ES8402315A1 - Procedimiento para preparar derivados de aminoglicosidos. - Google Patents

Procedimiento para preparar derivados de aminoglicosidos.

Info

Publication number
ES8402315A1
ES8402315A1 ES514767A ES514767A ES8402315A1 ES 8402315 A1 ES8402315 A1 ES 8402315A1 ES 514767 A ES514767 A ES 514767A ES 514767 A ES514767 A ES 514767A ES 8402315 A1 ES8402315 A1 ES 8402315A1
Authority
ES
Spain
Prior art keywords
derivatives
pharmaceuticals
processes
production
pharmaceutical compositions
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES514767A
Other languages
English (en)
Other versions
ES514767A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sandoz AG
Original Assignee
Sandoz AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sandoz AG filed Critical Sandoz AG
Publication of ES514767A0 publication Critical patent/ES514767A0/es
Publication of ES8402315A1 publication Critical patent/ES8402315A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/22—Cyclohexane rings, substituted by nitrogen atoms
    • C07H15/222—Cyclohexane rings substituted by at least two nitrogen atoms
    • C07H15/224—Cyclohexane rings substituted by at least two nitrogen atoms with only one saccharide radical directly attached to the cyclohexyl radical, e.g. destomycin, fortimicin, neamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/22—Cyclohexane rings, substituted by nitrogen atoms
    • C07H15/222—Cyclohexane rings substituted by at least two nitrogen atoms
    • C07H15/226—Cyclohexane rings substituted by at least two nitrogen atoms with at least two saccharide radicals directly attached to the cyclohexane rings
    • C07H15/234—Cyclohexane rings substituted by at least two nitrogen atoms with at least two saccharide radicals directly attached to the cyclohexane rings attached to non-adjacent ring carbon atoms of the cyclohexane rings, e.g. kanamycins, tobramycin, nebramycin, gentamicin A2

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Oncology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Communicable Diseases (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

PROCEDIMIENTO PARA PREPARAR DERIVADOS DE AMINOGLICOSIDOS, DE FORMULA (I), EN LA QUE R1 REPRESENTA HIDROGENO O UN GRUPO BENCENICO; R2 REPRESENTA HIDROXI O AMINO; R3 REPRESENTA HIDROGENO O HIDROXI; R4 REPRESENTA HIDROGENO O HIDROXI; R5 REPRESENTA AMINO, METILAMINO O DIMETILAMINO; Y R6 REPRESENTA HIDROGENO O METILO. CONSISTE EN SEPARAR AL MENOS UN GRUPO PROTECTOR DE UN COMPUESTO EN FORMA PROTEGIDA QUE TIENE LA SECUENCIA DE LA FORMULA (I) ANTERIORMENTE DEFINIDA, TAL COMO UN GRUPO TERC-BUTILOXICARBONILO O P-METOXIBENCILO PROTECTOR, POR TRATAMIENTO CON TRIS-TRIFLUORACETATO DE BORO, EN PRESENCIA DE TIOANISOL Y UN DISOLVENTE O DILUYENTE ORGANICO INERTE, TAL COMO EL ACIDO TRIFLUORACETICO, A UNA TEMPERATURA COMPRENDIDA ENTRE -25 Y 10 GRADOS. EL COMPUESTO OBTENIDO SE RECUPERA EN FORMA LIBRE O EN FORMA DE UNA SAL O COMPLEJO. DE APLICACION COMO ANTIBIOTICOS CON ACTIVIDAD ANTIBACTERIANA. *FORMULA*.
ES514767A 1981-08-07 1982-08-05 Procedimiento para preparar derivados de aminoglicosidos. Expired ES8402315A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CH510781 1981-08-07

Publications (2)

Publication Number Publication Date
ES514767A0 ES514767A0 (es) 1984-01-16
ES8402315A1 true ES8402315A1 (es) 1984-01-16

Family

ID=4288039

Family Applications (1)

Application Number Title Priority Date Filing Date
ES514767A Expired ES8402315A1 (es) 1981-08-07 1982-08-05 Procedimiento para preparar derivados de aminoglicosidos.

Country Status (13)

Country Link
US (1) US4503046A (es)
EP (1) EP0072351B1 (es)
JP (1) JPS5838299A (es)
AT (1) ATE14437T1 (es)
AU (1) AU8678682A (es)
CA (1) CA1196629A (es)
DE (1) DE3264906D1 (es)
DK (1) DK351982A (es)
ES (1) ES8402315A1 (es)
FI (1) FI822671L (es)
IL (1) IL66473A0 (es)
PT (1) PT75385B (es)
ZA (1) ZA825730B (es)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3334383A1 (de) * 1982-09-30 1984-04-05 Sandoz-Patent-GmbH, 7850 Lörrach Neue aminglykosidderivate, verfahren zu ihrer herstellung und ihre verwendung
US4493831A (en) * 1982-10-25 1985-01-15 Fujisawa Pharmaceutical Co., Ltd. Aminoglycoside derivatives
US6653456B2 (en) * 2001-07-31 2003-11-25 Roche Diagnostics Corporation Site-specific aminoglycoside derivatives and their use in immunodiagnostic assays
US7794713B2 (en) 2004-04-07 2010-09-14 Lpath, Inc. Compositions and methods for the treatment and prevention of hyperproliferative diseases
US20080213274A1 (en) * 2005-10-28 2008-09-04 Sabbadini Roger A Compositions and methods for the treatment and prevention of fibrotic, inflammatory, and neovascularization conditions of the eye
US20090074720A1 (en) * 2005-10-28 2009-03-19 Sabbadini Roger A Methods for decreasing immune response and treating immune conditions
US7862812B2 (en) * 2006-05-31 2011-01-04 Lpath, Inc. Methods for decreasing immune response and treating immune conditions

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4062947A (en) * 1975-11-04 1977-12-13 Schering Corporation Di-N-alkylaminoglycosides, methods for their manufacture and novel intermediates useful therein, method for their use as antibacterial agents and pharmaceutical compositions useful therefor
US4085208A (en) * 1976-06-21 1978-04-18 Schering Corporation Process for preparing 4,6-di-O-(aminoglycosyl)-1,3-diaminocyclitols and novel 1-epimers and 1-N-alkyl derivatives produced thereby; methods for the use of the 1-epimer derivatives as antibacterial agents and compositions useful therefor
DE2737264A1 (de) * 1977-08-18 1979-03-01 Bayer Ag Pseudotrisaccharide

Also Published As

Publication number Publication date
IL66473A0 (en) 1982-12-31
EP0072351A1 (en) 1983-02-16
PT75385A (en) 1982-09-01
FI822671A0 (fi) 1982-07-30
DE3264906D1 (en) 1985-08-29
ATE14437T1 (de) 1985-08-15
CA1196629A (en) 1985-11-12
DK351982A (da) 1983-02-08
ES514767A0 (es) 1984-01-16
FI822671L (fi) 1983-02-08
JPS5838299A (ja) 1983-03-05
PT75385B (en) 1985-06-28
US4503046A (en) 1985-03-05
AU8678682A (en) 1983-02-10
EP0072351B1 (en) 1985-07-24
ZA825730B (en) 1984-03-28

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 20010402