ES8600289A1 - Un procedimiento para preparar piridazino (4,3-c) isoquinoleinas - Google Patents

Un procedimiento para preparar piridazino (4,3-c) isoquinoleinas

Info

Publication number
ES8600289A1
ES8600289A1 ES534200A ES534200A ES8600289A1 ES 8600289 A1 ES8600289 A1 ES 8600289A1 ES 534200 A ES534200 A ES 534200A ES 534200 A ES534200 A ES 534200A ES 8600289 A1 ES8600289 A1 ES 8600289A1
Authority
ES
Spain
Prior art keywords
pyridazino
isoquinoline derivatives
amino
phenyl
groups
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES534200A
Other languages
English (en)
Other versions
ES534200A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Gruppo Lepetit SpA
Original Assignee
Gruppo Lepetit SpA
Lepetit SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gruppo Lepetit SpA, Lepetit SpA filed Critical Gruppo Lepetit SpA
Publication of ES8600289A1 publication Critical patent/ES8600289A1/es
Publication of ES534200A0 publication Critical patent/ES534200A0/es
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/44—Iso-indoles; Hydrogenated iso-indoles
    • C07D209/46—Iso-indoles; Hydrogenated iso-indoles with an oxygen atom in position 1
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
    • C07D237/02—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings
    • C07D237/06—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D237/10—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D237/14—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Anesthesiology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

PROCEDIMIENTO PARA PREPARAR PIRIDAZINO (4,3-C) ISOQUINOLEINAS.COMPRENDE: A) HACER REACCIONAR A UNA 6H- (2) BVENZOPIRANO (4,3,C)-PIRIDAZIN-6-ONA DE FORMULA (II) CON EXCESO DE AMONIACO O UNA SAL DEL MISMO, PARA OBTENER UNA PIRIDAZINO (4,3,C) ISOQUILEIN 6 (5H) ONA DE FORMULA (III); B) CLORAR A (III) CON PCL5 O POCL3, PARA OBTENER UN COMPUESTO DE FORMULA (IV) Y C) HACER REACCIONAR A (IV) CON UN GRUPO AMINO DE FORMULA -NRAR5, PARA OBTENER UN COMPUESTO DE FORMULA (I) Y SUS SALES DE ADICION FARMACEUTICAMENTE ACEPTABLES. SIENDO, R, METILO, FENILO, FENILO SUSTITUIDO POR 1 A 3 SUSTITUYENTES SELECCIONADOS ENTRE ALQUILO DE C 1 A 4, ALCOXI C 1 A 4 Y OTROS; R1, UN GRUPO DE FORMULA (-NR4R5); R2 Y R3, H HAL, ALQUILO DE C 1 A 4 Y OTROS Y R4 Y R5, H, ALQUILO DE C 1 A 4, ALQUENILO DE C 2 A 4 Y OTROS.SE UTILIZAN PARA PREDECIR EL EFECTO ANSIOLITICO DE LOS FARMACOS.
ES534200A 1983-07-12 1984-07-11 Un procedimiento para preparar piridazino (4,3-c) isoquinoleinas Granted ES534200A0 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT22013/83A IT1194309B (it) 1983-07-12 1983-07-12 Derivati 3-fenil-piridazino (4,3-c) isochinolinici

Publications (2)

Publication Number Publication Date
ES8600289A1 true ES8600289A1 (es) 1985-06-01
ES534200A0 ES534200A0 (es) 1985-06-01

Family

ID=11190189

Family Applications (1)

Application Number Title Priority Date Filing Date
ES534200A Granted ES534200A0 (es) 1983-07-12 1984-07-11 Un procedimiento para preparar piridazino (4,3-c) isoquinoleinas

Country Status (20)

Country Link
US (1) US4716159A (es)
EP (1) EP0134461B1 (es)
JP (1) JPS6048989A (es)
KR (1) KR910005849B1 (es)
AT (1) ATE30157T1 (es)
AU (1) AU570057B2 (es)
CA (1) CA1229602A (es)
DE (1) DE3466690D1 (es)
DK (1) DK323484A (es)
ES (1) ES534200A0 (es)
FI (1) FI77861C (es)
GR (1) GR82126B (es)
HU (1) HU193687B (es)
IL (1) IL72308A (es)
IT (1) IT1194309B (es)
NO (1) NO160613C (es)
NZ (1) NZ208864A (es)
PH (1) PH22631A (es)
PT (1) PT78891B (es)
ZA (1) ZA844970B (es)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0633277B2 (ja) * 1986-01-10 1994-05-02 吉富製薬株式会社 ベンゾチオピラノ〔４，３−ｃ〕ピリダジン化合物
DE3814552A1 (de) * 1988-04-29 1989-11-09 Hoechst Ag 9-oxo-1,9a-10-triaza-9-hydro-anthracen- verbindungen, verfahren zu ihrer herstellung und ihre verwendung als farbmittel

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4062958A (en) * 1976-09-22 1977-12-13 American Cyanamid Company Method of treating anxiety and compositions therefor

Also Published As

Publication number Publication date
IT8322013A0 (it) 1983-07-12
HUT34975A (en) 1985-05-28
EP0134461A1 (en) 1985-03-20
DE3466690D1 (de) 1987-11-12
FI842586A (fi) 1985-01-13
KR910005849B1 (ko) 1991-08-05
IT1194309B (it) 1988-09-14
DK323484D0 (da) 1984-06-29
NO160613C (no) 1989-05-10
HU193687B (en) 1987-11-30
NO842825L (no) 1985-01-14
ZA844970B (en) 1985-03-27
PH22631A (en) 1988-10-28
CA1229602A (en) 1987-11-24
NZ208864A (en) 1988-06-30
PT78891A (en) 1984-08-01
NO160613B (no) 1989-01-30
GR82126B (es) 1984-12-13
KR850001209A (ko) 1985-03-16
JPS6048989A (ja) 1985-03-16
FI842586A0 (fi) 1984-06-27
JPH0559915B2 (es) 1993-09-01
ATE30157T1 (de) 1987-10-15
FI77861C (fi) 1989-05-10
US4716159A (en) 1987-12-29
DK323484A (da) 1985-01-13
ES534200A0 (es) 1985-06-01
AU3022184A (en) 1985-01-17
AU570057B2 (en) 1988-03-03
EP0134461B1 (en) 1987-10-07
PT78891B (en) 1986-10-23
IL72308A (en) 1987-11-30
IL72308A0 (en) 1984-11-30
FI77861B (fi) 1989-01-31

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 19970401