ES8801286A1 - Un procedimiento para preparar derivados de penem - Google Patents
Un procedimiento para preparar derivados de penemInfo
- Publication number
- ES8801286A1 ES8801286A1 ES556137A ES556137A ES8801286A1 ES 8801286 A1 ES8801286 A1 ES 8801286A1 ES 556137 A ES556137 A ES 556137A ES 556137 A ES556137 A ES 556137A ES 8801286 A1 ES8801286 A1 ES 8801286A1
- Authority
- ES
- Spain
- Prior art keywords
- penem
- derivatives
- stability
- cephalosporing
- dehydropeptidase
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- C07D499/88—Compounds with a double bond between positions 2 and 3 and a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Oncology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Communicable Diseases (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Pens And Brushes (AREA)
- Steroid Compounds (AREA)
- Electroluminescent Light Sources (AREA)
- Magnetic Resonance Imaging Apparatus (AREA)
- Diaphragms For Electromechanical Transducers (AREA)
- Electrotherapy Devices (AREA)
- Materials For Medical Uses (AREA)
- Inks, Pencil-Leads, Or Crayons (AREA)
- Compositions Of Macromolecular Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Cephalosporin Compounds (AREA)
Abstract
PROCEDIMIENTO PARA LA PREPARACION DE DERIVADOS DE PENEM REPRESENTADOS POR LA FORMULA GENERAL (I). COMPRENDE LAS OPERACIONES DE HACER REACCIONAR UN COMPUESTO DE FORMULA GENERAL (II), EN LA QUE R1 ES HIDROGENO, UN GRUPO ALQUILO O UN GRUPO HIDROXI-ALQUILO; R''2 REPRESENTA UN RESIDUO ESTER QUE PUEDE ACTUAR TAMBIEN SIMULTANEAMENTE COMO GRUPO PROTECTOR; Y R5 ES ALQUILO, ARILO O UN ARALQUILO, CON UN COMPUESTO DE TIOL REPRESENTADO POR LA FORMULA GENERAL (III), EN LA QUE R3 REPRESENTA UN GRUPO BICICLO-HETEROCICLICO SUSTITUIDO O NO, EN UN DISOLVENTE SELECCIONADO ENTRE N,N-DIMETILFORMAMIDA, DIMETILSULFOXIDO, TETRAHIDROFURANO Y HEXAMETILFOSFOTRIAMIDA, Y A UNA TEMPERATURA COMPRENDIDA ENTRE C50 GRADOS Y LA TEMPERATURA AMBIENTE. DE APLICACION COMO ANTIBIOTICOS EN EL TRATAMIENTO DE ENFERMEDADES INFECCIOSAS.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP13139485 | 1985-06-17 | ||
JP21342085 | 1985-09-26 |
Publications (2)
Publication Number | Publication Date |
---|---|
ES8801286A1 true ES8801286A1 (es) | 1988-01-01 |
ES556137A0 ES556137A0 (es) | 1988-01-01 |
Family
ID=26466241
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES556137A Expired ES8801286A1 (es) | 1985-06-17 | 1986-06-17 | Un procedimiento para preparar derivados de penem |
Country Status (14)
Country | Link |
---|---|
US (2) | US4962202A (es) |
EP (1) | EP0210883B1 (es) |
JP (2) | JPH0826040B2 (es) |
AT (1) | ATE118007T1 (es) |
AU (2) | AU593558B2 (es) |
CA (1) | CA1339860C (es) |
DE (1) | DE3650221T2 (es) |
DK (1) | DK171644B1 (es) |
ES (1) | ES8801286A1 (es) |
FI (1) | FI87218C (es) |
GR (1) | GR861568B (es) |
IE (1) | IE67525B1 (es) |
NO (1) | NO167982C (es) |
YU (1) | YU46172B (es) |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA1339860C (en) * | 1985-06-17 | 1998-05-12 | Tsunehiko Soga | Derivatives of penem |
DK175069B1 (da) * | 1986-03-11 | 2004-05-24 | Hoffmann La Roche | Pyrocatecholderivater |
JP2579472B2 (ja) * | 1986-12-17 | 1997-02-05 | 第一製薬株式会社 | ペネム化合物 |
JP2708576B2 (ja) * | 1988-11-08 | 1998-02-04 | 第一製薬株式会社 | カルバペネム誘導体 |
US5541694A (en) * | 1993-05-24 | 1996-07-30 | Nikon Corporation | Light shielding blade caulking pin |
Family Cites Families (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4168314A (en) * | 1977-11-17 | 1979-09-18 | Merck & Co., Inc. | 6-(1'-Hydroxyethyl)-2-aminoethylthio-pen-2-em-3-carboxylic acid |
JPS58198486A (ja) * | 1982-05-14 | 1983-11-18 | Sankyo Co Ltd | ペネムまたはカルバペネム−3−カルボン酸誘導体およびその製法 |
US4650794A (en) * | 1982-04-29 | 1987-03-17 | Merck & Co., Inc. | 6-(1-hydroxyethyl)-2-carbamimidoyl-pen-2-em-3-carboxylic acids |
JPS58180490A (ja) * | 1982-03-01 | 1983-10-21 | メルク・エンド・カムパニ−・インコ−ポレ−テツド | 6−置換−2−カルバムイミドイル−ペン−2−エム−3−カルボン酸 |
US4748162A (en) * | 1982-03-01 | 1988-05-31 | Merck & Co., Inc. | 6-substituted-2-carbaminidoyl-pen-2-em-3-carboxylic acids |
NO831160L (no) * | 1982-04-08 | 1983-10-10 | Erba Farmitalia | Fremstilling av substituerte penem-derivater |
ZA836966B (en) * | 1982-09-28 | 1984-04-25 | Bristol Myers Co | Carbapenem antibiotics |
ZA841781B (en) * | 1983-03-14 | 1985-07-31 | Schering Corp | Penim compounds,methods for their preparation and pharmaceutical compositions containing them |
US4772597A (en) * | 1983-10-14 | 1988-09-20 | Pfizer Inc. | 2-azacycloalkylthiopenem derivatives |
IE851586L (en) * | 1984-07-02 | 1986-01-02 | Interchem Internat S A | I methylcarbapenems having a 2-quaternary¹heteroarylalkylthio substituent |
CA1273011A (en) * | 1984-07-02 | 1990-08-21 | Susan M. Schmitt | Carbapenems having an externally alkylated mono- or bicyclic 2-quaternary heteroarylalkylthio substituent |
GB8509180D0 (en) * | 1985-04-10 | 1985-05-15 | Erba Farmitalia | Penem derivatives |
CA1339860C (en) * | 1985-06-17 | 1998-05-12 | Tsunehiko Soga | Derivatives of penem |
JP2579472B2 (ja) * | 1986-12-17 | 1997-02-05 | 第一製薬株式会社 | ペネム化合物 |
-
1986
- 1986-06-13 CA CA000511536A patent/CA1339860C/en not_active Expired - Fee Related
- 1986-06-16 IE IE159386A patent/IE67525B1/en not_active IP Right Cessation
- 1986-06-17 EP EP86401308A patent/EP0210883B1/en not_active Expired - Lifetime
- 1986-06-17 FI FI862566A patent/FI87218C/fi not_active IP Right Cessation
- 1986-06-17 NO NO862411A patent/NO167982C/no not_active IP Right Cessation
- 1986-06-17 AT AT86401308T patent/ATE118007T1/de not_active IP Right Cessation
- 1986-06-17 JP JP61141171A patent/JPH0826040B2/ja not_active Expired - Lifetime
- 1986-06-17 DK DK283586A patent/DK171644B1/da not_active IP Right Cessation
- 1986-06-17 GR GR861568A patent/GR861568B/el unknown
- 1986-06-17 DE DE3650221T patent/DE3650221T2/de not_active Expired - Fee Related
- 1986-06-17 AU AU58909/86A patent/AU593558B2/en not_active Ceased
- 1986-06-17 YU YU104986A patent/YU46172B/sh unknown
- 1986-06-17 ES ES556137A patent/ES8801286A1/es not_active Expired
-
1988
- 1988-01-11 US US07/117,617 patent/US4962202A/en not_active Expired - Fee Related
-
1989
- 1989-11-17 AU AU44784/89A patent/AU626606B2/en not_active Ceased
- 1989-12-07 US US07/449,391 patent/US5079357A/en not_active Expired - Fee Related
-
1993
- 1993-06-17 JP JP5145807A patent/JP2691678B2/ja not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
DK171644B1 (da) | 1997-03-03 |
DE3650221D1 (de) | 1995-03-16 |
US4962202A (en) | 1990-10-09 |
IE861593L (en) | 1986-12-17 |
AU626606B2 (en) | 1992-08-06 |
JP2691678B2 (ja) | 1997-12-17 |
AU5890986A (en) | 1986-12-24 |
DK283586A (da) | 1986-12-18 |
NO862411D0 (no) | 1986-06-17 |
US5079357A (en) | 1992-01-07 |
EP0210883A3 (en) | 1987-07-01 |
EP0210883A2 (en) | 1987-02-04 |
DE3650221T2 (de) | 1995-06-22 |
AU4478489A (en) | 1990-03-08 |
FI87218C (fi) | 1992-12-10 |
YU104986A (en) | 1988-02-29 |
YU46172B (sh) | 1993-05-28 |
DK283586D0 (da) | 1986-06-17 |
GR861568B (en) | 1986-10-17 |
IE67525B1 (en) | 1996-04-03 |
NO167982C (no) | 1992-01-02 |
CA1339860C (en) | 1998-05-12 |
NO167982B (no) | 1991-09-23 |
AU593558B2 (en) | 1990-02-15 |
JPH0826040B2 (ja) | 1996-03-13 |
JPS62149683A (ja) | 1987-07-03 |
JPH06184146A (ja) | 1994-07-05 |
FI862566A0 (fi) | 1986-06-17 |
EP0210883B1 (en) | 1995-02-01 |
NO862411L (no) | 1986-12-18 |
FI862566A (fi) | 1986-12-18 |
ES556137A0 (es) | 1988-01-01 |
FI87218B (fi) | 1992-08-31 |
ATE118007T1 (de) | 1995-02-15 |
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