ES8801903A1 - Procedimiento para preparar derivados de cinolina - Google Patents
Procedimiento para preparar derivados de cinolinaInfo
- Publication number
- ES8801903A1 ES8801903A1 ES557522A ES557522A ES8801903A1 ES 8801903 A1 ES8801903 A1 ES 8801903A1 ES 557522 A ES557522 A ES 557522A ES 557522 A ES557522 A ES 557522A ES 8801903 A1 ES8801903 A1 ES 8801903A1
- Authority
- ES
- Spain
- Prior art keywords
- alkyl
- optionally substituted
- independently represent
- represent hydrogen
- substituted aryl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 125000000259 cinnolinyl group Chemical class N1=NC(=CC2=CC=CC=C12)* 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 6
- 229910052739 hydrogen Inorganic materials 0.000 abstract 4
- 239000001257 hydrogen Substances 0.000 abstract 4
- 125000003107 substituted aryl group Chemical group 0.000 abstract 4
- 125000001316 cycloalkyl alkyl group Chemical group 0.000 abstract 3
- 150000002431 hydrogen Chemical class 0.000 abstract 3
- 125000003342 alkenyl group Chemical group 0.000 abstract 2
- 125000004183 alkoxy alkyl group Chemical group 0.000 abstract 2
- 125000000304 alkynyl group Chemical group 0.000 abstract 2
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 2
- 125000003709 fluoroalkyl group Chemical group 0.000 abstract 2
- 125000000262 haloalkenyl group Chemical group 0.000 abstract 2
- 125000002768 hydroxyalkyl group Chemical group 0.000 abstract 2
- -1 4,5-dihydro-2-thiazolyl Chemical group 0.000 abstract 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 150000001204 N-oxides Chemical class 0.000 abstract 1
- 125000002252 acyl group Chemical group 0.000 abstract 1
- 125000004450 alkenylene group Chemical group 0.000 abstract 1
- 125000003302 alkenyloxy group Chemical group 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000002947 alkylene group Chemical group 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
- 125000004430 oxygen atom Chemical group O* 0.000 abstract 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
- C07D237/26—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings condensed with carbocyclic rings or ring systems
- C07D237/28—Cinnolines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
- C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
- C07F7/1804—Compounds having Si-O-C linkages
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Thiazole And Isothizaole Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Abstract
DERIVADOS DE CINOLINA (I) SE PREPARAN HACIENDO REACCIONAR UN COMPUESTO (II) CON UNA AMINA DE FORMULA NHRR9, ENTRE C10JC Y LA TEMPERATURA DE EBULLICION DEL DISOLVENTE, TRAS LO CUAL, AL COMPUESTO OBTENIDO (I) SE LE AÑADE UN ACIDO QUE PROPORCIONE UN ANION FARMACEUTICAMENTE ACEPTABLE. R3 ES UNA AMIDA (III); R4 ESNH; R5, R6, R7 Y R8 SE ESCOGEN ENTRE HIDROGENO, ALQUILO C1-10, ALQUENILO C2-10 Y OTROS; A ES UN GRUPO DE ACIDO CARBOXILICO O DERIVADO DE ACIDO CON SUSTITUYENTE DESPLAZABLE CON AMINA NHRR9, DONDE R Y R9 PUEDEN SER HIDROGENO (PERO NO A LA VEZ), ALQUILO C1-10, ALQUENILO C3-10 Y OTROS. DE APLICACION COMO DEPRESORES DEL SISTEMA NERVIOSO CENTRAL Y COMO ANXIOLITICOS.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB858513639A GB8513639D0 (en) | 1985-05-30 | 1985-05-30 | Cinnoline compounds |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| ES557522A0 ES557522A0 (es) | 1988-03-01 |
| ES8801903A1 true ES8801903A1 (es) | 1988-03-01 |
Family
ID=10579908
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES555546A Expired ES8801803A1 (es) | 1985-05-30 | 1986-05-30 | Procedimiento para preparar derivados de cinalina. |
| ES557522A Expired ES8801903A1 (es) | 1985-05-30 | 1987-04-30 | Procedimiento para preparar derivados de cinolina |
| ES557790A Expired ES8802611A1 (es) | 1985-05-30 | 1987-12-16 | Procedimiento para preparar 4-amino-8-butilinolina-3-n-ciclopropilmetil carboxamida. |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES555546A Expired ES8801803A1 (es) | 1985-05-30 | 1986-05-30 | Procedimiento para preparar derivados de cinalina. |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES557790A Expired ES8802611A1 (es) | 1985-05-30 | 1987-12-16 | Procedimiento para preparar 4-amino-8-butilinolina-3-n-ciclopropilmetil carboxamida. |
Country Status (25)
| Country | Link |
|---|---|
| US (1) | US4886800A (es) |
| EP (1) | EP0205272B1 (es) |
| JP (1) | JPH0713062B2 (es) |
| KR (1) | KR900004402B1 (es) |
| CN (1) | CN1014060B (es) |
| AR (1) | AR242026A1 (es) |
| AT (1) | ATE66215T1 (es) |
| AU (1) | AU592086B2 (es) |
| CA (1) | CA1309406C (es) |
| DE (1) | DE3680828D1 (es) |
| DK (1) | DK162221C (es) |
| ES (3) | ES8801803A1 (es) |
| FI (1) | FI85584C (es) |
| GB (2) | GB8513639D0 (es) |
| GR (1) | GR861411B (es) |
| HU (1) | HU199433B (es) |
| IE (1) | IE58782B1 (es) |
| IL (1) | IL78992A0 (es) |
| MW (1) | MW4386A1 (es) |
| NO (1) | NO171592C (es) |
| PH (1) | PH23518A (es) |
| PL (1) | PL149227B1 (es) |
| PT (1) | PT82678B (es) |
| SU (1) | SU1500158A3 (es) |
| ZA (1) | ZA863664B (es) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB8702288D0 (en) * | 1987-02-02 | 1987-03-11 | Erba Farmitalia | Cinnoline-carboxamides |
| DE68902490T2 (de) * | 1988-02-09 | 1992-12-24 | Ici America Inc | Pharmazeutische zusammensetzung. |
| US4925844A (en) * | 1988-02-09 | 1990-05-15 | Ici Americas Inc. | Antagonizing the pharmacological effects of a benzodiazepine receptor agonist |
| JPH09510695A (ja) * | 1994-01-03 | 1997-10-28 | エイシア・ファーマシュウティカルズ，インコーポレイテッド | ８−アザ、６−アザ、および６，８−ジアザ−１，４−ジヒドロキノキサリン−２，３−ジオン類およびそのグリシン／ｎｍｄａリセプターに対するアンタゴニストとしての使用 |
| JP2003529601A (ja) | 2000-03-21 | 2003-10-07 | ファルマシア・アンド・アップジョン・カンパニー | 抗ウイルス剤としての４−オキソ−１，４−ジヒドロ［１，８］ナフチリジン−３−カルボキサミド |
| EP1265873B1 (en) | 2000-03-21 | 2003-10-15 | PHARMACIA & UPJOHN COMPANY | 4-oxo-1,4-dihydro-3-cinnolinecarboxamides as antiviral agents |
| WO2001081318A1 (en) | 2000-03-21 | 2001-11-01 | Pharmacia & Upjohn Company | 4-hydroxycinnoline-3-carboxyamides as antiviral agents |
| MXPA02009250A (es) | 2000-03-21 | 2003-03-12 | Upjohn Co | 4-hidroxi-1,8-naftiridin--3-carboxamidas como agentes antivirales. |
| ES2391472T3 (es) * | 2005-12-20 | 2012-11-27 | Astrazeneca Ab | Derivados de cinnolina sustituidos como moduladores del receptor de GABAA y método para su síntesis |
| US7465795B2 (en) | 2005-12-20 | 2008-12-16 | Astrazeneca Ab | Compounds and uses thereof |
| TW200911760A (en) * | 2007-06-19 | 2009-03-16 | Astrazeneca Ab | Compounds and uses thereof |
| WO2010123443A1 (en) * | 2009-04-21 | 2010-10-28 | Astrazeneca Ab | Pharmaceutical composition comprising 4-amino-8-(2-fluoro-6-methoxy-phenyl)-n- propylcinnoline-3-carboxamide hydrogen sulphate. |
| WO2010123441A1 (en) * | 2009-04-21 | 2010-10-28 | Astrazeneca Ab | Crystalline form of 4-amino-8-(2-fluoro-6-methoxy-phenyl)-n-propylcinnoline-3- carboxamide hydrogen sulphate, for treatment of anxiety disorders |
| WO2010123440A1 (en) * | 2009-04-21 | 2010-10-28 | Astrazeneca Ab | Pharmaceutical composition comprising 4-amino-8-(2-fluoro-6-methoxy-phenyl)-n- propylcinnoline-3-carboxamide hydrogen sulphate and rate-controlling polymer |
| KR20140041583A (ko) * | 2011-05-23 | 2014-04-04 | 엘란 파마슈티컬스, 엘엘씨 | Ｌｒｒｋ2 키나제 활성의 억제제 |
| CN111905828B (zh) * | 2020-08-24 | 2022-04-19 | 万华化学集团股份有限公司 | 一种萘基配体mof活性炭复合催化剂及其制备方法和用途 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3657241A (en) * | 1970-03-12 | 1972-04-18 | Dow Chemical Co | Substituted cinnoline compounds |
| GB1306839A (en) * | 1970-10-16 | 1973-02-14 | Ici Ltd | Pharmaceutical compositions |
| GB1474399A (en) * | 1974-08-19 | 1977-05-25 | Ici Ltd | Cinnolin-3-yl carboxylic acids and derivatives thereof |
| US4085103A (en) * | 1974-11-07 | 1978-04-18 | Imperial Chemical Industries Limited | 6-Substituted-4-hydroxycinnolin-3-yl-carboxylic acids and esters thereof |
| GB1472766A (en) * | 1974-11-07 | 1977-05-04 | Ici Ltd | Hydroxycinnoline derivatives processes for their preparation and their use in pharmaceutical compositions |
| DD123525A1 (es) * | 1976-02-10 | 1977-01-05 | ||
| US4379929A (en) * | 1981-03-19 | 1983-04-12 | Eli Lilly And Company | 4(1H)-Oxocinnoline-3-carboxylic acid derivatives |
| US4729782A (en) * | 1983-09-14 | 1988-03-08 | Lafarge Coppee | Pollen suppressant comprising a fused pyridazinone |
| GB8702288D0 (en) * | 1987-02-02 | 1987-03-11 | Erba Farmitalia | Cinnoline-carboxamides |
-
1985
- 1985-05-30 GB GB858513639A patent/GB8513639D0/en active Pending
-
1986
- 1986-05-09 GB GB868611419A patent/GB8611419D0/en active Pending
- 1986-05-13 IE IE126786A patent/IE58782B1/en not_active IP Right Cessation
- 1986-05-16 ZA ZA863664A patent/ZA863664B/xx unknown
- 1986-05-20 PH PH33792A patent/PH23518A/en unknown
- 1986-05-22 AU AU57819/86A patent/AU592086B2/en not_active Ceased
- 1986-05-23 DE DE8686303963T patent/DE3680828D1/de not_active Expired - Lifetime
- 1986-05-23 EP EP86303963A patent/EP0205272B1/en not_active Expired - Lifetime
- 1986-05-23 AT AT86303963T patent/ATE66215T1/de not_active IP Right Cessation
- 1986-05-28 HU HU862243A patent/HU199433B/hu not_active IP Right Cessation
- 1986-05-29 US US06/868,791 patent/US4886800A/en not_active Expired - Lifetime
- 1986-05-29 SU SU864027693A patent/SU1500158A3/ru active
- 1986-05-29 CA CA000510335A patent/CA1309406C/en not_active Expired - Lifetime
- 1986-05-29 NO NO862141A patent/NO171592C/no unknown
- 1986-05-30 DK DK256386A patent/DK162221C/da not_active IP Right Cessation
- 1986-05-30 PL PL1986259791A patent/PL149227B1/pl unknown
- 1986-05-30 PT PT82678A patent/PT82678B/pt unknown
- 1986-05-30 MW MW43/86A patent/MW4386A1/xx unknown
- 1986-05-30 KR KR1019860004274A patent/KR900004402B1/ko not_active IP Right Cessation
- 1986-05-30 AR AR86304166A patent/AR242026A1/es active
- 1986-05-30 JP JP61123840A patent/JPH0713062B2/ja not_active Expired - Lifetime
- 1986-05-30 CN CN86104358A patent/CN1014060B/zh not_active Expired
- 1986-05-30 ES ES555546A patent/ES8801803A1/es not_active Expired
- 1986-05-30 GR GR861411A patent/GR861411B/el unknown
- 1986-05-30 FI FI862315A patent/FI85584C/fi not_active IP Right Cessation
- 1986-06-02 IL IL78992A patent/IL78992A0/xx not_active IP Right Cessation
-
1987
- 1987-04-30 ES ES557522A patent/ES8801903A1/es not_active Expired
- 1987-12-16 ES ES557790A patent/ES8802611A1/es not_active Expired
Also Published As
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FD1A | Patent lapsed |
Effective date: 20080116 |