ES8605517A1 - Un procedimiento para la preparacion de pirazolopiridinas. - Google Patents

Un procedimiento para la preparacion de pirazolopiridinas.

Info

Publication number
ES8605517A1
ES8605517A1 ES540610A ES540610A ES8605517A1 ES 8605517 A1 ES8605517 A1 ES 8605517A1 ES 540610 A ES540610 A ES 540610A ES 540610 A ES540610 A ES 540610A ES 8605517 A1 ES8605517 A1 ES 8605517A1
Authority
ES
Spain
Prior art keywords
alkyl
hydrogen
alkoxy
hydroxy
cor5
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES540610A
Other languages
English (en)
Other versions
ES540610A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Beecham Group PLC
Original Assignee
Beecham Group PLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Beecham Group PLC filed Critical Beecham Group PLC
Publication of ES540610A0 publication Critical patent/ES540610A0/es
Publication of ES8605517A1 publication Critical patent/ES8605517A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D231/38—Nitrogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Pulmonology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

PROCEDIMIENTO PARA LA PREPARACION DE PIRAZOLOPIRIDINAS. CONSISTE EN HACER REACCIONAR UN COMPUESTO DE FORMULA (IX) CON UN COMPUESTO DE FORMULA (X), EN DISOLVENTE INERTE, COMO TOLUENO, ETANOL, DIOXANO O AGUA, A TEMPERATURAS ELEVADAS, PARA OBTENER UN COMPUESTO DE FORMULA (I) O UNA SAL FARMACEUTICAMENTE ACEPTABLE, POR ADICION DEL ACIDO CORRESPONDIENTE. SIENDO: Q, GRUPO SALIENTE; R1, COR5, O GRUPO ESTER O AMIDO FARMACEUTICAMENTE ACEPTABLE; R2, H, ALQUILO DE C 1 A 6 Y OTROS; R3, ALQUILO DE C 1 A 10, ALCOXI DE C 1 A 4 Y OTROS; R4, H, ALQUILO DE C 1 A 4; R5, HIDROXI; R1, R1 O GRUPO CONVERTIBLE EN R1; R2, R2 O GRUPO CONVERTIBLE EN R2; R3, R3 O GRUPO O ATOMO CONVERTIBLE EN R3; X, NR; R, H, OXIGENO Y OTROS; Y X2, NR, OXIGENO O AZUFRE. SE UTILIZAN COMO ANTIINFLAMATORIOS DE USO TOPICO.
ES540610A 1984-02-22 1985-02-21 Un procedimiento para la preparacion de pirazolopiridinas. Expired ES8605517A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB848404586A GB8404586D0 (en) 1984-02-22 1984-02-22 Compounds

Publications (2)

Publication Number Publication Date
ES540610A0 ES540610A0 (es) 1986-03-16
ES8605517A1 true ES8605517A1 (es) 1986-03-16

Family

ID=10556990

Family Applications (1)

Application Number Title Priority Date Filing Date
ES540610A Expired ES8605517A1 (es) 1984-02-22 1985-02-21 Un procedimiento para la preparacion de pirazolopiridinas.

Country Status (8)

Country Link
US (1) US4621089A (es)
EP (1) EP0154220A3 (es)
JP (1) JPS60214787A (es)
AU (1) AU3897385A (es)
ES (1) ES8605517A1 (es)
GB (1) GB8404586D0 (es)
GR (1) GR850440B (es)
ZA (1) ZA851279B (es)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0193329A3 (en) * 1985-02-22 1987-08-19 Beecham Group Plc Pyrazolopyridines, their preparation and pharmaceutical compositions containing them
AT382377B (de) * 1985-04-27 1987-02-25 Beecham Group Plc Verfahren zur herstellung von neuen 7-substituierten aminopyrazolo(4,3-b)pyridinen
EP0239191A3 (en) * 1986-01-30 1988-07-20 Beecham Group Plc Pyrazolo[4,3-b]pyridine derivatives, process for their preparation and pharmaceutical compositions containing them
GB8609421D0 (en) * 1986-04-17 1986-05-21 Beecham Group Plc Compounds
PE20020506A1 (es) * 2000-08-22 2002-07-09 Glaxo Group Ltd Derivados de pirazol fusionados como inhibidores de la proteina cinasa
ATE300541T1 (de) * 2000-12-15 2005-08-15 Glaxo Group Ltd Pyrazolopyridinderivate
ES2245380T3 (es) 2000-12-15 2006-01-01 Glaxo Group Limited Pirazolopiridinas.
DE60201074T2 (de) * 2001-03-08 2005-09-15 Smithkline Beecham Corp. Pyrazolopyridinderivate
EP1372643A1 (en) 2001-03-30 2004-01-02 Smithkline Beecham Corporation Pyrazolopyridines, process for their preparation and use as therapeutic compounds
EP1372642A1 (en) * 2001-03-30 2004-01-02 SmithKline Beecham Corporation Use of pyrazolopyridines as therapeutic compounds
ATE332301T1 (de) 2001-04-10 2006-07-15 Smithkline Beecham Corp Antivirale pyrazolopyridin verbindungen
ES2242028T3 (es) 2001-04-27 2005-11-01 Smithkline Beecham Corporation Derivados de pirazolo(1,5-a)piridina.
IL158667A0 (en) * 2001-06-21 2004-05-12 Smithkline Beecham Corp Imidazo [1,2-a] pyridine derivatives for the prophylaxis and treatment of herpes viral infections
DE60220525T2 (de) * 2001-09-07 2008-02-07 Smithkline Beecham Corp. Pyrazolo-pyridine für die behandlung von herpes-ansteckungen
ATE326466T1 (de) * 2001-10-05 2006-06-15 Smithkline Beecham Corp Imidazopyridinderivate zur verwendung bei der behandlung von herpes-vireninfektion
EP1453830B1 (en) * 2001-12-11 2007-09-12 SmithKline Beecham Corporation Pyrazolo-pyridine derivatives as antiherpes agents
US7153863B2 (en) * 2002-10-03 2006-12-26 Smithkline Beecham Corporation Therapeutic compounds based on pyrazolopyridline derivatives
PE20110570A1 (es) * 2008-07-01 2011-08-26 Genentech Inc Heterociclos biciclicos sustituidos
AU2009266953A1 (en) * 2008-07-01 2010-01-07 Genentech, Inc. Isoindolone derivatives as MEK kinase inhibitors and methods of use
WO2011056895A1 (en) * 2009-11-03 2011-05-12 University Of Notre Dame Du Lac Ionic liquids comprising heteraromatic anions
US10385251B2 (en) 2013-09-30 2019-08-20 University Of Notre Dame Du Lac Compounds, complexes, compositions, methods and systems for heating and cooling
WO2015069799A1 (en) 2013-11-05 2015-05-14 University Of Notre Dame Du Lac Carbon dioxide capture using phase change ionic liquids

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5814436B2 (ja) * 1975-12-22 1983-03-18 タイホウヤクヒンコウギヨウ カブシキガイシヤ ピラゾロピリジンユウドウタイノセイゾウホウ

Also Published As

Publication number Publication date
EP0154220A3 (en) 1986-07-16
ZA851279B (en) 1986-05-28
AU3897385A (en) 1985-08-29
EP0154220A2 (en) 1985-09-11
ES540610A0 (es) 1986-03-16
GB8404586D0 (en) 1984-03-28
GR850440B (es) 1985-06-19
US4621089A (en) 1986-11-04
JPS60214787A (ja) 1985-10-28

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