JPS57108016A - Antithrombotic agent - Google Patents
Antithrombotic agentInfo
- Publication number
- JPS57108016A JPS57108016A JP18446680A JP18446680A JPS57108016A JP S57108016 A JPS57108016 A JP S57108016A JP 18446680 A JP18446680 A JP 18446680A JP 18446680 A JP18446680 A JP 18446680A JP S57108016 A JPS57108016 A JP S57108016A
- Authority
- JP
- Japan
- Prior art keywords
- compound
- antithrombotic agent
- benzisothiazolin
- salt
- prepared
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Landscapes
- Thiazole And Isothizaole Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
PURPOSE: To provide an antithrombotic agent having blood platelet coagulation suppressing activity and low toxicity, by using 2,1-benzisothiazolin-3-one derivative or its salt as an active component.
CONSTITUTION: An antithrombotic agent is prepared by using the compound of formulaI(R is group of formula II or III) or its salt as an active component, and forming to tablet, powder, capsule, injection, etc. Since the compound of formulaIis a safe compound having extremely high LD50, it can be administered at a considerably high dose, and its minimum effective dose is 10W500mg per dose for adult. The compound of formulaIwherein R is group of formula III, is a novel compound which can be prepared by dispersing 5-chlorosulfonyl-1- methyl-2,1-benzisothiazolin-3-one in water, adding 2-hydroxypropylamine and triethylamine to the dispersion, and reacting at room temperature.
COPYRIGHT: (C)1982,JPO&Japio
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP18446680A JPS57108016A (en) | 1980-12-25 | 1980-12-25 | Antithrombotic agent |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP18446680A JPS57108016A (en) | 1980-12-25 | 1980-12-25 | Antithrombotic agent |
Publications (2)
Publication Number | Publication Date |
---|---|
JPS57108016A true JPS57108016A (en) | 1982-07-05 |
JPH0129770B2 JPH0129770B2 (en) | 1989-06-14 |
Family
ID=16153640
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP18446680A Granted JPS57108016A (en) | 1980-12-25 | 1980-12-25 | Antithrombotic agent |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS57108016A (en) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8524745B2 (en) * | 2011-12-12 | 2013-09-03 | Allergan, Inc. | Benzisothiazol-3(1H)-one-5-sulfonyl derivatives as chemokine receptor modulators |
-
1980
- 1980-12-25 JP JP18446680A patent/JPS57108016A/en active Granted
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8524745B2 (en) * | 2011-12-12 | 2013-09-03 | Allergan, Inc. | Benzisothiazol-3(1H)-one-5-sulfonyl derivatives as chemokine receptor modulators |
Also Published As
Publication number | Publication date |
---|---|
JPH0129770B2 (en) | 1989-06-14 |
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