ES8308883A1 - Procedimiento para la obtencion de 2-arilimidazopiridinas. - Google Patents
Procedimiento para la obtencion de 2-arilimidazopiridinas.Info
- Publication number
- ES8308883A1 ES8308883A1 ES515084A ES515084A ES8308883A1 ES 8308883 A1 ES8308883 A1 ES 8308883A1 ES 515084 A ES515084 A ES 515084A ES 515084 A ES515084 A ES 515084A ES 8308883 A1 ES8308883 A1 ES 8308883A1
- Authority
- ES
- Spain
- Prior art keywords
- groups
- substituted
- case
- hydroxyl
- alkynyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C65/00—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
- C07C65/21—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing ether groups, groups, groups, or groups
- C07C65/24—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing ether groups, groups, groups, or groups polycyclic
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C65/00—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
- C07C65/21—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing ether groups, groups, groups, or groups
- C07C65/28—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing ether groups, groups, groups, or groups having unsaturation outside the aromatic rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
PROCEDIMIENTO PARA LA OBTENCION DE 2-ARILIMIDAZOPIRIDINAS Y DE SUS SALES FISIOLOGICAMENTE COMPATIBLES, DE FORMULA (I), EN LA QUE -A=B- ES -CH=N- O -N=CH-; Y AR ES UN RADICAL ARILICO SUSTITUIDO. CONSISTE EN LA REACCION DE UNA DIAMINOPIRIDINA DE FORMULA (II) CON UN ACIDO BENZOICO DE FORMULA HOOC-AR, O CON UNO DE SUS DERIVADOS REACTIVOS, O CON UN ALDEHIDO DE FORMULA OCH-AR, EN LAS QUE -A=B- Y AR TIENEN EL MISMO SIGNIFICADO QUE EN LA FORMULA (I). LA REACCION SE LLEVA A CABO EN UN DISOLVENTE INERTE, A TEMPERATURAS ENTRE -20 C Y 250 C, EMPLEANDO SIMULTANEAMENTE UN AGENTE DE OXIDACION CUANDO SE UTILIZA EL ALDEHIDO COMO REACTIVO. ESTOS COMPUESTOS TIENEN APLICACIONES FARMACOLOGICAS PARA COMBATIR LA INSUFICIENCIA CARDIACA.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE19813132754 DE3132754A1 (de) | 1981-08-19 | 1981-08-19 | "2-aryl-imidazo(4,5-b)pyridine, diese enthaltende pharmazeutische zubereitungen und verfahren zu ihrer herstellung" |
DE19813139064 DE3139064A1 (de) | 1981-10-01 | 1981-10-01 | 2-aryl-imidazo(4,5-c)pyridine, diese enthaltende pharmazeutische zubereitungen und verfahren zu ihrer herstellung |
Publications (2)
Publication Number | Publication Date |
---|---|
ES515084A0 ES515084A0 (es) | 1983-10-01 |
ES8308883A1 true ES8308883A1 (es) | 1983-10-01 |
Family
ID=25795377
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES515084A Expired ES8308883A1 (es) | 1981-08-19 | 1982-08-18 | Procedimiento para la obtencion de 2-arilimidazopiridinas. |
Country Status (9)
Country | Link |
---|---|
US (2) | US4616090A (es) |
EP (1) | EP0072926B1 (es) |
AU (1) | AU557714B2 (es) |
CA (2) | CA1207791A (es) |
DE (1) | DE3273461D1 (es) |
ES (1) | ES8308883A1 (es) |
HK (1) | HK7289A (es) |
HU (1) | HU189170B (es) |
IL (1) | IL66571A0 (es) |
Families Citing this family (19)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ES8401486A1 (es) * | 1981-11-10 | 1983-12-01 | Wellcome Found | Un procedimiento para la preparacion de nuevos derivados de imidazo (4,5-c)piridina. |
RO86850B (ro) * | 1982-05-03 | 1985-05-31 | Eli Lilly And Company | Procedeu pentru prepararea unor 2-fenilimidazo [4,5 c] piridine |
US4904785A (en) * | 1982-05-03 | 1990-02-27 | Eli Lilly And Company | 2-phenylimidazo[4,5-c]pyridines |
US4758574A (en) * | 1982-05-03 | 1988-07-19 | Eli Lilly And Company | 2-phenylimidazio (4,5-c) pyridines |
DE3224512A1 (de) * | 1982-07-01 | 1984-01-05 | Dr. Karl Thomae Gmbh, 7950 Biberach | Neue imidazolderivate, ihre herstellung und diese verbindungen enthaltende arzneimittel |
DE3324115A1 (de) * | 1983-07-05 | 1985-01-17 | Dr. Karl Thomae Gmbh, 7950 Biberach | Neue imidazole, ihre herstellung und diese verbindungen enthaltende arzneimittel |
CH656126A5 (de) * | 1983-08-18 | 1986-06-13 | Ciba Geigy Ag | Durch 2-propynyloxygruppen substituierte phthalsaeureanhydride. |
US4515796A (en) * | 1983-09-08 | 1985-05-07 | Eli Lilly And Company | Certain naphthalenyl imidazo compounds and their pharmaceutical use |
US4533734A (en) * | 1983-11-10 | 1985-08-06 | Eli Lilly And Company | Inotropic agents |
AT379395B (de) * | 1983-11-14 | 1985-12-27 | Laevosan Gmbh & Co Kg | Verfahren zur herstellung von neuen 2(2-thienyl)-imidazo (4,5-b) pyridin-derivaten und deren pharmazeutisch vertraeglichen saeureadditionssalzen |
GR850426B (es) * | 1984-02-24 | 1985-06-18 | Lilly Co Eli | |
US4578387A (en) * | 1984-03-05 | 1986-03-25 | Eli Lilly And Company | Inotropic agents |
DE3445299A1 (de) * | 1984-12-12 | 1986-06-19 | Dr. Karl Thomae Gmbh, 7950 Biberach | Neue imidazoderivate, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung |
IL78241A0 (en) * | 1985-03-29 | 1986-07-31 | Lilly Co Eli | Synthesis of inotropic imidazo(4,5-c)pyridine |
US4720501A (en) * | 1985-10-09 | 1988-01-19 | Chemi Linz Aktiengesellschaft | 2-(2-thienyl)-imidazo(4,5-c)pyridine derivatives and salts thereof useful in the treatment of myocardial insufficiency |
US4740599A (en) * | 1986-10-03 | 1988-04-26 | Eli Lilly And Company | Synthesis of alkylsulfinyl substituted 2-phenylimidazo(4,5-c)pyridines |
WO1994021591A1 (en) * | 1993-03-25 | 1994-09-29 | Kao Corporation | Dermatologic preparation and novel benzoic acid derivative |
IL111613A0 (en) * | 1993-11-12 | 1995-01-24 | Rhone Poulenc Rorer Ltd | Substituted phenyl compounds, their preparation and pharmaceutical compositions containing them |
JP2007063225A (ja) * | 2005-09-01 | 2007-03-15 | Takeda Chem Ind Ltd | イミダゾピリジン化合物 |
Family Cites Families (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2774791A (en) * | 1953-10-19 | 1956-12-18 | Monsanto Chemicals | Water soluble substituted p-hydroxybenzaldehyde-alkali metal and alkaline earth metal carbonate and bicarbonate solid complexes |
GB1186504A (en) * | 1966-10-15 | 1970-04-02 | Fisons Pest Control Ltd | Substituted Heterocyclic Compounds |
US3985891A (en) * | 1973-02-03 | 1976-10-12 | Boehringer Ingelheim Gmbh | 2-Phenyl-imidazo (4,5-b)pyridines and salts thereof |
DE2305339C3 (de) * | 1973-02-03 | 1980-05-08 | Dr. Karl Thomae Gmbh, 7950 Biberach | Imidazo [4,5-b] pyridine, ihre Herstellung und ihre Verwendung als Cardiötonica |
SU566842A1 (ru) * | 1976-01-06 | 1977-07-30 | Донецкое Отделение Физико-Органической Химии Института Физической Химии Им.Л.В.Писаржевского Ан Украинской Сср | Способ получени замещенных имидазопиридинов |
DE2641060A1 (de) * | 1976-09-11 | 1978-03-16 | Hoechst Ag | Beta-lactamverbindungen und verfahren zu ihrer herstellung |
US4287346A (en) * | 1979-02-16 | 1981-09-01 | Eisai Co., Ltd. | Cyanoguanidine derivatives |
US4281005A (en) * | 1979-03-05 | 1981-07-28 | Merck & Co., Inc. | Novel 2-pyridylimidazole compounds |
DE2927987A1 (de) * | 1979-07-11 | 1981-02-05 | Thomae Gmbh Dr K | Neue 2-alkoxyphenyl-imidazo eckige klammer auf 4,5-b eckige klammer zu pyridine, deren herstellung und deren verwendung als arzneimittel |
DE3037464A1 (de) * | 1980-10-03 | 1982-05-19 | Dr. Karl Thomae Gmbh, 7950 Biberach | 6-hydroxy-2-phenyl-imidazo 4,5-b zu pyridine, ihre herstellung und diese sie enthaltende arzneimittel |
DE3108027A1 (de) * | 1981-03-03 | 1982-09-16 | Dr. Karl Thomae Gmbh, 7950 Biberach | Mittel zur behandlung von koronaren herzerkrankungen |
ES8401486A1 (es) * | 1981-11-10 | 1983-12-01 | Wellcome Found | Un procedimiento para la preparacion de nuevos derivados de imidazo (4,5-c)piridina. |
US4758574A (en) * | 1982-05-03 | 1988-07-19 | Eli Lilly And Company | 2-phenylimidazio (4,5-c) pyridines |
US4904785A (en) * | 1982-05-03 | 1990-02-27 | Eli Lilly And Company | 2-phenylimidazo[4,5-c]pyridines |
-
1982
- 1982-07-23 DE DE8282106638T patent/DE3273461D1/de not_active Expired
- 1982-07-23 EP EP82106638A patent/EP0072926B1/de not_active Expired
- 1982-08-03 AU AU86692/82A patent/AU557714B2/en not_active Ceased
- 1982-08-18 CA CA000409694A patent/CA1207791A/en not_active Expired
- 1982-08-18 ES ES515084A patent/ES8308883A1/es not_active Expired
- 1982-08-18 IL IL66571A patent/IL66571A0/xx not_active IP Right Cessation
- 1982-08-19 US US06/409,471 patent/US4616090A/en not_active Expired - Fee Related
- 1982-08-19 HU HU822693A patent/HU189170B/hu not_active IP Right Cessation
-
1984
- 1984-03-29 US US06/595,010 patent/US5104881A/en not_active Expired - Fee Related
-
1986
- 1986-04-10 CA CA000506385A patent/CA1294277C/en not_active Expired - Fee Related
-
1989
- 1989-01-26 HK HK72/89A patent/HK7289A/xx unknown
Also Published As
Publication number | Publication date |
---|---|
HU189170B (en) | 1986-06-30 |
ES515084A0 (es) | 1983-10-01 |
DE3273461D1 (en) | 1986-10-30 |
EP0072926B1 (de) | 1986-09-24 |
US4616090A (en) | 1986-10-07 |
EP0072926A1 (de) | 1983-03-02 |
IL66571A0 (en) | 1982-12-31 |
CA1207791A (en) | 1986-07-15 |
CA1294277C (en) | 1992-01-14 |
AU8669282A (en) | 1983-02-24 |
AU557714B2 (en) | 1987-01-08 |
HK7289A (en) | 1989-02-03 |
US5104881A (en) | 1992-04-14 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FD1A | Patent lapsed |
Effective date: 20000301 |