ES8601138A1 - Un procedimiento para preparar derivados de 5-(piridinil o fenil)-2(1h)-piridinona - Google Patents

Un procedimiento para preparar derivados de 5-(piridinil o fenil)-2(1h)-piridinona

Info

Publication number
ES8601138A1
ES8601138A1 ES527344A ES527344A ES8601138A1 ES 8601138 A1 ES8601138 A1 ES 8601138A1 ES 527344 A ES527344 A ES 527344A ES 527344 A ES527344 A ES 527344A ES 8601138 A1 ES8601138 A1 ES 8601138A1
Authority
ES
Spain
Prior art keywords
compounds
pyridinones
pyridinyl
hydroxyphenyl
cardiotonics
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES527344A
Other languages
English (en)
Other versions
ES527344A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
STWB Inc
Original Assignee
Sterling Drug Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US06/442,623 external-priority patent/US4431651A/en
Application filed by Sterling Drug Inc filed Critical Sterling Drug Inc
Publication of ES527344A0 publication Critical patent/ES527344A0/es
Publication of ES8601138A1 publication Critical patent/ES8601138A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/62—Oxygen or sulfur atoms
    • C07D213/63—One oxygen atom
    • C07D213/64—One oxygen atom attached in position 2 or 6
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D211/84—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms
    • C07D211/86—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/54—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/55—Acids; Esters
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/54—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/57—Nitriles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pyridine Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

PROCEDIMIENTO PARA LA PREPARACION DE DERIVADOS DE 5-(PIRIDINIL O FENIL)-2(1H) PIRIDINONA DE FORMULA GENERAL (I) EN LA QUE Q ES 4-(O 3)-HIDROXIFENILO 4(O 3)-METOXIFENILO O 4(O 3)-PIRIDINILO; R1 ES HIDROGENO; R2 ES METILO; Y R ES ALQUILO INFERIOR Y SUS SALES DE ADICION FARMACEUTICAMENTE ACEPTABLES. CONSISTE EN CALENTAR UNA MEZCLA DE UNA 1-Q-2-ALCANONA DE FORMULA GENERAL: Q-CH2-C(FO)R Y ACETO-ACETAMIDA CON ACIDO POLIFOSFORICO. SI SE DESEA EL COMPUESTO OBTENIDO EN EL QUE Q ES 4(O 3)-METOXIFENILO SE PUEDE CONVERTIR EN OTRO EN EL QUE Q ES 4(O 3)-HIDROXIFENILO. DE APLICACION EN EL TRATAMIENTO DEL DOLOR FIEBRE E INFLAMACION.
ES527344A 1982-11-18 1983-11-17 Un procedimiento para preparar derivados de 5-(piridinil o fenil)-2(1h)-piridinona Expired ES8601138A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US06/442,623 US4431651A (en) 1982-11-18 1982-11-18 2-Pyridinones and their use as cardiotonic agents
US44324982A 1982-11-22 1982-11-22

Publications (2)

Publication Number Publication Date
ES527344A0 ES527344A0 (es) 1985-10-01
ES8601138A1 true ES8601138A1 (es) 1985-10-01

Family

ID=27033231

Family Applications (1)

Application Number Title Priority Date Filing Date
ES527344A Expired ES8601138A1 (es) 1982-11-18 1983-11-17 Un procedimiento para preparar derivados de 5-(piridinil o fenil)-2(1h)-piridinona

Country Status (11)

Country Link
EP (1) EP0109628A1 (es)
KR (1) KR840006625A (es)
AU (1) AU2141383A (es)
DK (1) DK527383A (es)
ES (1) ES8601138A1 (es)
FI (1) FI834215A (es)
GR (1) GR79123B (es)
IL (1) IL70169A0 (es)
NO (1) NO834227L (es)
NZ (1) NZ206215A (es)
PT (1) PT77670B (es)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3427146A1 (de) * 1984-07-24 1986-02-06 Dynamit Nobel Ag, 5210 Troisdorf Neue pyridon-derivate
DE3433953A1 (de) * 1984-09-15 1986-03-27 A. Nattermann & Cie GmbH, 5000 Köln Neue, eine imidazol-gruppe enthaltende 3,4-dihydro-2(1h)-pyridone und2(1h)-pyridone, verfahren zu ihrer herstellung und diese enthaltende arzneimittel
PE20060285A1 (es) 2004-03-30 2006-05-08 Aventis Pharma Inc Piridonas sustituidas como inhibidores de pol(adp-ribosa)-polimerasa (parp)
DE102004050196A1 (de) * 2004-10-15 2006-04-20 Sanofi-Aventis Deutschland Gmbh Substituierte 2-Pyridon-Derivate, Verfahren zu ihrer Herstellung und ihre Verwendung als Medikament
WO2008133660A2 (en) 2006-11-21 2008-11-06 Qd Vision, Inc. Nanocrystals including a group iiia element and a group va element, method, composition, device and other prodcucts
WO2013028253A1 (en) 2011-08-19 2013-02-28 Qd Vision, Inc. Semiconductor nanocrystals and methods
WO2013173409A1 (en) 2012-05-15 2013-11-21 Qd Vision, Inc. Semiconductor nanocrystals and methods of preparation

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3718743A (en) * 1970-11-19 1973-02-27 Merck & Co Inc 5-phenyl-2-piperidones and 5-phenyl-2-thiopiperidones in compositions and methods for treating pain, fever and inflammation
NZ195564A (en) * 1979-11-26 1983-09-30 Sterling Drug Inc 5-pyridinyl-2(1h)-pyridinones pharmaceutical compositions intermediate pyridine compounds
FI820573L (fi) * 1981-03-03 1982-09-04 Lilly Co Eli 1-bentsoyl-3-(arylpyridyl)ureafoereningar beroerande eller till dessa hoerande foerbaettringar
US4465686A (en) * 1981-09-08 1984-08-14 Sterling Drug Inc. 5-(Hydroxy- and/or amino-phenyl)-6-(lower-alkyl)-2-(1H)-pyridinones, their cardiotonic use and preparation

Also Published As

Publication number Publication date
DK527383D0 (da) 1983-11-17
NO834227L (no) 1984-05-21
IL70169A0 (en) 1984-02-29
FI834215A0 (fi) 1983-11-17
PT77670A (en) 1983-12-01
GR79123B (es) 1984-10-02
KR840006625A (ko) 1984-12-01
AU2141383A (en) 1984-05-24
ES527344A0 (es) 1985-10-01
NZ206215A (en) 1986-01-24
PT77670B (en) 1986-03-27
FI834215A (fi) 1984-05-19
DK527383A (da) 1984-05-19
EP0109628A1 (en) 1984-05-30

Similar Documents

Publication Publication Date Title
EP0191860A4 (en) COMPOUND OF LIQUID CRYSTALS.
DK496681A (da) Fremgangsmaade til fremstilling af i 5-stilling substituerede 2,4-diminopyri idiner
ES8700661A1 (es) Un procedimiento para preparar derivados de pirimidina
ES8202343A1 (es) Un procedimiento para preparar imidazo-piridinas
ES460040A1 (es) Un procedimiento para preparar derivados de 4-hidroxifeni- lalcanolaminas.
ES8601138A1 (es) Un procedimiento para preparar derivados de 5-(piridinil o fenil)-2(1h)-piridinona
SE8005946L (sv) 6-pyridazinoner och komposition anvendbar sasom cardiotonikum
DK155321C (da) Analogifremgangsmaade til fremstilling af 3,4,5-trihydroxypiperidinderivater
FI812681L (fi) Sammansaettningar av polyolefinmjoel saerskilt av polyetenmjoel med baettre adhesion och artiklar tillverkade av eller som skall tillverkas av saodana sammansaettningar
MY102973A (en) Isoindolinyl alkyl piperazines
ES8606233A1 (es) Un procedimiento para la preparacion de fosfatidos de eter de glicol
SE8101591L (sv) Pyrazolopyridinderivat och forfarande for framstellning derav
IE781193L (en) Nitroso-ureas
ES8603458A1 (es) Un procedimiento para preparar una 3-r1-4-r2-5-q-6-r-2(1h)-piridinona
JPS52285A (en) Preparation of n1 *22tetrahydrofuryl**55fluorouracil
ES8506301A1 (es) Un procedimiento para preparar 2-alcoxi-5-(piridinil) piridinas
ES456090A1 (es) Un procedimiento para la preparacion de un compuesto sulfo- nilbencimidazol.
ES8502434A1 (es) Un procedimiento para preparar una 1-r1-3-amino-5-py-6-r-2-(1h) piridinona.
ATE14125T1 (de) 5-(4-phenyl-1-piperidinyl)methyl-2,3-dihydro-2oxo-1h-imidazol-4-carbonsaeure-derivate.
ES8308875A1 (es) Procedimiento para preparar 4-aminometil-5-acil-1,3-dihidro-2h-imidazol-2-onas.
ES8202006A1 (es) Un procedimiento para preparar derivados de imidazo (4,5-b) piridina
ES8308871A1 (es) Procedimiento para la preparacion de 4-(4-fenil-1-piperidinil) metil-5-acil-1,3-dihidro-2h-imidazol-2-onas.
ATE15184T1 (de) Fluorphenoxybenzylester, ihre herstellung und ihre verwendung als schaedlingsbekaempfungsmittel.
JPS529060A (en) Polyester composition
JPS5646873A (en) 2-guanidinothiazole derivative and its preparation