ES8701764A1 - Procedimiento para preparar derivados de 7-oxo-4-tia-1-aza- biciclo(3,2,0)hept-2-eno - Google Patents

Procedimiento para preparar derivados de 7-oxo-4-tia-1-aza- biciclo(3,2,0)hept-2-eno

Info

Publication number
ES8701764A1
ES8701764A1 ES546802A ES546802A ES8701764A1 ES 8701764 A1 ES8701764 A1 ES 8701764A1 ES 546802 A ES546802 A ES 546802A ES 546802 A ES546802 A ES 546802A ES 8701764 A1 ES8701764 A1 ES 8701764A1
Authority
ES
Spain
Prior art keywords
formula
group
compound
image
thia
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES546802A
Other languages
English (en)
Other versions
ES546802A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sanofi Aventis UK Holdings Ltd
Original Assignee
Hoechst UK Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB848422842A external-priority patent/GB8422842D0/en
Priority claimed from GB848428968A external-priority patent/GB8428968D0/en
Application filed by Hoechst UK Ltd filed Critical Hoechst UK Ltd
Publication of ES546802A0 publication Critical patent/ES546802A0/es
Publication of ES8701764A1 publication Critical patent/ES8701764A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D499/88—Compounds with a double bond between positions 2 and 3 and a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C327/00—Thiocarboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
    • C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D205/06—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D205/08—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
    • C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D205/06—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D205/08—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams
    • C07D205/09—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams with a sulfur atom directly attached in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • C07F7/1804—Compounds having Si-O-C linkages
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

Abstract

PROCEDIMIENTO PARA PREPARAR DERIVADOS DE 7-OXO-4-TIA-1-AZABICICLO 3,2,0 HEPT-2-ENO DE FORMULA (I) Y SUS SALES FISIOLOGICAMENTE TOLERABLES Y SUS ESTERES. LA REACCION PARTE DE COMPUESTOS QUE SE HACEN REACCIONAR CON AMINAS R1NH2 PARA DAR COMPUESTOS DE LA FORMULA (I) O SUS ESTERES, A TRAVES DE LAS SIGUIENTES ETAPAS: HIDROLISIS DE LOS ESTERES PARA DAR ACIDOS DE FORMULA (I), REACCION DEL ACIDO O UNA SAL DEL MISMO CON UN AGENTE CAPAZ DE FORMAR UN ESTER, INTERCAMBIO DE ESTERES CATALIZADO POR ACIDO O BASE PARA DAR UN ESTER DIFERENTE, FORMACION DE SALES Y SALES DE ADICION, E HIDROLISIS DE LOS GRUPOS ESTER PARA FORMAR ESTERES DIFERENTES. LOS COMPUESTOS DE FORMULA (I) (Y ESTERES DE LOS MISMOS EN EL GRUPO CARBOXILICO DE POSICION 2) QUE TIENEN UN GRUPO HIDROXI ESTERIFICADO EN POSICION 8 TIENEN PROPIEDADES ANTIBACTERIANAS E INHIBIDORAS DE LAS B-LACTAMASAS.
ES546802A 1984-09-10 1985-09-09 Procedimiento para preparar derivados de 7-oxo-4-tia-1-aza- biciclo(3,2,0)hept-2-eno Expired ES8701764A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB848422842A GB8422842D0 (en) 1984-09-10 1984-09-10 7-oxo-4-thia-1-azabicyclo/3,2,0/hept-2-ene derivatives
GB848428968A GB8428968D0 (en) 1984-11-16 1984-11-16 7-oxo-3-thia-1-azabicyclo-(3,2,0)hept-2-ene derivatives

Publications (2)

Publication Number Publication Date
ES546802A0 ES546802A0 (es) 1986-12-01
ES8701764A1 true ES8701764A1 (es) 1986-12-01

Family

ID=26288204

Family Applications (3)

Application Number Title Priority Date Filing Date
ES546802A Expired ES8701764A1 (es) 1984-09-10 1985-09-09 Procedimiento para preparar derivados de 7-oxo-4-tia-1-aza- biciclo(3,2,0)hept-2-eno
ES553593A Expired ES8706625A1 (es) 1984-09-10 1986-04-01 Un procedimiento para preparar derivados de azetidina
ES553597A Expired ES553597A1 (es) 1984-09-10 1986-04-01 Un procedimiento para preparar derivados de azetidina

Family Applications After (2)

Application Number Title Priority Date Filing Date
ES553593A Expired ES8706625A1 (es) 1984-09-10 1986-04-01 Un procedimiento para preparar derivados de azetidina
ES553597A Expired ES553597A1 (es) 1984-09-10 1986-04-01 Un procedimiento para preparar derivados de azetidina

Country Status (14)

Country Link
US (1) US4849419A (es)
EP (1) EP0174561A1 (es)
KR (1) KR860002510A (es)
AU (1) AU4718885A (es)
DK (1) DK410185A (es)
ES (3) ES8701764A1 (es)
FI (1) FI853421L (es)
GB (1) GB2164334B (es)
GR (1) GR852179B (es)
HU (1) HU197014B (es)
IL (1) IL76328A0 (es)
NO (5) NO853511L (es)
NZ (1) NZ213394A (es)
PT (1) PT81101B (es)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8416565D0 (en) * 1984-06-29 1984-08-01 Hoechst Uk Ltd Antibacterial derivatives
GB8520631D0 (en) * 1985-08-16 1985-09-25 Hoechst Uk Ltd Derivatives
GB2195627A (en) * 1986-08-12 1988-04-13 Hoechst Uk Ltd Penem derivatives
ES2148135T3 (es) * 1988-10-24 2000-10-16 Norwich Eaton Pharma Nuevos esteres antimicrobianos de quinolonil lactamas.
CN100417654C (zh) * 2004-01-09 2008-09-10 中国医学科学院医药生物技术研究所 2-苯羧酸酯青霉烯类化合物及其制备方法和应用

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4168314A (en) * 1977-11-17 1979-09-18 Merck & Co., Inc. 6-(1'-Hydroxyethyl)-2-aminoethylthio-pen-2-em-3-carboxylic acid
JPS5625110A (en) * 1978-12-18 1981-03-10 Bristol Myers Co Antibacterial
ES8305366A1 (es) * 1981-07-08 1983-04-01 Hoechst Uk Ltd "procedimiento para la preparacion de derivados de penem".
EP0185651A1 (en) * 1981-07-08 1986-06-25 Hoechst Uk Limited Intermediates for the production of antibacterial penem derivates
ATE35270T1 (de) * 1982-07-08 1988-07-15 Hoechst Uk Ltd Antibakterielle penem-derivate.
US4595539A (en) * 1983-06-10 1986-06-17 Pfizer Inc. Preparation of penem derivatives and azetidinone intermediates

Also Published As

Publication number Publication date
GB2164334B (en) 1988-08-03
NO860104L (no) 1986-03-11
US4849419A (en) 1989-07-18
GB2164334A (en) 1986-03-19
DK410185A (da) 1986-03-11
ES546802A0 (es) 1986-12-01
HU197014B (en) 1989-02-28
NO853511L (no) 1986-03-11
FI853421A0 (fi) 1985-09-06
FI853421L (fi) 1986-03-11
PT81101B (en) 1987-03-30
NO860105L (no) 1986-03-11
ES553593A0 (es) 1987-06-16
EP0174561A1 (en) 1986-03-19
ES553597A1 (es) 1987-09-01
KR860002510A (ko) 1986-04-26
GR852179B (es) 1986-01-10
AU4718885A (en) 1986-03-27
ES8706625A1 (es) 1987-06-16
DK410185D0 (da) 1985-09-09
NO860103L (no) 1986-03-11
GB8516494D0 (en) 1985-07-31
NZ213394A (en) 1988-07-28
HUT38353A (en) 1986-05-28
PT81101A (en) 1985-10-01
IL76328A0 (en) 1986-01-31
NO860106L (no) 1986-03-11

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