ES8404786A1 - Procedimiento para la fabricacion de esteres de derivados de la 4-hidroximetil-1-ftalazona y sal correspondiente. - Google Patents
Procedimiento para la fabricacion de esteres de derivados de la 4-hidroximetil-1-ftalazona y sal correspondiente.Info
- Publication number
- ES8404786A1 ES8404786A1 ES519091A ES519091A ES8404786A1 ES 8404786 A1 ES8404786 A1 ES 8404786A1 ES 519091 A ES519091 A ES 519091A ES 519091 A ES519091 A ES 519091A ES 8404786 A1 ES8404786 A1 ES 8404786A1
- Authority
- ES
- Spain
- Prior art keywords
- image
- amine
- substituted
- hydrogen
- phthalazones
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 150000002148 esters Chemical class 0.000 title abstract 2
- 150000001412 amines Chemical class 0.000 abstract 4
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 3
- 125000004432 carbon atom Chemical group C* 0.000 abstract 2
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 2
- 229910052739 hydrogen Inorganic materials 0.000 abstract 2
- 239000001257 hydrogen Substances 0.000 abstract 2
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 1
- 206010065559 Cerebral arteriosclerosis Diseases 0.000 abstract 1
- 206010008132 Cerebral thrombosis Diseases 0.000 abstract 1
- 206010008190 Cerebrovascular accident Diseases 0.000 abstract 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 201000001429 Intracranial Thrombosis Diseases 0.000 abstract 1
- 229910006069 SO3H Inorganic materials 0.000 abstract 1
- 208000006011 Stroke Diseases 0.000 abstract 1
- 150000001335 aliphatic alkanes Chemical class 0.000 abstract 1
- 150000001336 alkenes Chemical class 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 150000004945 aromatic hydrocarbons Chemical class 0.000 abstract 1
- 125000003710 aryl alkyl group Chemical group 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 201000002676 cerebral atherosclerosis Diseases 0.000 abstract 1
- 230000002490 cerebral effect Effects 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- -1 cyclic imine Chemical class 0.000 abstract 1
- 150000001924 cycloalkanes Chemical class 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 201000005851 intracranial arteriosclerosis Diseases 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
- C07D237/26—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings condensed with carbocyclic rings or ring systems
- C07D237/30—Phthalazines
- C07D237/32—Phthalazines with oxygen atoms directly attached to carbon atoms of the nitrogen-containing ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/645—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having two nitrogen atoms as the only ring hetero atoms
- C07F9/6509—Six-membered rings
- C07F9/650905—Six-membered rings having the nitrogen atoms in the positions 1 and 2
- C07F9/650947—Six-membered rings having the nitrogen atoms in the positions 1 and 2 condensed with carbocyclic rings or carbocyclic ring systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Cardiology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
PROCEDIMIENTO PARA LA OBTENCION DE ESTERES DE DERIVADOS DE LA 4-HIDROXIMETIL-1-FTALAZONA Y DE SUS SALES, DE FORMULA (I), EN LA QUE R1 ES ALQUILO C1-6 Y WK PUEDE SER VARIOS TIPOS DE RADICALES.CONSISTE EN LA REACCION DE UN DERIVADO DE METIL-6,8-DIMETIL-7-ALCOXIC ARBONIL-1-FTALAZONA 4-SUSTITUIDA, DE UN COMPUESTO DE FORMULA (II), CON UN COMPUESTO DE FORMULA WK-COOH, EN LAS QUE D ES UN HALOGENO O UN GRUPO SULFONILOXI; Y R1 Y WK TIENEN EL MISMO SIGNIFICADO QUE EN LA FORMULA (I). LA REACCION SE EFECTUA EN UN DISOLVENTE POLAR ORGANICO, EN PRESENCIA DE UNA BASE, A TEMPERATURASENTRE 0J Y LA DE EBULLICION DEL DISOLVENTE.ESTOS COMPUESTOS TIENEN APLICACIONES FARMACOLOGICAS PARA EL TRATAMIENTO DE LA APOPLEJIA CEREBRAL, TROMBOSIS CEREBRAL Y ARTERIOESCLEROSIS.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP56210448A JPS58116471A (ja) | 1981-12-29 | 1981-12-29 | ４−ヒドロキシメチル−１−フタラゾンエステル誘導体およびその塩 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| ES8404786A1 true ES8404786A1 (es) | 1984-05-16 |
| ES519091A0 ES519091A0 (es) | 1984-05-16 |
Family
ID=16589493
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES519091A Granted ES519091A0 (es) | 1981-12-29 | 1982-12-29 | Procedimiento para la fabricacion de esteres de derivados de la 4-hidroximetil-1-ftalazona y sal correspondiente. |
Country Status (10)
| Country | Link |
|---|---|
| JP (1) | JPS58116471A (es) |
| BE (1) | BE895500A (es) |
| DE (1) | DE3248431A1 (es) |
| DK (1) | DK572782A (es) |
| ES (1) | ES519091A0 (es) |
| FR (1) | FR2518991A1 (es) |
| GB (1) | GB2112389A (es) |
| IT (1) | IT8225026A0 (es) |
| NL (1) | NL8205038A (es) |
| SE (1) | SE8207194L (es) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB2127805A (en) * | 1982-09-13 | 1984-04-18 | Showa Denko Kk | Phthalazones |
| AU3328499A (en) * | 1998-03-14 | 1999-10-11 | Byk Gulden Lomberg Chemische Fabrik Gmbh | Phthalazinone pde iii/iv inhibitors |
| DE19921567A1 (de) * | 1999-05-11 | 2000-11-16 | Basf Ag | Verwendung von Phthalazine-Derivaten |
| YU86001A (sh) | 1999-06-07 | 2004-07-15 | Altana Pharma Ag. | Novi preparat i oblik, u kojem se daje lek, koji sadrži aktivno jedinjenje labilno prema kiselini |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AR205004A1 (es) * | 1973-10-30 | 1976-03-31 | Ishikawa M | Procedimiento para preparar derivados de 6,8-dialquil-7-alcoxi-carbonil-4-hidroximetil-1-ftalazona y la 7,8-lactona |
-
1981
- 1981-12-29 JP JP56210448A patent/JPS58116471A/ja active Pending
-
1982
- 1982-12-16 SE SE8207194A patent/SE8207194L/xx not_active Application Discontinuation
- 1982-12-23 DE DE19823248431 patent/DE3248431A1/de not_active Withdrawn
- 1982-12-23 DK DK572782A patent/DK572782A/da not_active Application Discontinuation
- 1982-12-23 GB GB08236624A patent/GB2112389A/en not_active Withdrawn
- 1982-12-28 BE BE0/209822A patent/BE895500A/fr not_active IP Right Cessation
- 1982-12-28 FR FR8221930A patent/FR2518991A1/fr not_active Withdrawn
- 1982-12-29 ES ES519091A patent/ES519091A0/es active Granted
- 1982-12-29 NL NL8205038A patent/NL8205038A/nl not_active Application Discontinuation
- 1982-12-29 IT IT8225026A patent/IT8225026A0/it unknown
Also Published As
| Publication number | Publication date |
|---|---|
| SE8207194L (sv) | 1983-06-30 |
| DE3248431A1 (de) | 1983-07-14 |
| ES519091A0 (es) | 1984-05-16 |
| JPS58116471A (ja) | 1983-07-11 |
| BE895500A (fr) | 1983-04-15 |
| NL8205038A (nl) | 1983-07-18 |
| GB2112389A (en) | 1983-07-20 |
| DK572782A (da) | 1983-06-30 |
| IT8225026A0 (it) | 1982-12-29 |
| SE8207194D0 (sv) | 1982-12-16 |
| FR2518991A1 (fr) | 1983-07-01 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| ES8607287A1 (es) | Un procedimiento para preparar derivados de 1,8-naftiridina | |
| ATE215078T1 (de) | Verbessertes verfahren zum herstellen von geschützten 3,4-dihydroxybuttersäure estern | |
| DK0659174T3 (da) | Derivater af valproinsyre og 2-valproensyreamider samt deres anvendelse som antikonvulsive midler | |
| GR78508B (es) | ||
| ES456240A1 (es) | Procedimiento para la fabricacion de fibras, materiales tex-tiles y pastas de papel que tienen un mejor grado de blancu-ra. | |
| TW363055B (en) | Process for purifying crude (meth)acrylic acid | |
| IE811073L (en) | Heparin esters | |
| DE68918609D1 (de) | Piperidinoalkyl-Derivate von Carbonsäure-Amiden. | |
| DK0460488T3 (da) | Svovlholdige heterocykliske forbindelser | |
| ES8404786A1 (es) | Procedimiento para la fabricacion de esteres de derivados de la 4-hidroximetil-1-ftalazona y sal correspondiente. | |
| ATE214070T1 (de) | Galanthaminderivate und verfahren zu deren herstellung | |
| ES2019552A6 (es) | Procedimiento para la preparacion de glicerofosfolipidos. | |
| ATE61369T1 (de) | Verfahren zur herstellung von oximosilanen. | |
| UA43338C2 (uk) | Похідні бензолу | |
| HU900840D0 (en) | Process for preparation of aralkyl-amine-derivatives and compositions containing them | |
| ATE50558T1 (de) | Verfahren zur optischen auftrennung racemischer gemische von alpha-naphthylpropionsaeuren. | |
| GB2017087A (en) | Process for the preparation of xanthone derivatives | |
| ES8200113A1 (es) | Un procedimiento para la preparacion de derivados de cefalosporina. | |
| ES456416A1 (es) | Procedimiento para la obtencion de derivados de 14-dioxi- vincanol. | |
| EP0390305A3 (en) | Diester and keto-ester derivatives of polyhydroxy compounds and production thereof | |
| ES471267A1 (es) | Procedimiento para la preparacion de alquilo inferior 2-tri-(inferior) alquilsililacetileno-n-carbetoxiglicinatos y ami-no acidos derivados de ellos | |
| GB1445668A (en) | Process for obtaining the optical isomers of penicillamine | |
| ES8608538A1 (es) | Procedimiento para la preparacion de esteres alquilicos de alfa-l-aspartil-l-fenilalanina | |
| ES8200092A1 (es) | Procedimiento para la sintesis de esteres de la n-(4'hidro- xifenil) acetamida con acidos 5-benzoil-1-metilpirrol-2-ace-tico | |
| HUT58273A (en) | Process for producing aminoketon compounds and pharmaceutical compositions containing them |