JPS57108016A - Antithrombotic agent - Google Patents

Antithrombotic agent

Info

Publication number
JPS57108016A
JPS57108016A JP18446680A JP18446680A JPS57108016A JP S57108016 A JPS57108016 A JP S57108016A JP 18446680 A JP18446680 A JP 18446680A JP 18446680 A JP18446680 A JP 18446680A JP S57108016 A JPS57108016 A JP S57108016A
Authority
JP
Japan
Prior art keywords
compound
antithrombotic agent
benzisothiazolin
salt
prepared
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP18446680A
Other languages
Japanese (ja)
Other versions
JPH0129770B2 (en
Inventor
Koji Yamada
Tamotsu Hashimoto
Masaori Naruse
Hideki Shinno
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
PAAMAKEMU ASIA KK
Permachem Asia Ltd
KH Neochem Co Ltd
Original Assignee
PAAMAKEMU ASIA KK
Kyowa Hakko Kogyo Co Ltd
Permachem Asia Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by PAAMAKEMU ASIA KK, Kyowa Hakko Kogyo Co Ltd, Permachem Asia Ltd filed Critical PAAMAKEMU ASIA KK
Priority to JP18446680A priority Critical patent/JPS57108016A/en
Publication of JPS57108016A publication Critical patent/JPS57108016A/en
Publication of JPH0129770B2 publication Critical patent/JPH0129770B2/ja
Granted legal-status Critical Current

Links

Landscapes

  • Thiazole And Isothizaole Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

PURPOSE: To provide an antithrombotic agent having blood platelet coagulation suppressing activity and low toxicity, by using 2,1-benzisothiazolin-3-one derivative or its salt as an active component.
CONSTITUTION: An antithrombotic agent is prepared by using the compound of formulaI(R is group of formula II or III) or its salt as an active component, and forming to tablet, powder, capsule, injection, etc. Since the compound of formulaIis a safe compound having extremely high LD50, it can be administered at a considerably high dose, and its minimum effective dose is 10W500mg per dose for adult. The compound of formulaIwherein R is group of formula III, is a novel compound which can be prepared by dispersing 5-chlorosulfonyl-1- methyl-2,1-benzisothiazolin-3-one in water, adding 2-hydroxypropylamine and triethylamine to the dispersion, and reacting at room temperature.
COPYRIGHT: (C)1982,JPO&Japio
JP18446680A 1980-12-25 1980-12-25 Antithrombotic agent Granted JPS57108016A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP18446680A JPS57108016A (en) 1980-12-25 1980-12-25 Antithrombotic agent

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP18446680A JPS57108016A (en) 1980-12-25 1980-12-25 Antithrombotic agent

Publications (2)

Publication Number Publication Date
JPS57108016A true JPS57108016A (en) 1982-07-05
JPH0129770B2 JPH0129770B2 (en) 1989-06-14

Family

ID=16153640

Family Applications (1)

Application Number Title Priority Date Filing Date
JP18446680A Granted JPS57108016A (en) 1980-12-25 1980-12-25 Antithrombotic agent

Country Status (1)

Country Link
JP (1) JPS57108016A (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8524745B2 (en) * 2011-12-12 2013-09-03 Allergan, Inc. Benzisothiazol-3(1H)-one-5-sulfonyl derivatives as chemokine receptor modulators

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8524745B2 (en) * 2011-12-12 2013-09-03 Allergan, Inc. Benzisothiazol-3(1H)-one-5-sulfonyl derivatives as chemokine receptor modulators

Also Published As

Publication number Publication date
JPH0129770B2 (en) 1989-06-14

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