ES8706707A1 - Procedimiento para la obtencion de 3-amino-1-hidroxi-propan-1,1-difosfonato disordico - Google Patents

Procedimiento para la obtencion de 3-amino-1-hidroxi-propan-1,1-difosfonato disordico

Info

Publication number
ES8706707A1
ES8706707A1 ES555602A ES555602A ES8706707A1 ES 8706707 A1 ES8706707 A1 ES 8706707A1 ES 555602 A ES555602 A ES 555602A ES 555602 A ES555602 A ES 555602A ES 8706707 A1 ES8706707 A1 ES 8706707A1
Authority
ES
Spain
Prior art keywords
diphosphonate
disodium
amino
propane
hydroxy
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES555602A
Other languages
English (en)
Other versions
ES555602A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novartis AG
Henkel AG and Co KGaA
Original Assignee
Ciba Geigy AG
Henkel AG and Co KGaA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=4263070&utm_source=***_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ES8706707(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Ciba Geigy AG, Henkel AG and Co KGaA filed Critical Ciba Geigy AG
Publication of ES8706707A1 publication Critical patent/ES8706707A1/es
Publication of ES555602A0 publication Critical patent/ES555602A0/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/06—Phosphorus compounds without P—C bonds
    • C07F9/16—Esters of thiophosphoric acids or thiophosphorous acids
    • C07F9/165—Esters of thiophosphoric acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C07F9/3804—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)] not used, see subgroups
    • C07F9/3839—Polyphosphonic acids
    • C07F9/3873—Polyphosphonic acids containing nitrogen substituent, e.g. N.....H or N-hydrocarbon group which can be substituted by halogen or nitro(so), N.....O, N.....S, N.....C(=X)- (X =O, S), N.....N, N...C(=X)...N (X =O, S)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
    • A61P3/14—Drugs for disorders of the metabolism for electrolyte homeostasis for calcium homeostasis

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Obesity (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Hematology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Diabetes (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Rheumatology (AREA)
  • Endocrinology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

METODO DE OBTENER 3-AMINO-1-HIDROXI-PROPAN-1,1-DIFOSFONATO DISODICO. CONSISTE EN HACER REACCIOANR ACIDO 3-AMINO-1-HIDROXI-PROPAN-1,1-DIFOSFONICO, EN SUSPENSION Y/O SOLUCION QUE CONTIENE AGUA CON LA CANTIDAD NECESARIA DE LEJIA SODICA ACUOSA, PARA OBTENER 3-AMINO-1-HIDROXI-PROPAN-1,1-DIFOSFONATO DISODICO DE FORMULA (I), DESPUES DE LO CUAL SE HACE CRISTALIZAR DE COMO MINIMO SOLUCION SATURADA QUE CONTIENE AGUA EN FORMA DE LA NUEVA FORMA QUE CONTIENE AGUA DE CRISTALIZACION; AISLAR EL PRODUCTO Y SECAR A TEMPERATURA NORMAL O LIGERAMENTE ELEVADA. LA NEUTRALIZACION SE REALIZA A 35-85GC. TIENEN APLICACIONES FARMACEUTICAS EN EL TRATAMIENTO DE PERTURBACIONES EN EL METABOLISMO DE CALCIO Y DE FOSFATO. *FORMULA*
ES555602A 1984-08-06 1986-06-02 Procedimiento para la obtencion de 3-amino-1-hidroxi-propan-1,1-difosfonato disordico Expired ES8706707A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CH376884 1984-08-06

Publications (2)

Publication Number Publication Date
ES8706707A1 true ES8706707A1 (es) 1987-07-01
ES555602A0 ES555602A0 (es) 1987-07-01

Family

ID=4263070

Family Applications (2)

Application Number Title Priority Date Filing Date
ES545899A Expired ES8701188A1 (es) 1984-08-06 1985-08-05 Procedimiento para la obtencion de 3-amino-1-hidroxi-propan-1,1-difosfonato disodico
ES555602A Expired ES8706707A1 (es) 1984-08-06 1986-06-02 Procedimiento para la obtencion de 3-amino-1-hidroxi-propan-1,1-difosfonato disordico

Family Applications Before (1)

Application Number Title Priority Date Filing Date
ES545899A Expired ES8701188A1 (es) 1984-08-06 1985-08-05 Procedimiento para la obtencion de 3-amino-1-hidroxi-propan-1,1-difosfonato disodico

Country Status (26)

Country Link
US (2) US4639338A (es)
EP (1) EP0177443B1 (es)
JP (1) JPS6143196A (es)
KR (1) KR940000817B1 (es)
AR (4) AR240832A1 (es)
AT (1) ATE47396T1 (es)
AU (1) AU591066B2 (es)
CA (1) CA1255694A (es)
CY (1) CY1570A (es)
DD (1) DD239597A5 (es)
DE (1) DE3573783D1 (es)
DK (1) DK167282B1 (es)
DO (1) DOP1990004769A (es)
ES (2) ES8701188A1 (es)
FI (1) FI79712C (es)
GR (1) GR851910B (es)
HK (1) HK42591A (es)
HU (1) HU193124B (es)
IE (1) IE58077B1 (es)
IL (1) IL75990A (es)
MX (1) MX9203373A (es)
NO (1) NO165401C (es)
PH (1) PH24854A (es)
PT (1) PT80916B (es)
SG (1) SG91390G (es)
ZA (1) ZA855892B (es)

Families Citing this family (59)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH664158A5 (fr) * 1984-07-18 1988-02-15 Symphar Sa Derives propylidenediphosphonates-1,3 substitues en position 2, leur procede de preparation et compositions pharmaceutiques les contenant.
ES2039237T3 (es) * 1986-04-24 1993-09-16 Fujisawa Pharmaceutical Co., Ltd. Procedimiento para preparar nuevos compuestos de acido difosfonico.
US4963681A (en) * 1987-07-06 1990-10-16 Norwich Eaton Pharmaceuticals, Inc. Process for synthesis of aminomethylene phosphonoalkylphosphinates
IL86951A (en) * 1987-07-06 1996-07-23 Procter & Gamble Pharma Methylene phosphonoalkylphosphinates and pharmaceutical preparations containing them
IT1222734B (it) * 1987-09-25 1990-09-12 Scalvo S P A Formulaziopne farmaceutiche e forme di dosaggio per la somminaistarzione rettale di calcitonina
PH26923A (en) * 1989-03-08 1992-12-03 Ciba Geigy N-substituted amino alkanediphosphonic acids
US4922007A (en) * 1989-06-09 1990-05-01 Merck & Co., Inc. Process for preparing 4-amino-1-hydroxybutylidene-1,1-bisphosphonic acid or salts thereof
PH27186A (en) * 1989-09-07 1993-04-16 Ciba Geigy Ag Double-coated granules of disodium pamidronate
US5019651A (en) * 1990-06-20 1991-05-28 Merck & Co., Inc. Process for preparing 4-amino-1-hydroxybutylidene-1,1-bisphosphonic acid (ABP) or salts thereof
EP0541037A3 (en) * 1991-11-06 1997-02-26 Takeda Chemical Industries Ltd Squalene synthetase inhibitory composition and use thereof
US5270365A (en) * 1991-12-17 1993-12-14 Merck & Co., Inc. Prevention and treatment of periodontal disease with alendronate
TW237386B (es) 1992-04-15 1995-01-01 Ciba Geigy
US6406714B1 (en) 1992-12-02 2002-06-18 Merck & Co., Inc. Dry mix formulation for bisphosphonic acids
US5358941A (en) * 1992-12-02 1994-10-25 Merck & Co., Inc. Dry mix formulation for bisphosphonic acids with lactose
JP3266395B2 (ja) * 1993-11-24 2002-03-18 富士写真フイルム株式会社 有機薬品の晶析方法
TW390813B (en) * 1994-04-29 2000-05-21 Merck & Co Inc Wet granulation formulation for bisphosphonic acids
US20010007863A1 (en) * 1998-06-18 2001-07-12 Merck & Co., Inc. Wet granulation formulation for bisphosphonic acids
GB9408775D0 (en) * 1994-05-04 1994-06-22 Ciba Geigy Ag Use of certain methanebisphosphonic acid derivatives to prevent prothesis loosening and prothesis migration
DE19719680A1 (de) 1997-05-09 1998-11-19 Boehringer Mannheim Gmbh Verwendung von Diphosphonsäuren zur präventiven Behandlung von Spätfolgen bei Harnblasenerweiterung oder Harnblasenersatz
EP0891979B1 (en) * 1997-07-15 2004-10-20 Gador S.A. A crystalline form of monohydrate monosodium salt of the N,N-Dimethyl-3-amino-1-Hydroxypropan-1,1-Disphosphonic acid and the procedure for its preparation
EP1702924A3 (en) * 1998-08-27 2007-07-18 Teva Pharmaceutical Industries Ltd Novel hydrate forms of alendronate sodium, processes for manufacture thereof, and pharmaceutical compositions thereof
PL346347A1 (en) 1998-08-27 2002-02-11 Teva Pharma Novel hydrate forms of alendronate sodium, processes for manufacture thereof, and pharmaceutical compositions thereof
EP0998932A1 (de) 1998-10-09 2000-05-10 Boehringer Mannheim Gmbh Feste pharmazeutische Darreichungsform enthaltend Diphosphonsäure oder deren Salze und Verfahren zu ihrer Herstellung
EP0998933A1 (de) 1998-10-09 2000-05-10 Boehringer Mannheim Gmbh Verfahren zur Herstellung von bisphosphonathaltigen pharmazeutischen Zusammensetzungen zur oralen Applikation
US6160165A (en) * 1998-12-10 2000-12-12 Aesgen, Inc. Method for preparation of disodium pamidronate
US6794536B1 (en) 1998-12-10 2004-09-21 Aesqen, Inc. Method for preparation of disodium pamidronate
ATE238315T1 (de) * 1998-12-10 2003-05-15 Aesgen Inc Verfahren zur herstellung von dinatriumpamidronat
US6315566B1 (en) 1999-05-18 2001-11-13 3M Innovative Properties Company Dental materials
US6143919A (en) * 1999-05-18 2000-11-07 3M Innovative Properties Company Polymerizable acidic compounds and methods of preparation
US6963008B2 (en) * 1999-07-19 2005-11-08 Teva Pharmaceutical Industries Ltd. Hydrate forms of alendronate sodium, processes for manufacture thereof, and pharmaceutical compositions thereof
ES2153794B1 (es) * 1999-08-06 2001-10-16 Medichem Sa Procedimiento para la obtencion del acido 4-amino-1-hidroxibutiliden-1,1-bisfosfonico y de su sal monosodica trihidratada.
KR100343232B1 (ko) * 1999-12-10 2002-07-10 김재윤 결정성 파미드론산 이나트륨염 수화물과 그의 제조방법
CA2406446A1 (en) * 2000-09-18 2002-03-21 Gregory Paul Handreck Diphosphonate solutions
BRPI0116865B8 (pt) * 2001-01-23 2021-05-25 Gador Sa composição compreendendo bisfosfonatos para prevenção e/ou tratamento de doenças metabólicas dos ossos, processo para preparar tal composição e uso desta
BR0209361A (pt) 2001-05-02 2004-06-08 Sicor Inc Dissódio de pamidronato injetável
CA2372450A1 (en) * 2001-05-10 2001-09-19 Pharmaceutical Partners Of Canada Inc. Liquid injectable formulation of disodium pamidronate
ITMI20012751A1 (it) * 2001-12-21 2003-06-21 Lyogen Ltd Sale monosodico dell'acido pamidronico e procedimento per la sua preparazione
WO2003057136A2 (en) * 2001-12-24 2003-07-17 Teva Pharmaceutical Industries Ltd. Dosage form with a core tablet of active ingredient sheathed in a compressed annular body of powder or granular material, and process and tooling for producing it
US20040052843A1 (en) * 2001-12-24 2004-03-18 Lerner E. Itzhak Controlled release dosage forms
EP2316468A1 (en) 2002-02-22 2011-05-04 Shire LLC Delivery system and methods for protecting and administering dextroamphetamine
US20040138180A1 (en) * 2002-10-03 2004-07-15 Barr Laboratories, Inc. Bisphosphonate composition and process for the preparation thereof
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US20050119230A1 (en) * 2003-09-18 2005-06-02 Alexandra Glausch Pharmaceutical products comprising bisphosphonated
WO2005054260A1 (en) * 2003-12-04 2005-06-16 Mustafa Nevzat Ilac Sanayii A.S. Method for producing pure disodium pamidronate
ATE475412T1 (de) 2004-05-24 2010-08-15 Warner Chilcott Co Llc Enterische feste orale dosierform eines bisphosphonats mit einem chelate
WO2008128056A1 (en) * 2004-10-08 2008-10-23 The Board Of Trustees Of The University Of Illinois Bisphosphonate compounds and methods with enhanced potency for multiple targets including fpps, ggpps, and dpps
US7358361B2 (en) * 2004-10-08 2008-04-15 The Board Of Trustees Of The University Of Illinois Biophosphonate compounds and methods for bone resorption diseases, cancer, bone pain, immune disorders, and infectious diseases
KR20080111070A (ko) * 2006-03-17 2008-12-22 더 보오드 오브 트러스티스 오브 더 유니버시티 오브 일리노이즈 비스포스포네이트 화합물 및 방법
US20100144679A1 (en) * 2007-03-21 2010-06-10 Duke University Medication kits and formulations for preventing, treating or reducing secondary fractures after previous fracture
EP2234608A2 (en) 2007-12-11 2010-10-06 Viamet Pharmaceuticals, Inc. Metalloenzyme inhibitors using metal binding moieties in combination with targeting moieties
HUE025737T2 (en) 2009-09-01 2016-05-30 Univ Duke Bisphosphonate compositions and methods for treating heart failure
FR2954320B1 (fr) 2009-12-17 2012-06-15 Cll Pharma Composition pharmaceutique orale suprabiodisponible contenant un acide biphosphonique ou un de ses sels
CA2795886A1 (en) 2010-04-16 2011-10-20 Novartis Ag Methods and compositions for improving implant osseointegration
CN104010647A (zh) 2011-11-16 2014-08-27 杜克大学 用于治疗和/或减轻心功能障碍的双膦酸盐组合物及方法
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JPS5283957A (en) * 1975-12-01 1977-07-13 Henkel & Cie Gmbh Medicine for treating metabolic obstruction of calcium
SE7612534L (sv) * 1975-12-01 1977-06-02 Henkel & Cie Gmbh Forfarande for framstellning av farmaceutiska preparat for behandling av storningar i kalciumemnesomsettning
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Also Published As

Publication number Publication date
NO165401C (no) 1991-02-06
AR244696A1 (es) 1993-11-30
PH24854A (en) 1990-12-26
GR851910B (es) 1985-12-03
IE58077B1 (en) 1993-06-30
AR240832A1 (es) 1991-02-28
HU193124B (en) 1987-08-28
ES545899A0 (es) 1986-11-16
DK167282B1 (da) 1993-10-04
ES555602A0 (es) 1987-07-01
PT80916A (en) 1985-09-01
FI79712C (fi) 1990-02-12
IE851931L (en) 1986-02-06
ES8701188A1 (es) 1986-11-16
AR240832A2 (es) 1991-02-28
AR244698A1 (es) 1993-11-30
DE3573783D1 (en) 1989-11-23
DK355485D0 (da) 1985-08-05
US4639338A (en) 1987-01-27
EP0177443A1 (de) 1986-04-09
KR940000817B1 (ko) 1994-02-02
FI852986L (fi) 1986-02-07
DK355485A (da) 1986-02-07
AU591066B2 (en) 1989-11-30
KR860001821A (ko) 1986-03-22
ZA855892B (en) 1986-03-26
CY1570A (en) 1991-12-20
PT80916B (pt) 1987-12-30
FI852986A0 (fi) 1985-08-02
NO165401B (no) 1990-10-29
SG91390G (en) 1991-01-18
ATE47396T1 (de) 1989-11-15
JPH058717B2 (es) 1993-02-02
DOP1990004769A (es) 1999-08-19
AU4577785A (en) 1986-02-13
FI79712B (fi) 1989-10-31
AR244697A1 (es) 1993-11-30
DD239597A5 (de) 1986-10-01
JPS6143196A (ja) 1986-03-01
IL75990A (en) 1989-07-31
NO853087L (no) 1986-02-07
US4711880A (en) 1987-12-08
CA1255694A (en) 1989-06-13
EP0177443B1 (de) 1989-10-18
HUT38361A (en) 1986-05-28
HK42591A (en) 1991-06-07
MX9203373A (es) 1992-09-01

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Effective date: 20070508