ES2148135T3 - Nuevos esteres antimicrobianos de quinolonil lactamas. - Google Patents

Nuevos esteres antimicrobianos de quinolonil lactamas.

Info

Publication number
ES2148135T3
ES2148135T3 ES89870152T ES89870152T ES2148135T3 ES 2148135 T3 ES2148135 T3 ES 2148135T3 ES 89870152 T ES89870152 T ES 89870152T ES 89870152 T ES89870152 T ES 89870152T ES 2148135 T3 ES2148135 T3 ES 2148135T3
Authority
ES
Spain
Prior art keywords
lactam
new antimicrobial
esters
quinolonyl
quinolone
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES89870152T
Other languages
English (en)
Inventor
Ronald Eugene White
Thomas Prosser Demuth Jr
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Warner Chilcott Pharmaceuticals Inc
Original Assignee
Norwich Eaton Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Norwich Eaton Pharmaceuticals Inc filed Critical Norwich Eaton Pharmaceuticals Inc
Application granted granted Critical
Publication of ES2148135T3 publication Critical patent/ES2148135T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D463/00—Heterocyclic compounds containing 1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbacephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D463/10—Heterocyclic compounds containing 1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbacephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
    • C07D463/14—Heterocyclic compounds containing 1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbacephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hetero atoms directly attached in position 7
    • C07D463/16—Nitrogen atoms
    • C07D463/18—Nitrogen atoms further acylated by radicals derived from carboxylic acids or by nitrogen or sulfur analogues thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D477/00—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring
    • C07D477/10—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D505/00—Heterocyclic compounds containing 5-oxa-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. oxacephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

ESTERES LACTAM QUINOLONIL ANTIMICROBIALES QUE COMPRENDEN UNA PARTE QUE CONTIENE LACTAM LIGADO, POR UN GRUPO ESTER, AL GRUPO CARBOXI-3 DE UNA PARTE QUINOLONE. ESOS COMPONENTES SON DE LA FORMULA: EN DONDE (1) R3, R4 Y R5 JUNTO CON ENLACES "A" Y "B" FORMAN CIERTAS PARTES QUE CONTIENEN LACTAM SIMILARES A ESAS CONOCIDAS EN EL ARTE PARA TENER ACTIVIDAD ANTIMICROBIAL; Y (2) A, R6, R7 Y R8 FORMAN ALGUNO DE UNA VARIEDAD DE ESTRUCTURAS QUINOLONE O NAFTIRIDINE SIMILARES A ESAS CONOCIDAS EN EL ARTE PARA TENER ACTIVIDAD ANTIMICROBIAL.
ES89870152T 1988-10-24 1989-10-20 Nuevos esteres antimicrobianos de quinolonil lactamas. Expired - Lifetime ES2148135T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US26179888A 1988-10-24 1988-10-24
US41803389A 1989-10-12 1989-10-12

Publications (1)

Publication Number Publication Date
ES2148135T3 true ES2148135T3 (es) 2000-10-16

Family

ID=26948845

Family Applications (1)

Application Number Title Priority Date Filing Date
ES89870152T Expired - Lifetime ES2148135T3 (es) 1988-10-24 1989-10-20 Nuevos esteres antimicrobianos de quinolonil lactamas.

Country Status (15)

Country Link
EP (1) EP0366641B1 (es)
JP (1) JPH03502933A (es)
KR (1) KR0157297B1 (es)
AT (1) ATE194353T1 (es)
AU (1) AU635226B2 (es)
CA (1) CA2001201C (es)
DE (1) DE68929227T2 (es)
DK (1) DK527489A (es)
ES (1) ES2148135T3 (es)
GR (1) GR3034367T3 (es)
HK (1) HK1013984A1 (es)
NZ (1) NZ231110A (es)
PH (1) PH31375A (es)
SG (1) SG67307A1 (es)
WO (1) WO1990004594A1 (es)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5147871A (en) * 1986-07-03 1992-09-15 Hoffmann La-Roche, Inc. Anti-bacterial cephalosporin compounds
US5336768A (en) * 1988-05-24 1994-08-09 Hoffmann-La Roche Inc. Antibacterial cephalosporin compounds
CS273349B2 (en) * 1988-03-31 1991-03-12 Hoffmann La Roche Method of cephalosporin's new derivatives production
US5328908A (en) * 1988-10-24 1994-07-12 Procter & Gamble Pharmaceuticals, Inc. Antimicrobial quinolone thioureas
EP0366189A3 (en) * 1988-10-24 1992-01-02 Norwich Eaton Pharmaceuticals, Inc. Novel antimicrobial lactam-quinolones
US5491139A (en) * 1988-10-24 1996-02-13 The Procter & Gamble Company Antimicrobial quinolonyl lactams
CA2001203C (en) * 1988-10-24 2001-02-13 Thomas P. Demuth, Jr. Novel antimicrobial dithiocarbamoyl quinolones
US5159077A (en) * 1989-07-21 1992-10-27 Hoffmann-La Roche Inc. Penam antibacterial compounds
US5162523A (en) * 1989-07-21 1992-11-10 Hoffmann-La Roche Inc. Cephalosporin antibacterial compounds
AU636913B2 (en) * 1989-10-11 1993-05-13 Takeda Chemical Industries Ltd. Tricyclic carbapenem compounds
ZA912279B (en) * 1990-04-09 1992-02-26 Hoffmann La Roche Carbapenem compounds
ES2147721T3 (es) * 1990-04-18 2000-10-01 Procter & Gamble Pharma Quinolonil lactamas antimicrobianas.
BR9206590A (pt) * 1991-10-01 1995-04-25 Procter & Gamble Pharma Processo para a obtenção de quinolonil lactamas antimicrobianas
DE4234330A1 (de) * 1992-10-12 1994-04-14 Bayer Ag Chinoloncarbonsäuren
NZ290722A (en) * 1994-08-02 1999-03-29 Procter & Gamble A process for making derivatives of quinolonyl lactam (qla's); intermediates
DE69515882T2 (de) * 1994-08-02 2000-11-02 Procter & Gamble Verfahren zur herstellung von antimikrobiellen verbindungen
US9670179B1 (en) * 2013-03-14 2017-06-06 University Of South Florida Antibiotic compositions and methods of use
CN105753887A (zh) * 2016-02-05 2016-07-13 东南大学 一种具有喹诺酮和β-内酰胺结构的化合物及其合成方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4794109A (en) * 1982-11-16 1988-12-27 Ciba-Geigy Corporation 6-hydroxy-lower alkylpenem compounds, pharmaceutical preparations that contain these compounds, and the use of the latter
GB2164334B (en) * 1984-09-10 1988-08-03 Hoechst Uk Ltd Antibacterial 7-oxo-4-thia-1-azabicyclo 3,2,0 hept-2-ene derivativess
US4861768A (en) * 1986-02-27 1989-08-29 Taiho Pharmaceutical Company, Limited 2 β-substituted thiomethylpenicillin derivatives and their preparation and use
ZA874696B (en) * 1986-07-03 1988-01-04 F. Hoffmann-La Roche & Co. Aktiengesellschaft Acyl derivatives

Also Published As

Publication number Publication date
DE68929227T2 (de) 2001-05-31
DK527489A (da) 1990-04-25
EP0366641B1 (en) 2000-07-05
JPH03502933A (ja) 1991-07-04
DK527489D0 (da) 1989-10-24
CA2001201C (en) 1998-12-22
KR900006343A (ko) 1990-05-08
EP0366641A3 (en) 1991-12-11
AU635226B2 (en) 1993-03-18
ATE194353T1 (de) 2000-07-15
CA2001201A1 (en) 1990-04-24
KR0157297B1 (ko) 1998-11-16
DE68929227D1 (de) 2000-08-10
NZ231110A (en) 1992-06-25
GR3034367T3 (en) 2000-12-29
WO1990004594A1 (en) 1990-05-03
AU4369489A (en) 1990-05-03
SG67307A1 (en) 1999-09-21
PH31375A (en) 1998-10-29
HK1013984A1 (en) 1999-09-17
EP0366641A2 (en) 1990-05-02

Similar Documents

Publication Publication Date Title
ES2148135T3 (es) Nuevos esteres antimicrobianos de quinolonil lactamas.
ES2101960T3 (es) Lactamas benzo-condensadas.
ES2118283T3 (es) Derivados de acidos benzofuranil- y -tiofenil-alcanocarboxilicos.
SE8701348L (sv) Forbettringar av farmaceutiskt godtagabara salter
KR960702464A (ko) Dc-89 유도체[dc-89 derivative]
EP0629627A3 (en) Bicyclic carboxylic acids and their derivatives as NEP and ACA inhibitors.
IL148516A (en) Retroviral protease inhibiting compound
DK543787A (da) Naphthyridin-, quinolin- og benzoxazincarboxylsyreforbindelser med antibakteriel aktivitet
EP0366193A3 (en) Novel antimicrobial quinolonyl lactams
GR3004139T3 (es)
ES2106825T3 (es) Derivados de piperidina.
AU1639888A (en) Novel oxetanocins
ES2106058T3 (es) Derivados de benzamida.
MY106269A (en) Novel antimicrobial quinolonyl lactam esters.
DE69014261D1 (de) N-Azabicyclo[3.3.0]octanamide von aromatischen Säuren.
MY106321A (en) Novel antimicrobial quinolonyl lactams
DE3869630D1 (de) 6-beta(substituierte)-(s)-hydroxymethylpenicillansaeure und deren derivate.
DK0589318T3 (da) Antibakterielle 7-(aminomethyl-oxa-7-azabicyclo-(3.3.0)oct-7-yl)quinolon- og -naphthyridoncarboxylsyre-derivater
EP0381114A3 (en) Exo-3',4'-0-benzylidene-3"-demethylchartreusin and its salts
ATE141918T1 (de) Isoquinolinderivate
DE3777724D1 (de) 2-amino-3-aroyl-gamma-oxobenzolbuttersaeure und ihre ester.
JPS6483067A (en) Quinoline-3-carboxylic acid derivative

Legal Events

Date Code Title Description
FG2A Definitive protection

Ref document number: 366641

Country of ref document: ES