ES8703870A1 - Procedimiento para preparar compuestos de 5-alquil-1-fenil-2-piperazinoalquilpirazolin-3-ona. - Google Patents
Procedimiento para preparar compuestos de 5-alquil-1-fenil-2-piperazinoalquilpirazolin-3-ona.Info
- Publication number
- ES8703870A1 ES8703870A1 ES555007A ES555007A ES8703870A1 ES 8703870 A1 ES8703870 A1 ES 8703870A1 ES 555007 A ES555007 A ES 555007A ES 555007 A ES555007 A ES 555007A ES 8703870 A1 ES8703870 A1 ES 8703870A1
- Authority
- ES
- Spain
- Prior art keywords
- compounds
- phenyl
- preparation
- alkyl
- alkylpyrazolin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 150000001875 compounds Chemical class 0.000 title abstract 4
- 239000003814 drug Substances 0.000 title 1
- 239000000543 intermediate Substances 0.000 title 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 2
- 125000002947 alkylene group Chemical group 0.000 abstract 1
- 230000003266 anti-allergic effect Effects 0.000 abstract 1
- 125000006165 cyclic alkyl group Chemical group 0.000 abstract 1
- 230000000144 pharmacologic effect Effects 0.000 abstract 1
- 125000004076 pyridyl group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D231/18—One oxygen or sulfur atom
- C07D231/20—One oxygen atom attached in position 3 or 5
- C07D231/22—One oxygen atom attached in position 3 or 5 with aryl radicals attached to ring nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- Pulmonology (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Immunology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
PROCEDIMIENTO PARA PREPARAR COMPUESTOS DE 5-ALQUIL-1-FENIL-2-PIPERAZINOALQUILPIRAZOLIN-3-ONA. CONSISTE EN REDUCIR COMPUESTOS DE FORMULA (II) PARA OBTENER COMPUESTOS 5-ALQUIL-1-FENIL-PIPERAZINOALQUILPIRAZOLIN-3-ONA DE FORMULA (I) DONDE R1 ES UN GRUPO ALQUILO DE CADENA LINEAL, RAMIFICADO O CICLICO CON HASTA 6 ATOMOS DE CARBONO; R2 SIGNIFICA H, HALOGENO, TRIFLUOROMETILO, HIDROXI, ALQUILO INFERIOR O ALCOXI INFERIOR; R3 SIGNIFICA H, HALOGENO, ALQUILO INFERIOR O ALCOXI INFERIOR, O R2 Y R3 ESTAN UNIDOS A ATOMOS DE CARBONO CONTIGUOS Y SIGNIFICAN EN COMUN UN GRUPO ALQUILENDIOXI CON C 1 A 2; Y Z SIGNIFICA UNA CADENA ALQUILENO CON C 2 A 3. TIENEN PROPIEDADES FARMACOLOGICAS POR SUS CUALIDADES ANTIALERGICAS.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE19843442860 DE3442860A1 (de) | 1984-11-24 | 1984-11-24 | 5-alkyl-1-phenyl-2-piperazinoalkylpyrazolin-3- on-verbindungen sowie verfahren und zwischenprodukte zu ihrer herstellung und diese verbindungen enthaltende arzneimittel |
Publications (2)
Publication Number | Publication Date |
---|---|
ES555007A0 ES555007A0 (es) | 1987-03-01 |
ES8703870A1 true ES8703870A1 (es) | 1987-03-01 |
Family
ID=6251032
Family Applications (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES549176A Expired ES8700253A1 (es) | 1984-11-24 | 1985-11-22 | Procedimiento para preparar compuestos de 5-alquil-1-fenil- -2-piperazinoalquilpirazolin-3-ona |
ES555007A Expired ES8703870A1 (es) | 1984-11-24 | 1986-05-16 | Procedimiento para preparar compuestos de 5-alquil-1-fenil-2-piperazinoalquilpirazolin-3-ona. |
ES555006A Expired ES8703869A1 (es) | 1984-11-24 | 1986-05-16 | Procedimiento para preparar compuestos de 5-alaquil-1-fenil-2-piperazinoalquilpirazolin-3-ona. |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES549176A Expired ES8700253A1 (es) | 1984-11-24 | 1985-11-22 | Procedimiento para preparar compuestos de 5-alquil-1-fenil- -2-piperazinoalquilpirazolin-3-ona |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES555006A Expired ES8703869A1 (es) | 1984-11-24 | 1986-05-16 | Procedimiento para preparar compuestos de 5-alaquil-1-fenil-2-piperazinoalquilpirazolin-3-ona. |
Country Status (18)
Country | Link |
---|---|
US (1) | US4672063A (es) |
EP (1) | EP0185909B1 (es) |
JP (1) | JPS61148164A (es) |
AT (1) | ATE50448T1 (es) |
AU (1) | AU578395B2 (es) |
CA (1) | CA1247101A (es) |
DD (1) | DD239793A5 (es) |
DE (2) | DE3442860A1 (es) |
DK (1) | DK540585A (es) |
ES (3) | ES8700253A1 (es) |
FI (1) | FI854603A (es) |
GR (1) | GR852813B (es) |
HU (1) | HU195211B (es) |
IL (1) | IL77124A (es) |
NO (1) | NO164351C (es) |
NZ (1) | NZ214289A (es) |
PT (1) | PT81545B (es) |
ZA (1) | ZA858418B (es) |
Families Citing this family (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
NZ219380A (en) * | 1986-02-27 | 1990-06-26 | Duphar Int Res | (n-piperidinyl)- and (n-piperazinyl)-methylazole derivatives and pharmaceutical compositions |
FR2648135B1 (fr) * | 1989-06-07 | 1991-09-27 | Pf Medicament | Derives de phenyl-1-dihydro-1,4 amino-3 oxo-4 pyridazines, leur preparation et leur application en therapeutique |
FR2676733B1 (fr) * | 1991-05-22 | 1993-10-01 | Fabre Medicament Pierre | Derives de phenyl-1 dihydro-1,4 hydroxy-3 oxo-4 pyridazines, leur preparation et leur application en therapeutique. |
US5219856A (en) * | 1992-04-06 | 1993-06-15 | E. I. Du Pont De Nemours And Company | Angiotensin-II receptor blocking, heterocycle substituted imidazoles |
US7589199B2 (en) * | 2002-06-12 | 2009-09-15 | Chemocentryx, Inc. | Substituted piperazines |
US7842693B2 (en) * | 2002-06-12 | 2010-11-30 | Chemocentryx, Inc. | Substituted piperazines |
US20050256130A1 (en) * | 2002-06-12 | 2005-11-17 | Chemocentryx, Inc. | Substituted piperazines |
DE60328690D1 (de) | 2002-06-12 | 2009-09-17 | Chemocentryx Inc | 1-aryl-4-substituierte piperazin-derivate zur verwendung als ccr1-antagonisten zur behandlung von entzündungen und immunerkrankungen |
US7435831B2 (en) * | 2004-03-03 | 2008-10-14 | Chemocentryx, Inc. | Bicyclic and bridged nitrogen heterocycles |
CN1950082B (zh) * | 2004-03-03 | 2013-02-06 | 凯莫森特里克斯股份有限公司 | 双环和桥连的含氮杂环化物 |
US8927546B2 (en) * | 2006-02-28 | 2015-01-06 | Dart Neuroscience (Cayman) Ltd. | Therapeutic piperazines |
ES2462240T3 (es) * | 2006-02-28 | 2014-05-22 | Dart Neuroscience (Cayman) Ltd | Piperazinas terapéuticas como inhibidores de PDE4 |
JP2008148592A (ja) * | 2006-12-15 | 2008-07-03 | Sk Sangyo Kk | 防風網 |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3169966A (en) * | 1961-01-24 | 1965-02-16 | Ciba Geigy Corp | Aminopyrazoles |
US3362956A (en) * | 1965-08-19 | 1968-01-09 | Sterling Drug Inc | 1-[(heterocyclyl)-lower-alkyl]-4-substituted-piperazines |
IT1052130B (it) * | 1973-10-15 | 1981-06-20 | Sigma Tau Ind Farmaceuti | Derivati del triazolinone e procedimento per la loro preparazione |
DE3132916A1 (de) * | 1981-08-20 | 1983-03-03 | Kali-Chemie Pharma Gmbh, 3000 Hannover | 1-phenylindazol-3-on-verbindungen sowie verfahren und zwischenprodukte zu ihrer herstellung und diese verbindungen enthaltende arzneimittel |
DE3132915A1 (de) * | 1981-08-20 | 1983-03-03 | Kali-Chemie Pharma Gmbh, 3000 Hannover | 1,5-diphenylpyrazolin-3-on-verbindungen sowie verfahren und zwischenprodukte zu ihrer herstellung und diese verbindungen enthaltende arzneimittel |
-
1984
- 1984-11-24 DE DE19843442860 patent/DE3442860A1/de not_active Withdrawn
-
1985
- 1985-11-01 ZA ZA858418A patent/ZA858418B/xx unknown
- 1985-11-14 EP EP85114466A patent/EP0185909B1/de not_active Expired - Lifetime
- 1985-11-14 AT AT85114466T patent/ATE50448T1/de not_active IP Right Cessation
- 1985-11-14 DE DE8585114466T patent/DE3576075D1/de not_active Expired - Fee Related
- 1985-11-20 HU HU854414A patent/HU195211B/hu not_active IP Right Cessation
- 1985-11-21 GR GR852813A patent/GR852813B/el unknown
- 1985-11-21 US US06/800,327 patent/US4672063A/en not_active Expired - Fee Related
- 1985-11-21 FI FI854603A patent/FI854603A/fi not_active Application Discontinuation
- 1985-11-21 DD DD85283095A patent/DD239793A5/de not_active IP Right Cessation
- 1985-11-22 ES ES549176A patent/ES8700253A1/es not_active Expired
- 1985-11-22 NO NO854677A patent/NO164351C/no unknown
- 1985-11-22 DK DK540585A patent/DK540585A/da not_active Application Discontinuation
- 1985-11-22 AU AU50350/85A patent/AU578395B2/en not_active Ceased
- 1985-11-22 IL IL77124A patent/IL77124A/xx unknown
- 1985-11-22 NZ NZ214289A patent/NZ214289A/xx unknown
- 1985-11-22 PT PT81545A patent/PT81545B/pt not_active IP Right Cessation
- 1985-11-22 CA CA000496048A patent/CA1247101A/en not_active Expired
- 1985-11-25 JP JP60262725A patent/JPS61148164A/ja active Pending
-
1986
- 1986-05-16 ES ES555007A patent/ES8703870A1/es not_active Expired
- 1986-05-16 ES ES555006A patent/ES8703869A1/es not_active Expired
Also Published As
Publication number | Publication date |
---|---|
HUT38927A (en) | 1986-07-28 |
JPS61148164A (ja) | 1986-07-05 |
DK540585A (da) | 1986-05-25 |
ES555007A0 (es) | 1987-03-01 |
NZ214289A (en) | 1988-10-28 |
IL77124A0 (en) | 1986-04-29 |
HU195211B (en) | 1988-04-28 |
CA1247101A (en) | 1988-12-20 |
PT81545B (pt) | 1988-01-22 |
IL77124A (en) | 1990-03-19 |
EP0185909A1 (de) | 1986-07-02 |
EP0185909B1 (de) | 1990-02-21 |
FI854603A0 (fi) | 1985-11-21 |
NO164351B (no) | 1990-06-18 |
GR852813B (es) | 1986-03-21 |
AU578395B2 (en) | 1988-10-20 |
ES8703869A1 (es) | 1987-03-01 |
NO164351C (no) | 1990-09-26 |
ES549176A0 (es) | 1986-10-01 |
ATE50448T1 (de) | 1990-03-15 |
DK540585D0 (da) | 1985-11-22 |
PT81545A (en) | 1985-12-01 |
DE3442860A1 (de) | 1986-05-28 |
DE3576075D1 (de) | 1990-03-29 |
AU5035085A (en) | 1986-07-17 |
DD239793A5 (de) | 1986-10-08 |
NO854677L (no) | 1986-05-26 |
US4672063A (en) | 1987-06-09 |
ZA858418B (en) | 1986-07-30 |
ES8700253A1 (es) | 1986-10-01 |
ES555006A0 (es) | 1987-03-01 |
FI854603A (fi) | 1986-05-25 |
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