ES8701782A1 - Un procedimiento para la fabricacion de derivados peptidicos inhibidores de la renina y de las proteasas acidas - Google Patents

Un procedimiento para la fabricacion de derivados peptidicos inhibidores de la renina y de las proteasas acidas

Info

Publication number
ES8701782A1
ES8701782A1 ES551820A ES551820A ES8701782A1 ES 8701782 A1 ES8701782 A1 ES 8701782A1 ES 551820 A ES551820 A ES 551820A ES 551820 A ES551820 A ES 551820A ES 8701782 A1 ES8701782 A1 ES 8701782A1
Authority
ES
Spain
Prior art keywords
peptide derivatives
acid proteases
inhibiting renin
derivatives inhibiting
renin
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES551820A
Other languages
English (en)
Other versions
ES551820A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sanofi SA
Institut National de la Sante et de la Recherche Medicale INSERM
Original Assignee
Sanofi SA
Institut National de la Sante et de la Recherche Medicale INSERM
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from FR8501981A external-priority patent/FR2577225B1/fr
Priority claimed from FR8501982A external-priority patent/FR2577226B1/fr
Application filed by Sanofi SA, Institut National de la Sante et de la Recherche Medicale INSERM filed Critical Sanofi SA
Publication of ES8701782A1 publication Critical patent/ES8701782A1/es
Publication of ES551820A0 publication Critical patent/ES551820A0/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/0227—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the (partial) peptide sequence -Phe-His-NH-(X)2-C(=0)-, e.g. Renin-inhibitors with n = 2 - 6; for n > 6 see C07K5/06 - C07K5/10
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/0205—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-(X)3-C(=0)-, e.g. statine or derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/02—Linear peptides containing at least one abnormal peptide link
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/86—Renin inhibitors

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

PROCEDIMIENTO DE PREPARACION DE PEPTIDOS DE FORMULA GENERAL (I), DONDE R1 ES ACILO, ALQUILSULFONILO O FENILSULFONILO; R2 ES UN ALQUILO INFERIOR SUSTITUIDO O NO CON FENILO, NAFTILO, CICLOHEXILO O PIRIDILO; R3 ES ALQUNEILO INFERIOR, FENILO, NAFTILO, CICLOALQUILO (C3-C6), HETEROCICLO MONOCICLICO (DE 5 O 6 ATOMOS), ALQUILO INFERIOR SUSTITUIDO CON DIVERSOS SUSTITUYENTES, CON LA CONDICION DE QUE R3 NO SEA (IMIDAZOLIL-4)-METILO; R4 ES OH, ALCOXI INFERIOR, BENZILOXI O AMINO LIBRE O SUSTITUIDO. SE OBTIENEN A PARTIR DE UN COMPUESTO H-Y-RK4 DONDE RK4 ES ALCOXI INFERIOR, BENCILOXI O AMINO LIBRE O SUSTITUIDO CON UNO O DOS ALQUILOS INFERIORES E Y ES UN RESTO DE AMINOACIDOS: STA, LEU, PHE O SER POR PROCEDIMIENTOS CONOCIDOS DE SINTESIS DE PEPTIDOS. SON INHIBIDORES DE RENINA Y PROTEASAS ACIDAS.
ES551820A 1985-02-12 1986-02-11 Un procedimiento para la fabricacion de derivados peptidicos inhibidores de la renina y de las proteasas acidas Expired ES8701782A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR8501981A FR2577225B1 (fr) 1985-02-12 1985-02-12 Derives peptidiques inhibiteurs de la renine et des proteases acides
FR8501982A FR2577226B1 (fr) 1985-02-12 1985-02-12 Analogues de pepstatine inhibiteurs de la renine et des proteases acides

Publications (2)

Publication Number Publication Date
ES8701782A1 true ES8701782A1 (es) 1986-12-16
ES551820A0 ES551820A0 (es) 1986-12-16

Family

ID=26224369

Family Applications (2)

Application Number Title Priority Date Filing Date
ES551820A Expired ES8701782A1 (es) 1985-02-12 1986-02-11 Un procedimiento para la fabricacion de derivados peptidicos inhibidores de la renina y de las proteasas acidas
ES551821A Expired ES8701783A1 (es) 1985-02-12 1986-02-11 Procedimiento para la fabricacion de derivados peptidos analogos de la pepstatina.

Family Applications After (1)

Application Number Title Priority Date Filing Date
ES551821A Expired ES8701783A1 (es) 1985-02-12 1986-02-11 Procedimiento para la fabricacion de derivados peptidos analogos de la pepstatina.

Country Status (11)

Country Link
US (2) US4746648A (es)
EP (2) EP0193445B1 (es)
AT (2) ATE71111T1 (es)
AU (2) AU606572B2 (es)
CA (2) CA1286846C (es)
DE (2) DE3671021D1 (es)
DK (2) DK64186A (es)
ES (2) ES8701782A1 (es)
GR (2) GR860399B (es)
NZ (2) NZ215096A (es)
PT (2) PT81991B (es)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2585708B1 (fr) * 1985-07-31 1989-07-07 Sanofi Sa Derives aminoalcools peptidiques inhibiteurs de la resine et des proteases acides, leur procede de preparation et leur application en therapeutique
US4599198A (en) * 1985-08-02 1986-07-08 Pfizer Inc. Intermediates in polypeptide synthesis
DE3626130A1 (de) * 1986-08-01 1988-02-11 Merck Patent Gmbh Aminosaeurederivate
DE3640535A1 (de) * 1986-11-27 1988-06-01 Merck Patent Gmbh Peptide
EP0284510A3 (en) * 1987-03-24 1990-08-22 Asahi Breweries, Ltd. N-[N alpha-(1(S)-carboxy-3-cyclohexyl-propyl)-1-lysyl] N-cyclopentylglycine as antihypertensives
US4980283A (en) * 1987-10-01 1990-12-25 Merck & Co., Inc. Renin-inhibitory pepstatin phenyl derivatives
US4874745A (en) * 1987-10-01 1989-10-17 Merck & Co., Inc. Renin-inhibitory pepstatin phenyl derivatives
US5162527A (en) * 1987-10-26 1992-11-10 Warner-Lambert Company Renin inhibitors, processes for preparing them, methods for using them, and compositions containing them
AU2783189A (en) * 1987-10-26 1989-05-23 Warner-Lambert Company Renin inhibitors, processes for preparing them, methods for using them, and compositions containing them
IL92011A0 (en) * 1988-10-19 1990-07-12 Abbott Lab Heterocyclic peptide renin inhibitors
US5164388A (en) * 1988-10-19 1992-11-17 Abbott Laboratories Heterocyclic peptide renin inhibitors
KR900012945A (ko) * 1989-02-16 1990-09-03 가와무라 요시부미 렌닌 억제활성을 갖는 펩타이트, 그 제조방법 및 용도
FR2646354B1 (fr) * 1989-04-27 1994-06-10 Sanofi Sa Utilisation de peptides inhibiteurs de proteases acides pour la preparation de medicaments utiles pour le traitement de maladies virales
US5238923A (en) * 1989-05-26 1993-08-24 Warner-Lambert Company Amino-substituted heterocycles as renin inhibitors
US5149692A (en) * 1989-12-21 1992-09-22 Warner-Lambert Company Bisalkoxyphosphinyl compounds as renin inhibitors
US5071837A (en) * 1990-11-28 1991-12-10 Warner-Lambert Company Novel renin inhibiting peptides
US5833946A (en) * 1995-06-06 1998-11-10 Bayer Corporation Dissemination of fungal infections: animal model and method of prophylaxis
AT407043B (de) * 1998-01-23 2000-11-27 Martin Dr Kratzel Simplifizierte pepstatin-a-analoga, deren herstellung und verwendung
US7247704B2 (en) * 2000-12-18 2007-07-24 Arriva Pharmaceuticals, Inc. Multifunctional protease inhibitors and their use in treatment of disease
US7929913B2 (en) 2002-12-16 2011-04-19 Intel Corporation Adaptive receiver architecture
WO2012107153A1 (de) 2011-02-08 2012-08-16 Merck Patent Gmbh Aminostatin-derivate zur behandlung von arthrose
CN104507957B (zh) 2012-07-24 2018-12-25 默克专利股份有限公司 用于治疗关节病的羟基他汀衍生物
WO2014127881A1 (de) 2013-02-25 2014-08-28 Merck Patent Gmbh 2-amino-3,4-dihydrc-chinazolin derivate und ihre verwendung als cathepsin d inhibitoren
ES2759060T3 (es) 2013-08-06 2020-05-07 Merck Patent Gmbh Administración intraarticular de pepstatina para la artrosis

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1245217A (en) * 1981-12-10 1988-11-22 Joshua S. Boger Renin inhibitory peptides having phe su13 xx deletion
FR2531951A1 (fr) * 1982-08-17 1984-02-24 Sanofi Sa Derives peptidiques inhibiteurs de proteases acides, procede pour leur preparation et medicaments qui en contiennent
DE3381565D1 (de) * 1982-12-27 1990-06-21 Merck & Co Inc Reninhemmende tripeptide.

Also Published As

Publication number Publication date
DK64086D0 (da) 1986-02-10
DE3683170D1 (de) 1992-02-13
PT81990A (fr) 1986-03-01
NZ215097A (en) 1990-04-26
EP0193445A1 (fr) 1986-09-03
GR860399B (en) 1986-06-12
EP0193445B1 (fr) 1990-05-09
PT81991B (pt) 1988-03-03
DE3671021D1 (de) 1990-06-13
ES8701783A1 (es) 1987-01-01
AU606572B2 (en) 1991-02-14
DK64086A (da) 1986-08-13
NZ215096A (en) 1989-10-27
EP0192554A1 (fr) 1986-08-27
US4725580A (en) 1988-02-16
CA1286847C (en) 1991-07-23
ATE71111T1 (de) 1992-01-15
DK64186A (da) 1986-08-13
EP0192554B1 (fr) 1992-01-02
PT81991A (fr) 1986-03-01
ATE52518T1 (de) 1990-05-15
GR860398B (en) 1986-06-12
ES551821A0 (es) 1987-01-01
US4746648A (en) 1988-05-24
CA1286846C (en) 1991-07-23
AU5327286A (en) 1986-08-14
ES551820A0 (es) 1986-12-16
DK64186D0 (da) 1986-02-10
PT81990B (pt) 1988-03-03
AU606312B2 (en) 1991-02-07
AU5327386A (en) 1986-08-21

Similar Documents

Publication Publication Date Title
ES8701782A1 (es) Un procedimiento para la fabricacion de derivados peptidicos inhibidores de la renina y de las proteasas acidas
ES8401015A1 (es) Un metodo de preparacion de un peptido.
EP0163237A3 (en) Di- and tri-peptidal renin inhibitors
IL104716A (en) 7-1-oxo-2- (substituted mercapto)-3- phenylpropyl) amino| octahydro-6-pyrido £2, 1-a| benzazepine- 4-carboxylic acid derivatives and analogs, their preparation and pharmaceutical compositions containing them for inhibiting enkephalinase and ace
AP9200410A0 (en) Retroviral protease inhibitors.
ES2002469A6 (es) Un procedimiento para la preparacion de nuevos di -.tri -. y tetrapeptidos inhibidores de renina.
EP0221572A3 (en) N-substituted 3-piperidine-or 3-pyridine-carboxylic acids and derivatives thereof
IL86439A (en) Cyclic anticoagulant peptides
MY106352A (en) Hemoregulatory peptides.
IE852596L (en) Peptides active on the cns
EP0328090A3 (en) Lhrh analogs
EP0156319A3 (en) Renin inhibitors containing homophe 8
ZA86960B (en) Peptide derivatives,analogous to pepstatin,which inhibit renin and acid proteases
FR2526318B1 (fr) Analogues d'hormones neurohypophysaires ayant des proprietes inhibitrices
EP0147194A3 (en) Method and compositions for treating cerebral ischemia
RO87034B1 (ro) Medicament pentru tratamentul afectiunilor reumatismale

Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 19970401