ES8307297A1 - Proceso para la produccion microbiana de interferon fibro- blasto humano - Google Patents
Proceso para la produccion microbiana de interferon fibro- blasto humanoInfo
- Publication number
- ES8307297A1 ES8307297A1 ES505742A ES505742A ES8307297A1 ES 8307297 A1 ES8307297 A1 ES 8307297A1 ES 505742 A ES505742 A ES 505742A ES 505742 A ES505742 A ES 505742A ES 8307297 A1 ES8307297 A1 ES 8307297A1
- Authority
- ES
- Spain
- Prior art keywords
- polypeptides
- compositions containing
- interferon
- microbial production
- intermediates therefor
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/555—Interferons [IFN]
- C07K14/565—IFN-beta
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/70—Vectors or expression systems specially adapted for E. coli
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Biomedical Technology (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Microbiology (AREA)
- Plant Pathology (AREA)
- Physics & Mathematics (AREA)
- Crystallography & Structural Chemistry (AREA)
- Toxicology (AREA)
- Gastroenterology & Hepatology (AREA)
- Medicinal Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
PROCESO PARA LA PRODUCCION MICROBIANA DE INTERFERON FIBROBLASTO HUMANO. CONSISTE EN CULTIVAR UN MICROORGANISMO TRANSFORMADO CON UN VEHICULO DE EXPRESION MICROBIANA REPLICABLE, CAPAZ DE EXPRESAR DICHO POLIPEPTIDO EN UN MEDIO NUTRIENTE CONVENCIONAL QUE CONTENGA UN CARBONO Y UNA FUENTE DE NITROGENO, SEPARAR LOS MICROORGANISMOS OBTENIDOS DEL MEDIO NUTRIENTE Y AISLAR Y PURIFICAR DICHO POLIPEPTIDO UTILIZANDO METODOS CONOCIDOS. DICHO POLIPEPTIDO CONTIENE OPCIONALMENTE LA METIONINA AMINOACIDA COMO PRIMER AMINOACIDO DEL INTERFERON FIBROBLASTO. ADICIONALMENTE CONTIENE UN ACOPLADO SEGMENTABLE O PROTEINA DE SEÑAL MICROBIANA UNIDO AL TERMINAL-N DEL ORDINARIAMENTE PRIMER AMINOACIDO DEL INTERFERO
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US19079980A | 1980-09-25 | 1980-09-25 | |
US29189281A | 1981-08-11 | 1981-08-11 |
Publications (2)
Publication Number | Publication Date |
---|---|
ES505742A0 ES505742A0 (es) | 1983-07-01 |
ES8307297A1 true ES8307297A1 (es) | 1983-07-01 |
Family
ID=26886463
Family Applications (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES505742A Expired ES8307297A1 (es) | 1980-09-25 | 1981-09-24 | Proceso para la produccion microbiana de interferon fibro- blasto humano |
ES515033A Expired ES8306325A1 (es) | 1980-09-25 | 1982-08-16 | "proceso para la produccion microbiana de interferon fibroblasto humano". |
ES515032A Granted ES515032A0 (es) | 1980-09-25 | 1982-08-16 | "proceso para la produccion microbiana de interferon fibroblasto humano". |
Family Applications After (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES515033A Expired ES8306325A1 (es) | 1980-09-25 | 1982-08-16 | "proceso para la produccion microbiana de interferon fibroblasto humano". |
ES515032A Granted ES515032A0 (es) | 1980-09-25 | 1982-08-16 | "proceso para la produccion microbiana de interferon fibroblasto humano". |
Country Status (33)
Country | Link |
---|---|
US (1) | US5460811A (es) |
EP (1) | EP0048970A3 (es) |
AT (1) | AT380694B (es) |
AU (1) | AU582110B2 (es) |
BR (1) | BR8106137A (es) |
CA (1) | CA1341569C (es) |
CH (2) | CH656388A5 (es) |
DD (3) | DD209652A5 (es) |
DE (1) | DE3138096A1 (es) |
DK (1) | DK423381A (es) |
ES (3) | ES8307297A1 (es) |
FI (1) | FI812993L (es) |
FR (1) | FR2490675B1 (es) |
GB (1) | GB2098996B (es) |
GR (1) | GR81946B (es) |
HK (1) | HK43686A (es) |
IE (1) | IE51679B1 (es) |
IL (1) | IL63916A0 (es) |
IT (1) | IT1139487B (es) |
KE (1) | KE3630A (es) |
LU (1) | LU83648A1 (es) |
MC (1) | MC1423A1 (es) |
MT (1) | MTP900B (es) |
MY (1) | MY8600634A (es) |
NL (1) | NL8104400A (es) |
NO (1) | NO813248L (es) |
NZ (1) | NZ198445A (es) |
OA (1) | OA06908A (es) |
PL (1) | PL233194A1 (es) |
PT (1) | PT73728B (es) |
SE (1) | SE8105657L (es) |
YU (1) | YU44835B (es) |
ZW (1) | ZW23981A1 (es) |
Families Citing this family (45)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DK33181A (da) * | 1980-02-06 | 1981-08-07 | Searle & Co | Fremgangsmaade til fremstilling af et interferonlignende protein |
ZA811368B (en) | 1980-03-24 | 1982-04-28 | Genentech Inc | Bacterial polypedtide expression employing tryptophan promoter-operator |
IN156128B (es) * | 1980-04-03 | 1985-05-18 | Biogen Nv | |
DE3176011D1 (en) * | 1980-06-12 | 1987-04-23 | Japan Found Cancer | Plasmid |
DK489481A (da) * | 1980-11-10 | 1982-05-11 | Searle & Co | Plasmidvektor og frmgangsmaade til fremstilling deraf |
NZ199722A (en) * | 1981-02-25 | 1985-12-13 | Genentech Inc | Dna transfer vector for expression of exogenous polypeptide in yeast;transformed yeast strain |
JPS58110600A (ja) * | 1981-12-25 | 1983-07-01 | Kyowa Hakko Kogyo Co Ltd | ヒトβ型インタ−フエロン遺伝子を含む組みかえ体プラスミド |
IE54592B1 (en) * | 1982-03-08 | 1989-12-06 | Genentech Inc | Anumal interferons, processes involved in their production, compositions containing them, dna sequences coding therefor and espression vehicles containing such sequences and cells transformed thereby |
US5827694A (en) * | 1982-03-08 | 1998-10-27 | Genentech, Inc. | DNA encoding non-human animal interferons, vectors and hosts therefor, and recombinant production of IFN polypeptides |
US4775622A (en) * | 1982-03-08 | 1988-10-04 | Genentech, Inc. | Expression, processing and secretion of heterologous protein by yeast |
US6432677B1 (en) | 1982-03-08 | 2002-08-13 | Genentech, Inc. | Non-human animal interferons |
AU575301B2 (en) * | 1982-10-08 | 1988-07-28 | Juridical Foundation, Japanese Foundation For Cancer Research | Novel vector |
US5831023A (en) * | 1982-11-01 | 1998-11-03 | Genentech, Inc. | Recombinant animal interferon polypeptides |
US4511502A (en) * | 1982-12-22 | 1985-04-16 | Genentech, Inc. | Purification and activity assurance of precipitated heterologous proteins |
US4620948A (en) * | 1982-12-22 | 1986-11-04 | Genentech, Inc. | Purification and activity assurance of precipitated heterologous proteins |
US4512922A (en) * | 1982-12-22 | 1985-04-23 | Genentech, Inc. | Purification and activity assurance of precipitated heterologous proteins |
US4599197A (en) * | 1982-12-22 | 1986-07-08 | Genentech, Inc. | Purification and activity assurance of precipitated heterologous proteins |
US4518526A (en) * | 1982-12-22 | 1985-05-21 | Genentech, Inc. | Purification and activity assurance of precipitated heterologous proteins |
GR79124B (es) * | 1982-12-22 | 1984-10-02 | Genentech Inc | |
US5683688A (en) | 1984-05-31 | 1997-11-04 | Genentech, Inc. | Unglycosylated recombinant human lymphotoxin polypeptides and compositions |
GB8414354D0 (en) * | 1984-06-05 | 1984-07-11 | Biogen Nv | Purifying protein |
US5231176A (en) * | 1984-08-27 | 1993-07-27 | Genentech, Inc. | Distinct family DNA encoding of human leukocyte interferons |
ATE47864T1 (de) * | 1984-08-27 | 1989-11-15 | Genentech Inc | Verschiedenartige familie von menschlichen leukozyten-interferonen, zusammensetzungen, die diese enthalten, verfahren zu ihrer herstellung, sowie dna und transfektierte wirte hierfuer. |
US4680262A (en) * | 1984-10-05 | 1987-07-14 | Genentech, Inc. | Periplasmic protein recovery |
US5618920A (en) | 1985-11-01 | 1997-04-08 | Xoma Corporation | Modular assembly of antibody genes, antibodies prepared thereby and use |
EP0237019A3 (en) * | 1986-03-14 | 1988-03-09 | Toray Industries, Inc. | Interferon conjugate and production thereof using recombinant gene |
GB9022543D0 (en) * | 1990-10-17 | 1990-11-28 | Wellcome Found | Antibody production |
FR2686899B1 (fr) | 1992-01-31 | 1995-09-01 | Rhone Poulenc Rorer Sa | Nouveaux polypeptides biologiquement actifs, leur preparation et compositions pharmaceutiques les contenant. |
US5723125A (en) * | 1995-12-28 | 1998-03-03 | Tanox Biosystems, Inc. | Hybrid with interferon-alpha and an immunoglobulin Fc linked through a non-immunogenic peptide |
US20050002902A1 (en) * | 1995-12-28 | 2005-01-06 | Liming Yu | Hybrid with interferon-alpha and an immunoglobulin Fc for treatment of tumors and viral infections |
US20030026779A1 (en) * | 1999-10-15 | 2003-02-06 | Liming Yu | Treatment of tumors and viral infections with a hybrid conjugate of interferon and an immunoglobulin Fc |
US6713609B1 (en) * | 1996-07-16 | 2004-03-30 | Genentech, Inc. | Monoclonal antibodies to type I interferon receptor |
JP3576819B2 (ja) | 1997-07-30 | 2004-10-13 | キヤノン株式会社 | 情報処理装置及び印刷制御方法並びに記憶媒体 |
US20030018174A1 (en) * | 1997-10-06 | 2003-01-23 | Genentech, Inc. | Monoclonal antibodies to IFNAR2 |
EP1165835A2 (en) | 1999-03-24 | 2002-01-02 | Serono Genetics Institute S.A. | GENOMIC SEQUENCE OF THE $i(PURH) GENE AND $i(PURH)-RELATED BIALLELIC MARKERS |
WO2001079480A1 (en) | 2000-04-12 | 2001-10-25 | Human Genome Sciences, Inc. | Albumin fusion proteins |
US7544357B2 (en) * | 2001-01-09 | 2009-06-09 | Baylor Research Institute | Methods for treating autoimmune diseases in a subject and in vitro diagnostic assays |
EP1997829A1 (en) | 2001-12-21 | 2008-12-03 | Human Genome Sciences, Inc. | Albumin fusion proteins |
KR101271635B1 (ko) * | 2001-12-21 | 2013-06-12 | 휴먼 게놈 사이언시즈, 인코포레이티드 | 알부민 융합 단백질 |
PT1667708E (pt) | 2002-12-26 | 2012-09-14 | Mountain View Pharmaceuticals | Conjugados de interferão-beta-1b e polietileno glicol apresentando uma potência biológica in vitro aumentada |
EA013535B1 (ru) * | 2002-12-26 | 2010-06-30 | Маунтин Вью Фамэсьютикэлс, Инк. | Полимерный конъюгат биоактивного компонента (варианты), способ его получения и использования, фармацевтические продукты на его основе |
EP1594530A4 (en) | 2003-01-22 | 2006-10-11 | Human Genome Sciences Inc | HYBRID PROTEINS OF ALBUMIN |
CN103755800B (zh) | 2004-02-02 | 2016-02-24 | Ambrx公司 | 经修饰的人类生长激素多肽与其用途 |
JP2008543335A (ja) * | 2005-06-22 | 2008-12-04 | ジェネンテック・インコーポレーテッド | Ifnar2を標的とするための方法と組成物 |
MX2010008632A (es) | 2008-02-08 | 2010-08-30 | Ambrx Inc | Leptina-polipeptidos modificados y sus usos. |
Family Cites Families (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA1215921A (en) * | 1977-11-08 | 1986-12-30 | Arthur D. Riggs | Method and means for microbial polypeptide expression |
US4411994A (en) * | 1978-06-08 | 1983-10-25 | The President And Fellows Of Harvard College | Protein synthesis |
IN150740B (es) * | 1978-11-24 | 1982-12-04 | Hoffmann La Roche | |
US4332892A (en) * | 1979-01-15 | 1982-06-01 | President And Fellows Of Harvard College | Protein synthesis |
US4262090A (en) * | 1979-06-04 | 1981-04-14 | Cetus Corporation | Interferon production |
US4342832A (en) * | 1979-07-05 | 1982-08-03 | Genentech, Inc. | Method of constructing a replicable cloning vehicle having quasi-synthetic genes |
US4289689A (en) * | 1980-03-14 | 1981-09-15 | Hoffmann-La Roche Inc. | Preparation of homogeneous human fibroblast interferon |
ZA803943B (en) * | 1979-07-31 | 1981-06-24 | Hoffmann La Roche | Homogeneous fibroblast interferon and method for manufacture thereof |
AU538665B2 (en) * | 1979-10-30 | 1984-08-23 | Juridical Foundation, Japanese Foundation For Cancer Research | Human interferon dna |
IL58765A (en) * | 1979-11-21 | 1986-09-30 | Yeda Res & Dev | Process for the production of essentially pure messenger rna of human fibroblast interferon and process for the production of interferon beta |
US4418149A (en) * | 1980-01-10 | 1983-11-29 | President And Fellows Of Harvard College | Fused hybrid gene |
DK33181A (da) * | 1980-02-06 | 1981-08-07 | Searle & Co | Fremgangsmaade til fremstilling af et interferonlignende protein |
GB2068970B (en) * | 1980-02-06 | 1983-06-22 | Searle & Co | Recombinant dna technique for the preparation of a protein resembling human interferon |
DE3005843A1 (de) * | 1980-02-16 | 1981-09-10 | Hoechst Ag, 6000 Frankfurt | Genprodukt eines hoeheren organismus aus einem dieses gen enthaltenden mikroorganismus |
IN156128B (es) * | 1980-04-03 | 1985-05-18 | Biogen Nv | |
DE3176011D1 (en) * | 1980-06-12 | 1987-04-23 | Japan Found Cancer | Plasmid |
US4874702A (en) * | 1980-09-08 | 1989-10-17 | Biogen, Inc. | Vectors and methods for making such vectors and for expressive cloned genes |
-
1981
- 1981-09-23 NZ NZ198445A patent/NZ198445A/en unknown
- 1981-09-23 IL IL63916A patent/IL63916A0/xx unknown
- 1981-09-23 IT IT24109/81A patent/IT1139487B/it active
- 1981-09-23 FR FR8117933A patent/FR2490675B1/fr not_active Expired
- 1981-09-23 GR GR66114A patent/GR81946B/el unknown
- 1981-09-24 IE IE2224/81A patent/IE51679B1/en not_active IP Right Cessation
- 1981-09-24 AT AT0410381A patent/AT380694B/de not_active IP Right Cessation
- 1981-09-24 MT MT900A patent/MTP900B/xx unknown
- 1981-09-24 CH CH238/85A patent/CH656388A5/de not_active IP Right Cessation
- 1981-09-24 PT PT73728A patent/PT73728B/pt not_active IP Right Cessation
- 1981-09-24 AU AU75649/81A patent/AU582110B2/en not_active Ceased
- 1981-09-24 YU YU2297/81A patent/YU44835B/xx unknown
- 1981-09-24 MC MC811542A patent/MC1423A1/xx unknown
- 1981-09-24 NO NO813248A patent/NO813248L/no unknown
- 1981-09-24 CA CA000386573A patent/CA1341569C/en not_active Expired - Fee Related
- 1981-09-24 EP EP81107621A patent/EP0048970A3/en not_active Withdrawn
- 1981-09-24 DE DE19813138096 patent/DE3138096A1/de not_active Withdrawn
- 1981-09-24 NL NL8104400A patent/NL8104400A/nl not_active Application Discontinuation
- 1981-09-24 ES ES505742A patent/ES8307297A1/es not_active Expired
- 1981-09-24 BR BR8106137A patent/BR8106137A/pt unknown
- 1981-09-24 LU LU83648A patent/LU83648A1/de unknown
- 1981-09-24 SE SE8105657A patent/SE8105657L/ not_active Application Discontinuation
- 1981-09-24 ZW ZW239/81A patent/ZW23981A1/xx unknown
- 1981-09-24 GB GB8128952A patent/GB2098996B/en not_active Expired
- 1981-09-24 CH CH6169/81A patent/CH651309A5/de not_active IP Right Cessation
- 1981-09-24 DK DK423381A patent/DK423381A/da not_active Application Discontinuation
- 1981-09-25 DD DD81249414A patent/DD209652A5/de unknown
- 1981-09-25 OA OA57503A patent/OA06908A/xx unknown
- 1981-09-25 DD DD81233598A patent/DD202085A5/de unknown
- 1981-09-25 DD DD81249415A patent/DD209477A5/de unknown
- 1981-09-25 FI FI812993A patent/FI812993L/fi not_active Application Discontinuation
- 1981-09-25 PL PL23319481A patent/PL233194A1/xx unknown
-
1982
- 1982-08-16 ES ES515033A patent/ES8306325A1/es not_active Expired
- 1982-08-16 ES ES515032A patent/ES515032A0/es active Granted
-
1986
- 1986-04-14 KE KE3630A patent/KE3630A/xx unknown
- 1986-06-09 HK HK436/86A patent/HK43686A/xx unknown
- 1986-12-30 MY MY634/86A patent/MY8600634A/xx unknown
-
1989
- 1989-06-12 US US07/365,284 patent/US5460811A/en not_active Expired - Lifetime
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
ES8306325A1 (es) | "proceso para la produccion microbiana de interferon fibroblasto humano". | |
ES8207514A1 (es) | Un procedimiento para la preparacion de interferon | |
ES8304200A1 (es) | "un procedimiento para formar dna doble filamentado". | |
HK1013847A1 (en) | Gdf-1 and uog-1 proteins | |
IE822479L (en) | Dna molecules encoding certain mammalian proteins | |
AU575784B2 (en) | Swine growth hormone-like polypeptides | |
ES8506347A1 (es) | Un metodo para producir un polipeptido de tipo il-2-". | |
ES8609475A1 (es) | Procedimiento para preparar peptidos de interferon | |
EP0422217A4 (en) | Human recombinant placental ribonuclease inhibitor and method of production | |
EP0146903A3 (en) | Production of a vector encoding a novel hybrid interferon species |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
FD1A | Patent lapsed |
Effective date: 19970519 |