ES8607017A1 - Preparado solido en combinacion de dihidropiridina - Google Patents

Preparado solido en combinacion de dihidropiridina

Info

Publication number
ES8607017A1
ES8607017A1 ES543351A ES543351A ES8607017A1 ES 8607017 A1 ES8607017 A1 ES 8607017A1 ES 543351 A ES543351 A ES 543351A ES 543351 A ES543351 A ES 543351A ES 8607017 A1 ES8607017 A1 ES 8607017A1
Authority
ES
Spain
Prior art keywords
dihydropyridin
combinations
manufacture
dihydropyridines
dihydropyridine
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES543351A
Other languages
English (en)
Other versions
ES543351A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer AG
Original Assignee
Bayer AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer AG filed Critical Bayer AG
Publication of ES8607017A1 publication Critical patent/ES8607017A1/es
Publication of ES543351A0 publication Critical patent/ES543351A0/es
Expired legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Hydrogenated Pyridines (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

METODO DE PRODUCCION DE PREPARADOS SOLIDOS QUE CONTIENEN UNA PARTE DE UNA DIHIDROPIRIDINA DIFICILMENTE SOLUBLE, DE FORMULA (I), EN LA QUE X, R1, R2 Y R3 PUEDEN SER VARIOS TIPOS DE RADICALES, 0,5 A 10 PARTES DE UN B-BLOQUEADOR Y PRODUCTOS AUXILIARES Y SOPORTES. COMPRENDE LA REACCION DE ILIDENCOMPUESTOS DE FORMULA (II) CON ENAMINCOMPUESTOS DE FORMULA (III), ENLAS QUE TODOS LOS SIMBOLOS TIENEN EL MISMO SIGNIFICADO QUE EN LA FORMULA (I), EN PRESENCIA DE ALCOHOLES C1-4, A UNA TEMPERATURA COMPRENDIDA ENTRE 40JC Y 100JC; SEGUIDA DE LA GRANULACION DE 1 PARTE DE LA DIHIDROPIRIDINA FORMADA CON 0,5 A 10 PARTES DE B-BLOQUEADOR, PRODUCTOS AUXILIARES Y CARGA. ESTOS PREPARADOS TIENEN APLICACIONES FARMACOLOGICAS COMO AGENTES CORONARIOS Y DE LA PRESION SANGUINEA.
ES543351A 1984-05-23 1985-05-21 Preparado solido en combinacion de dihidropiridina Expired ES8607017A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19843419131 DE3419131A1 (de) 1984-05-23 1984-05-23 Dihydropyridinkombinationspraeparate und verfahren zu ihrer herstellung

Publications (2)

Publication Number Publication Date
ES8607017A1 true ES8607017A1 (es) 1986-06-01
ES543351A0 ES543351A0 (es) 1986-06-01

Family

ID=6236599

Family Applications (1)

Application Number Title Priority Date Filing Date
ES543351A Expired ES8607017A1 (es) 1984-05-23 1985-05-21 Preparado solido en combinacion de dihidropiridina

Country Status (8)

Country Link
EP (1) EP0163984A3 (es)
JP (1) JPS60255725A (es)
CN (1) CN85101697A (es)
AU (1) AU576244B2 (es)
DE (1) DE3419131A1 (es)
ES (1) ES8607017A1 (es)
GR (1) GR851245B (es)
ZA (1) ZA853877B (es)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3427402A1 (de) * 1984-07-25 1986-01-30 Bayer Ag, 5090 Leverkusen Neues kombinationspraeparat, verfahren zu seiner herstellung und seine verwendung als arzneimittel
DE3447170A1 (de) * 1984-12-22 1986-07-03 Bayer Ag, 5090 Leverkusen Mischung unterschiedlicher dihydropyridine, verfahren zu ihrer herstellung sowie ihre verwendung in arzneimitteln
JPS6396126A (ja) * 1986-10-13 1988-04-27 Taisho Pharmaceut Co Ltd 安定化組成物
SE8703881D0 (sv) * 1987-10-08 1987-10-08 Haessle Ab New pharmaceutical preparation
DE3829398A1 (de) * 1988-08-30 1990-03-08 Rentschler Arzneimittel Fixe arzneimittelkombination mit verzoegerter freisetzung
GB8926715D0 (en) * 1989-11-28 1990-01-17 Haessle Ab Improvements relating to the administration of pharmaceutical agents
JPH05221863A (ja) * 1991-08-09 1993-08-31 Taisho Pharmaceut Co Ltd 安定化方法
US7125565B2 (en) * 2000-12-01 2006-10-24 Kyowa Hakko Kogyo Co., Ltd. Composition improved in the solubility or oral absorbability
MX2007000911A (es) 2004-07-30 2007-04-12 Torrent Pharmaceuticals Ltd Nevibolol y sus sales farmaceuticamente aceptables, proceso para su preparacion y composiciones farmaceuticas de nevibolol.

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2117571C3 (de) * 1971-04-10 1979-10-11 Bayer Ag, 5090 Leverkusen Unsymmetrische 1,4-Dihydropyridin-33-dicarbonsäureester, Verfahren zu ihrer Herstellung sowie ihre Verwendung als Arzneimittel
DE2400819C2 (de) * 1974-01-09 1982-04-22 Bayer Ag, 5090 Leverkusen Verfahren zur Herstellung fester Zubereitungen von schwerlöslichen Arzneimittelwirkstoffen in feinster Verteilung
GB1579818A (en) * 1977-06-07 1980-11-26 Yamanouchi Pharma Co Ltd Nifedipine-containing solid preparation composition
EP0001247A1 (en) * 1977-09-14 1979-04-04 Kanebo, Ltd. Pharmaceutical preparation containing nifedipine and a method for producing the same.
CH655658B (es) * 1980-09-18 1986-05-15
GB2084017B (en) * 1980-09-18 1984-08-22 Sandoz Ltd Pharmaceutical compositions effective against coronary heat disease and hypertension
DE3419128A1 (de) * 1984-05-23 1985-11-28 Bayer Ag, 5090 Leverkusen Dihydropyridinpraeparate und verfahren zu ihrer herstellung
DE3419129A1 (de) * 1984-05-23 1985-11-28 Bayer Ag, 5090 Leverkusen Nifedipinpraeparate und verfahren zu ihrer herstellung

Also Published As

Publication number Publication date
ZA853877B (en) 1986-01-29
CN85101697A (zh) 1987-01-24
ES543351A0 (es) 1986-06-01
DE3419131A1 (de) 1985-11-28
GR851245B (es) 1985-11-25
JPS60255725A (ja) 1985-12-17
AU576244B2 (en) 1988-08-18
AU4281085A (en) 1985-11-28
EP0163984A3 (de) 1986-03-19
EP0163984A2 (de) 1985-12-11

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