ES8607331A1 - Process for the preparation of 4-substituted oxazaphosphorine derivatives - Google Patents
Process for the preparation of 4-substituted oxazaphosphorine derivativesInfo
- Publication number
- ES8607331A1 ES8607331A1 ES542606A ES542606A ES8607331A1 ES 8607331 A1 ES8607331 A1 ES 8607331A1 ES 542606 A ES542606 A ES 542606A ES 542606 A ES542606 A ES 542606A ES 8607331 A1 ES8607331 A1 ES 8607331A1
- Authority
- ES
- Spain
- Prior art keywords
- group
- optionally substituted
- preparation
- substituted
- halogen
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- ZZVDXRCAGGQFAK-UHFFFAOYSA-N 2h-oxazaphosphinine Chemical class N1OC=CC=P1 ZZVDXRCAGGQFAK-UHFFFAOYSA-N 0.000 title abstract 2
- 238000000034 method Methods 0.000 title abstract 2
- -1 benzylmercapto group Chemical group 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 229910052736 halogen Chemical group 0.000 abstract 2
- 150000002367 halogens Chemical group 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
- 150000002431 hydrogen Chemical class 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
- 230000007935 neutral effect Effects 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6564—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms
- C07F9/6581—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and nitrogen atoms with or without oxygen or sulfur atoms, as ring hetero atoms
- C07F9/6584—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and nitrogen atoms with or without oxygen or sulfur atoms, as ring hetero atoms having one phosphorus atom as ring hetero atom
- C07F9/65842—Cyclic amide derivatives of acids of phosphorus, in which one nitrogen atom belongs to the ring
- C07F9/65846—Cyclic amide derivatives of acids of phosphorus, in which one nitrogen atom belongs to the ring the phosphorus atom being part of a six-membered ring which may be condensed with another ring system
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
A novel process for the preparation of oxazaphosphorine derivatives of the general formula < IMAGE > and their neutral salts, by reaction of a compound of the general formula < IMAGE > in which B is the group A or in which B is a C1-C10-alkylmercapto group which is optionally substituted by a carboxyl group, a hydroxyl group or a C1-C4-carbalkoxy group, a benzylmercapto group, a phenylmercapto group which is optionally substituted by methyl or halogen, or a C1-C6-alkanoylthio group, or in which B represents the group -N(OH)-CO-NHR and R denotes hydrogen, a C1-C6-alkyl group, a benzyl group or a phenyl group which is optionally substituted by C1-C4-alkyl radicals or halogen and the group B can also be present in the salt form if it contains an acid group, with an excess of a compound of the formula A'H or A'Y, where A' is different from A and has one of the meanings given for A.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19843415726 DE3415726A1 (en) | 1984-04-27 | 1984-04-27 | Process for the preparation of 4-substituted oxazaphosphorine derivatives |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| ES8607331A1 true ES8607331A1 (en) | 1986-05-16 |
| ES542606A0 ES542606A0 (en) | 1986-05-16 |
Family
ID=6234515
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES542606A Expired ES8607331A1 (en) | 1984-04-27 | 1985-04-26 | Process for the preparation of 4-substituted oxazaphosphorine derivatives |
Country Status (9)
| Country | Link |
|---|---|
| AT (1) | AT385037B (en) |
| DD (1) | DD232496A5 (en) |
| DE (1) | DE3415726A1 (en) |
| DK (1) | DK188985A (en) |
| ES (1) | ES8607331A1 (en) |
| FI (1) | FI851656L (en) |
| GR (1) | GR850994B (en) |
| HU (1) | HUT40676A (en) |
| PT (1) | PT80356B (en) |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3220432A1 (en) * | 1981-03-24 | 1983-12-01 | Asta-Werke Ag, Chemische Fabrik, 4800 Bielefeld | Oxazaphosphorine-4-thioalkanesulphonic acid, its neutral salts, process for the preparation thereof and pharmaceutical preparations containing them |
| DE3111428A1 (en) * | 1981-03-24 | 1982-10-07 | Asta-Werke Ag, Chemische Fabrik, 4800 Bielefeld | OXAZAPHOSPHORIN-4-THIO-ALKANESULPHONIC ACIDS AND THEIR NEUTRAL SALTS, METHOD FOR THE PRODUCTION THEREOF AND PHARMACEUTICAL PREPARATIONS CONTAINING THEM |
| DE3220672A1 (en) * | 1981-03-24 | 1983-12-08 | Asta-Werke Ag, Chemische Fabrik, 4800 Bielefeld | Cis-oxazaphosphorine-4-thioalkanesulphonic acids, their neutral salts, process for the preparation thereof and pharmaceutical preparations containing them |
| EP0083439B1 (en) * | 1981-12-31 | 1989-07-26 | ASTA Pharma AG | 4-sulfido-oxaza phosphorines and their use in the treatment of cancer, and in immunosuppression |
-
1984
- 1984-04-27 DE DE19843415726 patent/DE3415726A1/en not_active Withdrawn
-
1985
- 1985-04-24 GR GR850994A patent/GR850994B/el unknown
- 1985-04-25 DD DD27556385A patent/DD232496A5/en unknown
- 1985-04-26 AT AT125685A patent/AT385037B/en not_active IP Right Cessation
- 1985-04-26 DK DK188985A patent/DK188985A/en not_active Application Discontinuation
- 1985-04-26 HU HU162385A patent/HUT40676A/en unknown
- 1985-04-26 FI FI851656A patent/FI851656L/en not_active Application Discontinuation
- 1985-04-26 ES ES542606A patent/ES8607331A1/en not_active Expired
- 1985-04-26 PT PT8035685A patent/PT80356B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| AT385037B (en) | 1988-02-10 |
| DK188985A (en) | 1985-10-28 |
| ATA125685A (en) | 1987-07-15 |
| PT80356B (en) | 1987-03-16 |
| DD232496A5 (en) | 1986-01-29 |
| DK188985D0 (en) | 1985-04-26 |
| FI851656L (en) | 1985-10-28 |
| PT80356A (en) | 1985-05-01 |
| HUT40676A (en) | 1987-01-28 |
| FI851656A0 (en) | 1985-04-26 |
| DE3415726A1 (en) | 1985-10-31 |
| ES542606A0 (en) | 1986-05-16 |
| GR850994B (en) | 1985-11-25 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FD1A | Patent lapsed |
Effective date: 20001102 |