ES8500243A1 - Procedimiento para la obtencion de derivados de la piridazina substituidos en posicion 3, activos sobre el sistema nervioso central - Google Patents
Procedimiento para la obtencion de derivados de la piridazina substituidos en posicion 3, activos sobre el sistema nervioso centralInfo
- Publication number
- ES8500243A1 ES8500243A1 ES529081A ES529081A ES8500243A1 ES 8500243 A1 ES8500243 A1 ES 8500243A1 ES 529081 A ES529081 A ES 529081A ES 529081 A ES529081 A ES 529081A ES 8500243 A1 ES8500243 A1 ES 8500243A1
- Authority
- ES
- Spain
- Prior art keywords
- group
- preparation
- nervous system
- central nervous
- pyridazine derivatives
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, ***e
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
- C07D237/02—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings
- C07D237/06—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D237/10—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D237/20—Nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
- C07D237/02—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings
- C07D237/06—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D237/10—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D237/24—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Neurosurgery (AREA)
- Life Sciences & Earth Sciences (AREA)
- Neurology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Biomedical Technology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Psychiatry (AREA)
- Anesthesiology (AREA)
- Pain & Pain Management (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
PROCEDIMIENTO PARA LA OBTENCION DE DERIVADOS DE PIRIDAZINA SUSTITUIDOS EN POSICION 3, DE FORMULA GENERAL (I), ASI COMO DE SUS SALES DE ADICION DE ACIDOS FARMACEUTICAMENTE ACEPTABLES.COMPRENDE LAS SIGUIENTES OPERACIONES: PRIMERA, SE HACE REACCIONAR UNA PIRIDAZINA CLORADA EN POSICION 3, DE FORMULA GENERAL (II), CON UN EXCESO DE HIDRATO DE HIDRAZINA, PARA FORMAR LA PIRIDAZINA DE FORMULA GENERAL (III); SEGUNDA, POR HIDROGENACION CATALITICA SE TRANSFORMA LA PIRIDAZINA EN LA AMINO-3 PIRIDAZINA; Y POR ULTIMO, SE HACE REACCIONAR LA AMINO-3 PIRIDAZINA CON UN COMPUESTO DE FORMULA: X-ALK-COO-R4.DE APLICACION EN COMPOSICIONES FARMACEUTICAS.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR8301234A FR2540113A1 (fr) | 1983-01-27 | 1983-01-27 | Acides derives de la pyridazine actifs sur le systeme nerveux central |
Publications (2)
Publication Number | Publication Date |
---|---|
ES8500243A1 true ES8500243A1 (es) | 1984-10-01 |
ES529081A0 ES529081A0 (es) | 1984-10-01 |
Family
ID=9285330
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES529081A Granted ES529081A0 (es) | 1983-01-27 | 1984-01-23 | Procedimiento para la obtencion de derivados de la piridazina substituidos en posicion 3, activos sobre el sistema nervioso central |
Country Status (27)
Country | Link |
---|---|
US (1) | US4721711A (es) |
EP (1) | EP0117779B1 (es) |
JP (1) | JPS59141564A (es) |
KR (1) | KR910000638B1 (es) |
AR (1) | AR240045A1 (es) |
AT (1) | ATE48417T1 (es) |
AU (2) | AU2372984A (es) |
CA (1) | CA1238637A (es) |
DD (1) | DD220026A5 (es) |
DE (1) | DE3480653D1 (es) |
DK (1) | DK162985C (es) |
ES (1) | ES529081A0 (es) |
FI (1) | FI78691C (es) |
FR (1) | FR2540113A1 (es) |
HU (1) | HU193890B (es) |
IE (1) | IE57054B1 (es) |
IL (1) | IL70756A (es) |
MA (1) | MA20018A1 (es) |
NO (1) | NO840313L (es) |
NZ (1) | NZ206945A (es) |
OA (1) | OA07644A (es) |
PH (1) | PH21162A (es) |
PL (1) | PL142340B1 (es) |
PT (1) | PT77993B (es) |
SG (1) | SG93690G (es) |
YU (1) | YU14284A (es) |
ZA (1) | ZA84502B (es) |
Families Citing this family (24)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2540113A1 (fr) * | 1983-01-27 | 1984-08-03 | Sanofi Sa | Acides derives de la pyridazine actifs sur le systeme nerveux central |
DE3664772D1 (en) * | 1985-01-14 | 1989-09-07 | Boehringer Ingelheim Kg | 12-amino pyridazinoû4',5':3,4¨pyrroloû2,1-a¨isoquinolines, process for their preparation and use |
US5082939A (en) * | 1987-01-08 | 1992-01-21 | I.S.F. Societa Per Azioni | Pyridazine derivatives |
US5106973A (en) * | 1987-11-23 | 1992-04-21 | Janssen Pharmaceutica N.V. | Pyridzainamine derivatives |
US5631255A (en) * | 1989-02-07 | 1997-05-20 | Sanofi | Pyridazine derivatives |
FR2663326B2 (fr) * | 1989-11-17 | 1992-10-16 | Sanofi Sa | Derives de la pyridazine, procede de preparation et compositions pharmaceutiques en contenant. |
FR2668151A1 (fr) * | 1990-10-23 | 1992-04-24 | Rhone Poulenc Agrochimie | Composes a groupe triazolopyridazine leurs preparations et compositions herbicides les contenant. |
FR2676444B1 (fr) * | 1991-05-16 | 1995-03-10 | Sanofi Elf | Nouveaux derives d'amino-3 pyridazines actifs sur le systeme nerveux central, procede de preparation et compositions pharmaceutiques en contenant. |
CN1038249C (zh) * | 1991-08-28 | 1998-05-06 | 罗姆和哈斯公司 | 含有二氢哒嗪酮及其相关化合物的杀菌组合物 |
US20100210590A1 (en) * | 1995-09-27 | 2010-08-19 | Northwestern University | Compositions and treatments for seizure-related disorders |
US20030176437A1 (en) * | 2001-08-31 | 2003-09-18 | D.M. Watterson | Anti-inflammatory and protein kinase inhibitor compositions and related methods for downregulation of detrimental cellular responses and inhibition of cell death |
EP1812007B1 (en) * | 2004-11-02 | 2011-09-07 | Northwestern University | Pyridazine compounds and methods |
ES2441718T3 (es) | 2004-11-02 | 2014-02-06 | Northwestern University | Compuestos de piridazina, composiciones y métodos |
US20090325973A1 (en) * | 2006-04-28 | 2009-12-31 | Watterson D Martin | Formulations containing pyridazine compounds |
EP2015750A2 (en) * | 2006-04-28 | 2009-01-21 | Northwestern University | Compositions and treatments using pyridazine compounds and cholinesterase inhibitors |
CA2650704A1 (en) * | 2006-04-28 | 2007-11-08 | Northwestern University | Salts of pyridazine compounds |
CN101668732A (zh) * | 2007-04-02 | 2010-03-10 | 同一世界健康研究院 | Cftr抑制剂化合物及其用途 |
WO2009131958A2 (en) * | 2008-04-21 | 2009-10-29 | Institute For Oneworld Health | Compounds, compositions and methods comprising triazine derivatives |
WO2009131951A2 (en) * | 2008-04-21 | 2009-10-29 | Institute For Oneworld Health | Compounds, compositions and methods comprising isoxazole derivatives |
WO2009131947A2 (en) * | 2008-04-21 | 2009-10-29 | Institute For Oneworld Health | Compounds, compositions and methods comprising pyridazine derivatives |
US8207205B2 (en) | 2008-04-21 | 2012-06-26 | Institute For Oneworld Health | Compounds, compositions and methods comprising oxadiazole derivatives |
JP2012503005A (ja) * | 2008-09-19 | 2012-02-02 | インスティテュート フォア ワンワールド ヘルス | イミダゾール誘導体およびトリアゾール誘導体を含む、化合物、組成物ならびに方法。 |
US8343976B2 (en) * | 2009-04-20 | 2013-01-01 | Institute For Oneworld Health | Compounds, compositions and methods comprising pyrazole derivatives |
US20100267706A1 (en) * | 2009-04-20 | 2010-10-21 | Institute For Oneworld Health | Compounds, Compositions and Methods Comprising Pyridazine Derivatives |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2510998B1 (fr) * | 1981-08-07 | 1986-01-10 | Sanofi Sa | Nouveaux derives amines de la pyridazine, leur procede de preparation et les medicaments, a action desinhibitrice, qui en comportent |
FR2510997A1 (fr) * | 1981-08-10 | 1983-02-11 | Sanofi Sa | Nouveaux derives de la methyl-4 phenyl-6 pyridazine, procede pour leur preparation et medicaments actifs sur le systeme nerveux central en contenant |
FR2540113A1 (fr) * | 1983-01-27 | 1984-08-03 | Sanofi Sa | Acides derives de la pyridazine actifs sur le systeme nerveux central |
CA1218655A (en) * | 1983-01-28 | 1987-03-03 | Kathleen Biziere | Process for the preparation of pyridazine derivatives having a psychotropic action |
-
1983
- 1983-01-27 FR FR8301234A patent/FR2540113A1/fr active Granted
-
1984
- 1984-01-18 CA CA000445481A patent/CA1238637A/en not_active Expired
- 1984-01-20 PH PH30135A patent/PH21162A/en unknown
- 1984-01-20 AR AR295532A patent/AR240045A1/es active
- 1984-01-23 IE IE149/84A patent/IE57054B1/en not_active IP Right Cessation
- 1984-01-23 IL IL70756A patent/IL70756A/xx unknown
- 1984-01-23 ZA ZA84502A patent/ZA84502B/xx unknown
- 1984-01-23 ES ES529081A patent/ES529081A0/es active Granted
- 1984-01-23 PT PT77993A patent/PT77993B/pt not_active IP Right Cessation
- 1984-01-24 AU AU23729/84A patent/AU2372984A/en not_active Abandoned
- 1984-01-25 DE DE8484400156T patent/DE3480653D1/de not_active Expired - Fee Related
- 1984-01-25 EP EP84400156A patent/EP0117779B1/fr not_active Expired
- 1984-01-25 AT AT84400156T patent/ATE48417T1/de not_active IP Right Cessation
- 1984-01-26 NZ NZ206945A patent/NZ206945A/en unknown
- 1984-01-26 OA OA58216A patent/OA07644A/xx unknown
- 1984-01-26 KR KR1019840000335A patent/KR910000638B1/ko not_active IP Right Cessation
- 1984-01-26 NO NO840313A patent/NO840313L/no unknown
- 1984-01-26 DD DD84259650A patent/DD220026A5/de not_active IP Right Cessation
- 1984-01-26 FI FI840323A patent/FI78691C/fi not_active IP Right Cessation
- 1984-01-26 MA MA20239A patent/MA20018A1/fr unknown
- 1984-01-26 HU HU84331A patent/HU193890B/hu not_active IP Right Cessation
- 1984-01-27 DK DK038984A patent/DK162985C/da active
- 1984-01-27 YU YU00142/84A patent/YU14284A/xx unknown
- 1984-01-27 PL PL1984245931A patent/PL142340B1/pl unknown
- 1984-01-27 JP JP59013234A patent/JPS59141564A/ja active Pending
-
1985
- 1985-10-03 US US06/783,686 patent/US4721711A/en not_active Expired - Fee Related
-
1988
- 1988-08-18 AU AU21421/88A patent/AU652118B2/en not_active Ceased
-
1990
- 1990-11-19 SG SG936/90A patent/SG93690G/en unknown
Also Published As
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FD1A | Patent lapsed |
Effective date: 19990201 |