ES8600322A1 - Un procedimiento para obtener compuestos de 2'-o-acil-, 3'-o-acil-, 2',3'-di-o-acil- y 2',3',5'-tri-o-acil-2-b-d-ribofuranosilselenazol-4-carboxamida - Google Patents
Un procedimiento para obtener compuestos de 2'-o-acil-, 3'-o-acil-, 2',3'-di-o-acil- y 2',3',5'-tri-o-acil-2-b-d-ribofuranosilselenazol-4-carboxamidaInfo
- Publication number
- ES8600322A1 ES8600322A1 ES527277A ES527277A ES8600322A1 ES 8600322 A1 ES8600322 A1 ES 8600322A1 ES 527277 A ES527277 A ES 527277A ES 527277 A ES527277 A ES 527277A ES 8600322 A1 ES8600322 A1 ES 8600322A1
- Authority
- ES
- Spain
- Prior art keywords
- ribofuranosylselenazole
- beta
- novel
- production
- methods
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- CKMBACZHCFMPLQ-DBRKOABJSA-N 2-[(2r,3r,4s,5r)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-1,3-selenazole-4-carboxamide Chemical class NC(=O)C1=C[se]C([C@H]2[C@@H]([C@H](O)[C@@H](CO)O2)O)=N1 CKMBACZHCFMPLQ-DBRKOABJSA-N 0.000 title 1
- -1 2- beta -D-ribofuranosylselenazole-4-carboxamide nucleoside Chemical class 0.000 abstract 1
- 241001465754 Metazoa Species 0.000 abstract 1
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 208000036142 Viral infection Diseases 0.000 abstract 1
- 230000000259 anti-tumor effect Effects 0.000 abstract 1
- 230000000840 anti-viral effect Effects 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 239000002777 nucleoside Substances 0.000 abstract 1
- 125000003729 nucleotide group Chemical group 0.000 abstract 1
- 230000000144 pharmacologic effect Effects 0.000 abstract 1
- 230000009385 viral infection Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D421/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having selenium, tellurium, or halogen atoms as ring hetero atoms
- C07D421/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having selenium, tellurium, or halogen atoms as ring hetero atoms containing two hetero rings
- C07D421/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having selenium, tellurium, or halogen atoms as ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/04—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
- C07D307/18—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D307/20—Oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H5/00—Compounds containing saccharide radicals in which the hetero bonds to oxygen have been replaced by the same number of hetero bonds to halogen, nitrogen, sulfur, selenium, or tellurium
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
Abstract
PROCEDIMIENTO PARA OBTENER DERIVADOS ACILICOS DE 2-BBB-D-RIBOFURANOSILSELENAZOL-4-CARBOXAMIDA.COMPRENDE; ACILAR 2-BBB-D-RIBOFURANOSILSELENAZOL-4-CARBOXAMIDA O EL DERIVADO DE 2K, 3K-O-ISOPROPILIDENO O DE 5K-O-TRIFENILMETILO, MEDIANTE REACCION CON UN AGENTE ACILANTE, TAL COMO UN ANHIDRIDO O CLORURO DE ACIDO, A LA TEMPERATURA AMBIENTE, HASTA QUE SEA COMPLETA LA REACCION; Y AISLAR EL PRODUCTO RESULTANTE, CON UN AGENTE DESPROTECTOR, TAL COMO ACIDO ACETICO, A TEMPERATURA ELEVADA, HASTA QUE LA REACCION SEA COMPLETA, O DESTRITILAR EL PRODUCTO ACILADO MEDIANTE TRATAMIENTO CON UN AGENTE DESPROTECTOR, TAL COMO ACIDO ACETICO, QUE SEPARARA SELECTIVAMENTE EL GRUPO TRITILO.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US36096882A | 1982-03-23 | 1982-03-23 | |
US06/465,221 US4531001A (en) | 1982-03-23 | 1983-02-15 | 2-β-D-ribofuranosylselenazole-4-carboxamide compounds |
Publications (2)
Publication Number | Publication Date |
---|---|
ES527277A0 ES527277A0 (es) | 1985-10-01 |
ES8600322A1 true ES8600322A1 (es) | 1985-10-01 |
Family
ID=27001098
Family Applications (5)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES520826A Expired ES8404373A1 (es) | 1982-03-23 | 1983-03-22 | Un procedimiento para obtener compuestos de ribofuranosilselenazol-4-carboxamida. |
ES527279A Expired ES8600323A1 (es) | 1982-03-23 | 1983-11-15 | Un procedimiento para obtener 2-(2,3,5-tri-o-aril-b-d-ribofuranosil)selenazol-4-carboxilatos de alcohilo o aralcohilo |
ES527277A Expired ES8600322A1 (es) | 1982-03-23 | 1983-11-15 | Un procedimiento para obtener compuestos de 2'-o-acil-, 3'-o-acil-, 2',3'-di-o-acil- y 2',3',5'-tri-o-acil-2-b-d-ribofuranosilselenazol-4-carboxamida |
ES527278A Granted ES527278A0 (es) | 1982-03-23 | 1983-11-15 | Un procedimiento para obtener 2,5-anhidro-3,4,6-tri-o-acil-d-alonselenocarboxamida |
ES527276A Granted ES527276A0 (es) | 1982-03-23 | 1983-11-15 | Un procedimiento para obtener compuestos de ribofuranosilselenazol-4-carboxamida-5'-fosfato |
Family Applications Before (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES520826A Expired ES8404373A1 (es) | 1982-03-23 | 1983-03-22 | Un procedimiento para obtener compuestos de ribofuranosilselenazol-4-carboxamida. |
ES527279A Expired ES8600323A1 (es) | 1982-03-23 | 1983-11-15 | Un procedimiento para obtener 2-(2,3,5-tri-o-aril-b-d-ribofuranosil)selenazol-4-carboxilatos de alcohilo o aralcohilo |
Family Applications After (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES527278A Granted ES527278A0 (es) | 1982-03-23 | 1983-11-15 | Un procedimiento para obtener 2,5-anhidro-3,4,6-tri-o-acil-d-alonselenocarboxamida |
ES527276A Granted ES527276A0 (es) | 1982-03-23 | 1983-11-15 | Un procedimiento para obtener compuestos de ribofuranosilselenazol-4-carboxamida-5'-fosfato |
Country Status (14)
Country | Link |
---|---|
US (1) | US4531001A (es) |
EP (1) | EP0089678B1 (es) |
KR (1) | KR880001869B1 (es) |
AU (1) | AU553665B2 (es) |
CA (1) | CA1209986A (es) |
DE (1) | DE3366378D1 (es) |
DK (2) | DK167765B1 (es) |
ES (5) | ES8404373A1 (es) |
FI (1) | FI76574C (es) |
GR (1) | GR78301B (es) |
IE (1) | IE54520B1 (es) |
NO (1) | NO155842C (es) |
NZ (1) | NZ203649A (es) |
PT (1) | PT76426B (es) |
Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4619996A (en) * | 1984-07-09 | 1986-10-28 | Warner-Lambert Company | Process for preparing 2-β-D-ribofuranosylselenazole-4-carboxamide |
US4801698A (en) * | 1986-08-15 | 1989-01-31 | Warner-Lambert Company | Process for preparing diaminopyrimido(4,5-d)pyrimidine glycoside and glycotide |
US5438131A (en) * | 1992-09-16 | 1995-08-01 | Bergstrom; Donald E. | 3-nitropyrrole nucleoside |
GB9307043D0 (en) * | 1993-04-05 | 1993-05-26 | Norsk Hydro As | Chemical compounds |
AU5298096A (en) * | 1995-02-17 | 1996-09-11 | Icn Pharmaceuticals, Inc. | Procedures for obtaining ribo-c-nucleosides |
YU67099A (sh) * | 1997-06-30 | 2002-06-19 | Icn Pharmaceuticals Inc. | Postupak za dobijanje tiazofurina i drugih c-nukleozida |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3423399A (en) * | 1966-06-09 | 1969-01-21 | Takeda Chemical Industries Ltd | Method for the production of 5'-ribonucleotide |
US3798209A (en) * | 1971-06-01 | 1974-03-19 | Icn Pharmaceuticals | 1,2,4-triazole nucleosides |
US3984396A (en) * | 1971-06-01 | 1976-10-05 | Icn Pharmaceuticals, Inc. | 1-(β,-D-ribofuranosyl)-1,2,4-triazole acid esters |
-
1983
- 1983-02-15 US US06/465,221 patent/US4531001A/en not_active Expired - Fee Related
- 1983-03-18 IE IE580/83A patent/IE54520B1/en not_active IP Right Cessation
- 1983-03-22 GR GR70837A patent/GR78301B/el unknown
- 1983-03-22 AU AU12693/83A patent/AU553665B2/en not_active Expired
- 1983-03-22 EP EP83102841A patent/EP0089678B1/en not_active Expired
- 1983-03-22 FI FI830941A patent/FI76574C/fi not_active IP Right Cessation
- 1983-03-22 CA CA000424166A patent/CA1209986A/en not_active Expired
- 1983-03-22 NO NO831012A patent/NO155842C/no unknown
- 1983-03-22 NZ NZ203694A patent/NZ203649A/xx unknown
- 1983-03-22 PT PT76426A patent/PT76426B/pt not_active IP Right Cessation
- 1983-03-22 KR KR1019830001203A patent/KR880001869B1/ko not_active IP Right Cessation
- 1983-03-22 DK DK129983A patent/DK167765B1/da not_active IP Right Cessation
- 1983-03-22 ES ES520826A patent/ES8404373A1/es not_active Expired
- 1983-03-22 DE DE8383102841T patent/DE3366378D1/de not_active Expired
- 1983-11-15 ES ES527279A patent/ES8600323A1/es not_active Expired
- 1983-11-15 ES ES527277A patent/ES8600322A1/es not_active Expired
- 1983-11-15 ES ES527278A patent/ES527278A0/es active Granted
- 1983-11-15 ES ES527276A patent/ES527276A0/es active Granted
-
1993
- 1993-03-08 DK DK025093A patent/DK172165B1/da not_active IP Right Cessation
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FD1A | Patent lapsed |
Effective date: 20040607 |