ES8703871A1 - Use of a protoberberine alkaloid and composition containing same. - Google Patents

Use of a protoberberine alkaloid and composition containing same.

Info

Publication number
ES8703871A1
ES8703871A1 ES522754A ES522754A ES8703871A1 ES 8703871 A1 ES8703871 A1 ES 8703871A1 ES 522754 A ES522754 A ES 522754A ES 522754 A ES522754 A ES 522754A ES 8703871 A1 ES8703871 A1 ES 8703871A1
Authority
ES
Spain
Prior art keywords
decrease
composition containing
protoberberine alkaloid
containing same
left ventricle
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES522754A
Other languages
Spanish (es)
Other versions
ES522754A0 (en
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of ES8703871A1 publication Critical patent/ES8703871A1/en
Publication of ES522754A0 publication Critical patent/ES522754A0/en
Expired legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
    • A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
    • A61K31/704—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin attached to a condensed carbocyclic ring system, e.g. sennosides, thiocolchicosides, escin, daunorubicin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Molecular Biology (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

A composition containing a protoberberine alkaloid or its salt which is effective to increase the contractility of the mammalian heart as shown by a positive inotropic effect (as evidenced by an increased dP/dT and dF/dT), accompanied by at least one the following symptoms: improved aortic blood flow, decrease in heart rate, decrease in systemic arterial pressure, reduction of afterload of the left ventricle, decrease in preload of the left ventricle, decrease in calculated vessel peripheral resistance, decrease in mean arterial pressure and freedom of arrhythmias, and its method of use.
ES522754A 1982-05-14 1983-05-14 Use of a protoberberine alkaloid and composition containing same. Expired ES8703871A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US37812282A 1982-05-14 1982-05-14
US40988382A 1982-08-20 1982-08-20

Publications (2)

Publication Number Publication Date
ES8703871A1 true ES8703871A1 (en) 1987-03-16
ES522754A0 ES522754A0 (en) 1987-03-16

Family

ID=27008080

Family Applications (1)

Application Number Title Priority Date Filing Date
ES522754A Expired ES8703871A1 (en) 1982-05-14 1983-05-14 Use of a protoberberine alkaloid and composition containing same.

Country Status (11)

Country Link
EP (1) EP0108147B1 (en)
AU (1) AU571184B2 (en)
CA (1) CA1220139A (en)
DE (1) DE3377695D1 (en)
ES (1) ES8703871A1 (en)
GR (1) GR79223B (en)
IE (1) IE55519B1 (en)
IL (1) IL68690A0 (en)
IT (1) IT1173712B (en)
PT (1) PT76690B (en)
WO (1) WO1983003970A1 (en)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100258849B1 (en) * 1998-04-24 2000-08-01 박원배 Pharmaceutically useful protoberberine derivative and its salts
DE60231426D1 (en) 2001-11-14 2009-04-16 Univ Rutgers SOLUBILIZED TOPOISOMERASE GIFT MEDIUM
DE60235287D1 (en) 2001-11-14 2010-03-25 Univ Rutgers SOLUBLY MADE TOPOISOMERASE GIFTS
ES2311639T3 (en) 2001-11-14 2009-02-16 Rutgers, The State University CYTOTOXIC AGENTS.
EP1453506B1 (en) 2001-11-14 2008-04-02 Rutgers, The State University Topoisomerase poison agents
AU2003265406A1 (en) 2002-08-09 2004-02-25 Edmond J. Lavoie Nitro and amino substituted topoisomerase agents
AU2003268075A1 (en) 2002-08-09 2004-02-25 Edmond J. Lavoie Nitro and amino substituted dibenzonaphthyridines as topoisomerase agents
WO2004014862A1 (en) 2002-08-09 2004-02-19 Rutgers, The State University Nitro and amino substituted heterocycles as topoisomerase i targeting agents
WO2004044174A2 (en) 2002-11-12 2004-05-27 Rutgers, The State University Topoisomerase-targeting agents
CN100441183C (en) * 2005-08-29 2008-12-10 中国医学科学院皮肤病研究所 Use of chloride 13-hexyl berberine and chloride 13-hexyl palmatine in preparation of medicine for treating moist tetter, dermatitis and psoriasis
JP5773888B2 (en) 2009-03-06 2015-09-02 ラットガーズ，ザ・ステート・ユニバーシティ・オブ・ニュージャージー Methylenedioxybenzo [I] phenanthridine derivatives used for cancer treatment
EP2405755A4 (en) * 2009-03-11 2012-11-28 Xintria Pharmaceutical Corp Inc Methods and compositions for the treatment of metabolic and cardiovascular disorders
WO2010127363A1 (en) 2009-05-01 2010-11-04 Rutgers, The State University Of New Jersey Toposiomerase inhibitors
US20140107505A1 (en) 2012-10-11 2014-04-17 Alon Marmor Determination of ventricular pressure and related values
CN109219610A (en) 2016-04-04 2019-01-15 新泽西州立拉特格斯大学 topoisomerase poisons

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL129028C (en) * 1964-02-13
US3420834A (en) * 1964-11-13 1969-01-07 Roussel Uclaf 2,3-dimethoxy-berbines substituted in the 10 position and process
JPS4942700A (en) * 1972-08-25 1974-04-22
US3920665A (en) * 1972-10-19 1975-11-18 Kanebo Ltd Berbine compounds
JPS523397B2 (en) * 1972-11-20 1977-01-27
US3910938A (en) * 1973-01-27 1975-10-07 Kanebo Ltd Berbine derivatives
US4042592A (en) * 1974-05-08 1977-08-16 Kanebo, Ltd. Novel dibenzo[a,g]quinolizinium compounds
US4087426A (en) * 1976-08-16 1978-05-02 Research Corporation Oxybisberberine and a process for its production
SE426548B (en) * 1978-12-05 1983-01-31 Haessle Ab SOLID PHARMACEUTICAL PREPARATION INCLUDING A THERAPEUTICALLY EFFECTIVE HEART GYCLOSIDE AND POLYMER

Also Published As

Publication number Publication date
WO1983003970A1 (en) 1983-11-24
IL68690A0 (en) 1983-09-30
AU571184B2 (en) 1988-04-14
DE3377695D1 (en) 1988-09-22
EP0108147A1 (en) 1984-05-16
IT1173712B (en) 1987-06-24
IT8348294A0 (en) 1983-05-13
PT76690B (en) 1986-03-19
CA1220139A (en) 1987-04-07
AU1706383A (en) 1983-12-02
GR79223B (en) 1984-10-22
PT76690A (en) 1983-06-01
IE55519B1 (en) 1990-10-10
EP0108147B1 (en) 1988-08-17
ES522754A0 (en) 1987-03-16
IE831098L (en) 1983-11-14
EP0108147A4 (en) 1984-09-13

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