PT81545A - Process for the preparation of 5-alkyl-1-phenyl-2-pyperazino-alkyl-pyrazolin-3-one - Google Patents
Process for the preparation of 5-alkyl-1-phenyl-2-pyperazino-alkyl-pyrazolin-3-oneInfo
- Publication number
- PT81545A PT81545A PT81545A PT8154585A PT81545A PT 81545 A PT81545 A PT 81545A PT 81545 A PT81545 A PT 81545A PT 8154585 A PT8154585 A PT 8154585A PT 81545 A PT81545 A PT 81545A
- Authority
- PT
- Portugal
- Prior art keywords
- alkyl
- phenyl
- preparation
- pyperazino
- pyrazolin
- Prior art date
Links
- 125000004432 carbon atom Chemical group C* 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 2
- 125000002947 alkylene group Chemical group 0.000 abstract 1
- 230000003266 anti-allergic effect Effects 0.000 abstract 1
- 125000006165 cyclic alkyl group Chemical group 0.000 abstract 1
- 230000000144 pharmacologic effect Effects 0.000 abstract 1
- 125000004076 pyridyl group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D231/18—One oxygen or sulfur atom
- C07D231/20—One oxygen atom attached in position 3 or 5
- C07D231/22—One oxygen atom attached in position 3 or 5 with aryl radicals attached to ring nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- Pulmonology (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Immunology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
5-alkyl-1-phenyl-2-piperazinoalkylpyrazolin-3-one compounds of the Formula <IMAGE> I in which R1 is a straight-chain, branched or cyclic alkyl group with up to 6 carbon atoms, Z is an alkylene chain with 2 to 4 carbon atoms, and 1-phenyl substituent is an optionally substituted phenyl ring, and R4 is a phenyl or pyridyl group which is optionally substituted and their preparation are described. The compounds have pharmacological, particularly antiallergic, properties.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19843442860 DE3442860A1 (en) | 1984-11-24 | 1984-11-24 | 5-ALKYL-1-PHENYL-2-PIPERAZINOALKYLPYRAZOLINE-3-ON COMPOUNDS AND METHODS AND INTERMEDIATE PRODUCTS FOR THEIR PRODUCTION AND MEDICINAL PRODUCTS CONTAINING THESE COMPOUNDS |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| PT81545A true PT81545A (en) | 1985-12-01 |
| PT81545B PT81545B (en) | 1988-01-22 |
Family
ID=6251032
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PT81545A PT81545B (en) | 1984-11-24 | 1985-11-22 | METHOD FOR PREPARING COMPOUNDS 5-ALOQUIL-1-PHENYL-2-PYRAZAZINE-ALKYL-PYRAZOLIN-3-ONA |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US4672063A (en) |
| EP (1) | EP0185909B1 (en) |
| JP (1) | JPS61148164A (en) |
| AT (1) | ATE50448T1 (en) |
| AU (1) | AU578395B2 (en) |
| CA (1) | CA1247101A (en) |
| DD (1) | DD239793A5 (en) |
| DE (2) | DE3442860A1 (en) |
| DK (1) | DK540585A (en) |
| ES (3) | ES8700253A1 (en) |
| FI (1) | FI854603A (en) |
| GR (1) | GR852813B (en) |
| HU (1) | HU195211B (en) |
| IL (1) | IL77124A (en) |
| NO (1) | NO164351C (en) |
| NZ (1) | NZ214289A (en) |
| PT (1) | PT81545B (en) |
| ZA (1) | ZA858418B (en) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NZ219380A (en) * | 1986-02-27 | 1990-06-26 | Duphar Int Res | (n-piperidinyl)- and (n-piperazinyl)-methylazole derivatives and pharmaceutical compositions |
| FR2648135B1 (en) * | 1989-06-07 | 1991-09-27 | Pf Medicament | PHENYL-1-DIHYDRO-1,4 AMINO-3 OXO-4 PYRIDAZINES DERIVATIVES, THEIR PREPARATION AND THEIR THERAPEUTIC APPLICATION |
| FR2676733B1 (en) * | 1991-05-22 | 1993-10-01 | Fabre Medicament Pierre | DERIVATIVES OF PHENYL-1 DIHYDRO-1,4 HYDROXY-3 OXO-4 PYRIDAZINES, THEIR PREPARATION AND THEIR THERAPEUTIC APPLICATION. |
| US5219856A (en) * | 1992-04-06 | 1993-06-15 | E. I. Du Pont De Nemours And Company | Angiotensin-II receptor blocking, heterocycle substituted imidazoles |
| US7589199B2 (en) * | 2002-06-12 | 2009-09-15 | Chemocentryx, Inc. | Substituted piperazines |
| US7842693B2 (en) * | 2002-06-12 | 2010-11-30 | Chemocentryx, Inc. | Substituted piperazines |
| US20050256130A1 (en) * | 2002-06-12 | 2005-11-17 | Chemocentryx, Inc. | Substituted piperazines |
| DE60328690D1 (en) | 2002-06-12 | 2009-09-17 | Chemocentryx Inc | 1-ARYL-4-SUBSTITUTED PIPERAZINE DERIVATIVES FOR USE AS CCR1 ANTAGONISTS FOR THE TREATMENT OF INFLAMMATORY DISEASES AND IMMUNE DISEASES |
| US7435831B2 (en) * | 2004-03-03 | 2008-10-14 | Chemocentryx, Inc. | Bicyclic and bridged nitrogen heterocycles |
| CN1950082B (en) * | 2004-03-03 | 2013-02-06 | 凯莫森特里克斯股份有限公司 | Bicyclic and bridged nitrogen heterocycles |
| US8927546B2 (en) * | 2006-02-28 | 2015-01-06 | Dart Neuroscience (Cayman) Ltd. | Therapeutic piperazines |
| ES2462240T3 (en) * | 2006-02-28 | 2014-05-22 | Dart Neuroscience (Cayman) Ltd | Therapeutic piperazines as PDE4 inhibitors |
| JP2008148592A (en) * | 2006-12-15 | 2008-07-03 | Sk Sangyo Kk | Windbreak net |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3169966A (en) * | 1961-01-24 | 1965-02-16 | Ciba Geigy Corp | Aminopyrazoles |
| US3362956A (en) * | 1965-08-19 | 1968-01-09 | Sterling Drug Inc | 1-[(heterocyclyl)-lower-alkyl]-4-substituted-piperazines |
| IT1052130B (en) * | 1973-10-15 | 1981-06-20 | Sigma Tau Ind Farmaceuti | TRIAZOLINONE DERIVATIVES AND PROCEDURE FOR THEIR PREPARATION |
| DE3132916A1 (en) * | 1981-08-20 | 1983-03-03 | Kali-Chemie Pharma Gmbh, 3000 Hannover | 1-PHENYLINDAZOL-3-ON COMPOUNDS, METHODS AND INTERMEDIATE PRODUCTS FOR THE PRODUCTION THEREOF AND MEDICINAL PRODUCTS CONTAINING THESE COMPOUNDS |
| DE3132915A1 (en) * | 1981-08-20 | 1983-03-03 | Kali-Chemie Pharma Gmbh, 3000 Hannover | 1,5-DIPHENYLPYRAZOLIN-3-ON-COMPOUNDS, METHODS AND INTERMEDIATE PRODUCTS FOR THEIR PRODUCTION AND MEDICINAL PRODUCTS CONTAINING THESE COMPOUNDS |
-
1984
- 1984-11-24 DE DE19843442860 patent/DE3442860A1/en not_active Withdrawn
-
1985
- 1985-11-01 ZA ZA858418A patent/ZA858418B/en unknown
- 1985-11-14 EP EP85114466A patent/EP0185909B1/en not_active Expired - Lifetime
- 1985-11-14 AT AT85114466T patent/ATE50448T1/en not_active IP Right Cessation
- 1985-11-14 DE DE8585114466T patent/DE3576075D1/en not_active Expired - Fee Related
- 1985-11-20 HU HU854414A patent/HU195211B/en not_active IP Right Cessation
- 1985-11-21 GR GR852813A patent/GR852813B/el unknown
- 1985-11-21 US US06/800,327 patent/US4672063A/en not_active Expired - Fee Related
- 1985-11-21 FI FI854603A patent/FI854603A/en not_active Application Discontinuation
- 1985-11-21 DD DD85283095A patent/DD239793A5/en not_active IP Right Cessation
- 1985-11-22 ES ES549176A patent/ES8700253A1/en not_active Expired
- 1985-11-22 NO NO854677A patent/NO164351C/en unknown
- 1985-11-22 DK DK540585A patent/DK540585A/en not_active Application Discontinuation
- 1985-11-22 AU AU50350/85A patent/AU578395B2/en not_active Ceased
- 1985-11-22 IL IL77124A patent/IL77124A/en unknown
- 1985-11-22 NZ NZ214289A patent/NZ214289A/en unknown
- 1985-11-22 PT PT81545A patent/PT81545B/en not_active IP Right Cessation
- 1985-11-22 CA CA000496048A patent/CA1247101A/en not_active Expired
- 1985-11-25 JP JP60262725A patent/JPS61148164A/en active Pending
-
1986
- 1986-05-16 ES ES555007A patent/ES8703870A1/en not_active Expired
- 1986-05-16 ES ES555006A patent/ES8703869A1/en not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| HUT38927A (en) | 1986-07-28 |
| JPS61148164A (en) | 1986-07-05 |
| DK540585A (en) | 1986-05-25 |
| ES555007A0 (en) | 1987-03-01 |
| NZ214289A (en) | 1988-10-28 |
| ES8703870A1 (en) | 1987-03-01 |
| IL77124A0 (en) | 1986-04-29 |
| HU195211B (en) | 1988-04-28 |
| CA1247101A (en) | 1988-12-20 |
| PT81545B (en) | 1988-01-22 |
| IL77124A (en) | 1990-03-19 |
| EP0185909A1 (en) | 1986-07-02 |
| EP0185909B1 (en) | 1990-02-21 |
| FI854603A0 (en) | 1985-11-21 |
| NO164351B (en) | 1990-06-18 |
| GR852813B (en) | 1986-03-21 |
| AU578395B2 (en) | 1988-10-20 |
| ES8703869A1 (en) | 1987-03-01 |
| NO164351C (en) | 1990-09-26 |
| ES549176A0 (en) | 1986-10-01 |
| ATE50448T1 (en) | 1990-03-15 |
| DK540585D0 (en) | 1985-11-22 |
| DE3442860A1 (en) | 1986-05-28 |
| DE3576075D1 (en) | 1990-03-29 |
| AU5035085A (en) | 1986-07-17 |
| DD239793A5 (en) | 1986-10-08 |
| NO854677L (en) | 1986-05-26 |
| US4672063A (en) | 1987-06-09 |
| ZA858418B (en) | 1986-07-30 |
| ES8700253A1 (en) | 1986-10-01 |
| ES555006A0 (en) | 1987-03-01 |
| FI854603A (en) | 1986-05-25 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MM3A | Annulment or lapse |
Free format text: LAPSE DUE TO NON-PAYMENT OF FEES Effective date: 19920122 |