ES8700934A1 - Procedimiento para la obtencion de liposomas - Google Patents

Procedimiento para la obtencion de liposomas

Info

Publication number
ES8700934A1
ES8700934A1 ES547889A ES547889A ES8700934A1 ES 8700934 A1 ES8700934 A1 ES 8700934A1 ES 547889 A ES547889 A ES 547889A ES 547889 A ES547889 A ES 547889A ES 8700934 A1 ES8700934 A1 ES 8700934A1
Authority
ES
Spain
Prior art keywords
liposomes
synthetic lipids
synthetic
substantially pure
relates
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES547889A
Other languages
English (en)
Other versions
ES547889A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novartis AG
Original Assignee
Ciba Geigy AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ciba Geigy AG filed Critical Ciba Geigy AG
Publication of ES8700934A1 publication Critical patent/ES8700934A1/es
Publication of ES547889A0 publication Critical patent/ES547889A0/es
Expired legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Liposomes
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S436/00—Chemistry: analytical and immunological testing
    • Y10S436/829—Liposomes, e.g. encapsulation
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00—Stock material or miscellaneous articles
    • Y10T428/29—Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof
    • Y10T428/2982—Particulate matter [e.g., sphere, flake, etc.]

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Dispersion Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Manufacturing Of Micro-Capsules (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

PROCEDIMIENTO PARA LA OBTENCION DE LIPOSOMAS. COMPRENDE LA PREPARACION DE UNA MEZCLA HOMOGENEA, DE FOSFOLIPIDOS SINTETICOS PUROS, DE FORMULAS (I) Y (II), EN LAS QUE R1 Y R2 REPRESENTAN ALQUENOILO C10-20 CON NUMERO PAR DE ATOMOS DE CARBONO, YB REPRESENTA EL CATION DE UNA BASE, RA, RB Y RC SON HIDROGENO O ALQUILO C1-4 Y N VALE 1 A 4, CON UNA SUSTANCIA LIPOFILA O UNA MEZCLA DE SUSTANCIAS CON EFECTO BIOLOGICO; LA MEZCLA SE OBTIENE POR DISPERSION EN FASE ACUOSA A LA TEMPERATURA AMBIENTE. LOS LIPOSOMAS TIENEN APLICACIONES FARMACOLOGICAS COMO SOPORTES DE PROTEINAS Y EN EL TRATAMIENTO DEL CANCER.
ES547889A 1984-10-16 1985-10-15 Procedimiento para la obtencion de liposomas Expired ES8700934A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CH495184 1984-10-16

Publications (2)

Publication Number Publication Date
ES8700934A1 true ES8700934A1 (es) 1986-11-16
ES547889A0 ES547889A0 (es) 1986-11-16

Family

ID=4285361

Family Applications (1)

Application Number Title Priority Date Filing Date
ES547889A Expired ES8700934A1 (es) 1984-10-16 1985-10-15 Procedimiento para la obtencion de liposomas

Country Status (21)

Country Link
US (1) US4971802A (es)
EP (1) EP0178624B1 (es)
JP (2) JPH0618773B2 (es)
KR (1) KR890000908B1 (es)
AT (1) ATE58474T1 (es)
AU (1) AU590221B2 (es)
CA (1) CA1260393A (es)
DD (1) DD239117A5 (es)
DE (1) DE3580648D1 (es)
DK (1) DK165220C (es)
ES (1) ES8700934A1 (es)
FI (1) FI86371C (es)
GR (1) GR852492B (es)
HK (1) HK135793A (es)
HU (1) HU198128B (es)
IE (1) IE58143B1 (es)
IL (1) IL76700A (es)
NO (1) NO171443C (es)
PH (1) PH22978A (es)
PT (1) PT81298B (es)
ZA (1) ZA857888B (es)

Families Citing this family (39)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2562421B1 (fr) * 1984-04-09 1989-02-17 Sandoz Sa Perfectionnements a la therapie par l'interleukine
US5243062A (en) * 1984-10-12 1993-09-07 Ciba-Geigy Corporation Substituted propane-phosphonous acid compounds
JPS61172833A (ja) * 1985-07-17 1986-08-04 Nakanishi Michio 消炎鎮痛性医薬組成物
US5133973A (en) * 1986-08-07 1992-07-28 Medice Chem.-Pharm. Fabrik Putter Gmbh & Co. Kg Pharmaceutical preparations
EP0256989A1 (en) * 1986-08-18 1988-02-24 Board Of Regents, The University Of Texas System Pharmaceutical administration systems containing chemotactic peptides
JPH0761940B2 (ja) * 1986-11-17 1995-07-05 株式会社資生堂 外皮用リポソ−ム製剤
EP0274219A3 (en) * 1986-12-04 1988-08-03 Takeda Chemical Industries, Ltd. Interleukin-2-containing liposome composition and method for the production thereof
US4944941A (en) * 1987-08-07 1990-07-31 Genentech, Inc. Methods and compositions for the treatment of lung conditions
US5830498A (en) * 1987-10-16 1998-11-03 Board Of Regents, The University Of Texas System Liposomal-polyene preliposomal powder and method for its preparation
US5178875A (en) * 1991-01-14 1993-01-12 The Board Of Regents, The University Of Texas System Liposomal-polyene preliposomal powder and method for its preparation
FI874742A (fi) * 1987-10-28 1989-04-29 K & V Licencing Oy Foerfarande foer framstaellning av liposomer.
EP0331635A3 (en) * 1988-02-29 1990-02-28 The Board of Regents of the University of Texas System Preparations for treating bladder cancer
DE3806852A1 (de) * 1988-03-03 1989-09-14 Knoll Ag Neue (alpha)-aminodicarbonsaeure-derivate, ihre herstellung und verwendung
EP0440742B1 (en) * 1988-10-27 1997-01-15 The Regents Of The University Of Minnesota Liposome immunoadjuvants containing il-2
US5270053A (en) * 1990-04-03 1993-12-14 Ciba-Geigy Corp. Parenterally administerable liposome formulation comprising synthetic lipid
DE59102143D1 (de) * 1990-04-03 1994-08-18 Ciba Geigy Ag Parenteral applizierbare Liposomenformulierung aus synthetischen Lipiden.
US5466468A (en) * 1990-04-03 1995-11-14 Ciba-Geigy Corporation Parenterally administrable liposome formulation comprising synthetic lipids
US5162361A (en) * 1990-04-10 1992-11-10 The United States Of America As Represented By The Secretary, Department Of Health And Human Services Method of treating diseases associated with elevated levels of interleukin 1
EP0467838A3 (en) * 1990-07-17 1992-09-02 Ciba-Geigy Ag Process for preparing an injectable liposome dispersion
JPH06507882A (ja) * 1990-12-03 1994-09-08 ネクスター・フアーマシユーテイカルズ・インコーポレイテツド 滑膜癒着の防止
WO1993012813A1 (en) * 1991-12-31 1993-07-08 Zymogenetics, Inc. Methods and compositions for reducing blood loss
PT100487B (pt) * 1992-05-14 1999-07-30 Univ Texas Formulacoes lipossomais de rifamicinas com elevada estabilidade e eficacia de incorporacao de antibiotico, e processo para a sua preparacao
EP0616801B1 (de) * 1993-03-24 1998-05-27 Novartis AG Verfahren zur Herstellung einer Liposomendispersion im Hochdruckbereich
EP0706374B1 (en) * 1993-06-30 1997-12-10 Genentech, Inc. Method for preparing liposomes
US5474985A (en) * 1993-12-22 1995-12-12 The Regents Of The University Of California Preventing and treating elevated intraocular pressure associated with administered or endogenous steroids using non-steroidal cyclooxygenase inhibitors
US5674888A (en) * 1995-06-07 1997-10-07 University Of California Method for the treatment of a trabecular meshwork whose cells are subject to inhibition of cell division
US6313106B1 (en) * 1995-06-07 2001-11-06 D-Pharm Ltd. Phospholipid derivatives of valproic acid and mixtures thereof
US5599535A (en) * 1995-06-07 1997-02-04 Regents Of The University Of California Methods for the cyto-protection of the trabecular meshwork
ATE310505T1 (de) * 1996-05-14 2005-12-15 Stanislaw R Burzynski Liposomale antineoplaston therapie mit bemerkenswert verbesserter antineoplastischer aktivität
US6723338B1 (en) * 1999-04-01 2004-04-20 Inex Pharmaceuticals Corporation Compositions and methods for treating lymphoma
GB9921958D0 (en) * 1999-09-16 1999-11-17 Pharmacia & Upjohn Spa Formulations for parenteral use of estramustine phosphate and sulfoalkylether-cyclodextrins
US7422733B2 (en) * 2000-11-29 2008-09-09 Bracco International B.V. Linkable sialyl Lewis X analogs
EP1909758A1 (en) * 2005-08-02 2008-04-16 I.D.M. Immuno-Designed Molecules Process for the preparation of liposomal formulations
JP4931527B2 (ja) * 2006-09-20 2012-05-16 富士フイルム株式会社 フッ素化ホスファチジルセリン化合物
WO2008074487A2 (en) * 2006-12-19 2008-06-26 Novosom Ag Lipids and lipid assemblies comprising transfection enhancer elements
US9758536B2 (en) 2011-12-07 2017-09-12 Omega Protein Corporation Phospholipid compositions enriched for palmitoleic, myristoleic or lauroleic acid, their preparation and their use in treating metabolic and cardiovascular disease
CA2891656C (en) 2012-11-20 2021-05-04 Spectrum Pharmaceuticals Method for the preparation of liposome encapsulated vincristine
TWI678213B (zh) 2015-07-22 2019-12-01 美商史倍壯製藥公司 用於長春新鹼硫酸鹽脂質體注射之即可使用的調配物
CN113995852B (zh) * 2021-11-08 2024-01-30 河北大学 Arg-脂质体微囊、微囊包封的鱼精蛋白-siRNA复合体及其制备方法和应用

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1523965A (en) * 1976-03-19 1978-09-06 Ici Ltd Pharmaceutical compositions containing steroids
USRE30748E (en) * 1976-10-12 1981-09-22 Phosphatidyl quaternary ammonium compounds
DE2647395C2 (de) * 1976-10-20 1984-03-29 A. Nattermann & Cie GmbH, 5000 Köln Verfahren zur Herstellung von Estern des Glycerophosphocholins
GB2026340B (en) * 1978-07-03 1982-12-22 Ash P Stabilising microvesicles
FI75578C (fi) * 1979-07-25 1988-07-11 Ciba Geigy Ag Analogifoerfarande foer framstaellning av farmakologiskt verkande lipofila fosfatidylmuramylpeptider.
US4302459A (en) * 1980-03-19 1981-11-24 The United States Of America As Represented By The Secretary Of The Army Liposome carriers in leishmaniasis chemotherapy with 8-aminoquinoline derivatives
IL64397A0 (en) * 1981-01-07 1982-02-28 Weder Hans G Process for the preparation of liposomal medicaments
US4485045A (en) * 1981-07-06 1984-11-27 Research Corporation Synthetic phosphatidyl cholines useful in forming liposomes
DE3374837D1 (en) * 1982-02-17 1988-01-21 Ciba Geigy Ag Lipids in the aqueous phase
DE3209537A1 (de) * 1982-03-16 1983-09-22 Siemens AG, 1000 Berlin und 8000 München Elektrokleinmotor mit einer vorrichtung zum einstellen des axialspiels
DE3239817A1 (de) * 1982-07-06 1984-01-12 Max Planck Gesellschaft zur Förderung der Wissenschaften e.V., 3400 Göttingen Neue glycerinderivate zur synthese von phospholipiden
US4666893A (en) * 1983-02-15 1987-05-19 St. Thomas Institute Methods of inducing resistance to bacterial and viral infections
US4515736A (en) * 1983-05-12 1985-05-07 The Regents Of The University Of California Method for encapsulating materials into liposomes
US4622219A (en) * 1983-06-17 1986-11-11 Haynes Duncan H Method of inducing local anesthesia using microdroplets of a general anesthetic
GB8322178D0 (en) * 1983-08-17 1983-09-21 Sterwin Ag Preparing aerosol compositions
DE3346525C2 (de) * 1983-12-22 1987-03-19 A. Nattermann & Cie GmbH, 5000 Köln Pharmazeutische Zubereitung mit speziellen 1,2-Diacyl-glycero-3-phosphocholinen zur Behandlung von Erkrankungen im Magen-Darmbereich
JPS6150912A (ja) * 1984-08-16 1986-03-13 Shionogi & Co Ltd リポソ−ム製剤の製造法
AU587600B2 (en) * 1985-01-11 1989-08-24 Regents Of The University Of California, The Method for preserving liposomes
US4774085A (en) * 1985-07-09 1988-09-27 501 Board of Regents, Univ. of Texas Pharmaceutical administration systems containing a mixture of immunomodulators

Also Published As

Publication number Publication date
HUT40332A (en) 1986-12-28
JPH0618773B2 (ja) 1994-03-16
NO171443C (no) 1993-03-17
FI853982A0 (fi) 1985-10-14
US4971802A (en) 1990-11-20
JPH0816067B2 (ja) 1996-02-21
EP0178624B1 (de) 1990-11-22
PT81298A (en) 1985-11-01
DK471085D0 (da) 1985-10-15
IL76700A0 (en) 1986-02-28
AU590221B2 (en) 1989-11-02
FI86371B (fi) 1992-05-15
NO171443B (no) 1992-12-07
NO854085L (no) 1986-04-17
DK165220B (da) 1992-10-26
CA1260393A (en) 1989-09-26
PT81298B (pt) 1988-02-17
JPS6197215A (ja) 1986-05-15
DE3580648D1 (de) 1991-01-03
ATE58474T1 (de) 1990-12-15
IL76700A (en) 1990-06-10
EP0178624A3 (en) 1987-05-27
ZA857888B (en) 1986-05-28
IE58143B1 (en) 1993-07-14
AU4871385A (en) 1986-04-24
IE852527L (en) 1986-04-16
GR852492B (es) 1986-02-11
DD239117A5 (de) 1986-09-17
FI86371C (fi) 1992-08-25
HK135793A (en) 1993-12-17
ES547889A0 (es) 1986-11-16
DK165220C (da) 1993-03-22
DK471085A (da) 1986-04-17
JPH07238038A (ja) 1995-09-12
FI853982L (fi) 1986-04-17
KR860003015A (ko) 1986-05-19
KR890000908B1 (ko) 1989-04-13
HU198128B (en) 1989-08-28
EP0178624A2 (de) 1986-04-23
PH22978A (en) 1989-02-24

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Legal Events

Date Code Title Description
PC1A Transfer granted
FD1A Patent lapsed

Effective date: 20060828