ES8802230A1 - Un procedimiento para la preparacion de derivados de b-lactama - Google Patents
Un procedimiento para la preparacion de derivados de b-lactamaInfo
- Publication number
- ES8802230A1 ES8802230A1 ES557783A ES557783A ES8802230A1 ES 8802230 A1 ES8802230 A1 ES 8802230A1 ES 557783 A ES557783 A ES 557783A ES 557783 A ES557783 A ES 557783A ES 8802230 A1 ES8802230 A1 ES 8802230A1
- Authority
- ES
- Spain
- Prior art keywords
- optionally substituted
- carbocyclic
- monocyclic
- image
- lactam antibiotics
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- C07D501/14—Compounds having a nitrogen atom directly attached in position 7
- C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
- C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
- C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
- C07D501/38—Methylene radicals, substituted by nitrogen atoms; Lactams thereof with the 2-carboxyl group; Methylene radicals substituted by nitrogen-containing hetero rings attached by the ring nitrogen atom; Quaternary compounds thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- C07D501/14—Compounds having a nitrogen atom directly attached in position 7
- C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
- C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
- C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
- C07D501/38—Methylene radicals, substituted by nitrogen atoms; Lactams thereof with the 2-carboxyl group; Methylene radicals substituted by nitrogen-containing hetero rings attached by the ring nitrogen atom; Quaternary compounds thereof
- C07D501/46—Methylene radicals, substituted by nitrogen atoms; Lactams thereof with the 2-carboxyl group; Methylene radicals substituted by nitrogen-containing hetero rings attached by the ring nitrogen atom; Quaternary compounds thereof with the 7-amino radical acylated by carboxylic acids containing hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- C07D501/14—Compounds having a nitrogen atom directly attached in position 7
- C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
- C07D501/18—7-Aminocephalosporanic or substituted 7-aminocephalosporanic acids
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Oncology (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Communicable Diseases (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Cephalosporin Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Pyrrole Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Polyesters Or Polycarbonates (AREA)
- Tires In General (AREA)
- Indole Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
LOS DERIVADOS DE BETA-LACTAMA (I), DONDE NO EXCLUSIVAMENTE, R1, R2 Y R3 PUEDEN SER ALQUILO SUSTITUIDO O NO SUSTITUIDO, ANILLO CARBOXICLICO O HETEROCICLICO; SE OBTIEEN SEPARANDO EN (II), UN GRUPO PROTECTOR DE AMINA, ENZIMATICAMENTE DISOCIABLE R16, COMO EL FENILACETILO O 2-FENILACETILO, MEDIANTE PENICILINA-G-ACILASA INMOVILIZADA A PH 7-8, EN AGUA O ACETONITRILO Y/O TETRAHIDROFURANO, A TEMPERATURA AMBIENTE. POSEEN ACTIVIDAD ANTIBACTERIANA, POR LO QUE EN MEDICINA SON APLICABLES EN EL TRATAMIENTO DE INFECCIONES LOCALES O SISTEMATICAS Y EN VETERINARIA Y MEZCLADAS CON PIENSO, SE UTILIZAN PARA EL ENGORDE DE ANIMALES.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE19843419012 DE3419012A1 (de) | 1984-05-22 | 1984-05-22 | Ss-lactamantibiotika, verfahren zu deren herstellung sowie ihre verwendung als arzneimittel oder wachstumsfoerderer in der tieraufzucht oder als antioxidantien |
Publications (2)
Publication Number | Publication Date |
---|---|
ES557783A0 ES557783A0 (es) | 1988-04-16 |
ES8802230A1 true ES8802230A1 (es) | 1988-04-16 |
Family
ID=6236533
Family Applications (4)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES543300A Expired ES8607295A1 (es) | 1984-05-22 | 1985-05-20 | Derivados de b-lactama |
ES552572A Expired ES8802524A1 (es) | 1984-05-22 | 1986-02-28 | Un procedimiento para la preparacion de derivados de beta-lactama. |
ES552571A Expired ES8800931A1 (es) | 1984-05-22 | 1986-02-28 | Un procedimiento para la obtencion de derivados de b-lactama |
ES557783A Expired ES8802230A1 (es) | 1984-05-22 | 1987-12-15 | Un procedimiento para la preparacion de derivados de b-lactama |
Family Applications Before (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES543300A Expired ES8607295A1 (es) | 1984-05-22 | 1985-05-20 | Derivados de b-lactama |
ES552572A Expired ES8802524A1 (es) | 1984-05-22 | 1986-02-28 | Un procedimiento para la preparacion de derivados de beta-lactama. |
ES552571A Expired ES8800931A1 (es) | 1984-05-22 | 1986-02-28 | Un procedimiento para la obtencion de derivados de b-lactama |
Country Status (18)
Country | Link |
---|---|
US (1) | US4632918A (es) |
EP (1) | EP0163190B1 (es) |
JP (1) | JPS60255795A (es) |
KR (1) | KR910002099B1 (es) |
CN (1) | CN85101682A (es) |
AT (1) | ATE51870T1 (es) |
AU (2) | AU572994B2 (es) |
CA (1) | CA1274821A (es) |
DE (2) | DE3419012A1 (es) |
DK (1) | DK226285A (es) |
ES (4) | ES8607295A1 (es) |
FI (1) | FI852003L (es) |
GR (1) | GR851222B (es) |
HU (1) | HU193760B (es) |
IL (1) | IL75239A (es) |
PH (1) | PH22345A (es) |
PT (1) | PT80492B (es) |
ZA (1) | ZA853829B (es) |
Families Citing this family (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3343208A1 (de) * | 1983-11-30 | 1985-06-05 | Bayer Ag, 5090 Leverkusen | Neue cephalosporine und verfahren zu ihrer herstellung |
FI851934L (fi) * | 1984-05-30 | 1985-12-01 | Ici Plc | Kefalosporinderivat. |
US4883868A (en) * | 1984-12-27 | 1989-11-28 | Banyu Pharmaceutical Co., Ltd. | 7-amino-3-(substituted isoindolinium)methyl-3-cephem derivatives |
JPS61205282A (ja) * | 1985-03-08 | 1986-09-11 | Sagami Chem Res Center | β−ラクタム化合物類 |
AU580855B2 (en) * | 1985-03-29 | 1989-02-02 | Shionogi & Co., Ltd. | Alkeneamidocephalosporin esters |
US4659812A (en) * | 1985-08-20 | 1987-04-21 | Bristol-Myers Company | Cephalosporin intermediates |
JPS62158291A (ja) * | 1986-01-07 | 1987-07-14 | Sagami Chem Res Center | セフアロスポリン誘導体 |
CA1293719C (en) * | 1986-09-22 | 1991-12-31 | Takao Takaya | Cephem compounds and processes for preparation thereof |
US5242913A (en) * | 1987-03-11 | 1993-09-07 | Pfizer Inc. | Substituted 3-cephem compounds as antibacterial agents |
IL86941A (en) * | 1987-07-10 | 1993-07-08 | Gist Brocades Nv | Process for the preparation of cephem compounds and some new cephalosporin derivatives prepared by this process |
CN1022837C (zh) * | 1988-03-16 | 1993-11-24 | 卫材株式会社 | 制备头孢烯衍生物的方法 |
US5017630A (en) * | 1989-08-17 | 1991-05-21 | Zeon Chemicals Usa, Inc. | Free flowing particles of an emulsion polymer having SiO2 incorporated therein |
TWI547496B (zh) | 2011-10-04 | 2016-09-01 | 葛蘭素集團公司 | 抗菌化合物 |
Family Cites Families (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB2076801A (en) * | 1980-04-14 | 1981-12-09 | Erba Farmitalia | alpha , beta -Disubstituted Acrylamido Cephalosporins |
CA1178947A (en) * | 1980-09-26 | 1984-12-04 | Sagami Chemical Research Center | .beta.-LACTAM COMPOUNDS AND PROCESS FOR THEIR PREPARATION |
DE3037997A1 (de) * | 1980-10-08 | 1982-05-13 | Bayer Ag | (beta) -lactamantibiotika, verfahren zu deren herstellung sowie sie enthaltende mittel |
DE3118732A1 (de) * | 1981-05-12 | 1982-12-02 | Hoechst Ag, 6000 Frankfurt | Cephalosporinderivate und verfahren zu ihrer herstellung |
US4396620A (en) * | 1981-09-08 | 1983-08-02 | Eli Lilly And Company | Cephalosporin quinolinium betaines |
US4401668A (en) * | 1981-10-02 | 1983-08-30 | Eli Lilly And Company | Pyrazinium substituted cephalosporins |
CA1201431A (en) * | 1981-12-17 | 1986-03-04 | Daiei Tunemoto | .beta.-LACTAM COMPOUNDS, PROCESS FOR THE PREPARATION THEREOF AND INTERMEDIATE PRODUCTS FOR THE PREPARATION THEREOF |
US4457929A (en) * | 1982-03-29 | 1984-07-03 | Bristol-Myers Company | 3-Quaternary ammonium methyl)-substituted cephalosporin derivatives |
DE3224866A1 (de) * | 1982-07-02 | 1984-01-05 | Bayer Ag, 5090 Leverkusen | Ss-lactamantibiotika, verfahren zu deren herstellung sowie sie enthaltende mittel |
DE3239365A1 (de) * | 1982-10-23 | 1984-04-26 | Bayer Ag, 5090 Leverkusen | Neue cephalosporine und verfahren zu ihrer herstellung |
US4525473A (en) * | 1983-03-30 | 1985-06-25 | Bristol-Myers Company | Cephalosporins |
DE3343208A1 (de) * | 1983-11-30 | 1985-06-05 | Bayer Ag, 5090 Leverkusen | Neue cephalosporine und verfahren zu ihrer herstellung |
-
1984
- 1984-05-22 DE DE19843419012 patent/DE3419012A1/de not_active Withdrawn
-
1985
- 1985-04-01 CN CN198585101682A patent/CN85101682A/zh active Pending
- 1985-05-03 PH PH32228A patent/PH22345A/en unknown
- 1985-05-06 US US06/730,979 patent/US4632918A/en not_active Expired - Fee Related
- 1985-05-13 DE DE8585105841T patent/DE3577093D1/de not_active Expired - Lifetime
- 1985-05-13 AT AT85105841T patent/ATE51870T1/de not_active IP Right Cessation
- 1985-05-13 EP EP19850105841 patent/EP0163190B1/de not_active Expired - Lifetime
- 1985-05-16 AU AU42564/85A patent/AU572994B2/en not_active Ceased
- 1985-05-17 JP JP60104108A patent/JPS60255795A/ja active Pending
- 1985-05-17 CA CA000481749A patent/CA1274821A/en not_active Expired - Lifetime
- 1985-05-20 IL IL75239A patent/IL75239A/xx unknown
- 1985-05-20 GR GR851222A patent/GR851222B/el unknown
- 1985-05-20 ES ES543300A patent/ES8607295A1/es not_active Expired
- 1985-05-20 PT PT80492A patent/PT80492B/pt not_active IP Right Cessation
- 1985-05-20 FI FI852003A patent/FI852003L/fi not_active Application Discontinuation
- 1985-05-21 KR KR1019850003476A patent/KR910002099B1/ko not_active IP Right Cessation
- 1985-05-21 ZA ZA853829A patent/ZA853829B/xx unknown
- 1985-05-21 HU HU851914A patent/HU193760B/hu not_active IP Right Cessation
- 1985-05-21 DK DK226285A patent/DK226285A/da not_active Application Discontinuation
-
1986
- 1986-02-28 ES ES552572A patent/ES8802524A1/es not_active Expired
- 1986-02-28 ES ES552571A patent/ES8800931A1/es not_active Expired
-
1987
- 1987-12-15 ES ES557783A patent/ES8802230A1/es not_active Expired
-
1988
- 1988-02-17 AU AU11989/88A patent/AU593460B2/en not_active Ceased
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