ES8404786A1 - Esters of 4-hydroxymethyl-1- phthalazones - Google Patents
Esters of 4-hydroxymethyl-1- phthalazonesInfo
- Publication number
- ES8404786A1 ES8404786A1 ES519091A ES519091A ES8404786A1 ES 8404786 A1 ES8404786 A1 ES 8404786A1 ES 519091 A ES519091 A ES 519091A ES 519091 A ES519091 A ES 519091A ES 8404786 A1 ES8404786 A1 ES 8404786A1
- Authority
- ES
- Spain
- Prior art keywords
- image
- amine
- substituted
- hydrogen
- phthalazones
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 150000002148 esters Chemical class 0.000 title abstract 2
- 150000001412 amines Chemical class 0.000 abstract 4
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 3
- 125000004432 carbon atom Chemical group C* 0.000 abstract 2
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 2
- 229910052739 hydrogen Inorganic materials 0.000 abstract 2
- 239000001257 hydrogen Substances 0.000 abstract 2
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 1
- 206010065559 Cerebral arteriosclerosis Diseases 0.000 abstract 1
- 206010008132 Cerebral thrombosis Diseases 0.000 abstract 1
- 206010008190 Cerebrovascular accident Diseases 0.000 abstract 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 201000001429 Intracranial Thrombosis Diseases 0.000 abstract 1
- 229910006069 SO3H Inorganic materials 0.000 abstract 1
- 208000006011 Stroke Diseases 0.000 abstract 1
- 150000001335 aliphatic alkanes Chemical class 0.000 abstract 1
- 150000001336 alkenes Chemical class 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 150000004945 aromatic hydrocarbons Chemical class 0.000 abstract 1
- 125000003710 aryl alkyl group Chemical group 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 201000002676 cerebral atherosclerosis Diseases 0.000 abstract 1
- 230000002490 cerebral effect Effects 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- -1 cyclic imine Chemical class 0.000 abstract 1
- 150000001924 cycloalkanes Chemical class 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 201000005851 intracranial arteriosclerosis Diseases 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
- C07D237/26—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings condensed with carbocyclic rings or ring systems
- C07D237/30—Phthalazines
- C07D237/32—Phthalazines with oxygen atoms directly attached to carbon atoms of the nitrogen-containing ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/645—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having two nitrogen atoms as the only ring hetero atoms
- C07F9/6509—Six-membered rings
- C07F9/650905—Six-membered rings having the nitrogen atoms in the positions 1 and 2
- C07F9/650947—Six-membered rings having the nitrogen atoms in the positions 1 and 2 condensed with carbocyclic rings or carbocyclic ring systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biochemistry (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Molecular Biology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Esters of 4-hydroxymethyl-1- phthalazones useful for treating cerebral apoplexy, cerebral thrombosis and atherosclerosis are compounds having the general formula < IMAGE > wherein R1 is a C1-C6 alkyl group and R2 is -SO3H, < IMAGE > wherein R3 is hydrogen, alkyl, aryl or aralkyl, or < IMAGE > wherein W is a group formed by removal of a hydrogen atom from a ring of a cyclic imine of 4 or 5 carbon atoms which may be substituted by hydroxyl or a residual group represented by the formula < IMAGE > wherein X is a residual group which may be substituted formed by removal of 3 hydrogen atoms from an alkane, alkene, cycloalkane or aromatic hydrocarbon of 6 to 12 carbon atoms one of Y and Z is hydrogen or carboxyl, amine or substituted amine and the other is carboxyl, amine or substituted amine or are physiologically acceptable salts thereof.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP56210448A JPS58116471A (en) | 1981-12-29 | 1981-12-29 | 4-hydroxymethyl-1-phthalazone ester derivative and its ester |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| ES519091A0 ES519091A0 (en) | 1984-05-16 |
| ES8404786A1 true ES8404786A1 (en) | 1984-05-16 |
Family
ID=16589493
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES519091A Expired ES8404786A1 (en) | 1981-12-29 | 1982-12-29 | Esters of 4-hydroxymethyl-1- phthalazones |
Country Status (10)
| Country | Link |
|---|---|
| JP (1) | JPS58116471A (en) |
| BE (1) | BE895500A (en) |
| DE (1) | DE3248431A1 (en) |
| DK (1) | DK572782A (en) |
| ES (1) | ES8404786A1 (en) |
| FR (1) | FR2518991A1 (en) |
| GB (1) | GB2112389A (en) |
| IT (1) | IT8225026A0 (en) |
| NL (1) | NL8205038A (en) |
| SE (1) | SE8207194L (en) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB2127805A (en) * | 1982-09-13 | 1984-04-18 | Showa Denko Kk | Phthalazones |
| EP1070056B1 (en) * | 1998-03-14 | 2004-06-30 | ALTANA Pharma AG | Phthalazinone pde iii/iv inhibitors |
| DE19921567A1 (en) * | 1999-05-11 | 2000-11-16 | Basf Ag | Use of phthalazine derivatives |
| ATE300285T1 (en) | 1999-06-07 | 2005-08-15 | Altana Pharma Ag | NEW PREPARATION AND PHARMACEUTICAL FORM CONTAINING AN ACID LABEL PROTON PUMP INHIBITOR |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AR205004A1 (en) * | 1973-10-30 | 1976-03-31 | Ishikawa M | PROCEDURE TO PREPARE 6,8-DIALKYL-7-ALCOXY-CARBONYL-4-HYDROXIMETHYL-1-PHTHALAZONE AND 7,8-LACTONE DERIVATIVES |
-
1981
- 1981-12-29 JP JP56210448A patent/JPS58116471A/en active Pending
-
1982
- 1982-12-16 SE SE8207194A patent/SE8207194L/en not_active Application Discontinuation
- 1982-12-23 GB GB08236624A patent/GB2112389A/en not_active Withdrawn
- 1982-12-23 DE DE19823248431 patent/DE3248431A1/en not_active Withdrawn
- 1982-12-23 DK DK572782A patent/DK572782A/en not_active Application Discontinuation
- 1982-12-28 BE BE0/209822A patent/BE895500A/en not_active IP Right Cessation
- 1982-12-28 FR FR8221930A patent/FR2518991A1/en not_active Withdrawn
- 1982-12-29 NL NL8205038A patent/NL8205038A/en not_active Application Discontinuation
- 1982-12-29 ES ES519091A patent/ES8404786A1/en not_active Expired
- 1982-12-29 IT IT8225026A patent/IT8225026A0/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| SE8207194L (en) | 1983-06-30 |
| DK572782A (en) | 1983-06-30 |
| IT8225026A0 (en) | 1982-12-29 |
| JPS58116471A (en) | 1983-07-11 |
| ES519091A0 (en) | 1984-05-16 |
| NL8205038A (en) | 1983-07-18 |
| SE8207194D0 (en) | 1982-12-16 |
| GB2112389A (en) | 1983-07-20 |
| DE3248431A1 (en) | 1983-07-14 |
| BE895500A (en) | 1983-04-15 |
| FR2518991A1 (en) | 1983-07-01 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| ATE215078T1 (en) | IMPROVED METHOD FOR PRODUCING PROTECTED 3,4-DIHYDROXYBUTURIC ACID ESTERS | |
| DK0659174T3 (en) | Derivatives of valproic acid and 2-valproic acid amides as well as their use as anticonvulsants | |
| GR78508B (en) | ||
| ES456240A1 (en) | Process for stabilizing solutions of peroxidic compounds used for bleaching | |
| TW363055B (en) | Process for purifying crude (meth)acrylic acid | |
| DE68918609D1 (en) | Piperidinoalkyl derivatives of carboxylic acid amides. | |
| ES8404786A1 (en) | Esters of 4-hydroxymethyl-1- phthalazones | |
| ATE214070T1 (en) | GALANTHAMIN DERIVATIVES AND METHOD FOR THE PRODUCTION THEREOF | |
| ES2019552A6 (en) | Process for the preparation of glycerophospholipids | |
| ATE61369T1 (en) | PROCESS FOR THE PREPARATION OF OXIMOSILANES. | |
| UA43338C2 (en) | Benzene derivatives | |
| HU900840D0 (en) | Process for preparation of aralkyl-amine-derivatives and compositions containing them | |
| ATE50558T1 (en) | METHOD FOR THE OPTICAL RESOLUTION OF RACEMIC MIXTURES OF ALPHA-NAPHTHYLPROPIONIC ACIDS. | |
| GB2017087A (en) | Process for the preparation of xanthone derivatives | |
| ES456416A1 (en) | Organic compounds | |
| EP0390305A3 (en) | Diester and keto-ester derivatives of polyhydroxy compounds and production thereof | |
| ES471267A1 (en) | Lower alkyl 2-tri-(lower)alkylsilylacetylene-N-carbethoxyglycinates and process for using same | |
| GB1445668A (en) | Process for obtaining the optical isomers of penicillamine | |
| ES8608538A1 (en) | Process for the preparation of alfa-L-aspartyl-L-phenylalanine alkyl esters. | |
| ES8200092A1 (en) | Esters of N-(4'-hydroxyphenyl)acetamide with 5-benzoyl-1-methylpyrrole-2-acetic acids. | |
| HUT58273A (en) | Process for producing aminoketon compounds and pharmaceutical compositions containing them | |
| BG100704A (en) | New piperazine derivatives and methods for their preparation as well as of the compounds containing them | |
| DE3662039D1 (en) | NOVEL DIAMINE DERIVATIVES | |
| KR850001308A (en) | Metal cleaning compositions | |
| ES478072A1 (en) | 2-Methoxybenzamides |