ES8707496A1 - Un procedimiento para preparar derivados de azetidinona - Google Patents
Un procedimiento para preparar derivados de azetidinonaInfo
- Publication number
- ES8707496A1 ES8707496A1 ES557088A ES557088A ES8707496A1 ES 8707496 A1 ES8707496 A1 ES 8707496A1 ES 557088 A ES557088 A ES 557088A ES 557088 A ES557088 A ES 557088A ES 8707496 A1 ES8707496 A1 ES 8707496A1
- Authority
- ES
- Spain
- Prior art keywords
- antibacterial
- thia
- azabicyclo
- hept
- oxo
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 230000000844 anti-bacterial effect Effects 0.000 title abstract 2
- OTTZHAVKAVGASB-UHFFFAOYSA-N hept-2-ene Chemical class CCCCC=CC OTTZHAVKAVGASB-UHFFFAOYSA-N 0.000 title 1
- FJNCXZZQNBKEJT-UHFFFAOYSA-N 8beta-hydroxymarrubiin Natural products O1C(=O)C2(C)CCCC3(C)C2C1CC(C)(O)C3(O)CCC=1C=COC=1 FJNCXZZQNBKEJT-UHFFFAOYSA-N 0.000 abstract 1
- 108090000204 Dipeptidase 1 Proteins 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 102000006635 beta-lactamase Human genes 0.000 abstract 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 150000002148 esters Chemical class 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
- C07C69/76—Esters of carboxylic acids having a carboxyl group bound to a carbon atom of a six-membered aromatic ring
- C07C69/84—Esters of carboxylic acids having a carboxyl group bound to a carbon atom of a six-membered aromatic ring of monocyclic hydroxy carboxylic acids, the hydroxy groups and the carboxyl groups of which are bound to carbon atoms of a six-membered aromatic ring
- C07C69/90—Esters of carboxylic acids having a carboxyl group bound to a carbon atom of a six-membered aromatic ring of monocyclic hydroxy carboxylic acids, the hydroxy groups and the carboxyl groups of which are bound to carbon atoms of a six-membered aromatic ring with esterified hydroxyl and carboxyl groups
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
- C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
- C07D205/06—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D205/08—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
- C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
- C07D205/06—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D205/08—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams
- C07D205/09—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams with a sulfur atom directly attached in position 4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- C07D499/88—Compounds with a double bond between positions 2 and 3 and a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
- C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
- C07F7/1804—Compounds having Si-O-C linkages
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
- C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
- C07F7/1896—Compounds having one or more Si-O-acyl linkages
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Communicable Diseases (AREA)
- Pharmacology & Pharmacy (AREA)
- Oncology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
PROCEDIMIENTO PARA LA PREPARACION DE DERIVADOS DE AZETIDINONA, DE FORMULA GENERAL (I), Y SUS SALES FISIOLOGICAMENTE ACEPTABLES. CONSISTE EN HACER REACCIONAR UN COMPUESTO DE FORMULA GENERAL (II), EN PRESENCIA DE UNA BASE, CON UN COMPUESTO DE FORMULA GENERAL (III), SEGUIDO DE UNA REACCION CON UN DERIVADO DE ACIDO CARBOXILICO ACTIVADO, EN LAS QUE R REPRESENTA UN ATOMO DE HIDROGENO O UN GRUPO PROTECTOR DE CARBOXI; X REPRESENTA UN ATOMO DE OXIGENO O DE AZUFRE; R4 REPRESENTA UN GRUPO ALQUILO CON HASTA CUATRO ATOMOS DE CARBONO O UN GRUPO FENILO; R14 Y R15 REPRESENTAN UN GRUPO FENILO O UN GRUPO ALQUILO; Y R13 REPRESENTA UN GRUPO PROTECTOR DE HIDROXI. DE APLICACION EN LA PREPARACION DE SUSTANCIAS QUE TIENEN ACTIVIDAD ANTIBACTERIANA O ACTIVIDAD INHIBIDORA.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB848416565A GB8416565D0 (en) | 1984-06-29 | 1984-06-29 | Antibacterial derivatives |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| ES8707496A1 true ES8707496A1 (es) | 1987-08-01 |
| ES557088A0 ES557088A0 (es) | 1987-08-01 |
Family
ID=10563160
Family Applications (11)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES544625A Expired ES8707963A1 (es) | 1984-06-29 | 1985-06-27 | Un procedimiento para preparar derivados de penem |
| ES551562A Expired ES8801660A1 (es) | 1984-06-29 | 1986-02-01 | Un procedimiento para preparar derivados de penem |
| ES551561A Expired ES9000004A1 (es) | 1984-06-29 | 1986-02-01 | Un procedimiento para preparar derivados de penem |
| ES557086A Expired ES8707539A1 (es) | 1984-06-29 | 1986-09-29 | Un procedimiento para preparar derivados de penem |
| ES557091A Expired ES8707498A1 (es) | 1984-06-29 | 1986-09-29 | Un procedimiento para preparar derivados de azetidinona |
| ES557090A Expired ES8707497A1 (es) | 1984-06-29 | 1986-09-29 | Un procedimiento para preparar derivados de azetidinona |
| ES557087A Expired ES8707495A1 (es) | 1984-06-29 | 1986-09-29 | Un procedimiento para preparar derivados de azetidinona |
| ES557092A Expired ES8800898A1 (es) | 1984-06-29 | 1986-09-29 | Un procedimiento para preparar derivados de azetidinona |
| ES557089A Expired ES8707540A1 (es) | 1984-06-29 | 1986-09-29 | Un procedimiento para preparar derivados de penem |
| ES557088A Expired ES8707496A1 (es) | 1984-06-29 | 1986-09-29 | Un procedimiento para preparar derivados de azetidinona |
| ES557535A Expired ES8801661A1 (es) | 1984-06-29 | 1987-05-13 | Un procedimiento para preparar derivados de penem |
Family Applications Before (9)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES544625A Expired ES8707963A1 (es) | 1984-06-29 | 1985-06-27 | Un procedimiento para preparar derivados de penem |
| ES551562A Expired ES8801660A1 (es) | 1984-06-29 | 1986-02-01 | Un procedimiento para preparar derivados de penem |
| ES551561A Expired ES9000004A1 (es) | 1984-06-29 | 1986-02-01 | Un procedimiento para preparar derivados de penem |
| ES557086A Expired ES8707539A1 (es) | 1984-06-29 | 1986-09-29 | Un procedimiento para preparar derivados de penem |
| ES557091A Expired ES8707498A1 (es) | 1984-06-29 | 1986-09-29 | Un procedimiento para preparar derivados de azetidinona |
| ES557090A Expired ES8707497A1 (es) | 1984-06-29 | 1986-09-29 | Un procedimiento para preparar derivados de azetidinona |
| ES557087A Expired ES8707495A1 (es) | 1984-06-29 | 1986-09-29 | Un procedimiento para preparar derivados de azetidinona |
| ES557092A Expired ES8800898A1 (es) | 1984-06-29 | 1986-09-29 | Un procedimiento para preparar derivados de azetidinona |
| ES557089A Expired ES8707540A1 (es) | 1984-06-29 | 1986-09-29 | Un procedimiento para preparar derivados de penem |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES557535A Expired ES8801661A1 (es) | 1984-06-29 | 1987-05-13 | Un procedimiento para preparar derivados de penem |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US4795748A (es) |
| EP (1) | EP0170028A1 (es) |
| JP (1) | JPS6118760A (es) |
| KR (1) | KR860000300A (es) |
| AU (1) | AU583521B2 (es) |
| DK (1) | DK296085A (es) |
| ES (11) | ES8707963A1 (es) |
| FI (1) | FI852554L (es) |
| GB (2) | GB8416565D0 (es) |
| GR (1) | GR851584B (es) |
| HU (3) | HU196809B (es) |
| IL (1) | IL75675A0 (es) |
| NO (3) | NO852356L (es) |
| NZ (1) | NZ212572A (es) |
| PH (1) | PH22117A (es) |
| PT (1) | PT80736B (es) |
| ZA (1) | ZA854901B (es) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB2195627A (en) * | 1986-08-12 | 1988-04-13 | Hoechst Uk Ltd | Penem derivatives |
| DE3882730D1 (de) * | 1987-02-11 | 1993-09-09 | Ciba Geigy Ag | Bicyclische beta-lactam-carbonsaeuren. |
| AT392903B (de) * | 1987-10-08 | 1991-07-10 | Hoechst Ag | Pharmazeutische zubereitung enthaltend ein cephalosporin und ein penemantibiotikum |
| SE535691C2 (sv) * | 2011-03-08 | 2012-11-13 | Kat2Biz Ab | Reduktion av C-O-bindningar via katalytisk transfer hydrogenolys |
| AU2013328883B2 (en) * | 2012-10-12 | 2018-08-02 | Eli Lilly And Company | Chemical engines and methods for their use, especially in the injection of highly viscous fluids |
| AU2018220724A1 (en) | 2017-02-17 | 2019-07-11 | Eli Lilly And Company | Processes and devices for delivery of fluid by chemical reaction |
| WO2019050791A1 (en) | 2017-09-08 | 2019-03-14 | Eli Lilly And Company | SYSTEM FOR CONTROLLING GENERATION OF GAS IN A DRUG DELIVERY DEVICE |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4168314A (en) * | 1977-11-17 | 1979-09-18 | Merck & Co., Inc. | 6-(1'-Hydroxyethyl)-2-aminoethylthio-pen-2-em-3-carboxylic acid |
| JPS5625110A (en) * | 1978-12-18 | 1981-03-10 | Bristol Myers Co | Antibacterial |
| EP0185651A1 (en) * | 1981-07-08 | 1986-06-25 | Hoechst Uk Limited | Intermediates for the production of antibacterial penem derivates |
| ES513672A0 (es) * | 1981-07-08 | 1983-04-01 | Hoechst Uk Ltd | "procedimiento para la preparacion de derivados de penem". |
| DE3377132D1 (en) * | 1982-07-08 | 1988-07-28 | Hoechst Uk Ltd | Antibacterial penem derivatives |
| GB2164334B (en) * | 1984-09-10 | 1988-08-03 | Hoechst Uk Ltd | Antibacterial 7-oxo-4-thia-1-azabicyclo 3,2,0 hept-2-ene derivativess |
-
1984
- 1984-06-29 GB GB848416565A patent/GB8416565D0/en active Pending
-
1985
- 1985-06-11 NO NO852356A patent/NO852356L/no unknown
- 1985-06-19 EP EP85107547A patent/EP0170028A1/en not_active Withdrawn
- 1985-06-24 HU HU855310A patent/HU196809B/hu unknown
- 1985-06-24 HU HU855309A patent/HU196748B/hu unknown
- 1985-06-24 HU HU852470A patent/HU194890B/hu not_active IP Right Cessation
- 1985-06-27 US US06/749,384 patent/US4795748A/en not_active Expired - Fee Related
- 1985-06-27 FI FI852554A patent/FI852554L/fi not_active Application Discontinuation
- 1985-06-27 ES ES544625A patent/ES8707963A1/es not_active Expired
- 1985-06-27 GR GR851584A patent/GR851584B/el unknown
- 1985-06-27 PH PH32465A patent/PH22117A/en unknown
- 1985-06-27 NZ NZ212572A patent/NZ212572A/xx unknown
- 1985-06-28 DK DK296085A patent/DK296085A/da not_active Application Discontinuation
- 1985-06-28 ZA ZA854901A patent/ZA854901B/xx unknown
- 1985-06-28 KR KR1019850004633A patent/KR860000300A/ko not_active Application Discontinuation
- 1985-06-28 IL IL75675A patent/IL75675A0/xx unknown
- 1985-06-28 AU AU44408/85A patent/AU583521B2/en not_active Expired - Fee Related
- 1985-06-28 PT PT80736A patent/PT80736B/pt unknown
- 1985-06-28 JP JP60140707A patent/JPS6118760A/ja active Pending
- 1985-06-28 GB GB8516493A patent/GB2161161B/en not_active Expired
-
1986
- 1986-02-01 ES ES551562A patent/ES8801660A1/es not_active Expired
- 1986-02-01 ES ES551561A patent/ES9000004A1/es not_active Expired
- 1986-03-14 NO NO860974A patent/NO860974L/no unknown
- 1986-03-14 NO NO860975A patent/NO860975L/no unknown
- 1986-09-29 ES ES557086A patent/ES8707539A1/es not_active Expired
- 1986-09-29 ES ES557091A patent/ES8707498A1/es not_active Expired
- 1986-09-29 ES ES557090A patent/ES8707497A1/es not_active Expired
- 1986-09-29 ES ES557087A patent/ES8707495A1/es not_active Expired
- 1986-09-29 ES ES557092A patent/ES8800898A1/es not_active Expired
- 1986-09-29 ES ES557089A patent/ES8707540A1/es not_active Expired
- 1986-09-29 ES ES557088A patent/ES8707496A1/es not_active Expired
-
1987
- 1987-05-13 ES ES557535A patent/ES8801661A1/es not_active Expired
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