ES8501363A1 - N-(substituted aminoalkanoyl)heterocyclic compounds - Google Patents
N-(substituted aminoalkanoyl)heterocyclic compoundsInfo
- Publication number
- ES8501363A1 ES8501363A1 ES521031A ES521031A ES8501363A1 ES 8501363 A1 ES8501363 A1 ES 8501363A1 ES 521031 A ES521031 A ES 521031A ES 521031 A ES521031 A ES 521031A ES 8501363 A1 ES8501363 A1 ES 8501363A1
- Authority
- ES
- Spain
- Prior art keywords
- lower alkyl
- alkylamino
- mercapto
- inclusive
- alkoxy
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
- C07D217/26—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
- C07K5/022—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2
- C07K5/0222—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2 with the first amino acid being heterocyclic, e.g. Pro, Trp
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Cardiology (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Heart & Thoracic Surgery (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Indole Compounds (AREA)
- Pyridine Compounds (AREA)
Abstract
Compounds of the formula < IMAGE > wherein R1 and R2 are hydrogen, lower alkyl or phenyl lower alkyl, R2, R3, R4, R5 and R6 are independently hydrogen, lower alkyl, lower alkenyl, lower alkynyl, aryl, fused aryl-cycloalkyl, aralkyl, cycloalkyl, heterocyclic, substituted lower alkyl, lower alkenyl, and lower alkynyl groups wherein the substituent is hydroxy, alkoxy, halo, amino, alkylamino, mercapto and alkylmercapto groups, and substituted cycloalkyl, aryl and heterocyclic groups in which the substituent is alkyl, hydroxy, alkoxy, hydroxyalkyl, halo, mercapto, alkylmercapto, mercaptoalkyl, haloalkyl, amino, alkylamino, aminoalkyl, nitro, methylenedioxy, and trifluoromethyl each R8 is lower alkyl, lower alkenyl, lower alkynyl, nitro, amino, alkylamino, dialkylamino, hydroxy, alkoxy, mercapto, alkylmercapto, hydroxyalkyl, mercaptoalkyl, halogen, haloalkyl, aminoalkyl, alkylaminoalkyl, dialkylaminoalky, sulfonamido, methylenedioxy, or trifluoromethyl, m is an integer from 0 to 2 inclusive m' is an integer from 1 to 3 inclusive, provided that when m is 0, m' is 2 or 3 and, when m is other than 0, m' is 1 or 2 n is an integer from 0 to 4 inclusive, and salts thereof, especially pharmaceutically acceptable salts with an acid or a base.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US24540781A | 1981-03-19 | 1981-03-19 |
Publications (2)
Publication Number | Publication Date |
---|---|
ES8501363A1 true ES8501363A1 (en) | 1984-12-01 |
ES521031A0 ES521031A0 (en) | 1984-12-01 |
Family
ID=22926526
Family Applications (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES510498A Expired ES8307718A1 (en) | 1981-03-19 | 1982-03-17 | N-(substituted aminoalkanoyl)heterocyclic compounds |
ES521031A Granted ES521031A0 (en) | 1981-03-19 | 1983-03-16 | PROCEDURES FOR OBTAINING AMIDOAMINOACIDES AND THE LIKE. |
ES521030A Granted ES521030A0 (en) | 1981-03-19 | 1983-03-16 | METHOD OF PREPARING AMINO AMINO ACIDS AND ANALOGS. |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES510498A Expired ES8307718A1 (en) | 1981-03-19 | 1982-03-17 | N-(substituted aminoalkanoyl)heterocyclic compounds |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES521030A Granted ES521030A0 (en) | 1981-03-19 | 1983-03-16 | METHOD OF PREPARING AMINO AMINO ACIDS AND ANALOGS. |
Country Status (21)
Country | Link |
---|---|
JP (1) | JPS57165355A (en) |
KR (1) | KR890001146B1 (en) |
AU (1) | AU558451B2 (en) |
BE (1) | BE892552A (en) |
CH (1) | CH658455A5 (en) |
DE (1) | DE3209708A1 (en) |
DK (1) | DK120982A (en) |
ES (3) | ES8307718A1 (en) |
FI (1) | FI820974L (en) |
FR (1) | FR2502149A1 (en) |
GB (1) | GB2095252B (en) |
IE (1) | IE53076B1 (en) |
IL (1) | IL65247A (en) |
IN (1) | IN156096B (en) |
IT (1) | IT1150697B (en) |
NL (1) | NL8201066A (en) |
NO (1) | NO820903L (en) |
NZ (1) | NZ200047A (en) |
PH (1) | PH18657A (en) |
SE (1) | SE8201654L (en) |
ZA (1) | ZA821833B (en) |
Families Citing this family (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3242599A1 (en) * | 1982-11-18 | 1984-05-24 | Dr. Karl Thomae Gmbh, 7950 Biberach | NEW BENZAZEPINE DERIVATIVES, THEIR PRODUCTION AND THEIR USE AS MEDICINAL PRODUCTS |
US4410520A (en) * | 1981-11-09 | 1983-10-18 | Ciba-Geigy Corporation | 3-Amino-[1]-benzazepin-2-one-1-alkanoic acids |
US4555502A (en) * | 1982-09-30 | 1985-11-26 | Merck & Co., Inc. | Aminoacyl-containing dipeptide derivatives useful as antihypertensives |
US4410807A (en) * | 1982-03-26 | 1983-10-18 | Kay Industries, Inc. | Regulating device for polyphase electrical circuits |
US4473575A (en) * | 1982-07-19 | 1984-09-25 | Ciba-Geigy Corporation | 3-Amino-(1)-benzazepin-2-one-1-alkanoic acids |
US4520025A (en) * | 1982-07-21 | 1985-05-28 | William H. Rorer, Inc. | Bicyclic nitrogen heterocyclic ethers and thioethers, and their pharmaceutical uses |
DE3302125A1 (en) * | 1983-01-22 | 1984-07-26 | Boehringer Ingelheim KG, 6507 Ingelheim | AMINO ACID DERIVATIVES, METHOD FOR THE PRODUCTION AND USE THEREOF |
FI841052A (en) * | 1983-03-16 | 1984-09-17 | Usv Pharma Corp | FOERENINGAR FOER BEHANDLING AV BLODTRYCKSSJUKDOMAR. |
DE3333454A1 (en) * | 1983-09-16 | 1985-04-11 | Hoechst Ag, 6230 Frankfurt | METHOD FOR PRODUCING N-ALKYLATED DIPEPTIDES AND THEIR ESTERS |
DE3622297A1 (en) * | 1986-07-03 | 1988-01-07 | Basf Ag | DISAZOTHIOPHENE DYES |
US5246943A (en) * | 1992-05-19 | 1993-09-21 | Warner-Lambert Company | Substituted 1,2,3,4-tetahydroisoquinolines with angiotensin II receptor antagonist properties |
ES2122941B1 (en) * | 1997-05-29 | 1999-07-01 | Esteve Quimica Sa | PROCEDURE FOR OBTAINING QUINAPRIL CHLORHYDRATE AND SOLVATES USEFUL FOR THE ISOLATION AND PURIFICATION OF QUINAPRIL CHLORHYDRATE. |
SI1333026T1 (en) | 2002-01-30 | 2007-10-31 | Servier Lab | Process for the preparation of high purity perindopril and intermediates useful in the synthesis |
ES2286325T3 (en) | 2002-12-16 | 2007-12-01 | Lupin Limited | CRYSTALLINE FORM OF QUINAPRIL CHLORHYDRATE AND PROCESS FOR PREPARATION. |
EP1603558B1 (en) * | 2003-02-28 | 2008-05-21 | Les Laboratoires Servier S.A. | Process for preparation of perindopril and salts thereof |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2503155A2 (en) * | 1980-10-02 | 1982-10-08 | Science Union & Cie | NOVEL SUBSTITUTED IMINO DIACIDES, PROCESSES FOR THEIR PREPARATION AND THEIR USE AS AN ENZYME INHIBITOR |
EP0278530A3 (en) * | 1980-08-30 | 1989-08-02 | Hoechst Aktiengesellschaft | Amino acid derivatives, process for their preparation, agents containing them and their use |
US4344949A (en) * | 1980-10-03 | 1982-08-17 | Warner-Lambert Company | Substituted acyl derivatives of 1,2,3,4-tetrahydroisoquinoline-3-carboxylic acids |
GB2086390B (en) * | 1980-11-03 | 1984-06-06 | Ciba Geigy Ag | 1-carboxy-azaalkanoylindoline-2-carboxylic acids process for their manufacture pharmaceutical preparations containing these compounds and their therapeutic application |
-
1982
- 1982-03-08 IN IN265/CAL/82A patent/IN156096B/en unknown
- 1982-03-15 PH PH26998A patent/PH18657A/en unknown
- 1982-03-15 IL IL65247A patent/IL65247A/en unknown
- 1982-03-15 NL NL8201066A patent/NL8201066A/en not_active Application Discontinuation
- 1982-03-16 SE SE8201654A patent/SE8201654L/en not_active Application Discontinuation
- 1982-03-16 AU AU81584/82A patent/AU558451B2/en not_active Ceased
- 1982-03-17 DE DE19823209708 patent/DE3209708A1/en not_active Withdrawn
- 1982-03-17 ES ES510498A patent/ES8307718A1/en not_active Expired
- 1982-03-17 GB GB8207770A patent/GB2095252B/en not_active Expired
- 1982-03-18 BE BE0/207610A patent/BE892552A/en not_active IP Right Cessation
- 1982-03-18 NO NO820903A patent/NO820903L/en unknown
- 1982-03-18 IT IT20259/82A patent/IT1150697B/en active
- 1982-03-18 JP JP57041801A patent/JPS57165355A/en active Pending
- 1982-03-18 DK DK120982A patent/DK120982A/en not_active Application Discontinuation
- 1982-03-18 ZA ZA821833A patent/ZA821833B/en unknown
- 1982-03-18 NZ NZ200047A patent/NZ200047A/en unknown
- 1982-03-18 CH CH1691/82A patent/CH658455A5/en not_active IP Right Cessation
- 1982-03-18 KR KR8201157A patent/KR890001146B1/en active
- 1982-03-19 FI FI820974A patent/FI820974L/en not_active Application Discontinuation
- 1982-03-19 IE IE635/82A patent/IE53076B1/en unknown
- 1982-03-19 FR FR8204738A patent/FR2502149A1/en active Granted
-
1983
- 1983-03-16 ES ES521031A patent/ES521031A0/en active Granted
- 1983-03-16 ES ES521030A patent/ES521030A0/en active Granted
Also Published As
Publication number | Publication date |
---|---|
CH658455A5 (en) | 1986-11-14 |
SE8201654L (en) | 1982-09-20 |
IL65247A (en) | 1987-07-31 |
ES521031A0 (en) | 1984-12-01 |
DK120982A (en) | 1982-09-20 |
IN156096B (en) | 1985-05-11 |
AU8158482A (en) | 1982-09-23 |
GB2095252A (en) | 1982-09-29 |
GB2095252B (en) | 1985-04-17 |
NL8201066A (en) | 1982-10-18 |
FR2502149A1 (en) | 1982-09-24 |
KR830009065A (en) | 1983-12-17 |
IE53076B1 (en) | 1988-06-08 |
IL65247A0 (en) | 1982-05-31 |
DE3209708A1 (en) | 1982-10-21 |
NO820903L (en) | 1982-09-20 |
FI820974L (en) | 1982-09-20 |
IT1150697B (en) | 1986-12-17 |
NZ200047A (en) | 1985-07-12 |
AU558451B2 (en) | 1987-01-29 |
ES8404317A1 (en) | 1984-05-16 |
IT8220259A0 (en) | 1982-03-18 |
KR890001146B1 (en) | 1989-04-25 |
FR2502149B1 (en) | 1985-01-18 |
ES510498A0 (en) | 1983-08-01 |
ES521030A0 (en) | 1984-05-16 |
IE820635L (en) | 1982-09-19 |
JPS57165355A (en) | 1982-10-12 |
BE892552A (en) | 1982-09-20 |
PH18657A (en) | 1985-08-29 |
ZA821833B (en) | 1983-01-26 |
ES8307718A1 (en) | 1983-08-01 |
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