ES8609277A1 - Procedimiento para la obtencion de 1-(bis-(4-fluorofenil)- metil)-4-(3-fenil-2-propenil)-hexahidro-1h-1, 4-diacepina - Google Patents
Procedimiento para la obtencion de 1-(bis-(4-fluorofenil)- metil)-4-(3-fenil-2-propenil)-hexahidro-1h-1, 4-diacepinaInfo
- Publication number
- ES8609277A1 ES8609277A1 ES544299A ES544299A ES8609277A1 ES 8609277 A1 ES8609277 A1 ES 8609277A1 ES 544299 A ES544299 A ES 544299A ES 544299 A ES544299 A ES 544299A ES 8609277 A1 ES8609277 A1 ES 8609277A1
- Authority
- ES
- Spain
- Prior art keywords
- diazepine
- hexahydro
- propenyl
- bis
- phenyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
- C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
- C07D243/08—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 not condensed with other rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
- A61P3/14—Drugs for disorders of the metabolism for electrolyte homeostasis for calcium homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Diabetes (AREA)
- Endocrinology (AREA)
- Rheumatology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
PROCEDIMIENTO PARA LA PREPARACION DE 1-BIS-(4-FLUOROFENIL)-METIL-4-(3-FENIL-2-PROPENIL)-HEXAHIDRO-1H-1,4-DIACEPINA DE FORMULA (I), SUS SALES CON ACIDOS NO TOXICOS, ESPECIALMENTE EL DICLORHIDRATO, Y COMPOSICIONES QUE CONTIENEN ESTAS SUSTANCIAS COMO PRINCIPIO ACTIVO. SE HACE REACCIONAR 1-ETOXICARBONIL-HEXAHIDRO-1,4-DIACEPINA, CON CLORURO DE CINAMILO EN PRESENCIA DE TRIETILAMINA, PARA OBTENER 1-ETOXICARBONIL-4-(3-FENIL-2-PROPENIL)-HEXAHIDRO-1,4-DIACEPINA DE FORMULA (III), QUE POR HIDROLISIS ALCALINA EN ETANOL, SE TRANSFORMA EN 4-(3-FENIL-2-PROPENIL)-1H-HEXAHIDRO-1,4-DIACEPINA DE FORMULA (IV), QUE A SU VEZ SE HACE REACCIONAR CON UNA CANTIDAD EQUIMOLAR DE BIS-(40FLUOROFENIL)-CLOROMETANO EN PRESENCIA DE TRIETILAMINA EN EXCESO PARA DAR LA 1-BIS-(4-FLUOROFENIL)-METIL-4-(3-FENIL-2-PROPENIL)-HEXAHIDRO-1H-1,4-DIACEPINA. EL COMPUESTO SE DESTINA AL TRATAMIENTO DE TRASTORNOS CIRCULATORIOS DIVERSOS.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IT21471/84A IT1196150B (it) | 1984-06-19 | 1984-06-19 | Derivati di 1-(bis-(4-fluorofenil)metil)-4-(3-fenil-2-propenil)-esaidro-1h-1,4-diazepina ad attivita' calcio antagonista,sua preparazione e composizioni che lo contengono |
Publications (2)
Publication Number | Publication Date |
---|---|
ES8609277A1 true ES8609277A1 (es) | 1986-09-01 |
ES544299A0 ES544299A0 (es) | 1986-09-01 |
Family
ID=11182299
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES544299A Expired ES8609277A1 (es) | 1984-06-19 | 1985-06-18 | Procedimiento para la obtencion de 1-(bis-(4-fluorofenil)- metil)-4-(3-fenil-2-propenil)-hexahidro-1h-1, 4-diacepina |
Country Status (8)
Country | Link |
---|---|
EP (1) | EP0166302A3 (es) |
JP (1) | JPS6117574A (es) |
KR (1) | KR860000269A (es) |
DE (1) | DE166302T1 (es) |
ES (1) | ES8609277A1 (es) |
FI (1) | FI852423L (es) |
IL (1) | IL75386A0 (es) |
IT (1) | IT1196150B (es) |
Families Citing this family (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
SE9504661D0 (sv) | 1995-12-22 | 1995-12-22 | Astra Pharma Inc | New compounds |
SE9504662D0 (sv) * | 1995-12-22 | 1995-12-22 | Astra Pharma Inc | New compounds |
WO1997044329A1 (en) * | 1996-05-20 | 1997-11-27 | Teijin Limited | Diarylalkyl cyclic diamine derivatives as chemokine receptor antagonists |
SE9904673D0 (sv) | 1999-12-20 | 1999-12-20 | Astra Pharma Inc | Novel compounds |
SE9904674D0 (sv) | 1999-12-20 | 1999-12-20 | Astra Pharma Inc | Novel compounds |
SE0001209D0 (sv) | 2000-04-04 | 2000-04-04 | Astrazeneca Canada Inc | Novel compounds |
MY140070A (en) | 2001-05-18 | 2009-11-30 | Astrazeneca Ab | 4-(phenyl-piperazinyl-methyl) benzamide derivatives and their use for the treatment of pain, anxiety or gastrointestinal disorders |
SE0203303D0 (sv) | 2002-11-07 | 2002-11-07 | Astrazeneca Ab | Novel Compounds |
SE0203302D0 (sv) | 2002-11-07 | 2002-11-07 | Astrazeneca Ab | Novel Compounds |
SE0203300D0 (sv) | 2002-11-07 | 2002-11-07 | Astrazeneca Ab | Novel Compounds |
DK1781631T3 (da) | 2004-08-02 | 2012-05-14 | Astrazeneca Ab | Diarylmethylpiperazinderivater, præparater dermed og anvendelser deraf |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
BE790971A (fr) * | 1971-11-09 | 1973-05-07 | Janssen Pharmaceutica Nv | Metode ter voorkoming van patologische reakties die de funktie van het komplement vereisen |
-
1984
- 1984-06-19 IT IT21471/84A patent/IT1196150B/it active
-
1985
- 1985-06-03 IL IL75386A patent/IL75386A0/xx unknown
- 1985-06-12 DE DE198585107220T patent/DE166302T1/de active Pending
- 1985-06-12 EP EP85107220A patent/EP0166302A3/en not_active Withdrawn
- 1985-06-17 KR KR1019850004283A patent/KR860000269A/ko not_active Application Discontinuation
- 1985-06-18 FI FI852423A patent/FI852423L/fi not_active Application Discontinuation
- 1985-06-18 ES ES544299A patent/ES8609277A1/es not_active Expired
- 1985-06-18 JP JP60132886A patent/JPS6117574A/ja active Pending
Also Published As
Publication number | Publication date |
---|---|
DE166302T1 (de) | 1986-05-22 |
IT8421471A0 (it) | 1984-06-19 |
KR860000269A (ko) | 1986-01-27 |
IL75386A0 (en) | 1985-10-31 |
EP0166302A2 (en) | 1986-01-02 |
JPS6117574A (ja) | 1986-01-25 |
FI852423A0 (fi) | 1985-06-18 |
ES544299A0 (es) | 1986-09-01 |
EP0166302A3 (en) | 1986-03-26 |
IT1196150B (it) | 1988-11-10 |
IT8421471A1 (it) | 1985-12-19 |
FI852423L (fi) | 1985-12-20 |
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