ES8706707A1 - Procedimiento para la obtencion de 3-amino-1-hidroxi-propan-1,1-difosfonato disordico - Google Patents
Procedimiento para la obtencion de 3-amino-1-hidroxi-propan-1,1-difosfonato disordicoInfo
- Publication number
- ES8706707A1 ES8706707A1 ES555602A ES555602A ES8706707A1 ES 8706707 A1 ES8706707 A1 ES 8706707A1 ES 555602 A ES555602 A ES 555602A ES 555602 A ES555602 A ES 555602A ES 8706707 A1 ES8706707 A1 ES 8706707A1
- Authority
- ES
- Spain
- Prior art keywords
- diphosphonate
- disodium
- amino
- propane
- hydroxy
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 230000004048 modification Effects 0.000 title abstract 3
- 238000012986 modification Methods 0.000 title abstract 3
- 239000013078 crystal Substances 0.000 title abstract 2
- CEYUIFJWVHOCPP-UHFFFAOYSA-L disodium;(3-amino-1-hydroxy-1-phosphonatopropyl)phosphonic acid Chemical compound [Na+].[Na+].NCCC(O)(P(O)([O-])=O)P(O)([O-])=O CEYUIFJWVHOCPP-UHFFFAOYSA-L 0.000 title abstract 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 2
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 abstract 1
- 241001465754 Metazoa Species 0.000 abstract 1
- 229910019142 PO4 Inorganic materials 0.000 abstract 1
- 229910052791 calcium Inorganic materials 0.000 abstract 1
- 239000011575 calcium Substances 0.000 abstract 1
- 238000002425 crystallisation Methods 0.000 abstract 1
- 230000008025 crystallization Effects 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000035475 disorder Diseases 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 230000004060 metabolic process Effects 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 abstract 1
- 239000010452 phosphate Substances 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/06—Phosphorus compounds without P—C bonds
- C07F9/16—Esters of thiophosphoric acids or thiophosphorous acids
- C07F9/165—Esters of thiophosphoric acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
- C07F9/3804—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)] not used, see subgroups
- C07F9/3839—Polyphosphonic acids
- C07F9/3873—Polyphosphonic acids containing nitrogen substituent, e.g. N.....H or N-hydrocarbon group which can be substituted by halogen or nitro(so), N.....O, N.....S, N.....C(=X)- (X =O, S), N.....N, N...C(=X)...N (X =O, S)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
- A61P3/14—Drugs for disorders of the metabolism for electrolyte homeostasis for calcium homeostasis
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Obesity (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Hematology (AREA)
- General Chemical & Material Sciences (AREA)
- Diabetes (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Rheumatology (AREA)
- Endocrinology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
METODO DE OBTENER 3-AMINO-1-HIDROXI-PROPAN-1,1-DIFOSFONATO DISODICO. CONSISTE EN HACER REACCIOANR ACIDO 3-AMINO-1-HIDROXI-PROPAN-1,1-DIFOSFONICO, EN SUSPENSION Y/O SOLUCION QUE CONTIENE AGUA CON LA CANTIDAD NECESARIA DE LEJIA SODICA ACUOSA, PARA OBTENER 3-AMINO-1-HIDROXI-PROPAN-1,1-DIFOSFONATO DISODICO DE FORMULA (I), DESPUES DE LO CUAL SE HACE CRISTALIZAR DE COMO MINIMO SOLUCION SATURADA QUE CONTIENE AGUA EN FORMA DE LA NUEVA FORMA QUE CONTIENE AGUA DE CRISTALIZACION; AISLAR EL PRODUCTO Y SECAR A TEMPERATURA NORMAL O LIGERAMENTE ELEVADA. LA NEUTRALIZACION SE REALIZA A 35-85GC. TIENEN APLICACIONES FARMACEUTICAS EN EL TRATAMIENTO DE PERTURBACIONES EN EL METABOLISMO DE CALCIO Y DE FOSFATO. *FORMULA*
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CH376884 | 1984-08-06 |
Publications (2)
Publication Number | Publication Date |
---|---|
ES8706707A1 true ES8706707A1 (es) | 1987-07-01 |
ES555602A0 ES555602A0 (es) | 1987-07-01 |
Family
ID=4263070
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES545899A Expired ES8701188A1 (es) | 1984-08-06 | 1985-08-05 | Procedimiento para la obtencion de 3-amino-1-hidroxi-propan-1,1-difosfonato disodico |
ES555602A Expired ES8706707A1 (es) | 1984-08-06 | 1986-06-02 | Procedimiento para la obtencion de 3-amino-1-hidroxi-propan-1,1-difosfonato disordico |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES545899A Expired ES8701188A1 (es) | 1984-08-06 | 1985-08-05 | Procedimiento para la obtencion de 3-amino-1-hidroxi-propan-1,1-difosfonato disodico |
Country Status (26)
Country | Link |
---|---|
US (2) | US4639338A (es) |
EP (1) | EP0177443B1 (es) |
JP (1) | JPS6143196A (es) |
KR (1) | KR940000817B1 (es) |
AR (4) | AR240832A1 (es) |
AT (1) | ATE47396T1 (es) |
AU (1) | AU591066B2 (es) |
CA (1) | CA1255694A (es) |
CY (1) | CY1570A (es) |
DD (1) | DD239597A5 (es) |
DE (1) | DE3573783D1 (es) |
DK (1) | DK167282B1 (es) |
DO (1) | DOP1990004769A (es) |
ES (2) | ES8701188A1 (es) |
FI (1) | FI79712C (es) |
GR (1) | GR851910B (es) |
HK (1) | HK42591A (es) |
HU (1) | HU193124B (es) |
IE (1) | IE58077B1 (es) |
IL (1) | IL75990A (es) |
MX (1) | MX9203373A (es) |
NO (1) | NO165401C (es) |
PH (1) | PH24854A (es) |
PT (1) | PT80916B (es) |
SG (1) | SG91390G (es) |
ZA (1) | ZA855892B (es) |
Families Citing this family (59)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CH664158A5 (fr) * | 1984-07-18 | 1988-02-15 | Symphar Sa | Derives propylidenediphosphonates-1,3 substitues en position 2, leur procede de preparation et compositions pharmaceutiques les contenant. |
ES2039237T3 (es) * | 1986-04-24 | 1993-09-16 | Fujisawa Pharmaceutical Co., Ltd. | Procedimiento para preparar nuevos compuestos de acido difosfonico. |
US4963681A (en) * | 1987-07-06 | 1990-10-16 | Norwich Eaton Pharmaceuticals, Inc. | Process for synthesis of aminomethylene phosphonoalkylphosphinates |
IL86951A (en) * | 1987-07-06 | 1996-07-23 | Procter & Gamble Pharma | Methylene phosphonoalkylphosphinates and pharmaceutical preparations containing them |
IT1222734B (it) * | 1987-09-25 | 1990-09-12 | Scalvo S P A | Formulaziopne farmaceutiche e forme di dosaggio per la somminaistarzione rettale di calcitonina |
PH26923A (en) * | 1989-03-08 | 1992-12-03 | Ciba Geigy | N-substituted amino alkanediphosphonic acids |
US4922007A (en) * | 1989-06-09 | 1990-05-01 | Merck & Co., Inc. | Process for preparing 4-amino-1-hydroxybutylidene-1,1-bisphosphonic acid or salts thereof |
PH27186A (en) * | 1989-09-07 | 1993-04-16 | Ciba Geigy Ag | Double-coated granules of disodium pamidronate |
US5019651A (en) * | 1990-06-20 | 1991-05-28 | Merck & Co., Inc. | Process for preparing 4-amino-1-hydroxybutylidene-1,1-bisphosphonic acid (ABP) or salts thereof |
EP0541037A3 (en) * | 1991-11-06 | 1997-02-26 | Takeda Chemical Industries Ltd | Squalene synthetase inhibitory composition and use thereof |
US5270365A (en) * | 1991-12-17 | 1993-12-14 | Merck & Co., Inc. | Prevention and treatment of periodontal disease with alendronate |
TW237386B (es) | 1992-04-15 | 1995-01-01 | Ciba Geigy | |
US6406714B1 (en) | 1992-12-02 | 2002-06-18 | Merck & Co., Inc. | Dry mix formulation for bisphosphonic acids |
US5358941A (en) * | 1992-12-02 | 1994-10-25 | Merck & Co., Inc. | Dry mix formulation for bisphosphonic acids with lactose |
JP3266395B2 (ja) * | 1993-11-24 | 2002-03-18 | 富士写真フイルム株式会社 | 有機薬品の晶析方法 |
TW390813B (en) * | 1994-04-29 | 2000-05-21 | Merck & Co Inc | Wet granulation formulation for bisphosphonic acids |
US20010007863A1 (en) * | 1998-06-18 | 2001-07-12 | Merck & Co., Inc. | Wet granulation formulation for bisphosphonic acids |
GB9408775D0 (en) * | 1994-05-04 | 1994-06-22 | Ciba Geigy Ag | Use of certain methanebisphosphonic acid derivatives to prevent prothesis loosening and prothesis migration |
DE19719680A1 (de) | 1997-05-09 | 1998-11-19 | Boehringer Mannheim Gmbh | Verwendung von Diphosphonsäuren zur präventiven Behandlung von Spätfolgen bei Harnblasenerweiterung oder Harnblasenersatz |
EP0891979B1 (en) * | 1997-07-15 | 2004-10-20 | Gador S.A. | A crystalline form of monohydrate monosodium salt of the N,N-Dimethyl-3-amino-1-Hydroxypropan-1,1-Disphosphonic acid and the procedure for its preparation |
EP1702924A3 (en) * | 1998-08-27 | 2007-07-18 | Teva Pharmaceutical Industries Ltd | Novel hydrate forms of alendronate sodium, processes for manufacture thereof, and pharmaceutical compositions thereof |
PL346347A1 (en) | 1998-08-27 | 2002-02-11 | Teva Pharma | Novel hydrate forms of alendronate sodium, processes for manufacture thereof, and pharmaceutical compositions thereof |
EP0998932A1 (de) | 1998-10-09 | 2000-05-10 | Boehringer Mannheim Gmbh | Feste pharmazeutische Darreichungsform enthaltend Diphosphonsäure oder deren Salze und Verfahren zu ihrer Herstellung |
EP0998933A1 (de) | 1998-10-09 | 2000-05-10 | Boehringer Mannheim Gmbh | Verfahren zur Herstellung von bisphosphonathaltigen pharmazeutischen Zusammensetzungen zur oralen Applikation |
US6160165A (en) * | 1998-12-10 | 2000-12-12 | Aesgen, Inc. | Method for preparation of disodium pamidronate |
US6794536B1 (en) | 1998-12-10 | 2004-09-21 | Aesqen, Inc. | Method for preparation of disodium pamidronate |
ATE238315T1 (de) * | 1998-12-10 | 2003-05-15 | Aesgen Inc | Verfahren zur herstellung von dinatriumpamidronat |
US6315566B1 (en) | 1999-05-18 | 2001-11-13 | 3M Innovative Properties Company | Dental materials |
US6143919A (en) * | 1999-05-18 | 2000-11-07 | 3M Innovative Properties Company | Polymerizable acidic compounds and methods of preparation |
US6963008B2 (en) * | 1999-07-19 | 2005-11-08 | Teva Pharmaceutical Industries Ltd. | Hydrate forms of alendronate sodium, processes for manufacture thereof, and pharmaceutical compositions thereof |
ES2153794B1 (es) * | 1999-08-06 | 2001-10-16 | Medichem Sa | Procedimiento para la obtencion del acido 4-amino-1-hidroxibutiliden-1,1-bisfosfonico y de su sal monosodica trihidratada. |
KR100343232B1 (ko) * | 1999-12-10 | 2002-07-10 | 김재윤 | 결정성 파미드론산 이나트륨염 수화물과 그의 제조방법 |
CA2406446A1 (en) * | 2000-09-18 | 2002-03-21 | Gregory Paul Handreck | Diphosphonate solutions |
BRPI0116865B8 (pt) * | 2001-01-23 | 2021-05-25 | Gador Sa | composição compreendendo bisfosfonatos para prevenção e/ou tratamento de doenças metabólicas dos ossos, processo para preparar tal composição e uso desta |
BR0209361A (pt) | 2001-05-02 | 2004-06-08 | Sicor Inc | Dissódio de pamidronato injetável |
CA2372450A1 (en) * | 2001-05-10 | 2001-09-19 | Pharmaceutical Partners Of Canada Inc. | Liquid injectable formulation of disodium pamidronate |
ITMI20012751A1 (it) * | 2001-12-21 | 2003-06-21 | Lyogen Ltd | Sale monosodico dell'acido pamidronico e procedimento per la sua preparazione |
WO2003057136A2 (en) * | 2001-12-24 | 2003-07-17 | Teva Pharmaceutical Industries Ltd. | Dosage form with a core tablet of active ingredient sheathed in a compressed annular body of powder or granular material, and process and tooling for producing it |
US20040052843A1 (en) * | 2001-12-24 | 2004-03-18 | Lerner E. Itzhak | Controlled release dosage forms |
EP2316468A1 (en) | 2002-02-22 | 2011-05-04 | Shire LLC | Delivery system and methods for protecting and administering dextroamphetamine |
US20040138180A1 (en) * | 2002-10-03 | 2004-07-15 | Barr Laboratories, Inc. | Bisphosphonate composition and process for the preparation thereof |
NZ536273A (en) * | 2002-12-20 | 2007-08-31 | Hoffmann La Roche | High dose ibandronate formulation |
US20050119230A1 (en) * | 2003-09-18 | 2005-06-02 | Alexandra Glausch | Pharmaceutical products comprising bisphosphonated |
WO2005054260A1 (en) * | 2003-12-04 | 2005-06-16 | Mustafa Nevzat Ilac Sanayii A.S. | Method for producing pure disodium pamidronate |
ATE475412T1 (de) | 2004-05-24 | 2010-08-15 | Warner Chilcott Co Llc | Enterische feste orale dosierform eines bisphosphonats mit einem chelate |
WO2008128056A1 (en) * | 2004-10-08 | 2008-10-23 | The Board Of Trustees Of The University Of Illinois | Bisphosphonate compounds and methods with enhanced potency for multiple targets including fpps, ggpps, and dpps |
US7358361B2 (en) * | 2004-10-08 | 2008-04-15 | The Board Of Trustees Of The University Of Illinois | Biophosphonate compounds and methods for bone resorption diseases, cancer, bone pain, immune disorders, and infectious diseases |
KR20080111070A (ko) * | 2006-03-17 | 2008-12-22 | 더 보오드 오브 트러스티스 오브 더 유니버시티 오브 일리노이즈 | 비스포스포네이트 화합물 및 방법 |
US20100144679A1 (en) * | 2007-03-21 | 2010-06-10 | Duke University | Medication kits and formulations for preventing, treating or reducing secondary fractures after previous fracture |
EP2234608A2 (en) | 2007-12-11 | 2010-10-06 | Viamet Pharmaceuticals, Inc. | Metalloenzyme inhibitors using metal binding moieties in combination with targeting moieties |
HUE025737T2 (en) | 2009-09-01 | 2016-05-30 | Univ Duke | Bisphosphonate compositions and methods for treating heart failure |
FR2954320B1 (fr) | 2009-12-17 | 2012-06-15 | Cll Pharma | Composition pharmaceutique orale suprabiodisponible contenant un acide biphosphonique ou un de ses sels |
CA2795886A1 (en) | 2010-04-16 | 2011-10-20 | Novartis Ag | Methods and compositions for improving implant osseointegration |
CN104010647A (zh) | 2011-11-16 | 2014-08-27 | 杜克大学 | 用于治疗和/或减轻心功能障碍的双膦酸盐组合物及方法 |
GB201200868D0 (en) | 2012-01-19 | 2012-02-29 | Depuy Int Ltd | Bone filler composition |
SI2849758T1 (en) * | 2012-05-14 | 2018-07-31 | Anatecip Bioventures Ii Llc | COMPOSITION CONTAINING ZOLEDORNIH ALI OR RELATED COMPOUNDS FOR THE PREPARATION OF INHALANE PATIENTS AND RELATED STATIONS |
US11654152B2 (en) | 2012-05-14 | 2023-05-23 | Antecip Bioventures Ii Llc | Compositions for oral administration of zoledronic acid or related compounds for treating disease |
KR101995432B1 (ko) * | 2016-10-13 | 2019-07-02 | 엘지전자 주식회사 | 공기조화기 및 그 제어방법 |
EP3553067A1 (en) * | 2018-04-10 | 2019-10-16 | Abiogen Pharma S.p.A. | Polymorph of sodium neridronate and preparation process thereof |
Family Cites Families (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE2130794C3 (de) * | 1971-06-22 | 1974-07-11 | Joh. A. Benckiser Gmbh, 6700 Ludwigshafen | Verfahren zur Herstellung von l-Hydroxy-S-amino-propan-ljl-diphosphonsäure |
DE2405254C2 (de) * | 1974-02-04 | 1982-05-27 | Henkel KGaA, 4000 Düsseldorf | Verwendung von 3-Amino-1-Hydroxypropan-1, 1-diphosphonsäure oder ihrer wasserlöslichen Salze bei der Beeinflußung von Calciumstoffwechselstörungen im menschlichen oder tierischen Körper |
US4134969A (en) * | 1974-02-04 | 1979-01-16 | Henkel Kommanditgesellschaft Auf Aktien (Henkel Kgaa) | Method of treatment of calcium disorders using aminoalkane-diphosphonic acids |
DE2534391C2 (de) * | 1975-08-01 | 1983-01-13 | Henkel KGaA, 4000 Düsseldorf | 1-Hydroxy-3-aminoalkan-1,1-diphosphonsäuren |
JPS5283957A (en) * | 1975-12-01 | 1977-07-13 | Henkel & Cie Gmbh | Medicine for treating metabolic obstruction of calcium |
SE7612534L (sv) * | 1975-12-01 | 1977-06-02 | Henkel & Cie Gmbh | Forfarande for framstellning av farmaceutiska preparat for behandling av storningar i kalciumemnesomsettning |
DE2553963A1 (de) * | 1975-12-01 | 1977-06-08 | Henkel & Cie Gmbh | Pharmazeutische praeparate zur behandlung von stoerungen des calciumstoffwechsels |
SE409706B (sv) * | 1976-05-21 | 1979-09-03 | Astra Pharma Prod | Forfarande for framstellning av n,n-dimetyl-3-(4-bromfenyl)-3-3(3-pyridyl)-allylamin dihydroklorid monohydrat |
DE2702631A1 (de) * | 1977-01-22 | 1978-07-27 | Henkel Kgaa | Verfahren zur herstellung von 1-hydroxy-3-amino-propan-1,1-diphosphonsaeuren |
DE2943498C2 (de) * | 1979-10-27 | 1983-01-27 | Henkel KGaA, 4000 Düsseldorf | Verfahren zur Herstellung von 3-Amino-1-hydroxypropan-1,1-diphosphonsäure |
DE3016289A1 (de) * | 1980-04-28 | 1981-10-29 | Henkel KGaA, 4000 Düsseldorf | Verfahren zur herstellung von omega -amino-1-hydroxyalkyliden-1,1-bis-phosphonsaeuren |
US4304734A (en) * | 1980-10-16 | 1981-12-08 | Vysoka Skola Chemicko-Technologicka | 6-Amino-1-hydroxyhexylidene diphosphonic acid, salts and a process for production thereof |
DE3151038A1 (de) * | 1981-12-23 | 1983-07-28 | Henkel KGaA, 4000 Düsseldorf | Verfahren zur herstellung von 3-amino-1-hydroxypropan-1,1-diphosphonsaeure |
US4446052A (en) * | 1982-05-17 | 1984-05-01 | The Procter & Gamble Company | Aqueous gel containing tricalcium di(1-hydroxy-3-aminopropane-1,1-diphosphonate |
CH664158A5 (fr) * | 1984-07-18 | 1988-02-15 | Symphar Sa | Derives propylidenediphosphonates-1,3 substitues en position 2, leur procede de preparation et compositions pharmaceutiques les contenant. |
-
1985
- 1985-07-29 US US06/759,985 patent/US4639338A/en not_active Expired - Lifetime
- 1985-07-30 DE DE8585810352T patent/DE3573783D1/de not_active Expired
- 1985-07-30 AT AT85810352T patent/ATE47396T1/de not_active IP Right Cessation
- 1985-07-30 EP EP85810352A patent/EP0177443B1/de not_active Expired
- 1985-08-01 PH PH32593A patent/PH24854A/en unknown
- 1985-08-01 IL IL75990A patent/IL75990A/xx not_active IP Right Cessation
- 1985-08-02 CA CA000488039A patent/CA1255694A/en not_active Expired
- 1985-08-02 IE IE193185A patent/IE58077B1/en not_active IP Right Cessation
- 1985-08-02 FI FI852986A patent/FI79712C/fi not_active IP Right Cessation
- 1985-08-05 DD DD85279373A patent/DD239597A5/de not_active IP Right Cessation
- 1985-08-05 GR GR851910A patent/GR851910B/el unknown
- 1985-08-05 ZA ZA855892A patent/ZA855892B/xx unknown
- 1985-08-05 DK DK355485A patent/DK167282B1/da not_active IP Right Cessation
- 1985-08-05 AU AU45777/85A patent/AU591066B2/en not_active Expired
- 1985-08-05 PT PT80916A patent/PT80916B/pt unknown
- 1985-08-05 ES ES545899A patent/ES8701188A1/es not_active Expired
- 1985-08-05 HU HU842978A patent/HU193124B/hu unknown
- 1985-08-05 JP JP60171301A patent/JPS6143196A/ja active Granted
- 1985-08-05 KR KR1019850005620A patent/KR940000817B1/ko not_active IP Right Cessation
- 1985-08-05 NO NO853087A patent/NO165401C/no not_active IP Right Cessation
- 1985-08-06 AR AR301204A patent/AR240832A1/es active
-
1986
- 1986-06-02 ES ES555602A patent/ES8706707A1/es not_active Expired
- 1986-09-08 US US06/905,097 patent/US4711880A/en not_active Expired - Lifetime
-
1989
- 1989-06-29 AR AR89314298A patent/AR244698A1/es active
- 1989-06-29 AR AR89314299A patent/AR244696A1/es active
- 1989-06-29 AR AR89314300A patent/AR244697A1/es active
-
1990
- 1990-11-13 SG SG913/90A patent/SG91390G/en unknown
- 1990-11-20 DO DO1990004769A patent/DOP1990004769A/es unknown
-
1991
- 1991-05-30 HK HK425/91A patent/HK42591A/xx not_active IP Right Cessation
- 1991-12-20 CY CY1570A patent/CY1570A/xx unknown
-
1992
- 1992-06-25 MX MX9203373A patent/MX9203373A/es unknown
Also Published As
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