ES8708220A1 - Procedimiento para la obtencion de halogeno-hidroxi-flavonas - Google Patents

Procedimiento para la obtencion de halogeno-hidroxi-flavonas

Info

Publication number
ES8708220A1
ES8708220A1 ES549255A ES549255A ES8708220A1 ES 8708220 A1 ES8708220 A1 ES 8708220A1 ES 549255 A ES549255 A ES 549255A ES 549255 A ES549255 A ES 549255A ES 8708220 A1 ES8708220 A1 ES 8708220A1
Authority
ES
Spain
Prior art keywords
halogen
hydroxy flavone
flavone
hydroxy
halogenohydroxyflavones
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES549255A
Other languages
English (en)
Other versions
ES549255A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck Patent GmbH
Original Assignee
Merck Patent GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Patent GmbH filed Critical Merck Patent GmbH
Publication of ES549255A0 publication Critical patent/ES549255A0/es
Publication of ES8708220A1 publication Critical patent/ES8708220A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/22—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4
    • C07D311/26—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4 with aromatic rings attached in position 2 or 3
    • C07D311/28—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4 with aromatic rings attached in position 2 or 3 with aromatic rings attached in position 2 only
    • C07D311/30—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4 with aromatic rings attached in position 2 or 3 with aromatic rings attached in position 2 only not hydrogenated in the hetero ring, e.g. flavones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/10—Drugs for disorders of the endocrine system of the posterior pituitary hormones, e.g. oxytocin, ADH
    • A61P5/12—Drugs for disorders of the endocrine system of the posterior pituitary hormones, e.g. oxytocin, ADH for decreasing, blocking or antagonising the activity of the posterior pituitary hormones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/655—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms
    • C07F9/6552—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms the oxygen atom being part of a six-membered ring
    • C07F9/65522—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms the oxygen atom being part of a six-membered ring condensed with carbocyclic rings or carbocyclic ring systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Public Health (AREA)
  • Endocrinology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Diabetes (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrane Compounds (AREA)

Abstract

PROCEDIMIENTO PARA OBTENER HALOGENO-HIDROXI-FLAVONAS. CONSISTE EN TRATAR A UN COMPUESTO DE FORMULA (II) CON UN AGENTE DESHIDRATANTE (DIOXIDO DE SELENIO O PEROXIDO DE HIDROGENO), EN PRESENCIA DE DIOXANO O CLOROFORMO Y ENTRE 0G Y 120GC, PARA OBTENER HALOGENOHIDROXI-FLAVONAS DE FORMULA (I), SUS ESTERES DE ACIDO SULFURICO Y ACIDO FOSFORICO. SIENDO: R, ALQUILO DE C 1 A 3; X, HALOGENO; Y M, N Y P, DE 1, 2 O 3. SE UTILIZA EN EL TRATAMIENTO DE LA HIPERFUNCION DE LAS GLANDULAS TIROIDES. *FORMULA*
ES549255A 1984-11-26 1985-11-25 Procedimiento para la obtencion de halogeno-hidroxi-flavonas Expired ES8708220A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE3443007 1984-11-26
DE19853505611 DE3505611A1 (de) 1984-11-26 1985-02-19 Halogen-hydroxy-flavone

Publications (2)

Publication Number Publication Date
ES549255A0 ES549255A0 (es) 1987-10-01
ES8708220A1 true ES8708220A1 (es) 1987-10-01

Family

ID=25826817

Family Applications (1)

Application Number Title Priority Date Filing Date
ES549255A Expired ES8708220A1 (es) 1984-11-26 1985-11-25 Procedimiento para la obtencion de halogeno-hidroxi-flavonas

Country Status (7)

Country Link
US (2) US4713465A (es)
EP (1) EP0183169B1 (es)
JP (1) JPH0749427B2 (es)
AU (1) AU586649B2 (es)
DE (2) DE3505611A1 (es)
ES (1) ES8708220A1 (es)
HU (1) HU194856B (es)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ZA873745B (en) * 1986-06-04 1988-10-26 Daiichi Seiyaku Co Benzopyran derivatives
USH1427H (en) * 1988-04-06 1995-04-04 Briet; Phillipe Substituted flavonoid compounds, their salts, their manufacture and their use in combination with interleukin-2
DE4011187A1 (de) * 1990-04-06 1991-10-10 Hoechst Ag Substituierte 3-thia- bzw. 3-oxa-alkyl-flavone, verfahren zu ihrer herstellung, verwendung derselben, arzneimittel auf basis dieser verbindungen sowie zwischenprodukte
EP0674530B1 (en) * 1992-12-21 2004-09-01 Mallinckrodt Inc. Radiolabeled polyhydric phenol compounds
US5703130A (en) * 1995-06-07 1997-12-30 Institute Of Materia Medica, An Institute Of The Chinese Academy Of Medical Sciences Chalcone retinoids and methods of use of same
US5716982A (en) * 1995-06-07 1998-02-10 Institute Of Materia Medica, An Institute Of The Chinese Academy Of Medical Sciences Retinoids and methods of use of same
US5968940A (en) * 1995-06-08 1999-10-19 Institute Of Materia Medica Retinoids and methods of use of same
PL179170B1 (pl) * 1995-09-15 2000-07-31 Inst Lekow Nowe zwiazki,pochodne genisteiny PL PL PL PL
AUPQ008299A0 (en) * 1999-04-30 1999-05-27 G.J. Consultants Pty Ltd Isoflavone metabolites
DE10242045B4 (de) * 2002-09-11 2014-03-20 Valmet Automotive Oy Cabriolet-Fahrzeug
US7373991B2 (en) * 2005-07-18 2008-05-20 Schlumberger Technology Corporation Swellable elastomer-based apparatus, oilfield elements comprising same, and methods of using same in oilfield applications
US9120744B2 (en) * 2007-04-16 2015-09-01 The Regents Of The University Of Michigan Plasminogen activator inhibitor-1 inhibitors and methods of use thereof to modulate lipid metabolism
DE102011080517A1 (de) 2011-08-05 2013-02-07 Endress + Hauser Conducta Gesellschaft für Mess- und Regeltechnik mbH + Co. KG Messaufnehmer zur Bestimmung einer eine Aktivität eines Ziel-Ions in einem Messmedium repräsentierenden Messgröße

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH473114A (de) * 1963-08-28 1969-05-31 Merck Ag E Verfahren zur Herstellung von substituierten Flavanoiden
CH471113A (de) * 1965-01-29 1969-04-15 Merck Ag E Verfahren zur Herstellung von wasserlöslichen Flavanoidderivaten
DE1518015C3 (de) * 1965-04-23 1974-06-06 Merck Patent Gmbh, 6100 Darmstadt Substituierte Flavanderivate sowie Verfahren zu ihrer Herstellung
FR5443M (es) * 1966-04-26 1967-10-09
NZ193316A (en) * 1979-04-10 1984-07-31 Hoffmann La Roche 3-alkoxyflavone derivatives and pharmaceutical compositions
IT1134205B (it) * 1980-11-11 1986-08-13 Bonomelli Spa Processo per la produzione di derivati flavonici ad attivita' medicinale
EP0108986A1 (en) * 1982-11-02 1984-05-23 Hokuriku Pharmaceutical Co.,Ltd N-substituted flavone-8-carboxamides
FR2543550B1 (fr) * 1983-04-01 1985-08-09 Cortial Nouveaux derives de la tetrahydroxy-3', 4',5,7 flavone, leur methode de preparation et leur emploi therapeutique

Also Published As

Publication number Publication date
EP0183169A2 (de) 1986-06-04
EP0183169A3 (en) 1987-04-22
DE3570077D1 (en) 1989-06-15
DE3505611A1 (de) 1986-05-28
HU194856B (en) 1988-03-28
ES549255A0 (es) 1987-10-01
AU586649B2 (en) 1989-07-20
EP0183169B1 (de) 1989-05-10
JPH0749427B2 (ja) 1995-05-31
JPS61130284A (ja) 1986-06-18
HUT40098A (en) 1986-11-28
US4788215A (en) 1988-11-29
US4713465A (en) 1987-12-15
AU4988885A (en) 1986-06-05

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 20000201