the condensed rings being a six-membered aromatic ring
    • C07C2602/10One of the condensed rings being a six-membered aromatic ring the other ring being six-membered, e.g. tetraline
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2602/00Systems containing two condensed rings
    • C07C2602/02Systems containing two condensed rings the rings having only two atoms in common
    • C07C2602/14All rings being cycloaliphatic
    • C07C2602/26All rings being cycloaliphatic the ring system containing ten carbon atoms
    • C07C2602/28Hydrogenated naphthalenes
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2603/00Systems containing at least three condensed rings
    • C07C2603/02Ortho- or ortho- and peri-condensed systems
    • C07C2603/04Ortho- or ortho- and peri-condensed systems containing three rings
    • C07C2603/22Ortho- or ortho- and peri-condensed systems containing three rings containing only six-membered rings
    • C07C2603/26Phenanthrenes; Hydrogenated phenanthrenes

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Immunology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
FI900083A 1989-01-09 1990-01-08 Menetelmä terapeuttisesti aktiivisten tetraliinijohdannaisten valmista miseksi FI100799B (fi)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP89400056A EP0381902A1 (en) 1989-01-09 1989-01-09 Tetralin derivatives

Publications (3)

Publication Number Publication Date
FI900083A0 FI900083A0 (fi) 1990-01-08
FI900083A FI900083A (fi) 1990-07-10
FI100799B true FI100799B (fi) 1998-02-27

Family

ID=8202914

Family Applications (1)

Application Number Title Priority Date Filing Date
FI900083A FI100799B (fi) 1989-01-09 1990-01-08 Menetelmä terapeuttisesti aktiivisten tetraliinijohdannaisten valmista miseksi

Country Status (21)

Country Link
US (1) US5041673A (fi)
EP (2) EP0381902A1 (fi)
JP (1) JP2761955B2 (fi)
KR (1) KR0177805B1 (fi)
CN (1) CN1022319C (fi)
AR (1) AR247722A1 (fi)
AT (1) ATE94533T1 (fi)
AU (1) AU620676B2 (fi)
CA (1) CA2007261C (fi)
DE (1) DE69003257T2 (fi)
DK (1) DK0378456T3 (fi)
ES (1) ES2060076T3 (fi)
FI (1) FI100799B (fi)
HU (1) HU212494B (fi)
IE (1) IE62997B1 (fi)
IL (1) IL92986A (fi)
NO (1) NO171722C (fi)
NZ (1) NZ232031A (fi)
PH (1) PH27288A (fi)
PT (1) PT92808B (fi)
ZA (1) ZA9034B (fi)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5071875A (en) * 1989-09-25 1991-12-10 Northwestern University Substituted 2-amidotetralins as melatonin agonists and antagonists
GB9509156D0 (en) 1995-05-05 1995-06-28 Sandoz Ltd Organic compounds
US6844368B1 (en) 1998-12-22 2005-01-18 Edward Roberts Compounds useful in pain management
WO2000037426A1 (en) * 1998-12-22 2000-06-29 Astrazeneca Ab Novel oxo-aminotetralin compounds useful in pain management
PL207809B1 (pl) 2003-11-20 2011-02-28 Invento Społka Z Ograniczoną Odpowiedzialnością Preforma pojemnika z tworzywa sztucznego, zwłaszcza do środków spożywczych
CN102631664B (zh) * 2011-01-28 2014-10-01 上海来益生物药物研究开发中心有限责任公司 3-氨基-2-羟基-4-苯基-缬氨酰-异亮氨酸的应用
WO2021039023A1 (ja) * 2019-08-23 2021-03-04 持田製薬株式会社 ヘテロシクリデンアセトアミド誘導体の製造方法
JP7320113B2 (ja) * 2019-08-23 2023-08-02 持田製薬株式会社 ヘテロシクリデンアセトアミド誘導体の製造方法
CN112275147B (zh) * 2020-09-01 2021-08-13 中国科学院山西煤炭化学研究所 一种自聚微孔聚酰亚胺气体分离膜及其制备方法和应用
WO2023154896A2 (en) * 2022-02-11 2023-08-17 Adarx Pharmaceuticals, Inc. Trkb ligand conjugated compounds and uses thereof

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4267373A (en) * 1972-07-03 1981-05-12 E. R. Squibb & Sons, Inc. 5,6,7,8-Tetrahydronaphthalene hypotensive agents
JPS561305B2 (fi) * 1972-12-18 1981-01-13
US3993677A (en) * 1975-11-03 1976-11-23 American Cyanamid Company 1,2,3,4-Tetrahydro-4-oxo-1-naphthylisocyanate
US4049717A (en) * 1976-05-13 1977-09-20 American Cyanamid Company Novel 1,2,3,4-tetrahydro-4-oxo-(oxy)-1-naphthylamines and method of preparation thereof
US4041070A (en) * 1976-07-14 1977-08-09 American Cyanamid Company Tetrahydro-4-imino-1-naphthylureas
US4051183A (en) * 1976-09-02 1977-09-27 American Cyanamid Company 1-benzoyl-3-(1,2,3,4-tetrahydro-4-oxo-1-naphthyl)-urea, a novel and useful intermediate for the preparation of animal growth promoting agents
JPS6045179B2 (ja) * 1977-06-08 1985-10-08 フナイ薬品工業株式会社 新規環状アミノアルコ−ル類およびその製造法

Also Published As

Publication number Publication date
IE62997B1 (en) 1995-03-08
FI900083A (fi) 1990-07-10
DK0378456T3 (da) 1993-10-25
HUT58271A (en) 1992-02-28
NO900074D0 (no) 1990-01-08
CN1022319C (zh) 1993-10-06
PT92808A (pt) 1990-07-31
PT92808B (pt) 1995-12-29
AU4782790A (en) 1990-07-12
JP2761955B2 (ja) 1998-06-04
NO900074L (no) 1990-07-10
KR0177805B1 (ko) 1999-05-15
US5041673A (en) 1991-08-20
EP0381902A1 (en) 1990-08-16
ZA9034B (en) 1990-10-31
EP0378456B1 (en) 1993-09-15
IE900067L (en) 1990-07-09
IL92986A (en) 1994-05-30
CN1044460A (zh) 1990-08-08
AR247722A1 (es) 1995-03-31
JPH02233650A (ja) 1990-09-17
DE69003257D1 (de) 1993-10-21
FI900083A0 (fi) 1990-01-08
CA2007261C (en) 2000-04-11
ES2060076T3 (es) 1994-11-16
AU620676B2 (en) 1992-02-20
NO171722B (no) 1993-01-18
IL92986A0 (en) 1990-09-17
ATE94533T1 (de) 1993-10-15
NO171722C (no) 1993-04-28
PH27288A (en) 1993-05-04
HU900068D0 (en) 1990-03-28
NZ232031A (en) 1992-07-28
HU212494B (en) 1996-07-29
KR900011709A (ko) 1990-08-02
CA2007261A1 (en) 1990-07-09
EP0378456A1 (en) 1990-07-18
DE69003257T2 (de) 1994-01-13

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Legal Events

Date Code Title Description
FG Patent granted

Owner name: MERRELL DOW PHARMACEUTICALS INC.

MM Patent lapsed

Owner name: MERRELL DOW PHARMACEUTICALS INC.