ES8501399A1 - Procedimiento para preparar 3-amino-6-aril-1, 2, 4-triazolo (4, 3-b) piridazinas - Google Patents
Procedimiento para preparar 3-amino-6-aril-1, 2, 4-triazolo (4, 3-b) piridazinasInfo
- Publication number
- ES8501399A1 ES8501399A1 ES530639A ES530639A ES8501399A1 ES 8501399 A1 ES8501399 A1 ES 8501399A1 ES 530639 A ES530639 A ES 530639A ES 530639 A ES530639 A ES 530639A ES 8501399 A1 ES8501399 A1 ES 8501399A1
- Authority
- ES
- Spain
- Prior art keywords
- carbon atoms
- formula
- groups
- alkyl
- compound
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
- C07D237/02—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings
- C07D237/06—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D237/10—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D237/20—Nitrogen atoms
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Neurosurgery (AREA)
- Life Sciences & Earth Sciences (AREA)
- Neurology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Biomedical Technology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Anesthesiology (AREA)
- Pain & Pain Management (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Steroid Compounds (AREA)
- Liquid Crystal Substances (AREA)
Abstract
PROCEDIMIENTO PARA PREPARAR 3-AMINO-6-ARIL-1,2,4-TRIAZOLO 4,3-B PIRIDAZINAS.CONSISTE EN HACER REACCIONAR UN COMPUESTO DE FORMULA (IV) EN DONDE R SIGNIFICA CLORO, BROMO O METILTIO, Y AR, R Y R TIENEN LOS SIGNIFICADOS INDICADOS PARA LA FORMULA (I), CON AMONIACO, PARA DAR UN COMPUESTO DE FORMULA (I) DONDE R Y R REPRESENTAN HIDROGENO, GRUPOS ALCOHILO CON C 1 A 6, FENILO O CLORO, Y AR REPRESENTA RADICALES AROMATICOS TALES COMO FENILO, FENILSULFINILFENILO, 1- O 2-NAFTILO. EL COMPUESTO ASI OBTENIDO SE TRANSFORMA, CON UN ACIDO FISIOLOGICAMENTE TOLERABLE, EN LA SAL.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE19823217325 DE3217325A1 (de) | 1982-05-08 | 1982-05-08 | 3-amino-6-aryl-1,2,4-triazolo(4,3-b)-pyridazine, ihre herstellung und ihre verwendung |
Publications (2)
Publication Number | Publication Date |
---|---|
ES8501399A1 true ES8501399A1 (es) | 1984-11-16 |
ES530639A0 ES530639A0 (es) | 1984-11-16 |
Family
ID=6163075
Family Applications (4)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES522144A Granted ES522144A0 (es) | 1982-05-08 | 1983-05-06 | Procedimiento para la preparacion de 3-amino-6-aril-1,2,4-triazolo(4,3-b)piridazinas. |
ES530640A Granted ES530640A0 (es) | 1982-05-08 | 1984-03-15 | Procedimiento para preparar 3-amino-6-aril-1, 2, 4-triazolo-(4, 3-b) piridazinas |
ES530639A Granted ES530639A0 (es) | 1982-05-08 | 1984-03-15 | Procedimiento para preparar 3-amino-6-aril-1, 2, 4-triazolo (4, 3-b) piridazinas |
ES530638A Expired ES8501398A1 (es) | 1982-05-08 | 1984-03-15 | Procedimiento para preparar 3-amino-6-aril-1, 2, 4-triazolo (4, 3-b) piridazinas |
Family Applications Before (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES522144A Granted ES522144A0 (es) | 1982-05-08 | 1983-05-06 | Procedimiento para la preparacion de 3-amino-6-aril-1,2,4-triazolo(4,3-b)piridazinas. |
ES530640A Granted ES530640A0 (es) | 1982-05-08 | 1984-03-15 | Procedimiento para preparar 3-amino-6-aril-1, 2, 4-triazolo-(4, 3-b) piridazinas |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES530638A Expired ES8501398A1 (es) | 1982-05-08 | 1984-03-15 | Procedimiento para preparar 3-amino-6-aril-1, 2, 4-triazolo (4, 3-b) piridazinas |
Country Status (19)
Country | Link |
---|---|
EP (1) | EP0094038B1 (es) |
JP (1) | JPS58203992A (es) |
KR (1) | KR840004753A (es) |
AT (1) | ATE24728T1 (es) |
AU (1) | AU1434383A (es) |
CA (1) | CA1201122A (es) |
DE (2) | DE3217325A1 (es) |
DK (1) | DK204783A (es) |
ES (4) | ES522144A0 (es) |
FI (1) | FI831548L (es) |
GR (1) | GR79281B (es) |
HU (1) | HU189277B (es) |
IE (1) | IE55096B1 (es) |
IL (1) | IL68611A0 (es) |
MA (1) | MA19791A1 (es) |
NO (1) | NO831614L (es) |
NZ (1) | NZ204153A (es) |
PT (1) | PT76654B (es) |
ZA (1) | ZA833239B (es) |
Families Citing this family (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3311753A1 (de) * | 1983-03-31 | 1984-10-04 | Hoechst Ag, 6230 Frankfurt | Substituierte 6-aryl-1,2,4-triazolo(4,3-b)pyridazine - ihre herstellung und verwendung - |
FR2562071B1 (fr) * | 1984-03-30 | 1986-12-19 | Sanofi Sa | Triazolo(4,3-b)pyridazines, procede pour leur preparation et compositions pharmaceutiques les contenant |
US4654343A (en) * | 1985-10-31 | 1987-03-31 | American Cyanamid Company | N-substituted-N[3-(1,2,4-triazolo[4,3-b]pyridazin-6-yl)phenyl]alkanamides, carbamates and ureas |
ES2543813T3 (es) | 2004-11-02 | 2015-08-24 | Northwestern University | Compuestos de piridazina para el tratamiento de enfermedades inflamatorias |
ATE523199T1 (de) | 2004-11-02 | 2011-09-15 | Univ Northwestern | Pyridazinverbindungen und verfahren |
WO2007127375A2 (en) | 2006-04-28 | 2007-11-08 | Northwestern University | Formulations containing pyridazine compounds for treating neuroinflammatory diseases |
WO2007127474A2 (en) | 2006-04-28 | 2007-11-08 | Northwestern University | Compositions and treatments using pyridazine compounds and cholinesterase inhibitors |
EP2131839A2 (en) * | 2007-03-02 | 2009-12-16 | Northwestern University | Compositions comprising derivatives of 3-phenylpyridazine for treating seizure-related disorders |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
NL128809C (es) * | 1966-06-18 | |||
US3708484A (en) * | 1970-10-16 | 1973-01-02 | Sandoz Ag | Amino and substituted amino-s-triazolo-(4,3-b)-pyridazines |
DE2113438A1 (de) * | 1971-03-19 | 1972-09-21 | Boehringer Mannheim Gmbh | Nitrofuryl-triazolo[4,3-b]pyridazinderivate |
CA1080712A (en) * | 1976-09-22 | 1980-07-01 | Jay D. Albright | Hypotensive agents |
US4260756A (en) * | 1979-11-15 | 1981-04-07 | American Cyanamid Company | 6- And 8-heteroaryl-1,2,4-triazolo[4,3-b]pyridazines |
-
1982
- 1982-05-08 DE DE19823217325 patent/DE3217325A1/de not_active Withdrawn
-
1983
- 1983-05-04 GR GR71294A patent/GR79281B/el unknown
- 1983-05-05 EP EP83104427A patent/EP0094038B1/de not_active Expired
- 1983-05-05 DE DE8383104427T patent/DE3368931D1/de not_active Expired
- 1983-05-05 FI FI831548A patent/FI831548L/fi not_active Application Discontinuation
- 1983-05-05 AT AT83104427T patent/ATE24728T1/de not_active IP Right Cessation
- 1983-05-06 DK DK204783A patent/DK204783A/da not_active Application Discontinuation
- 1983-05-06 AU AU14343/83A patent/AU1434383A/en not_active Abandoned
- 1983-05-06 ES ES522144A patent/ES522144A0/es active Granted
- 1983-05-06 CA CA000427630A patent/CA1201122A/en not_active Expired
- 1983-05-06 ZA ZA833239A patent/ZA833239B/xx unknown
- 1983-05-06 HU HU831579A patent/HU189277B/hu unknown
- 1983-05-06 KR KR1019830001924A patent/KR840004753A/ko not_active Application Discontinuation
- 1983-05-06 MA MA20012A patent/MA19791A1/fr unknown
- 1983-05-06 IE IE1043/83A patent/IE55096B1/en unknown
- 1983-05-06 NZ NZ204153A patent/NZ204153A/en unknown
- 1983-05-06 NO NO831614A patent/NO831614L/no unknown
- 1983-05-06 PT PT76654A patent/PT76654B/pt unknown
- 1983-05-06 IL IL68611A patent/IL68611A0/xx unknown
- 1983-05-06 JP JP58078423A patent/JPS58203992A/ja active Pending
-
1984
- 1984-03-15 ES ES530640A patent/ES530640A0/es active Granted
- 1984-03-15 ES ES530639A patent/ES530639A0/es active Granted
- 1984-03-15 ES ES530638A patent/ES8501398A1/es not_active Expired
Also Published As
Publication number | Publication date |
---|---|
ES530638A0 (es) | 1984-11-16 |
FI831548L (fi) | 1983-11-09 |
JPS58203992A (ja) | 1983-11-28 |
EP0094038A1 (de) | 1983-11-16 |
KR840004753A (ko) | 1984-10-24 |
ES530639A0 (es) | 1984-11-16 |
PT76654B (de) | 1986-01-28 |
CA1201122A (en) | 1986-02-25 |
ES8501400A1 (es) | 1984-11-16 |
DK204783A (da) | 1983-11-09 |
PT76654A (de) | 1983-06-01 |
DE3217325A1 (de) | 1983-11-10 |
HU189277B (en) | 1986-06-30 |
NZ204153A (en) | 1985-04-30 |
MA19791A1 (fr) | 1983-12-31 |
NO831614L (no) | 1983-11-09 |
DK204783D0 (da) | 1983-05-06 |
IL68611A0 (en) | 1983-09-30 |
GR79281B (es) | 1984-10-22 |
ES8405800A1 (es) | 1984-06-16 |
ATE24728T1 (de) | 1987-01-15 |
ES8501398A1 (es) | 1984-11-16 |
FI831548A0 (fi) | 1983-05-05 |
AU1434383A (en) | 1983-11-10 |
DE3368931D1 (en) | 1987-02-12 |
ES522144A0 (es) | 1984-06-16 |
IE55096B1 (en) | 1990-05-23 |
EP0094038B1 (de) | 1987-01-07 |
ZA833239B (en) | 1984-01-25 |
ES530640A0 (es) | 1984-11-16 |
IE831043L (en) | 1983-11-08 |
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