ES8706833A1 - Un procedimiento para preparar un aminoacido opticamente activo - Google Patents

Un procedimiento para preparar un aminoacido opticamente activo

Info

Publication number
ES8706833A1
ES8706833A1 ES554324A ES554324A ES8706833A1 ES 8706833 A1 ES8706833 A1 ES 8706833A1 ES 554324 A ES554324 A ES 554324A ES 554324 A ES554324 A ES 554324A ES 8706833 A1 ES8706833 A1 ES 8706833A1
Authority
ES
Spain
Prior art keywords
alpha
optically active
hydantoins
amino acid
carbamoyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES554324A
Other languages
English (en)
Other versions
ES554324A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Kanegafuchi Chemical Industry Co Ltd
Original Assignee
Kanegafuchi Chemical Industry Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kanegafuchi Chemical Industry Co Ltd filed Critical Kanegafuchi Chemical Industry Co Ltd
Publication of ES554324A0 publication Critical patent/ES554324A0/es
Publication of ES8706833A1 publication Critical patent/ES8706833A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/72—Two oxygen atoms, e.g. hydantoin
    • C07D233/74—Two oxygen atoms, e.g. hydantoin with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to other ring members
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
    • C07D311/68—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4 with nitrogen atoms directly attached in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D317/46—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D317/48—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring
    • C07D317/50—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to atoms of the carbocyclic ring
    • C07D317/60—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/10—Spiro-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/02—Oxygen as only ring hetero atoms
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/10—Nitrogen as only ring hetero atom
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/18—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing at least two hetero rings condensed among themselves or condensed with a common carbocyclic ring system, e.g. rifamycin
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P41/00—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture
    • C12P41/006—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by reactions involving C-N bonds, e.g. nitriles, amides, hydantoins, carbamates, lactames, transamination reactions, or keto group formation from racemic mixtures
    • C12P41/009—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by reactions involving C-N bonds, e.g. nitriles, amides, hydantoins, carbamates, lactames, transamination reactions, or keto group formation from racemic mixtures by reactions involving hydantoins or carbamoylamino compounds

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Analytical Chemistry (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

METODO DE PREPARAR AMINOACIDO OPTICAMENTE ACTIVO. CONSISTE EN CONVERTIR ENZIMATICAMENTE UNA CONFIGURACION DE N-CARBAMOIL-ALFA-AMINOACIDO RACEMICO DE FORMULA (I), DONDE R ELEVADO A 1 Y R ELEVADO A 2, DIFERENTES ENTRE SI, SON INDEPENDIENTEMENTE UN GRUPO ALQUILO, ARALQUILO, ARILO, ALQUILO SUSTITUIDO, ARALQUILO SUSTITUIDO O UN GRUPO ARILO SUSTITUIDO, Y SEPARAR EL N-CARBAMOIL-ALFA-AMINOACIDO OPTICAMENTE ACTIVO NO REACCIONADO DE LAS HIDANTOINAS FORMADAS E HIDROLIZARLO CON UN ALCALI PARA FORMAR EL CORRESPONDIENTE AMINOACIDO OPTICAMENTE ACTIVO. TIENEN APLICACIONES FARMACEUTICAS COMO AGENTES ANTICONVULSIONANTES. *FORMULA*
ES554324A 1984-09-17 1986-04-24 Un procedimiento para preparar un aminoacido opticamente activo Expired ES8706833A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP59195392A JPS6172762A (ja) 1984-09-17 1984-09-17 光学活性ヒダントイン類の製造法

Publications (2)

Publication Number Publication Date
ES554324A0 ES554324A0 (es) 1987-07-01
ES8706833A1 true ES8706833A1 (es) 1987-07-01

Family

ID=16340383

Family Applications (4)

Application Number Title Priority Date Filing Date
ES547004A Expired ES8701734A1 (es) 1984-09-17 1985-09-16 Un procedimiento para preparar hidantoinas opticamente acti-vas
ES554324A Expired ES8706833A1 (es) 1984-09-17 1986-04-24 Un procedimiento para preparar un aminoacido opticamente activo
ES554323A Expired ES8706832A1 (es) 1984-09-17 1986-04-24 Un procedimiento para preparar hidantoinas opticamente activas
ES554322A Expired ES8706831A1 (es) 1984-09-17 1986-04-24 Un procedimiento para preparar un aminoacido opticamente activo

Family Applications Before (1)

Application Number Title Priority Date Filing Date
ES547004A Expired ES8701734A1 (es) 1984-09-17 1985-09-16 Un procedimiento para preparar hidantoinas opticamente acti-vas

Family Applications After (2)

Application Number Title Priority Date Filing Date
ES554323A Expired ES8706832A1 (es) 1984-09-17 1986-04-24 Un procedimiento para preparar hidantoinas opticamente activas
ES554322A Expired ES8706831A1 (es) 1984-09-17 1986-04-24 Un procedimiento para preparar un aminoacido opticamente activo

Country Status (6)

Country Link
US (1) US4812406A (es)
EP (1) EP0175312B1 (es)
JP (1) JPS6172762A (es)
CA (1) CA1318874C (es)
DE (1) DE3581248D1 (es)
ES (4) ES8701734A1 (es)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5190867A (en) * 1986-05-08 1993-03-02 Shell International Petroleum Company, Ltd. Process for the preparation of R-2,2-R1,R2 -1,3-dioxolane-4-methanol
DE3769066D1 (de) * 1986-08-28 1991-05-08 Sanwa Kagaku Kenkyusho Co Hydantoin-derivate zur behandlung von komplikationen bei diabetes.
DE19524519B4 (de) * 1995-07-05 2004-10-14 Robert Bosch Gmbh Schneidwerk für Gartenhäcksler
JPH1072446A (ja) * 1996-06-24 1998-03-17 Sumitomo Chem Co Ltd １−置換−ヒダントイン類の製造法
SE0100902D0 (sv) 2001-03-15 2001-03-15 Astrazeneca Ab Compounds
EP1550725A4 (en) * 2002-06-05 2010-08-25 Kaneka Corp PROCESS FOR PRODUCING OPTICALLY ACTIVE alpha-METHYLCYSTEINE DERIVATIVE
SE0202539D0 (sv) 2002-08-27 2002-08-27 Astrazeneca Ab Compounds
US20060051846A1 (en) * 2002-09-06 2006-03-09 Kaneka Corporation Process for producing l-alpha-methylcysteine derivative
AU2003289242A1 (en) * 2003-01-10 2004-08-10 Kaneka Corporation PROCESS FOR PRODUCING OPTICALLY ACTIVE Alpha-METHYLCYSTEINE DERIVATIVE
SE0401762D0 (sv) 2004-07-05 2004-07-05 Astrazeneca Ab Novel compounds
US7648992B2 (en) 2004-07-05 2010-01-19 Astrazeneca Ab Hydantoin derivatives for the treatment of obstructive airway diseases
SE0403085D0 (sv) 2004-12-17 2004-12-17 Astrazeneca Ab Novel componds
SE0403086D0 (sv) 2004-12-17 2004-12-17 Astrazeneca Ab Compounds
TW200800954A (en) * 2006-03-16 2008-01-01 Astrazeneca Ab Novel crystal modifications
TW200831488A (en) 2006-11-29 2008-08-01 Astrazeneca Ab Novel compounds

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT987278B (it) * 1973-05-11 1975-02-20 Snam Progetti Procedimento per la preparazione di l carbamil ammino acidi e dei corrispondenti l amminoacidi
IT1046399B (it) * 1975-05-12 1980-06-30 Snam Progetti Procedimento per la preparazione di d carbamil amminoacidi e dei corrispondenti d amminoacidi
JPS5391189A (en) * 1976-12-30 1978-08-10 Kanegafuchi Chem Ind Co Ltd Preparation of d-n-carbamoyl-alpha-amino acids
IT1109506B (it) * 1978-05-23 1985-12-16 Snam Progetti Processo enzimatico-microbiologico per la produzione di amminoacidi otticamente attivi a partire da idantoine e/o carbamil-derivati racemi
US4286098A (en) * 1980-03-28 1981-08-25 Pfizer Inc. Process for the preparation of chiral hydantoins
DE3031151A1 (de) * 1980-08-18 1982-04-15 Basf Ag, 6700 Ludwigshafen Verfahren zur herstellung von d-n-carbamoyl-(alpha)-aminosaeuren und mikroorganismen dafuer
IT1209495B (it) * 1984-02-02 1989-08-30 A San Donato Milanese Milano Procedimento per la preparazione di l-alfa-amminoacidi.

Also Published As

Publication number Publication date
ES554322A0 (es) 1987-07-01
ES8706832A1 (es) 1987-07-01
EP0175312A3 (en) 1987-04-29
ES554323A0 (es) 1987-07-01
ES8701734A1 (es) 1986-12-01
ES8706831A1 (es) 1987-07-01
US4812406A (en) 1989-03-14
CA1318874C (en) 1993-06-08
DE3581248D1 (de) 1991-02-14
EP0175312B1 (en) 1991-01-09
EP0175312A2 (en) 1986-03-26
JPH0239B2 (es) 1990-01-05
JPS6172762A (ja) 1986-04-14
ES554324A0 (es) 1987-07-01
ES547004A0 (es) 1986-12-01

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 20020506