ES8703871A1 - Use of a protoberberine alkaloid and composition containing same. - Google Patents
Use of a protoberberine alkaloid and composition containing same.Info
- Publication number
- ES8703871A1 ES8703871A1 ES522754A ES522754A ES8703871A1 ES 8703871 A1 ES8703871 A1 ES 8703871A1 ES 522754 A ES522754 A ES 522754A ES 522754 A ES522754 A ES 522754A ES 8703871 A1 ES8703871 A1 ES 8703871A1
- Authority
- ES
- Spain
- Prior art keywords
- decrease
- composition containing
- protoberberine alkaloid
- containing same
- left ventricle
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
- A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
- A61K31/704—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin attached to a condensed carbocyclic ring system, e.g. sennosides, thiocolchicosides, escin, daunorubicin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Molecular Biology (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
A composition containing a protoberberine alkaloid or its salt which is effective to increase the contractility of the mammalian heart as shown by a positive inotropic effect (as evidenced by an increased dP/dT and dF/dT), accompanied by at least one the following symptoms: improved aortic blood flow, decrease in heart rate, decrease in systemic arterial pressure, reduction of afterload of the left ventricle, decrease in preload of the left ventricle, decrease in calculated vessel peripheral resistance, decrease in mean arterial pressure and freedom of arrhythmias, and its method of use.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US37812282A | 1982-05-14 | 1982-05-14 | |
US40988382A | 1982-08-20 | 1982-08-20 |
Publications (2)
Publication Number | Publication Date |
---|---|
ES8703871A1 true ES8703871A1 (en) | 1987-03-16 |
ES522754A0 ES522754A0 (en) | 1987-03-16 |
Family
ID=27008080
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES522754A Expired ES8703871A1 (en) | 1982-05-14 | 1983-05-14 | Use of a protoberberine alkaloid and composition containing same. |
Country Status (11)
Country | Link |
---|---|
EP (1) | EP0108147B1 (en) |
AU (1) | AU571184B2 (en) |
CA (1) | CA1220139A (en) |
DE (1) | DE3377695D1 (en) |
ES (1) | ES8703871A1 (en) |
GR (1) | GR79223B (en) |
IE (1) | IE55519B1 (en) |
IL (1) | IL68690A0 (en) |
IT (1) | IT1173712B (en) |
PT (1) | PT76690B (en) |
WO (1) | WO1983003970A1 (en) |
Families Citing this family (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR100258849B1 (en) * | 1998-04-24 | 2000-08-01 | 박원배 | Pharmaceutically useful protoberberine derivative and its salts |
DE60231426D1 (en) | 2001-11-14 | 2009-04-16 | Univ Rutgers | SOLUBILIZED TOPOISOMERASE GIFT MEDIUM |
DE60235287D1 (en) | 2001-11-14 | 2010-03-25 | Univ Rutgers | SOLUBLY MADE TOPOISOMERASE GIFTS |
ES2311639T3 (en) | 2001-11-14 | 2009-02-16 | Rutgers, The State University | CYTOTOXIC AGENTS. |
EP1453506B1 (en) | 2001-11-14 | 2008-04-02 | Rutgers, The State University | Topoisomerase poison agents |
AU2003265406A1 (en) | 2002-08-09 | 2004-02-25 | Edmond J. Lavoie | Nitro and amino substituted topoisomerase agents |
AU2003268075A1 (en) | 2002-08-09 | 2004-02-25 | Edmond J. Lavoie | Nitro and amino substituted dibenzonaphthyridines as topoisomerase agents |
WO2004014862A1 (en) | 2002-08-09 | 2004-02-19 | Rutgers, The State University | Nitro and amino substituted heterocycles as topoisomerase i targeting agents |
WO2004044174A2 (en) | 2002-11-12 | 2004-05-27 | Rutgers, The State University | Topoisomerase-targeting agents |
CN100441183C (en) * | 2005-08-29 | 2008-12-10 | 中国医学科学院皮肤病研究所 | Use of chloride 13-hexyl berberine and chloride 13-hexyl palmatine in preparation of medicine for treating moist tetter, dermatitis and psoriasis |
JP5773888B2 (en) | 2009-03-06 | 2015-09-02 | ラットガーズ,ザ・ステート・ユニバーシティ・オブ・ニュージャージー | Methylenedioxybenzo [I] phenanthridine derivatives used for cancer treatment |
EP2405755A4 (en) * | 2009-03-11 | 2012-11-28 | Xintria Pharmaceutical Corp Inc | Methods and compositions for the treatment of metabolic and cardiovascular disorders |
WO2010127363A1 (en) | 2009-05-01 | 2010-11-04 | Rutgers, The State University Of New Jersey | Toposiomerase inhibitors |
US20140107505A1 (en) | 2012-10-11 | 2014-04-17 | Alon Marmor | Determination of ventricular pressure and related values |
CN109219610A (en) | 2016-04-04 | 2019-01-15 | 新泽西州立拉特格斯大学 | topoisomerase poisons |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
NL129028C (en) * | 1964-02-13 | |||
US3420834A (en) * | 1964-11-13 | 1969-01-07 | Roussel Uclaf | 2,3-dimethoxy-berbines substituted in the 10 position and process |
JPS4942700A (en) * | 1972-08-25 | 1974-04-22 | ||
US3920665A (en) * | 1972-10-19 | 1975-11-18 | Kanebo Ltd | Berbine compounds |
JPS523397B2 (en) * | 1972-11-20 | 1977-01-27 | ||
US3910938A (en) * | 1973-01-27 | 1975-10-07 | Kanebo Ltd | Berbine derivatives |
US4042592A (en) * | 1974-05-08 | 1977-08-16 | Kanebo, Ltd. | Novel dibenzo[a,g]quinolizinium compounds |
US4087426A (en) * | 1976-08-16 | 1978-05-02 | Research Corporation | Oxybisberberine and a process for its production |
SE426548B (en) * | 1978-12-05 | 1983-01-31 | Haessle Ab | SOLID PHARMACEUTICAL PREPARATION INCLUDING A THERAPEUTICALLY EFFECTIVE HEART GYCLOSIDE AND POLYMER |
-
1983
- 1983-05-12 IE IE1098/83A patent/IE55519B1/en not_active IP Right Cessation
- 1983-05-13 WO PCT/US1983/000729 patent/WO1983003970A1/en active IP Right Grant
- 1983-05-13 IT IT48294/83A patent/IT1173712B/en active
- 1983-05-13 CA CA000428157A patent/CA1220139A/en not_active Expired
- 1983-05-13 AU AU17063/83A patent/AU571184B2/en not_active Ceased
- 1983-05-13 DE DE8383902149T patent/DE3377695D1/en not_active Expired
- 1983-05-13 EP EP83902149A patent/EP0108147B1/en not_active Expired
- 1983-05-13 PT PT76690A patent/PT76690B/en not_active IP Right Cessation
- 1983-05-13 GR GR71343A patent/GR79223B/el unknown
- 1983-05-13 IL IL68690A patent/IL68690A0/en active IP Right Grant
- 1983-05-14 ES ES522754A patent/ES8703871A1/en not_active Expired
Also Published As
Publication number | Publication date |
---|---|
WO1983003970A1 (en) | 1983-11-24 |
IL68690A0 (en) | 1983-09-30 |
AU571184B2 (en) | 1988-04-14 |
DE3377695D1 (en) | 1988-09-22 |
EP0108147A1 (en) | 1984-05-16 |
IT1173712B (en) | 1987-06-24 |
IT8348294A0 (en) | 1983-05-13 |
PT76690B (en) | 1986-03-19 |
CA1220139A (en) | 1987-04-07 |
AU1706383A (en) | 1983-12-02 |
GR79223B (en) | 1984-10-22 |
PT76690A (en) | 1983-06-01 |
IE55519B1 (en) | 1990-10-10 |
EP0108147B1 (en) | 1988-08-17 |
ES522754A0 (en) | 1987-03-16 |
IE831098L (en) | 1983-11-14 |
EP0108147A4 (en) | 1984-09-13 |
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