ES8706117A1 - Procedimiento para preparar 1,3,4,5-tetrahidro-benz cd indolaminas oxigenadas en posicion 6 - Google Patents

Procedimiento para preparar 1,3,4,5-tetrahidro-benz cd indolaminas oxigenadas en posicion 6

Info

Publication number
ES8706117A1
ES8706117A1 ES551944A ES551944A ES8706117A1 ES 8706117 A1 ES8706117 A1 ES 8706117A1 ES 551944 A ES551944 A ES 551944A ES 551944 A ES551944 A ES 551944A ES 8706117 A1 ES8706117 A1 ES 8706117A1
Authority
ES
Spain
Prior art keywords
tetrahydrobenz
oxygenated
indol
amines
alkyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES551944A
Other languages
English (en)
Other versions
ES551944A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
SmithKline Beecham Corp
Original Assignee
SmithKline Beecham Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by SmithKline Beecham Corp filed Critical SmithKline Beecham Corp
Publication of ES8706117A1 publication Critical patent/ES8706117A1/es
Publication of ES551944A0 publication Critical patent/ES551944A0/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, ***e
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56—Ring systems containing three or more rings
    • C07D209/80—[b, c]- or [b, d]-condensed
    • C07D209/90—Benzo [c, d] indoles; Hydrogenated benzo [c, d] indoles

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Psychiatry (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Pain & Pain Management (AREA)
  • Indole Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

METODO DE PREPARAR 1,3,4,5-TETRAHIDRO-BENZC,DINDOL-AMINAS OXIGENADAS EN POSICION 6. CONSISTE EN LA AMINACION REDUCTORA DE UN COMPUESTO DE FORMULA (II) DONDE R4 ES ALQUILO DE C 1 A 5, USANDO CIANOBOROHIDRURO SODICO Y UNA AMINA DE FORMULA R2R3NH, PARA OBTENER 1,3,4,5-TETRAHIDRO-BENZC,DINDOL-AMINAS OXIGENADAS EN POSICION 6 DE FORMULA (I) DONDE R1 ES H O ALQUILO DE C 1 A 5; Y R2 Y R3, QUE SON IGUALES O DIFERENTES, SON HIDROGENO, ALQUILO DE C 1 A 4, FENIL (CH2)N DONDE N ES 0-3, CICLOALQUILO DE C 5 A 6 O ALQUENILO DE C 3 A 5. TIENEN UTILIDAD FARMACOLOGICA PARA EL TRATAMIENTO DE ENFERMEDADES CARDIOVASCULARES.
ES551944A 1984-05-24 1986-02-13 Procedimiento para preparar 1,3,4,5-tetrahidro-benz cd indolaminas oxigenadas en posicion 6 Expired ES8706117A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US61383984A 1984-05-24 1984-05-24

Publications (2)

Publication Number Publication Date
ES8706117A1 true ES8706117A1 (es) 1987-06-01
ES551944A0 ES551944A0 (es) 1987-06-01

Family

ID=24458880

Family Applications (2)

Application Number Title Priority Date Filing Date
ES543421A Expired ES8700233A1 (es) 1984-05-24 1985-05-23 Un procedimiento para preparar 1,3,4,5-tetrahidro-benz(cd) indolaminas oxigenadas en posicion 6
ES551944A Expired ES8706117A1 (es) 1984-05-24 1986-02-13 Procedimiento para preparar 1,3,4,5-tetrahidro-benz cd indolaminas oxigenadas en posicion 6

Family Applications Before (1)

Application Number Title Priority Date Filing Date
ES543421A Expired ES8700233A1 (es) 1984-05-24 1985-05-23 Un procedimiento para preparar 1,3,4,5-tetrahidro-benz(cd) indolaminas oxigenadas en posicion 6

Country Status (11)

Country Link
EP (1) EP0162695B1 (es)
JP (1) JPS60258162A (es)
AT (1) ATE49592T1 (es)
AU (1) AU581000B2 (es)
CA (1) CA1266482A1 (es)
DE (1) DE3575420D1 (es)
DK (1) DK222385A (es)
ES (2) ES8700233A1 (es)
GR (1) GR851263B (es)
PT (1) PT80524B (es)
ZA (1) ZA853913B (es)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3346573A1 (de) * 1983-12-23 1985-07-04 Troponwerke GmbH & Co KG, 5000 Köln 1,3,4,5-tetrahydrobenz(c,d)indole, ein verfahren zu ihrer herstellung und ihre verwendung
IL74222A (en) * 1984-02-06 1988-07-31 Lilly Co Eli 6-substituted-4-dialkylamino tetrahydrobenz(c,d)indoles,their preparation and pharmaceutical compositions comprising them
US5026869A (en) * 1984-02-06 1991-06-25 Eli Lilly And Company 6-substituted-4-dialkylaminotetrahydrobenz(c,d)indoles
US4983622A (en) * 1984-02-06 1991-01-08 Eli Lilly And Company 6-substituted-4-dialkylaminotetrahydrobenz(c,d)indoles
DE3718892A1 (de) * 1987-06-05 1988-12-22 Bayer Ag Polyhydrobenz(c,d)indol-sulfonamide
DE3809155A1 (de) * 1988-03-18 1989-09-28 Bayer Ag 1,3,4,5-tetrahydrobenz-(c,d)-indole
US5204340A (en) * 1989-04-11 1993-04-20 Eli Lilly And Company Tetrahydrobenz(c,d)indole serotonin agonists
US5302612A (en) * 1990-02-26 1994-04-12 Eli Lilly And Company 6-substituted-hexahydrobenz[cd]indoles
US5229410A (en) * 1990-08-15 1993-07-20 Eli Lilly And Company 6-substituted-hexahydrobenz[cd]indoles
US5229409A (en) * 1990-08-15 1993-07-20 Eli Lilly And Company 6-substituted-tetrahydrobenz[cd]indoles
US5244911A (en) * 1991-03-28 1993-09-14 Eli Lilly And Company 6-heterocyclic-4-amino-1,2,2a,3,4,5-hexahydrobenz(cd)indoles and pharmaceutical use thereof
US5244912A (en) * 1991-03-28 1993-09-14 Eli Lilly And Company 6-heterocyclic-4-amino-1,3,4,5-tetrahydrobenz(cd)indoles and pharmaceutical use thereof
US5347013A (en) * 1991-03-28 1994-09-13 Eli Lilly And Company 6-heterocyclic-4-amino-1,2,2a,3,4,5-hexahydrobenz[cd]indoles
US5364856A (en) * 1991-03-28 1994-11-15 Eli Lilly And Company 6-heterocyclic-4-amino-1,3,4,5-tetrahydrobenz[CD]indoles
US5641794A (en) * 1991-03-28 1997-06-24 Eli Lilly Company 6-heterocyclic-4-amino-1,2,2a,3,4,5-hexahydrobenz[cd]indoles
NZ260667A (en) * 1993-06-10 1997-05-26 Lilly Co Eli Preventing emesis or treating sexual dysfunction using tetrahydrobenz[cd]indole 6-carboxamides
FR2732964B1 (fr) * 1995-04-14 1997-05-16 Adir Nouveaux amides tricycliques, leurs procedes de preparation et les compositions pharmaceutiques qui les contiennent

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3194811A (en) * 1963-09-05 1965-07-13 Merck & Co Inc Aroyl-benzindolyl acids
CH517732A (de) * 1969-10-24 1972-01-15 Sandoz Ag Verfahren zur Herstellung neuer Guanidin- Verbindungen
US4110339A (en) * 1977-11-25 1978-08-29 Eli Lilly And Company 4-(Di-n-propyl)amino-1,3,4,5-tetrahydrobenz[cd]indole
US4282240A (en) * 1979-11-23 1981-08-04 Merck & Co., Inc. Amino substituted tetrahydrobenzindoles
DE3346573A1 (de) * 1983-12-23 1985-07-04 Troponwerke GmbH & Co KG, 5000 Köln 1,3,4,5-tetrahydrobenz(c,d)indole, ein verfahren zu ihrer herstellung und ihre verwendung
IL74222A (en) * 1984-02-06 1988-07-31 Lilly Co Eli 6-substituted-4-dialkylamino tetrahydrobenz(c,d)indoles,their preparation and pharmaceutical compositions comprising them

Also Published As

Publication number Publication date
AU581000B2 (en) 1989-02-09
DE3575420D1 (de) 1990-02-22
PT80524A (en) 1985-06-01
ZA853913B (en) 1986-01-29
ES8700233A1 (es) 1986-09-16
EP0162695A1 (en) 1985-11-27
DK222385A (da) 1985-11-25
JPS60258162A (ja) 1985-12-20
GR851263B (es) 1985-11-25
ES543421A0 (es) 1986-09-16
PT80524B (en) 1987-04-06
DK222385D0 (da) 1985-05-20
EP0162695B1 (en) 1990-01-17
CA1266675C (es) 1990-03-13
ES551944A0 (es) 1987-06-01
ATE49592T1 (de) 1990-02-15
AU4279685A (en) 1985-11-28
CA1266482A1 (en) 1990-03-06

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 19970203