ES8500243A1 - Procedimiento para la obtencion de derivados de la piridazina substituidos en posicion 3, activos sobre el sistema nervioso central - Google Patents

Procedimiento para la obtencion de derivados de la piridazina substituidos en posicion 3, activos sobre el sistema nervioso central

Info

Publication number
ES8500243A1
ES8500243A1 ES529081A ES529081A ES8500243A1 ES 8500243 A1 ES8500243 A1 ES 8500243A1 ES 529081 A ES529081 A ES 529081A ES 529081 A ES529081 A ES 529081A ES 8500243 A1 ES8500243 A1 ES 8500243A1
Authority
ES
Spain
Prior art keywords
group
preparation
nervous system
central nervous
pyridazine derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES529081A
Other languages
English (en)
Other versions
ES529081A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sanofi SA
Original Assignee
Sanofi SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi SA filed Critical Sanofi SA
Publication of ES8500243A1 publication Critical patent/ES8500243A1/es
Publication of ES529081A0 publication Critical patent/ES529081A0/es
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, ***e
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
    • C07D237/02—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings
    • C07D237/06—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D237/10—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D237/20—Nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
    • C07D237/02—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings
    • C07D237/06—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D237/10—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D237/24—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Neurosurgery (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Neurology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biomedical Technology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Psychiatry (AREA)
  • Anesthesiology (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

PROCEDIMIENTO PARA LA OBTENCION DE DERIVADOS DE PIRIDAZINA SUSTITUIDOS EN POSICION 3, DE FORMULA GENERAL (I), ASI COMO DE SUS SALES DE ADICION DE ACIDOS FARMACEUTICAMENTE ACEPTABLES.COMPRENDE LAS SIGUIENTES OPERACIONES: PRIMERA, SE HACE REACCIONAR UNA PIRIDAZINA CLORADA EN POSICION 3, DE FORMULA GENERAL (II), CON UN EXCESO DE HIDRATO DE HIDRAZINA, PARA FORMAR LA PIRIDAZINA DE FORMULA GENERAL (III); SEGUNDA, POR HIDROGENACION CATALITICA SE TRANSFORMA LA PIRIDAZINA EN LA AMINO-3 PIRIDAZINA; Y POR ULTIMO, SE HACE REACCIONAR LA AMINO-3 PIRIDAZINA CON UN COMPUESTO DE FORMULA: X-ALK-COO-R4.DE APLICACION EN COMPOSICIONES FARMACEUTICAS.
ES529081A 1983-01-27 1984-01-23 Procedimiento para la obtencion de derivados de la piridazina substituidos en posicion 3, activos sobre el sistema nervioso central Granted ES529081A0 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR8301234A FR2540113A1 (fr) 1983-01-27 1983-01-27 Acides derives de la pyridazine actifs sur le systeme nerveux central

Publications (2)

Publication Number Publication Date
ES8500243A1 true ES8500243A1 (es) 1984-10-01
ES529081A0 ES529081A0 (es) 1984-10-01

Family

ID=9285330

Family Applications (1)

Application Number Title Priority Date Filing Date
ES529081A Granted ES529081A0 (es) 1983-01-27 1984-01-23 Procedimiento para la obtencion de derivados de la piridazina substituidos en posicion 3, activos sobre el sistema nervioso central

Country Status (27)

Country Link
US (1) US4721711A (es)
EP (1) EP0117779B1 (es)
JP (1) JPS59141564A (es)
KR (1) KR910000638B1 (es)
AR (1) AR240045A1 (es)
AT (1) ATE48417T1 (es)
AU (2) AU2372984A (es)
CA (1) CA1238637A (es)
DD (1) DD220026A5 (es)
DE (1) DE3480653D1 (es)
DK (1) DK162985C (es)
ES (1) ES529081A0 (es)
FI (1) FI78691C (es)
FR (1) FR2540113A1 (es)
HU (1) HU193890B (es)
IE (1) IE57054B1 (es)
IL (1) IL70756A (es)
MA (1) MA20018A1 (es)
NO (1) NO840313L (es)
NZ (1) NZ206945A (es)
OA (1) OA07644A (es)
PH (1) PH21162A (es)
PL (1) PL142340B1 (es)
PT (1) PT77993B (es)
SG (1) SG93690G (es)
YU (1) YU14284A (es)
ZA (1) ZA84502B (es)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2540113A1 (fr) * 1983-01-27 1984-08-03 Sanofi Sa Acides derives de la pyridazine actifs sur le systeme nerveux central
DE3664772D1 (en) * 1985-01-14 1989-09-07 Boehringer Ingelheim Kg 12-amino pyridazinoû4',5':3,4¨pyrroloû2,1-a¨isoquinolines, process for their preparation and use
US5082939A (en) * 1987-01-08 1992-01-21 I.S.F. Societa Per Azioni Pyridazine derivatives
US5106973A (en) * 1987-11-23 1992-04-21 Janssen Pharmaceutica N.V. Pyridzainamine derivatives
US5631255A (en) * 1989-02-07 1997-05-20 Sanofi Pyridazine derivatives
FR2663326B2 (fr) * 1989-11-17 1992-10-16 Sanofi Sa Derives de la pyridazine, procede de preparation et compositions pharmaceutiques en contenant.
FR2668151A1 (fr) * 1990-10-23 1992-04-24 Rhone Poulenc Agrochimie Composes a groupe triazolopyridazine leurs preparations et compositions herbicides les contenant.
FR2676444B1 (fr) * 1991-05-16 1995-03-10 Sanofi Elf Nouveaux derives d'amino-3 pyridazines actifs sur le systeme nerveux central, procede de preparation et compositions pharmaceutiques en contenant.
CN1038249C (zh) * 1991-08-28 1998-05-06 罗姆和哈斯公司 含有二氢哒嗪酮及其相关化合物的杀菌组合物
US20100210590A1 (en) * 1995-09-27 2010-08-19 Northwestern University Compositions and treatments for seizure-related disorders
US20030176437A1 (en) * 2001-08-31 2003-09-18 D.M. Watterson Anti-inflammatory and protein kinase inhibitor compositions and related methods for downregulation of detrimental cellular responses and inhibition of cell death
EP1812007B1 (en) * 2004-11-02 2011-09-07 Northwestern University Pyridazine compounds and methods
ES2441718T3 (es) 2004-11-02 2014-02-06 Northwestern University Compuestos de piridazina, composiciones y métodos
US20090325973A1 (en) * 2006-04-28 2009-12-31 Watterson D Martin Formulations containing pyridazine compounds
EP2015750A2 (en) * 2006-04-28 2009-01-21 Northwestern University Compositions and treatments using pyridazine compounds and cholinesterase inhibitors
CA2650704A1 (en) * 2006-04-28 2007-11-08 Northwestern University Salts of pyridazine compounds
CN101668732A (zh) * 2007-04-02 2010-03-10 同一世界健康研究院 Cftr抑制剂化合物及其用途
WO2009131958A2 (en) * 2008-04-21 2009-10-29 Institute For Oneworld Health Compounds, compositions and methods comprising triazine derivatives
WO2009131951A2 (en) * 2008-04-21 2009-10-29 Institute For Oneworld Health Compounds, compositions and methods comprising isoxazole derivatives
WO2009131947A2 (en) * 2008-04-21 2009-10-29 Institute For Oneworld Health Compounds, compositions and methods comprising pyridazine derivatives
US8207205B2 (en) 2008-04-21 2012-06-26 Institute For Oneworld Health Compounds, compositions and methods comprising oxadiazole derivatives
JP2012503005A (ja) * 2008-09-19 2012-02-02 インスティテュート フォア ワンワールド ヘルス イミダゾール誘導体およびトリアゾール誘導体を含む、化合物、組成物ならびに方法。
US8343976B2 (en) * 2009-04-20 2013-01-01 Institute For Oneworld Health Compounds, compositions and methods comprising pyrazole derivatives
US20100267706A1 (en) * 2009-04-20 2010-10-21 Institute For Oneworld Health Compounds, Compositions and Methods Comprising Pyridazine Derivatives

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2510998B1 (fr) * 1981-08-07 1986-01-10 Sanofi Sa Nouveaux derives amines de la pyridazine, leur procede de preparation et les medicaments, a action desinhibitrice, qui en comportent
FR2510997A1 (fr) * 1981-08-10 1983-02-11 Sanofi Sa Nouveaux derives de la methyl-4 phenyl-6 pyridazine, procede pour leur preparation et medicaments actifs sur le systeme nerveux central en contenant
FR2540113A1 (fr) * 1983-01-27 1984-08-03 Sanofi Sa Acides derives de la pyridazine actifs sur le systeme nerveux central
CA1218655A (en) * 1983-01-28 1987-03-03 Kathleen Biziere Process for the preparation of pyridazine derivatives having a psychotropic action

Also Published As

Publication number Publication date
SG93690G (en) 1991-01-18
DK162985B (da) 1992-01-06
KR910000638B1 (ko) 1991-01-31
YU14284A (en) 1986-12-31
PT77993A (fr) 1984-02-01
AU2372984A (en) 1984-08-02
PL245931A1 (en) 1985-07-16
OA07644A (fr) 1985-05-23
IE57054B1 (en) 1992-04-08
FI78691B (fi) 1989-05-31
NZ206945A (en) 1987-07-31
MA20018A1 (fr) 1984-10-01
PL142340B1 (en) 1987-10-31
IL70756A0 (en) 1984-04-30
HU193890B (en) 1987-12-28
KR840007586A (ko) 1984-12-08
AU2142188A (en) 1989-03-16
FI840323A (fi) 1984-07-28
DK38984D0 (da) 1984-01-27
FI840323A0 (fi) 1984-01-26
FR2540113A1 (fr) 1984-08-03
US4721711A (en) 1988-01-26
DK162985C (da) 1992-06-01
FR2540113B1 (es) 1985-05-17
AR240045A1 (es) 1990-01-31
IE840149L (en) 1984-07-27
DK38984A (da) 1984-07-28
ES529081A0 (es) 1984-10-01
PH21162A (en) 1987-08-05
ATE48417T1 (de) 1989-12-15
ZA84502B (en) 1984-09-26
DD220026A5 (de) 1985-03-20
EP0117779B1 (fr) 1989-12-06
JPS59141564A (ja) 1984-08-14
AU652118B2 (en) 1994-08-18
NO840313L (no) 1984-07-30
DE3480653D1 (de) 1990-01-11
PT77993B (fr) 1986-04-10
FI78691C (fi) 1989-09-11
CA1238637A (en) 1988-06-28
EP0117779A1 (fr) 1984-09-05
IL70756A (en) 1987-03-31

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 19990201